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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320047
Species: Homo sapiens
RGD Object: Gene
Symbol: DTYMK
Name: deoxythymidylate kinase
Acc ID: CHEBI:10110
Term: zidovudine
Definition: A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.
Chemical ID: MESH:D015215
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DTYMKaffects response to substanceEXP 6480464CTDDTYMK protein affects the susceptibility to ZidovudinePMID:28683400
DTYMKmultiple interactionsEXP 6480464CTD[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of and affects the phosphorylation of DNM1L protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of DNM1L mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the localization of DNM1L protein; DTYMK gene mutant form results in increased phosphorylation of and results in increased susceptibility to ZidovudinePMID:17375075 PMID:28683400
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