TK1 (thymidine kinase 1) - Rat Genome Database

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Gene: TK1 (thymidine kinase 1) Homo sapiens
Analyze
Symbol: TK1
Name: thymidine kinase 1
RGD ID: 736473
HGNC Page HGNC:11830
Description: Enables identical protein binding activity; thymidine kinase activity; and zinc ion binding activity. Involved in DNA synthesis involved in mitotic DNA replication; protein homotetramerization; and thymidine biosynthetic process. Predicted to be located in cytosol. Biomarker of breast cancer; cervix carcinoma; and lung non-small cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cytosolic thymidine kinase; thymidine kinase 1 soluble isoform; thymidine kinase 1, soluble; thymidine kinase, cytosolic; thymidine kinase-1; TK2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,174,079 - 78,187,204 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,174,091 - 78,187,233 (-)EnsemblGRCh38hg38GRCh38
GRCh371776,170,160 - 76,183,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,681,755 - 73,694,880 (-)NCBINCBI36Build 36hg18NCBI36
Build 341773,681,775 - 73,694,726NCBI
Celera1772,766,591 - 72,779,726 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,594,292 - 71,607,377 (-)NCBIHuRef
CHM1_11776,234,697 - 76,247,823 (-)NCBICHM1_1
T2T-CHM13v2.01779,068,173 - 79,081,298 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-schisandrin B  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-diaminotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (EXP)
2-palmitoylglycerol  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
azathioprine  (EXP)
beauvericin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
coumestrol  (EXP)
Cuprizon  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
cytarabine  (EXP)
D-glucitol  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
diclofenac  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
enniatin  (EXP)
Enterolactone  (EXP)
enzyme inhibitor  (EXP)
ethanol  (EXP)
ethyl methanesulfonate  (EXP)
fenvalerate  (ISO)
flavonoids  (EXP)
floxuridine  (EXP)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
FR900359  (EXP)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
geraniol  (EXP)
hydrogen peroxide  (EXP)
imidacloprid  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
lidocaine  (ISO)
menadione  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (EXP)
mitomycin C  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
naphthalene  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
niclosamide  (EXP)
nitric oxide  (EXP)
obeticholic acid  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phytoestrogen  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
potassium bromate  (ISO)
potassium dichromate  (EXP)
procarbazine  (ISO)
progesterone  (EXP,ISO)
resveratrol  (EXP)
rotenone  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sulindac sulfide  (EXP)
sunitinib  (EXP)
tamoxifen  (ISO)
Tanshinone I  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trabectedin  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
urethane  (EXP)
vancomycin  (ISO)
vinclozolin  (ISO)
zalcitabine  (EXP)
zidovudine  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

References

References - curated
# Reference Title Reference Citation
1. Clinical value of thymidine kinase in patients with cervical carcinoma. Fujiwaki R, etal., Oncology. 2001;61(1):47-54.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. The clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti-TK1 antibody. He Q, etal., Int J Biol Markers. 2000 Apr-Jun;15(2):139-46.
4. Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer. Li HX, etal., Oncol Rep. 2005 Jan;13(1):145-9.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:1370831   PMID:1848304   PMID:2026611   PMID:2263164   PMID:2538159   PMID:3128713   PMID:3301530   PMID:3335503   PMID:3785218   PMID:6549046   PMID:8786092   PMID:9575153  
PMID:10924519   PMID:11389691   PMID:11992400   PMID:12449723   PMID:12477932   PMID:12699056   PMID:14659972   PMID:14697231   PMID:14701726   PMID:14719072   PMID:15153115   PMID:15231747  
PMID:15353126   PMID:15489334   PMID:15611477   PMID:15733844   PMID:15809747   PMID:15978330   PMID:16169070   PMID:16964243   PMID:16969512   PMID:17065087   PMID:17227951   PMID:17407781  
PMID:18615770   PMID:19087190   PMID:19123476   PMID:19282758   PMID:19396699   PMID:19654105   PMID:19738201   PMID:19913121   PMID:19957115   PMID:20003201   PMID:20140744   PMID:20354751  
PMID:20372850   PMID:20450760   PMID:20479645   PMID:20544518   PMID:20544519   PMID:20554529   PMID:20560637   PMID:20592392   PMID:20628086   PMID:20849417   PMID:21461837   PMID:21505426  
PMID:21545220   PMID:21654808   PMID:21764789   PMID:21832049   PMID:21873635   PMID:21900206   PMID:21988832   PMID:22027876   PMID:22143937   PMID:22263569   PMID:22385435   PMID:22658674  
PMID:22741536   PMID:23116493   PMID:23179401   PMID:23229746   PMID:23693054   PMID:24455740   PMID:25416956   PMID:25769404   PMID:25796446   PMID:25881026   PMID:25921119   PMID:25964590  
PMID:26186194   PMID:26231311   PMID:26496610   PMID:26841866   PMID:27002755   PMID:27069161   PMID:27079872   PMID:27114546   PMID:27625087   PMID:28093273   PMID:28319085   PMID:28380382  
PMID:28514442   PMID:28515276   PMID:28651488   PMID:28675297   PMID:29162134   PMID:29189449   PMID:29247745   PMID:29266545   PMID:29467282   PMID:29490077   PMID:29575921   PMID:29656893  
PMID:29689706   PMID:29866926   PMID:29955894   PMID:30039979   PMID:30317880   PMID:30463901   PMID:30985967   PMID:31048545   PMID:31091453   PMID:31138881   PMID:31306099   PMID:31343991  
PMID:31346846   PMID:31589613   PMID:31871319   PMID:31937617   PMID:31980649   PMID:32202305   PMID:32296183   PMID:32336110   PMID:32345121   PMID:32382111   PMID:32466590   PMID:32490681  
PMID:32687490   PMID:32786267   PMID:32807901   PMID:32814053   PMID:32838362   PMID:32928264   PMID:33040823   PMID:33277362   PMID:33306668   PMID:33517301   PMID:33517319   PMID:33961781  
PMID:34299191   PMID:34521624   PMID:34591612   PMID:34672954   PMID:35156780   PMID:35220246   PMID:35256949   PMID:35563538   PMID:35696571   PMID:35944360   PMID:36114006   PMID:36215168  
PMID:36398662   PMID:36537216   PMID:36982234   PMID:37673047   PMID:37689310   PMID:37715794   PMID:37827155   PMID:38033034   PMID:38113892  


Genomics

Comparative Map Data
TK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,174,079 - 78,187,204 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,174,091 - 78,187,233 (-)EnsemblGRCh38hg38GRCh38
GRCh371776,170,160 - 76,183,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,681,755 - 73,694,880 (-)NCBINCBI36Build 36hg18NCBI36
Build 341773,681,775 - 73,694,726NCBI
Celera1772,766,591 - 72,779,726 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,594,292 - 71,607,377 (-)NCBIHuRef
CHM1_11776,234,697 - 76,247,823 (-)NCBICHM1_1
T2T-CHM13v2.01779,068,173 - 79,081,298 (-)NCBIT2T-CHM13v2.0
Tk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,706,345 - 117,716,913 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,706,352 - 117,716,918 (-)EnsemblGRCm39 Ensembl
GRCm3811117,815,519 - 117,826,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,815,526 - 117,826,092 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711117,676,833 - 117,687,328 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611117,631,616 - 117,642,043 (-)NCBIMGSCv36mm8
Celera11129,560,644 - 129,571,039 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
Tk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,533,449 - 103,544,818 (-)NCBIGRCr8
mRatBN7.210103,034,755 - 103,046,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,031,521 - 103,046,920 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,135,849 - 108,147,124 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,598,960 - 107,610,235 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,955,543 - 102,966,869 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,817,556 - 106,828,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,817,601 - 106,828,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,456,781 - 106,468,109 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10101,594,738 - 101,606,057 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
Tk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555064,379,830 - 4,394,713 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555064,379,830 - 4,390,729 (+)NCBIChiLan1.0ChiLan1.0
TK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,224,936 - 94,238,043 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,053,616 - 99,067,499 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,251,416 - 72,265,308 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11777,803,938 - 77,816,747 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,803,749 - 77,816,747 (-)Ensemblpanpan1.1panPan2
TK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,959,450 - 2,970,908 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl92,959,488 - 2,971,064 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,642,982 - 3,654,416 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.093,637,295 - 3,648,793 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl93,637,262 - 3,648,777 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.193,660,373 - 3,671,812 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,784,580 - 3,796,015 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,866,010 - 3,877,445 (+)NCBIUU_Cfam_GSD_1.0
Tk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,599,359 - 3,627,016 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,784,226 - 2,794,830 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365942,784,891 - 2,794,693 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,786,031 - 3,795,917 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,785,997 - 3,794,824 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,186,103 - 70,200,689 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1670,186,767 - 70,200,610 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607741,294,951 - 41,309,587 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248017,685,017 - 7,692,872 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248017,685,003 - 7,692,949 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TK1
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q25.3(chr17:78092236-83086677)x3 copy number gain See cases [RCV000050685] Chr17:78092236..83086677 [GRCh38]
Chr17:76088317..81044553 [GRCh37]
Chr17:73599912..78637842 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q24.3-25.3(chr17:69209079-83086677)x3 copy number gain See cases [RCV000052486] Chr17:69209079..83086677 [GRCh38]
Chr17:67205220..81044553 [GRCh37]
Chr17:64716815..78637842 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
NM_003258.5(TK1):c.596G>T (p.Gly199Val) single nucleotide variant not provided [RCV000122504] Chr17:78174868 [GRCh38]
Chr17:76170949 [GRCh37]
Chr17:17q25.3
uncertain significance
GRCh38/hg38 17q25.3(chr17:78092356-78444214)x1 copy number loss See cases [RCV000139522] Chr17:78092356..78444214 [GRCh38]
Chr17:76088437..76440296 [GRCh37]
Chr17:73600032..73951891 [NCBI36]
Chr17:17q25.3
likely benign
GRCh38/hg38 17q24.3-25.3(chr17:69916435-83102552)x3 copy number gain See cases [RCV000143342] Chr17:69916435..83102552 [GRCh38]
Chr17:67912576..81048189 [GRCh37]
Chr17:65424171..78653717 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh37/hg19 17q25.1-25.3(chr17:73951701-81041938)x3 copy number gain See cases [RCV000447539] Chr17:73951701..81041938 [GRCh37]
Chr17:17q25.1-25.3
pathogenic
GRCh37/hg19 17q24.2-25.3(chr17:64241326-81041938)x3 copy number gain See cases [RCV000447577] Chr17:64241326..81041938 [GRCh37]
Chr17:17q24.2-25.3
pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q25.1-25.3(chr17:73951701-81041938)x3 copy number gain See cases [RCV000510919] Chr17:73951701..81041938 [GRCh37]
Chr17:17q25.1-25.3
pathogenic
NM_003258.5(TK1):c.499G>A (p.Gly167Ser) single nucleotide variant Inborn genetic diseases [RCV003248073] Chr17:78175064 [GRCh38]
Chr17:76171145 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003258.5(TK1):c.245G>A (p.Arg82Gln) single nucleotide variant Inborn genetic diseases [RCV003259592] Chr17:78182647 [GRCh38]
Chr17:76178728 [GRCh37]
Chr17:17q25.3
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q24.2-25.3(chr17:67002415-81041938)x3 copy number gain See cases [RCV000512573] Chr17:67002415..81041938 [GRCh37]
Chr17:17q24.2-25.3
pathogenic
GRCh37/hg19 17q24.1-25.3(chr17:63689671-81041938)x3 copy number gain not provided [RCV000683952] Chr17:63689671..81041938 [GRCh37]
Chr17:17q24.1-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_003258.5(TK1):c.594C>T (p.Ala198=) single nucleotide variant not provided [RCV000967470] Chr17:78174870 [GRCh38]
Chr17:76170951 [GRCh37]
Chr17:17q25.3
benign
GRCh37/hg19 17q25.1-25.3(chr17:73261871-78608763)x3 copy number gain not provided [RCV001006919] Chr17:73261871..78608763 [GRCh37]
Chr17:17q25.1-25.3
pathogenic
GRCh37/hg19 17q24.1-25.3(chr17:62778720-81041938)x3 copy number gain not provided [RCV000849900] Chr17:62778720..81041938 [GRCh37]
Chr17:17q24.1-25.3
pathogenic
GRCh37/hg19 17q25.1-25.3(chr17:73481509-81043199)x3 copy number gain not provided [RCV002276051] Chr17:73481509..81043199 [GRCh37]
Chr17:17q25.1-25.3
pathogenic
NM_003258.5(TK1):c.695C>T (p.Pro232Leu) single nucleotide variant Inborn genetic diseases [RCV002968186] Chr17:78174769 [GRCh38]
Chr17:76170850 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003258.5(TK1):c.23C>T (p.Thr8Ile) single nucleotide variant Inborn genetic diseases [RCV002731976] Chr17:78186972 [GRCh38]
Chr17:76183053 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003258.5(TK1):c.132G>C (p.Gln44His) single nucleotide variant Inborn genetic diseases [RCV002729245] Chr17:78185132 [GRCh38]
Chr17:76181213 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003258.5(TK1):c.490A>C (p.Lys164Gln) single nucleotide variant Inborn genetic diseases [RCV002984084] Chr17:78175073 [GRCh38]
Chr17:76171154 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003258.5(TK1):c.462G>A (p.Met154Ile) single nucleotide variant Inborn genetic diseases [RCV002701601] Chr17:78175101 [GRCh38]
Chr17:76171182 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003258.5(TK1):c.556C>T (p.Arg186Trp) single nucleotide variant Inborn genetic diseases [RCV002827771] Chr17:78174908 [GRCh38]
Chr17:76170989 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003258.5(TK1):c.524T>C (p.Ile175Thr) single nucleotide variant Inborn genetic diseases [RCV002874285] Chr17:78174940 [GRCh38]
Chr17:76171021 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003258.5(TK1):c.218T>C (p.Met73Thr) single nucleotide variant Inborn genetic diseases [RCV003211705] Chr17:78182674 [GRCh38]
Chr17:76178755 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003258.5(TK1):c.577G>A (p.Ala193Thr) single nucleotide variant Inborn genetic diseases [RCV003378576] Chr17:78174887 [GRCh38]
Chr17:76170968 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003258.5(TK1):c.140A>G (p.Gln47Arg) single nucleotide variant Inborn genetic diseases [RCV003374124] Chr17:78185124 [GRCh38]
Chr17:76181205 [GRCh37]
Chr17:17q25.3
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR103A1hsa-miR-103a-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Target Of
Summary Value
Count of predictions:2632
Count of miRNA genes:814
Interacting mature miRNAs:981
Transcripts:ENST00000301634, ENST00000405273, ENST00000586613, ENST00000588734, ENST00000590430, ENST00000590862, ENST00000592126
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH11430  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,170,262 - 76,170,533UniSTSGRCh37
Build 361773,681,857 - 73,682,128RGDNCBI36
Celera1772,766,693 - 72,766,964RGD
Cytogenetic Map17q23.2-q25.3UniSTS
HuRef1771,594,394 - 71,594,665UniSTS
GeneMap99-GB4 RH Map17500.9UniSTS
GDB:178395  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,182,016 - 76,182,383UniSTSGRCh37
Build 361773,693,611 - 73,693,978RGDNCBI36
Celera1772,778,447 - 72,778,814RGD
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map17q23.2-q25.3UniSTS
HuRef1771,606,148 - 71,606,515UniSTS
GDB:180945  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,170,312 - 76,170,657UniSTSGRCh37
Build 361773,681,907 - 73,682,252RGDNCBI36
Celera1772,766,743 - 72,767,088RGD
Cytogenetic Map17q23.2-q25.3UniSTS
HuRef1771,594,444 - 71,594,789UniSTS
GDB:583421  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,170,482 - 76,170,874UniSTSGRCh37
Build 361773,682,077 - 73,682,469RGDNCBI36
Celera1772,766,913 - 72,767,305RGD
Cytogenetic Map17q23.2-q25.3UniSTS
HuRef1771,594,614 - 71,595,006UniSTS
PMC126057P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,183,076 - 76,183,278UniSTSGRCh37
Build 361773,694,671 - 73,694,873RGDNCBI36
Celera1772,779,517 - 72,779,719RGD
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map17q23.2-q25.3UniSTS
HuRef1771,607,168 - 71,607,370UniSTS
PMC140776P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,170,486 - 76,171,025UniSTSGRCh37
Build 361773,682,081 - 73,682,620RGDNCBI36
Celera1772,766,917 - 72,767,456RGD
Cytogenetic Map17q23.2-q25.3UniSTS
HuRef1771,594,618 - 71,595,157UniSTS
PMC303366P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,170,972 - 76,171,239UniSTSGRCh37
Build 361773,682,567 - 73,682,834RGDNCBI36
Celera1772,767,403 - 72,767,670RGD
Cytogenetic Map17q23.2-q25.3UniSTS
HuRef1771,595,104 - 71,595,371UniSTS
G06495  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,170,330 - 76,170,675UniSTSGRCh37
Build 361773,681,925 - 73,682,270RGDNCBI36
Celera1772,766,761 - 72,767,106RGD
Cytogenetic Map17q23.2-q25.3UniSTS
HuRef1771,594,462 - 71,594,807UniSTS
TK1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,171,164 - 76,171,634UniSTSGRCh37
GRCh371776,171,142 - 76,171,693UniSTSGRCh37
Build 361773,682,759 - 73,683,229RGDNCBI36
Celera1772,767,573 - 72,768,124UniSTS
Celera1772,767,595 - 72,768,065RGD
HuRef1771,595,296 - 71,595,766UniSTS
HuRef1771,595,274 - 71,595,825UniSTS
TK1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,171,164 - 76,171,634UniSTSGRCh37
GRCh371776,171,142 - 76,171,693UniSTSGRCh37
Build 361773,682,759 - 73,683,229RGDNCBI36
Celera1772,767,573 - 72,768,124UniSTS
Celera1772,767,595 - 72,768,065RGD
HuRef1771,595,296 - 71,595,766UniSTS
HuRef1771,595,274 - 71,595,825UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 5 2
Medium 1443 299 231 208 1212 163 907 712 175 259 441 706 58 91 309 4
Low 988 2585 1419 414 734 301 3433 1413 3385 159 999 900 113 1112 2465
Below cutoff 1 100 73 2 15 68 148 3 1 14

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_051962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001346663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA633286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC021593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC087645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW183491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI754079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K02581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC334339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000301634   ⟹   ENSP00000301634
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,174,091 - 78,187,052 (-)Ensembl
RefSeq Acc Id: ENST00000586613   ⟹   ENSP00000468278
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,174,926 - 78,187,063 (-)Ensembl
RefSeq Acc Id: ENST00000588734   ⟹   ENSP00000468425
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,174,121 - 78,187,233 (-)Ensembl
RefSeq Acc Id: ENST00000590430   ⟹   ENSP00000467121
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,174,830 - 78,187,038 (-)Ensembl
RefSeq Acc Id: ENST00000590862   ⟹   ENSP00000468556
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,174,702 - 78,187,036 (-)Ensembl
RefSeq Acc Id: ENST00000592126
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,175,069 - 78,187,021 (-)Ensembl
RefSeq Acc Id: NM_001346663   ⟹   NP_001333592
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,174,091 - 78,187,052 (-)NCBI
T2T-CHM13v2.01779,068,185 - 79,081,146 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001363848   ⟹   NP_001350777
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,174,079 - 78,187,204 (-)NCBI
T2T-CHM13v2.01779,068,173 - 79,081,298 (-)NCBI
Sequence:
RefSeq Acc Id: NM_003258   ⟹   NP_003249
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,174,091 - 78,187,052 (-)NCBI
GRCh371776,170,160 - 76,183,285 (-)ENTREZGENE
Build 361773,681,755 - 73,694,880 (-)NCBI Archive
HuRef1771,594,292 - 71,607,377 (-)ENTREZGENE
CHM1_11776,234,697 - 76,247,823 (-)NCBI
T2T-CHM13v2.01779,068,185 - 79,081,146 (-)NCBI
Sequence:
RefSeq Acc Id: NP_003249   ⟸   NM_003258
- Peptide Label: isoform 1
- UniProtKB: Q969V0 (UniProtKB/Swiss-Prot),   B2RC58 (UniProtKB/Swiss-Prot),   Q9UMG9 (UniProtKB/Swiss-Prot),   P04183 (UniProtKB/Swiss-Prot),   A0A384MDV9 (UniProtKB/TrEMBL),   B5BU32 (UniProtKB/TrEMBL),   B5BUF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001333592   ⟸   NM_001346663
- Peptide Label: isoform 2
- UniProtKB: K7ES52 (UniProtKB/TrEMBL),   K7ERJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001350777   ⟸   NM_001363848
- Peptide Label: isoform 3
- UniProtKB: K7ERV3 (UniProtKB/TrEMBL),   B5BU32 (UniProtKB/TrEMBL),   B5BUF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000468278   ⟸   ENST00000586613
RefSeq Acc Id: ENSP00000468425   ⟸   ENST00000588734
RefSeq Acc Id: ENSP00000301634   ⟸   ENST00000301634
RefSeq Acc Id: ENSP00000467121   ⟸   ENST00000590430
RefSeq Acc Id: ENSP00000468556   ⟸   ENST00000590862

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04183-F1-model_v2 AlphaFold P04183 1-234 view protein structure

Promoters
RGD ID:6794043
Promoter ID:HG_KWN:27242
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000301634,   ENST00000392388,   ENST00000405273,   ENST00000409257,   NR_027083,   OTTHUMT00000333208,   OTTHUMT00000333209,   OTTHUMT00000333210,   OTTHUMT00000333212,   OTTHUMT00000333217,   UC002JUX.2,   UC002JUZ.2,   UC002JVB.2,   UC010DHJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361773,694,629 - 73,695,129 (-)MPROMDB
RGD ID:6849726
Promoter ID:EP25035
Type:single initiation site
Name:HS_TK1
Description:Thymidine kinase.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Nuclease protection; Sequencing of a full-length cDNA
Regulation:dividing cells; (induced by or strongly expressed in) [S]
Position:
Human AssemblyChrPosition (strand)Source
Build 361773,694,731 - 73,694,791EPD
RGD ID:7236503
Promoter ID:EPDNEW_H23997
Type:initiation region
Name:TK1_1
Description:thymidine kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23998  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,187,051 - 78,187,111EPDNEW
RGD ID:7236505
Promoter ID:EPDNEW_H23998
Type:initiation region
Name:TK1_2
Description:thymidine kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23997  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,187,213 - 78,187,273EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11830 AgrOrtholog
COSMIC TK1 COSMIC
Ensembl Genes ENSG00000167900 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000301634 ENTREZGENE
  ENST00000301634.12 UniProtKB/Swiss-Prot
  ENST00000586613.1 UniProtKB/TrEMBL
  ENST00000588734 ENTREZGENE
  ENST00000588734.5 UniProtKB/TrEMBL
  ENST00000590430.5 UniProtKB/TrEMBL
  ENST00000590862 ENTREZGENE
  ENST00000590862.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000167900 GTEx
HGNC ID HGNC:11830 ENTREZGENE
Human Proteome Map TK1 Human Proteome Map
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thymidine_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thymidine_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7083 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 7083 ENTREZGENE
OMIM 188300 OMIM
PANTHER PTHR11441 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYMIDINE KINASE, CYTOSOLIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA352 PharmGKB, RGD
PIRSF TK_cell UniProtKB/TrEMBL
PROSITE TK_CELLULAR_TYPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A384MDV9 ENTREZGENE, UniProtKB/TrEMBL
  B2RC58 ENTREZGENE
  B5BU32 ENTREZGENE, UniProtKB/TrEMBL
  B5BUF9 ENTREZGENE, UniProtKB/TrEMBL
  K7ENW5_HUMAN UniProtKB/TrEMBL
  K7ERJ1 ENTREZGENE, UniProtKB/TrEMBL
  K7ERV3 ENTREZGENE, UniProtKB/TrEMBL
  K7ES52 ENTREZGENE, UniProtKB/TrEMBL
  KITH_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q969V0 ENTREZGENE
  Q9UMG9 ENTREZGENE
UniProt Secondary B2RC58 UniProtKB/Swiss-Prot
  Q969V0 UniProtKB/Swiss-Prot
  Q9UMG9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-12 TK1  thymidine kinase 1    thymidine kinase 1, soluble  Symbol and/or name change 5135510 APPROVED