CYP1B1 (cytochrome P450 family 1 subfamily B member 1) - Rat Genome Database

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Gene: CYP1B1 (cytochrome P450 family 1 subfamily B member 1) Homo sapiens
Analyze
Symbol: CYP1B1
Name: cytochrome P450 family 1 subfamily B member 1
RGD ID: 736765
HGNC Page HGNC
Description: Enables estrogen 16-alpha-hydroxylase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including arachidonic acid metabolic process; estrogen metabolic process; and retinoid metabolic process. Acts upstream of or within cellular response to organic cyclic compound. Predicted to be located in mitochondrion. Predicted to be active in intracellular membrane-bounded organelle. Implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Biomarker of urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aryl hydrocarbon hydroxylase; ASGD6; CP1B; CYPIB1; cytochrome P450 1B1; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome p450, subfamily 1b, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); dioxin-inducible cytochrome p450; flavoprotein-linked monooxygenase; GLC3A; hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P4501B1; xenobiotic monooxygenase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl238,066,973 - 38,109,902 (-)EnsemblGRCh38hg38GRCh38
GRCh38238,067,509 - 38,076,151 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37238,294,652 - 38,303,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36238,148,250 - 38,156,796 (-)NCBINCBI36hg18NCBI36
Build 34238,206,396 - 38,214,943NCBI
Celera238,135,623 - 38,144,201 (-)NCBI
Cytogenetic Map2p22.2NCBI
HuRef238,034,680 - 38,043,258 (-)NCBIHuRef
CHM1_1238,224,106 - 38,232,684 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(-)-trans-epsilon-viniferin  (EXP)
(R)-pantothenic acid  (EXP)
(S)-naringenin  (EXP,ISO)
1,2,3,4,6,7,8-Heptachlorodibenzodioxin  (ISO)
1,2,3,4,6,7,8-Heptachlorodibenzofuran  (ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (ISO)
1,2,3,6,7,8-Hexachlorodibenzodioxin  (ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP,ISO)
1,3-Dinitropyrene  (EXP)
1,4-dihydroxy-2-naphthoic acid  (EXP,ISO)
1,4-naphthoquinone  (EXP)
1,8-Dinitropyrene  (EXP)
1-hydroxy-2-naphthoic acid  (EXP,ISO)
1-methylphenanthrene  (ISO)
1-naphthol  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2'-deoxyguanosine  (EXP)
2'-hydroxychalcone  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3',4,4',5,5'-Hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dichlorophenol  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxy-17beta-estradiol  (EXP)
2-naphthol  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (EXP)
3,4,5,3',4',5'-Hexachlorobiphenyl  (ISO)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3-Methylchrysene  (EXP)
3-Nitrobenzanthrone  (EXP)
3-Nitrofluoranthene  (EXP)
4',5,7-trihydroxy-3'-methoxyflavone  (EXP)
4',5,7-Trimethoxyflavone  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxy-17beta-estradiol  (EXP)
4-hydroxychalcone  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-methoxy-17beta-estradiol  (EXP)
4-Methylchrysene  (EXP)
4-nonylphenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP)
5-Hydroxyflavone  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxyindole  (ISO)
5-Methylchrysene  (EXP)
6-chrysenamine  (ISO)
6-hydroxyluteolin  (EXP)
6-Methylchrysene  (EXP)
6-Nitrobenzo[a]pyrene  (EXP)
6-Nitrochrysene  (EXP)
6-prenylnaringenin  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-hydroxyflavone  (EXP)
8-Br-cAMP  (EXP,ISO)
9-phenanthrol  (EXP)
acenaphthene  (EXP)
acenaphthylene  (EXP,ISO)
actinomycin D  (EXP,ISO)
adefovir pivoxil  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
AH23848  (EXP)
aldehydo-D-glucose  (EXP)
alizarin  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
Aloe emodin  (EXP)
alpha-naphthoflavone  (EXP,ISO)
amentoflavone  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
amodiaquine  (EXP)
andrographolide  (ISO)
aniline  (EXP)
anthracene  (EXP)
anthraflavic acid  (EXP)
antimonite  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP,ISO)
arachidonic acid  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite ion  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
atrazine  (ISO)
avobenzone  (EXP)
baicalein  (EXP)
belinostat  (EXP)
benzene  (EXP)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
Benzo[a]pyrene-7,8-diol  (EXP,ISO)
benzo[a]pyrene-7,8-dione  (EXP)
benzo[b]fluoranthene  (EXP,ISO)
benzo[c]phenanthrene  (EXP)
benzo[e]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (EXP)
Benzo[j]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP,ISO)
bergomottin  (EXP)
beta-carboline  (EXP)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (ISO)
biochanin A  (EXP,ISO)
biotin  (EXP)
biphenyl  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brefeldin A  (EXP)
bucladesine  (ISO)
butan-1-ol  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
butyric acid  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calyculin a  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (ISO)
Carnosol  (EXP)
cefaloridine  (ISO)
ceric oxide  (ISO)
chelerythrine  (ISO)
chloroacetaldehyde  (EXP)
chloropicrin  (EXP)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
Chorionic gonadotropin  (ISO)
chromium atom  (EXP)
chromium(6+)  (EXP,ISO)
chrysene  (EXP,ISO)
chrysin  (EXP)
chrysin 5,7-dimethyl ether  (EXP)
chrysophanol  (EXP)
cidofovir anhydrous  (EXP)
cirsiliol  (EXP)
cisplatin  (EXP)
citral  (EXP)
clodronic acid  (EXP)
clothianidin  (EXP)
clozapine  (EXP)
Clozapine N-oxide  (EXP)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
cortisol  (ISO)
coumestrol  (EXP)
curcumin  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
cypermethrin  (ISO)
D-glucose  (EXP)
daidzein  (EXP,ISO)
daunorubicin  (EXP)
DDE  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
dextromethorphan  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
Dibenz[a,c]anthracene  (EXP)
dibenz[a,h]anthracene  (EXP,ISO)
Dibenzo[a,e]pyrene  (ISO)
dibenzo[a,l]pyrene  (EXP,ISO)
dibromoacetic acid  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (EXP)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dihydroergotamine  (ISO)
dimethyl sulfoxide  (EXP,ISO)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
diuron  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
Droloxifene  (EXP)
ellagic acid  (ISO)
ellipticine  (EXP,ISO)
emodin  (EXP)
enilconazole  (EXP)
Erucin  (ISO)
estrone  (EXP)
ethanol  (EXP,ISO)
ethoxyquin  (ISO)
ethylbenzene  (EXP)
ethylisopropylamiloride  (EXP)
eugenol  (EXP)
eupatorin  (EXP)
filipin III  (EXP)
fingolimod hydrochloride  (EXP)
flavanone  (EXP,ISO)
flavone  (EXP)
flavonol  (EXP)
fluoranthene  (EXP,ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (EXP)
fructose  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (EXP)
furan  (ISO)
galangin  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
genkwanin  (EXP)
gentamycin  (ISO)
geranial  (EXP)
geraniol  (EXP)
glucaric acid  (ISO)
glucoerucin  (ISO)
glucoerucin(1-)  (ISO)
glucoraphanin  (ISO)
glucose  (EXP)
glutathione  (EXP)
hesperetin  (EXP)
hexachlorobenzene  (ISO)
homoeriodictyol  (EXP)
hydrogen peroxide  (EXP)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
ICI 118551  (EXP)
ifosfamide  (EXP)
imperatorin  (EXP)
Indeno[1,2,3-cd]pyrene  (EXP)
indole-3-acetic acid  (EXP)
indole-3-methanol  (EXP,ISO)
indoles  (EXP)
indometacin  (EXP,ISO)
indoxyl sulfate  (EXP)
isoflavones  (ISO)
isoimperatorin  (EXP)
isoliquiritigenin  (EXP)
isopimpinellin  (EXP)
isoprenaline  (ISO)
isoproturon  (ISO)
isorhamnetin  (EXP)
ivermectin  (EXP,ISO)
kaempferol  (EXP)
ketoconazole  (EXP,ISO)
KN-93  (EXP)
kynurenine  (EXP)
L-methionine  (ISO)
L-tryptophan  (EXP)
lansoprazole  (EXP)
laquinimod  (EXP,ISO)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
Licochalcone A  (EXP)
linuron  (EXP,ISO)
lithocholic acid  (ISO)
luteolin  (EXP)
LY294002  (EXP)
lycopene  (ISO)
medroxyprogesterone acetate  (EXP)
MeIQx  (EXP)
melatonin  (EXP)
menadione  (EXP)
mephenytoin  (ISO)
mercury atom  (ISO)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methoxsalen  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
midazolam  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
monoethyl phthalate  (ISO)
myricetin  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-desmethylclozapine  (EXP)
N-Desmethyltamoxifen  (EXP)
N-hydroxy-PhIP  (EXP)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naphthalene  (EXP)
naphthalenes  (ISO)
naringin  (EXP)
nicardipine  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP,ISO)
nifedipine  (ISO)
nimesulide  (EXP)
nobiletin  (EXP)
NS-398  (EXP)
O-methyleugenol  (EXP)
o-xylene  (EXP)
okadaic acid  (EXP)
oltipraz  (EXP)
omeprazole  (EXP,ISO)
organoselenium compound  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (EXP)
panobinostat  (EXP)
paracetamol  (EXP)
paricalcitol  (EXP)
perfluorononanoic acid  (EXP)
phenanthrene  (EXP)
phenanthrenes  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
potassium dichromate  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
primaquine  (EXP)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP)
propranolol  (EXP)
prostaglandin E2  (EXP)
protein kinase inhibitor  (EXP)
purpurin  (EXP)
pyrene  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercitrin  (EXP)
quinidine  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
Rutecarpine  (EXP)
rutin  (EXP)
salicylamide  (EXP)
sanguinarine  (EXP)
SB 431542  (EXP)
scutellarein  (EXP)
senecionine  (EXP)
silicon dioxide  (EXP)
sinensetin  (EXP)
skatole  (EXP)
sodium acetate trihydrate  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium propionate  (EXP)
steviol  (EXP)
stevioside  (EXP)
stilbenoid  (EXP)
Sudan I  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (EXP)
sunitinib  (EXP,ISO)
suramin  (EXP)
tamoxifen  (EXP,ISO)
tangeretin  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrahydrocurcumin  (ISO)
tetraphene  (EXP,ISO)
thapsigargin  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
topotecan  (ISO)
tranilast  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP)
triclocarban  (EXP,ISO)
triclosan  (EXP,ISO)
trimethylarsine oxide  (ISO)
troglitazone  (EXP,ISO)
Tungsten carbide  (EXP)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
verapamil  (ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
wortmannin  (EXP,ISO)
Yessotoxin  (EXP)
zaragozic acid A  (ISO)
zearalenone  (EXP)
zidovudine  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEA,ISO)
angiogenesis  (IEA,ISO)
arachidonic acid metabolic process  (IDA)
benzene-containing compound metabolic process  (IEA,ISO)
blood vessel morphogenesis  (ISS)
cell adhesion  (ISS)
cellular aromatic compound metabolic process  (ISO)
cellular response to cAMP  (IEA,ISO)
cellular response to cortisol stimulus  (IEA,ISO)
cellular response to hydrogen peroxide  (ISS)
cellular response to luteinizing hormone stimulus  (IEA,ISO)
cellular response to organic cyclic compound  (IDA)
cellular response to progesterone stimulus  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
collagen fibril organization  (ISS)
dibenzo-p-dioxin metabolic process  (ISO)
DNA modification  (IEA,ISO)
endothelial cell migration  (ISO,ISS)
endothelial cell-cell adhesion  (IEA,ISO)
epoxygenase P450 pathway  (TAS)
estrogen metabolic process  (IDA,ISO)
estrous cycle  (IEA,ISO)
ganglion development  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (ISS)
male gonad development  (IEA,ISO)
membrane lipid catabolic process  (ISS)
negative regulation of cell adhesion mediated by integrin  (ISS)
negative regulation of cell migration  (ISS)
negative regulation of cell population proliferation  (ISS)
negative regulation of NF-kappaB transcription factor activity  (ISS)
nitric oxide biosynthetic process  (ISS)
omega-hydroxylase P450 pathway  (TAS)
positive regulation of angiogenesis  (ISS)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of DNA biosynthetic process  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (IEA,ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISS)
positive regulation of smooth muscle cell migration  (IEA,ISO)
positive regulation of translation  (IEA,ISO)
positive regulation of vascular endothelial growth factor production  (ISS)
regulation of reactive oxygen species metabolic process  (ISS)
response to arsenic-containing substance  (IEA,ISO)
response to dexamethasone  (IEA,ISO)
response to estradiol  (IEA,ISO)
response to follicle-stimulating hormone  (IEA,ISO)
response to indole-3-methanol  (IEA,ISO)
response to nutrient  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to steroid hormone  (ISO)
response to toxic substance  (IEA,ISO)
retina vasculature development in camera-type eye  (ISO)
retinal blood vessel morphogenesis  (ISS)
retinal metabolic process  (IDA)
retinol metabolic process  (IDA,IEA)
steroid metabolic process  (IDA,IEA)
sterol metabolic process  (TAS)
toxin metabolic process  (IEA,ISO)
trabecular meshwork development  (ISS)
xenobiotic metabolic process  (IDA,IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
1. Alfadhli S, etal., Am J Ophthalmol. 2006 Mar;141(3):512-6.
2. Bar-Yosef U, etal., J Glaucoma. 2010 Jan;19(1):35-8. doi: 10.1097/IJG.0b013e3181a98b6f.
3. Bhattacharjee A, etal., Mol Vis. 2008 May 8;14:841-50.
4. Bhattacharyya KK, etal., J Biol Chem 1995 May 12;270(19):11595-602.
5. Chakrabarti S, etal., Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5439-44.
6. Devlin AH, etal., Mol Carcinog. 2009 Feb;48(2):110-7. doi: 10.1002/mc.20459.
7. Edward D, etal., Ophthalmic Genet. 2004 Dec;25(4):257-70.
8. El-Gayar S, etal., Mol Vis. 2009 Jul 8;15:1325-31.
9. GOA_HUMAN data from the GO Consortium
10. Hilal L, etal., Mol Vis. 2010 Jul 2;16:1215-26.
11. Jennings BL, etal., Hypertension. 2010 Oct;56(4):667-74. doi: 10.1161/HYPERTENSIONAHA.110.154518. Epub 2010 Aug 30.
12. KEGG
13. Kumar A, etal., Mol Vis. 2007 Apr 30;13:667-76.
14. Libby RT, etal., Science 2003 Mar 7;299(5612):1578-81.
15. Melki R, etal., Mol Vis. 2005 Nov 23;11:1012-7.
16. Milla E, etal., Mol Vis. 2013 Aug 4;19:1707-22. Print 2013.
17. OMIM Disease Annotation Pipeline
18. Pipeline to import KEGG annotations from KEGG into RGD
19. Plasilova M, etal., J Med Genet. 1999 Apr;36(4):290-4.
20. Putluri N, etal., Cancer Res. 2011 Dec 15;71(24):7376-86. doi: 10.1158/0008-5472.CAN-11-1154. Epub 2011 Oct 11.
21. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. RGD automated import pipeline for gene-chemical interactions
23. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
24. Soley GC, etal., J Glaucoma. 2003 Feb;12(1):27-30.
25. Stoilov I, etal., Hum Mol Genet. 1997 Apr;6(4):641-7.
26. Trombino AF, etal., Breast Cancer Res Treat. 2000 Sep;63(2):117-31.
27. Watanabe J, etal., Pharmacogenetics. 2000 Feb;10(1):25-33.
28. Yang M, etal., Mol Vis. 2009;15:432-7. Epub 2009 Feb 27.
Additional References at PubMed
PMID:1925598   PMID:8175734   PMID:8910454   PMID:9463332   PMID:9497261   PMID:9823305   PMID:9890157   PMID:10614688   PMID:10681376   PMID:10871058   PMID:11221602   PMID:11303589  
PMID:11389067   PMID:11403040   PMID:11452143   PMID:11555828   PMID:11558822   PMID:11749050   PMID:11774072   PMID:11854439   PMID:11955671   PMID:12010864   PMID:12183407   PMID:12200121  
PMID:12372064   PMID:12385014   PMID:12415427   PMID:12419832   PMID:12477932   PMID:12520071   PMID:12525557   PMID:12598442   PMID:12602902   PMID:12618873   PMID:12692107   PMID:12718576  
PMID:12770747   PMID:12807732   PMID:12837283   PMID:12844487   PMID:12865317   PMID:14507861   PMID:14520706   PMID:14562027   PMID:14634838   PMID:14656940   PMID:14729846   PMID:14734460  
PMID:14744739   PMID:14961553   PMID:15072827   PMID:15075793   PMID:15102677   PMID:15122594   PMID:15128046   PMID:15177664   PMID:15199113   PMID:15255109   PMID:15255550   PMID:15258110  
PMID:15285606   PMID:15297370   PMID:15299091   PMID:15333708   PMID:15342454   PMID:15342556   PMID:15342693   PMID:15382051   PMID:15386537   PMID:15475877   PMID:15489334   PMID:15596250  
PMID:15636228   PMID:15654505   PMID:15723004   PMID:15733270   PMID:15734954   PMID:15734958   PMID:15774541   PMID:15777990   PMID:15808404