CYP1B1 (cytochrome P450 family 1 subfamily B member 1) - Rat Genome Database
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Gene: CYP1B1 (cytochrome P450 family 1 subfamily B member 1) Homo sapiens
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Symbol: CYP1B1
Name: cytochrome P450 family 1 subfamily B member 1
RGD ID: 736765
HGNC Page HGNC
Description: Exhibits estrogen 16-alpha-hydroxylase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including arachidonic acid metabolic process; estrogen metabolic process; and retinoid metabolic process. Predicted to localize to mitochondrion. Implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Biomarker of urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aryl hydrocarbon hydroxylase; ASGD6; CP1B; CYPIB1; cytochrome P450 1B1; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome p450, subfamily 1b, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); dioxin-inducible cytochrome p450; flavoprotein-linked monooxygenase; GLC3A; hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P4501B1; xenobiotic monooxygenase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl238,066,973 - 38,109,902 (-)EnsemblGRCh38hg38GRCh38
GRCh38238,067,509 - 38,076,151 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37238,294,746 - 38,303,323 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36238,148,250 - 38,156,796 (-)NCBINCBI36hg18NCBI36
Build 34238,206,396 - 38,214,943NCBI
Celera238,135,623 - 38,144,201 (-)NCBI
Cytogenetic Map2p22.2NCBI
HuRef238,034,680 - 38,043,258 (-)NCBIHuRef
CHM1_1238,224,106 - 38,232,684 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(-)-trans-epsilon-viniferin  (EXP)
(R)-pantothenic acid  (EXP)
(S)-naringenin  (EXP,ISO)
1,2,3,4,6,7,8-Heptachlorodibenzodioxin  (ISO)
1,2,3,4,6,7,8-Heptachlorodibenzofuran  (ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (ISO)
1,2,3,6,7,8-Hexachlorodibenzodioxin  (ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP,ISO)
1,3-Dinitropyrene  (EXP)
1,4-dihydroxy-2-naphthoic acid  (EXP,ISO)
1,4-naphthoquinone  (EXP)
1,8-Dinitropyrene  (EXP)
1-hydroxy-2-naphthoic acid  (EXP,ISO)
1-methylphenanthrene  (ISO)
1-naphthol  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2'-deoxyguanosine  (EXP)
2'-hydroxychalcone  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3',4,4',5,5'-Hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dichlorophenol  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxy-17beta-estradiol  (EXP)
2-naphthol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (EXP)
3,4,5,3',4',5'-Hexachlorobiphenyl  (ISO)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3-Methylchrysene  (EXP)
3-Nitrofluoranthene  (EXP)
4',5,7-trihydroxy-3'-methoxyflavone  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxy-17beta-estradiol  (EXP)
4-hydroxychalcone  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-methoxy-17beta-estradiol  (EXP)
4-Methylchrysene  (EXP)
4-nonylphenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-Methylchrysene  (EXP)
6-chrysenamine  (ISO)
6-hydroxyluteolin  (EXP)
6-Methylchrysene  (EXP)
6-Nitrobenzo[a]pyrene  (EXP)
6-Nitrochrysene  (EXP)
6-prenylnaringenin  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-hydroxyflavone  (EXP)
8-Br-cAMP  (EXP,ISO)
9-phenanthrol  (EXP)
acenaphthene  (EXP)
acenaphthylene  (EXP,ISO)
actinomycin D  (EXP,ISO)
adefovir pivoxil  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
AH23848  (EXP)
aldehydo-D-glucose  (EXP)
alizarin  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
Aloe emodin  (EXP)
alpha-naphthoflavone  (EXP,ISO)
amentoflavone  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
amodiaquine  (EXP)
andrographolide  (ISO)
aniline  (EXP)
anthracene  (EXP)
anthraflavic acid  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP,ISO)
arachidonic acid  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite ion  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
atrazine  (ISO)
avobenzone  (EXP)
baicalein  (EXP)
belinostat  (EXP)
benzene  (EXP)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
Benzo[a]pyrene-7,8-diol  (EXP,ISO)
benzo[a]pyrene-7,8-dione  (EXP)
benzo[b]fluoranthene  (EXP,ISO)
benzo[c]phenanthrene  (EXP)
benzo[e]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (EXP)
Benzo[j]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP,ISO)
bergomottin  (EXP)
beta-carboline  (EXP)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (ISO)
biochanin A  (EXP,ISO)
biotin  (EXP)
biphenyl  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brefeldin A  (EXP)
bucladesine  (ISO)
butan-1-ol  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
butyric acid  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calyculin a  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (ISO)
Carnosol  (EXP)
cefaloridine  (ISO)
ceric oxide  (ISO)
chelerythrine  (ISO)
chloroacetaldehyde  (EXP)
chloropicrin  (EXP)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
Chorionic gonadotropin  (ISO)
chromium atom  (EXP)
chromium(6+)  (EXP,ISO)
chrysene  (EXP,ISO)
chrysin  (EXP)
chrysin 5,7-dimethyl ether  (EXP)
chrysophanol  (EXP)
cidofovir anhydrous  (EXP)
cirsiliol  (EXP)
cisplatin  (EXP)
citral  (EXP)
clodronic acid  (EXP)
clothianidin  (EXP)
clozapine  (EXP)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
cortisol  (ISO)
coumestrol  (EXP)
curcumin  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
cypermethrin  (ISO)
D-glucose  (EXP)
daidzein  (EXP,ISO)
daunorubicin  (EXP)
DDE  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextromethorphan  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
Dibenz[a,c]anthracene  (EXP)
dibenz[a,h]anthracene  (EXP,ISO)
Dibenzo[a,e]pyrene  (ISO)
dibenzo[a,l]pyrene  (EXP,ISO)
dibromoacetic acid  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (EXP)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dihydroergotamine  (ISO)
dimethyl sulfoxide  (EXP)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
diuron  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
Droloxifene  (EXP)
ellagic acid  (ISO)
ellipticine  (EXP,ISO)
emodin  (EXP)
enilconazole  (EXP)
estrone  (EXP)
ethanol  (EXP,ISO)
ethoxyquin  (ISO)
ethylbenzene  (EXP)
ethylisopropylamiloride  (EXP)
eugenol  (EXP)
eupatorin  (EXP)
filipin III  (EXP)
fingolimod hydrochloride  (EXP)
flavanone  (EXP,ISO)
flavone  (EXP)
flavonol  (EXP)
fluoranthene  (EXP,ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (EXP)
fructose  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (EXP)
furan  (ISO)
galangin  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
genkwanin  (EXP)
gentamycin  (ISO)
geranial  (EXP)
geraniol  (EXP)
glucaric acid  (ISO)
glucoerucin  (ISO)
glucoerucin(1-)  (ISO)
glucoraphanin  (ISO)
glucose  (EXP)
glutathione  (EXP)
hesperetin  (EXP)
hexachlorobenzene  (ISO)
homoeriodictyol  (EXP)
hydrogen peroxide  (EXP)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
ICI 118551  (EXP)
ifosfamide  (EXP)
imperatorin  (EXP)
Indeno[1,2,3-cd]pyrene  (EXP)
indole-3-acetic acid  (EXP)
indole-3-methanol  (EXP,ISO)
indoles  (EXP)
indometacin  (EXP,ISO)
indoxyl sulfate  (EXP)
isoflavones  (ISO)
isoimperatorin  (EXP)
isoliquiritigenin  (EXP)
isopimpinellin  (EXP)
isoprenaline  (ISO)
isoproturon  (ISO)
isorhamnetin  (EXP)
ivermectin  (ISO)
kaempferol  (EXP)
ketoconazole  (EXP,ISO)
KN-93  (EXP)
L-methionine  (ISO)
lansoprazole  (EXP)
laquinimod  (EXP,ISO)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
linuron  (EXP,ISO)
lithocholic acid  (ISO)
luteolin  (EXP)
LY294002  (EXP)
lycopene  (ISO)
medroxyprogesterone acetate  (EXP)
MeIQx  (EXP)
melatonin  (EXP)
menadione  (EXP)
mephenytoin  (ISO)
mercury atom  (ISO)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methoxsalen  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
midazolam  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monocrotaline  (ISO)
monoethyl phthalate  (ISO)
myricetin  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-desmethylclozapine  (EXP)
N-Desmethyltamoxifen  (EXP)
N-hydroxy-PhIP  (EXP)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naphthalene  (EXP)
naphthalenes  (ISO)
naringin  (EXP)
Nicardipine  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP,ISO)
nifedipine  (ISO)
nimesulide  (EXP)
nobiletin  (EXP)
NS-398  (EXP)
O-methyleugenol  (EXP)
o-xylene  (EXP)
okadaic acid  (EXP)
oltipraz  (EXP)
omeprazole  (EXP,ISO)
organoselenium compound  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (EXP)
panobinostat  (EXP)
paracetamol  (EXP)
paricalcitol  (EXP)
perfluorononanoic acid  (EXP)
phenanthrene  (EXP)
phenanthrenes  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phenytoin  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
potassium dichromate  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
primaquine  (EXP)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP)
propranolol  (EXP)
prostaglandin E2  (EXP)
protein kinase inhibitor  (EXP)
purpurin  (EXP)
pyrene  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercitrin  (EXP)
quinidine  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
Rutecarpine  (EXP)
rutin  (EXP)
salicylamide  (EXP)
sanguinarine  (EXP)
SB 431542  (EXP)
scutellarein  (EXP)
senecionine  (EXP)
silicon dioxide  (EXP)
sinensetin  (EXP)
skatole  (EXP)
sodium acetate trihydrate  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium propionate  (EXP)
steviol  (EXP)
stevioside  (EXP)
stilbenoid  (EXP)
Sudan I  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (EXP)
sunitinib  (EXP,ISO)
suramin  (EXP)
tamoxifen  (EXP,ISO)
tangeretin  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrahydrocurcumin  (ISO)
tetraphene  (EXP,ISO)
thapsigargin  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
topotecan  (ISO)
tranilast  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP)
triclocarban  (EXP,ISO)
triclosan  (EXP,ISO)
trimethylarsine oxide  (ISO)
troglitazone  (EXP,ISO)
Tungsten carbide  (EXP)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
verapamil  (ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
wortmannin  (EXP,ISO)
Yessotoxin  (EXP)
zaragozic acid A  (ISO)
zearalenone  (EXP)
zidovudine  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
angiogenesis  (IEA)
arachidonic acid metabolic process  (IDA)
benzene-containing compound metabolic process  (ISO)
blood vessel morphogenesis  (ISS)
cell adhesion  (ISS)
cellular aromatic compound metabolic process  (IEA)
cellular response to cAMP  (ISO)
cellular response to cortisol stimulus  (ISO)
cellular response to hydrogen peroxide  (ISS)
cellular response to luteinizing hormone stimulus  (ISO)
cellular response to organic cyclic compound  (IDA)
cellular response to progesterone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
collagen fibril organization  (ISS)
dibenzo-p-dioxin metabolic process  (ISO)
DNA modification  (ISO)
endothelial cell migration  (ISS)
endothelial cell-cell adhesion  (IEA)
epoxygenase P450 pathway  (TAS)
estrogen metabolic process  (IDA)
estrous cycle  (ISO)
ganglion development  (ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (ISS)
male gonad development  (ISO)
membrane lipid catabolic process  (ISS)
negative regulation of cell adhesion mediated by integrin  (ISS)
negative regulation of cell migration  (ISS)
negative regulation of cell population proliferation  (ISS)
negative regulation of NF-kappaB transcription factor activity  (ISS)
nitric oxide biosynthetic process  (ISS)
obsolete oxidation-reduction process  (IEA,TAS)
omega-hydroxylase P450 pathway  (TAS)
positive regulation of angiogenesis  (ISS)
positive regulation of apoptotic process  (ISS)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISS)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of translation  (ISO)
positive regulation of vascular endothelial growth factor production  (ISS)
regulation of reactive oxygen species metabolic process  (ISS)
response to arsenic-containing substance  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to follicle-stimulating hormone  (ISO)
response to indole-3-methanol  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to steroid hormone  (ISO)
response to toxic substance  (IEA)
retina vasculature development in camera-type eye  (ISO)
retinal blood vessel morphogenesis  (ISS)
retinal metabolic process  (IDA)
retinol metabolic process  (IDA,IEA)
steroid metabolic process  (IDA,IEA)
sterol metabolic process  (TAS)
toxin metabolic process  (IEA)
trabecular meshwork development  (ISS)
visual perception  (TAS)
xenobiotic metabolic process  (IDA,IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
1. Alfadhli S, etal., Am J Ophthalmol. 2006 Mar;141(3):512-6.
2. Bar-Yosef U, etal., J Glaucoma. 2010 Jan;19(1):35-8. doi: 10.1097/IJG.0b013e3181a98b6f.
3. Bhattacharjee A, etal., Mol Vis. 2008 May 8;14:841-50.
4. Bhattacharyya KK, etal., J Biol Chem 1995 May 12;270(19):11595-602.
5. Chakrabarti S, etal., Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5439-44.
6. Devlin AH, etal., Mol Carcinog. 2009 Feb;48(2):110-7. doi: 10.1002/mc.20459.
7. Edward D, etal., Ophthalmic Genet. 2004 Dec;25(4):257-70.
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