Gene: CLCN3 (chloride voltage-gated channel 3) Homo sapiens
Symbol: CLCN3
Name: chloride voltage-gated channel 3
Description: This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: chloride channel 3; chloride channel protein 3; chloride channel, voltage-sensitive 3; chloride transporter ClC-3; ClC-3; CLC3; DKFZp564I0463; H(+)/Cl(-) exchange transporter 3; OTTHUMP00000219460; OTTHUMP00000219503; OTTHUMP00000219505; OTTHUMP00000219506
Mus musculus (house mouse) : Clcn3 (chloride channel, voltage-sensitive 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Clcn3 (chloride voltage-gated channel 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clcn3 (chloride voltage-gated channel 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCN3 (chloride voltage-gated channel 3)
Canis lupus familiaris (dog) : CLCN3 (chloride voltage-gated channel 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clcn3 (chloride voltage-gated channel 3)
more info ...
Related Pseudogenes: CLCN3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh384169,620,521 - 169,723,187 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374170,541,672 - 170,644,338 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364170,778,297 - 170,878,732 (+)NCBINCBI36hg18NCBI36
Build 344170,916,451 - 171,016,886NCBI
Celera4167,874,695 - 167,975,138 (+)NCBI
Cytogenetic Map4q33NCBI
HuRef4166,296,448 - 166,399,155 (+)NCBIHuRef
CHM1_14170,518,267 - 170,620,908 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CLCN3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730986
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2018-03-13
Status: ACTIVE