Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CLCN3 (chloride voltage-gated channel 3) Homo sapiens
Symbol: CLCN3
Name: chloride voltage-gated channel 3
Description: Exhibits PDZ domain binding activity; protein heterodimerization activity; and volume-sensitive chloride channel activity. Involved in chloride transmembrane transport and negative regulation of cell volume. Localizes to several cellular components, including the GABA-ergic synapse; cytoplasmic vesicle; and external side of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: chloride channel 3; chloride channel protein 3; chloride channel, voltage-sensitive 3; chloride transporter ClC-3; ClC-3; CLC3; DKFZp564I0463; H(+)/Cl(-) exchange transporter 3
Mus musculus (house mouse) : Clcn3 (chloride channel, voltage-sensitive 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Clcn3 (chloride voltage-gated channel 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clcn3 (chloride voltage-gated channel 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCN3 (chloride voltage-gated channel 3)
Canis lupus familiaris (dog) : CLCN3 (chloride voltage-gated channel 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clcn3 (chloride voltage-gated channel 3)
Sus scrofa (pig) : CLCN3 (chloride voltage-gated channel 3)
Chlorocebus sabaeus (African green monkey) : CLCN3 (chloride voltage-gated channel 3)
Heterocephalus glaber (naked mole-rat) : Clcn3 (chloride voltage-gated channel 3)
more info ...
Related Pseudogenes: CLCN3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl4169,612,633 - 169,723,673 (+)Ensembl
GRCh384169,620,578 - 169,723,673 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374170,541,672 - 170,644,338 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364170,778,297 - 170,878,732 (+)NCBINCBI36hg18NCBI36
Build 344170,916,451 - 171,016,886NCBI
Celera4167,874,695 - 167,975,138 (+)NCBI
Cytogenetic Map4q33NCBI
HuRef4166,296,448 - 166,399,155 (+)NCBIHuRef
CHM1_14170,518,267 - 170,620,908 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CLCN3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730986
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.