Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | decreases expression | ISO | Arpp21 (Mus musculus) | 6480464 | Nicotine results in decreased expression of ARPP21 mRNA | CTD | PMID:21955143 | 1,2-dichloroethane | decreases expression | ISO | Arpp21 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of ARPP21 mRNA | CTD | PMID:28960355 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | increases expression | ISO | Arpp21 (Mus musculus) | 6480464 | 1-Methyl-4-phenyl-1 more ... | CTD | PMID:29627306 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Arpp21 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARPP21 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ARPP21 mRNA | CTD | PMID:34747641 | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bisphenol S results in increased expression of ARPP21 mRNA | CTD | PMID:30616060 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Arpp21 (Mus musculus) | 6480464 | bisphenol S affects the methylation of ARPP21 gene | CTD | PMID:31683443 | 4,4'-sulfonyldiphenol | increases methylation | EXP | | 6480464 | bisphenol S results in increased methylation of ARPP21 gene | CTD | PMID:31601247 | 6-propyl-2-thiouracil | increases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of ARPP21 mRNA | CTD | PMID:24780913 | acetamide | increases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | acetamide results in increased expression of ARPP21 mRNA | CTD | PMID:31881176 | acrylamide | affects expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Acrylamide affects the expression of ARPP21 mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases methylation | EXP | | 6480464 | Aflatoxin B1 results in decreased methylation of ARPP21 gene and Aflatoxin B1 results in decreased methylation of ARPP21 intron | CTD | PMID:27153756 and PMID:30157460 | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of ARPP21 gene | CTD | PMID:28458013 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of ARPP21 mRNA | CTD | PMID:23724009 | AM-251 | increases expression | EXP | | 6480464 | AM 251 results in increased expression of ARPP21 mRNA | CTD | PMID:16500647 | amphetamine | decreases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Amphetamine results in decreased expression of ARPP21 mRNA | CTD | PMID:30779732 | beauvericin | increases expression | EXP | | 6480464 | beauvericin results in increased expression of ARPP21 mRNA | CTD | PMID:29203277 | benzo[a]pyrene | decreases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Benzo(a)pyrene results in decreased expression of ARPP21 mRNA | CTD | PMID:21839799 | benzo[a]pyrene | decreases methylation | EXP | | 6480464 | Benzo(a)pyrene results in decreased methylation of ARPP21 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of ARPP21 3' UTR and Benzo(a)pyrene affects the methylation of ARPP21 5' UTR | CTD | PMID:27901495 | bezafibrate | increases expression | ISO | Arpp21 (Mus musculus) | 6480464 | Bezafibrate results in increased expression of ARPP21 mRNA | CTD | PMID:18787029 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of ARPP21 mRNA | CTD | PMID:36005737 | bisphenol A | decreases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of ARPP21 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of ARPP21 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | Arpp21 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of ARPP21 mRNA | CTD | PMID:30951980 and PMID:32156529 | cadmium atom | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ARPP21 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ARPP21 mRNA | CTD | PMID:35301059 | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ARPP21 gene] | CTD | PMID:28238834 | chlorpyrifos | increases expression | ISO | Arpp21 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of ARPP21 mRNA | CTD | PMID:32715474 | cocaine | multiple interactions | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Cocaine inhibits the reaction [SK&F 81297 results in increased phosphorylation of ARPP21 protein] | CTD | PMID:11268215 | cocaine | increases expression | ISO | Arpp21 (Mus musculus) | 6480464 | Cocaine deficiency results in increased expression of ARPP21 mRNA | CTD | PMID:27126842 | Cuprizon | decreases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Cuprizone results in decreased expression of ARPP21 mRNA | CTD | PMID:26577399 | decabromodiphenyl ether | decreases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | decabromobiphenyl ether results in decreased expression of ARPP21 mRNA | CTD | PMID:23640034 | dexamethasone | decreases expression | ISO | Arpp21 (Mus musculus) | 6480464 | Dexamethasone results in decreased expression of ARPP21 mRNA | CTD | PMID:22733784 | endosulfan | decreases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of ARPP21 mRNA | CTD | PMID:29391264 | ethanol | decreases expression | ISO | Arpp21 (Mus musculus) | 6480464 | Ethanol results in decreased expression of ARPP21 mRNA | CTD | PMID:21955143 | ethanol | multiple interactions | ISO | Arpp21 (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of ARPP21 mRNA | CTD | PMID:30319688 | gentamycin | increases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of ARPP21 mRNA | CTD | PMID:33387578 | indinavir | multiple interactions | ISO | Arpp21 (Mus musculus) | 6480464 | [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNA | CTD | PMID:16931933 | indole-3-methanol | affects expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | indole-3-carbinol affects the expression of ARPP21 mRNA | CTD | PMID:21396975 | lamivudine | multiple interactions | ISO | Arpp21 (Mus musculus) | 6480464 | [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNA more ... | CTD | PMID:16931933 | lead diacetate | decreases expression | ISO | Arpp21 (Mus musculus) | 6480464 | lead acetate results in decreased expression of ARPP21 mRNA | CTD | PMID:20542052 | morphine | increases expression | ISO | Arpp21 (Mus musculus) | 6480464 | Morphine results in increased expression of ARPP21 mRNA | CTD | PMID:21955143 | morphine | decreases expression | ISO | Arpp21 (Mus musculus) | 6480464 | Morphine deficiency results in decreased expression of ARPP21 mRNA | CTD | PMID:27126842 | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of ARPP21 mRNA | CTD | PMID:24810058 | nicotine | decreases expression | ISO | Arpp21 (Mus musculus) | 6480464 | Nicotine results in decreased expression of ARPP21 mRNA | CTD | PMID:21955143 | nitrofen | decreases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | nitrofen results in decreased expression of ARPP21 mRNA | CTD | PMID:33484710 | oxaliplatin | multiple interactions | ISO | Arpp21 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of ARPP21 mRNA | CTD | PMID:25729387 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ARPP21 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | Arpp21 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of ARPP21 mRNA | CTD | PMID:20813756 | potassium dichromate | decreases expression | ISO | Arpp21 (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of ARPP21 mRNA | CTD | PMID:23608068 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of ARPP21 mRNA | CTD | PMID:29955902 | saquinavir | multiple interactions | ISO | Arpp21 (Mus musculus) | 6480464 | [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ARPP21 mRNA | CTD | PMID:16931933 | sodium arsenite | affects methylation | EXP | | 6480464 | sodium arsenite affects the methylation of ARPP21 gene | CTD | PMID:28589171 | sodium arsenite | decreases expression | ISO | Arpp21 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of ARPP21 mRNA | CTD | PMID:36209798 | Soman | increases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Soman results in increased expression of ARPP21 mRNA | CTD | PMID:19281266 | testosterone | decreases expression | EXP | | 6480464 | Testosterone results in decreased expression of ARPP21 mRNA | CTD | PMID:33359661 | thioacetamide | decreases expression | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of ARPP21 mRNA | CTD | PMID:23411599 | topotecan | multiple interactions | ISO | Arpp21 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of ARPP21 mRNA | CTD | PMID:25729387 | trichostatin A | increases expression | ISO | Arpp21 (Mus musculus) | 6480464 | trichostatin A results in increased expression of ARPP21 mRNA | CTD | PMID:24204683 | trimellitic anhydride | decreases expression | ISO | Arpp21 (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of ARPP21 mRNA | CTD | PMID:19042947 | valproic acid | affects splicing | ISO | Arpp21 (Rattus norvegicus) | 6480464 | Valproic Acid affects the splicing of ARPP21 mRNA | CTD | PMID:29427782 | vinclozolin | decreases methylation | ISO | Arpp21 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased methylation of ARPP21 gene | CTD | PMID:31682807 | zidovudine | multiple interactions | ISO | Arpp21 (Mus musculus) | 6480464 | [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNA more ... | CTD | PMID:16931933 | |