HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1) - Rat Genome Database

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Gene: HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1) Homo sapiens
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Symbol: HSD11B1
Name: hydroxysteroid 11-beta dehydrogenase 1
RGD ID: 737091
HGNC Page HGNC:5208
Description: Enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity; NADP binding activity; and protein homodimerization activity. Predicted to be involved in steroid catabolic process. Predicted to act upstream of or within lung development. Located in endoplasmic reticulum membrane. Implicated in cortisone reductase deficiency (multiple); hypertension (multiple); and type 2 diabetes mellitus. Biomarker of coronary artery disease and obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 7-oxosteroid reductase; corticosteroid 11-beta-dehydrogenase isozyme 1; CORTRD2; HDL; HSD11; HSD11B; HSD11L; hydroxysteroid (11-beta) dehydrogenase 1; MGC13539; SDR26C1; short chain dehydrogenase/reductase family 26C member 1; short chain dehydrogenase/reductase family 26C, member 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381209,686,179 - 209,734,929 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1209,686,178 - 209,734,949 (+)EnsemblGRCh38hg38GRCh38
GRCh371209,859,524 - 209,908,274 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361207,926,173 - 207,974,918 (+)NCBINCBI36Build 36hg18NCBI36
Build 341206,266,585 - 206,296,690NCBI
Celera1183,090,437 - 183,139,187 (+)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1180,534,794 - 180,583,575 (+)NCBIHuRef
CHM1_11211,131,921 - 211,180,673 (+)NCBICHM1_1
T2T-CHM13v2.01208,932,934 - 208,981,687 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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HSD11B1Humancoronary artery disease sexual_dimorphismIEP 329901914associated with obesity more ...RGD 
HSD11B1Humancortisone reductase deficiency  IAGP 1625067DNA:insertion more ...RGD 
HSD11B1HumanDiabetic Nephropathies susceptibilityIAGP 329902062DNA:SNO:intron: (rs17389016 and rs11799643) (human)RGD 
HSD11B1Humanessential hypertension susceptibilityIAGP 11353457DNA:SNP:insertion: ins4436A (rs45487298) (human)RGD 
HSD11B1Humanfamilial hyperlipidemia  ISOHsd11b1 (Rattus norvegicus)9068941mRNA and protein:increased expression:islet cells:diabetic but not prediabetic Zucker Diabetic Fatty (fa/fa) ratsRGDPMID:14697232 and REF_RGD_ID:1625074
HSD11B1Humanhypertension susceptibilityIAGP 329902060DNA:SNP:5'utr: (rs846910) (human)RGD 
HSD11B1HumanLeft Ventricular Hypertrophy susceptibilityIAGP 329901915DNA:SNP:5'utr: (rs846910) (human)RGD 
HSD11B1HumanMetabolic Syndrome  TAS 1625075potential therapeutic targetRGD 
HSD11B1HumanMetabolic Syndrome susceptibilityIAGP 329901919DNA:SNPs:5'utr more ...RGD 
HSD11B1HumanMetabolic Syndrome disease_progressionIEP 329901930mRNA:increased expression:ascending aorta and epicardial fat (human)RGD 
HSD11B1HumanMetabolic Syndrome susceptibilityIAGP 329901909DNA:SNP:: (rs846910) (human)RGD 
HSD11B1HumanMetabolic Syndrome susceptibilityIAGP 329901929DNA:SNP: (rs12086634)T>G (human)RGD 
HSD11B1Humanmyocardial infarction amelioratesISOHsd11b1 (Mus musculus)11087531 RGD 
HSD11B1Humanmyocardial infarction  ISOHsd11b1 (Mus musculus)329902054 RGD 
HSD11B1Humanobesity  IEP 1625071mRNA:increased expression:adipose tissue:13-fold higher in obese subjects than controls and protein expression also increasedRGD 
HSD11B1Humanpre-eclampsia susceptibilityIAGP 329901926DNA:SNPs more ...RGD 
HSD11B1Humanstatus epilepticus  ISOHsd11b1 (Rattus norvegicus)5686281mRNA:increased expression:hippocampusRGD 
HSD11B1Humantype 2 diabetes mellitus  TAS 1625075potential therapeutic targetRGD 
HSD11B1Humantype 2 diabetes mellitus susceptibilityIAGP 329901909DNA:SNPs:intron: (rs12086634 and rs846910) (human)RGD 
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HSD11B1Humanbladder exstrophy-epispadias-cloacal exstrophy complex  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Exstrophy-epispadias complexClinVarPMID:25741868
HSD11B1Humancortisone reductase deficiency 2  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: Cortisone reductase deficiency 2ClinVarPMID:21325058
HSD11B1Humancortisone reductase deficiency 2  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: Cortisone reductase deficiency 2ClinVarPMID:25741868
HSD11B1Humancortisone reductase deficiency 2  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: HSD11B1-related conditionClinVarPMID:25741868 and PMID:28492532
HSD11B1Humangastrointestinal stromal tumor  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
HSD11B1Humanparathyroid carcinoma  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
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HSD11B1HumanAbdominal Obesity  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:15199296
HSD11B1Humanallergic contact dermatitis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16033404
HSD11B1Humancortisone reductase deficiency  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25526675
HSD11B1HumanExperimental Diabetes Mellitus  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:14697232
HSD11B1Humanhyperglycemia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:14697232
HSD11B1Humanhypertension  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:9683905 more ...
HSD11B1HumanInsulin Resistance  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21786805
HSD11B1Humanobesity  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17628001 and PMID:21786805
HSD11B1Humanrheumatoid arthritis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:19192274
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HSD11B1Humanobesity  IEA 1331525 GAD 
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HSD11B1Humancortisone reductase deficiency 2  ISSHsd11b1 (Mus musculus)13592920OMIM:614662MouseDO 
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HSD11B1Humancortisone reductase deficiency 2  IAGP 7240710 OMIM 

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HSD11B1Human(+)-catechin multiple interactionsEXP 6480464Catechin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of HSD11B1 mRNA]CTDPMID:29935159
HSD11B1Human(1->4)-beta-D-glucan multiple interactionsISOHsd11b1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of HSD11B1 mRNACTDPMID:36331819
HSD11B1Human(S)-nicotine increases expressionISOHsd11b1 (Rattus norvegicus)6480464Nicotine results in increased expression of HSD11B1 mRNACTDPMID:22265867 and PMID:26803847
HSD11B1Human(S)-nicotine affects expressionISOHsd11b1 (Rattus norvegicus)6480464Nicotine affects the expression of HSD11B1 mRNACTDPMID:31972234
HSD11B1Human(S)-nicotine multiple interactionsISOHsd11b1 (Rattus norvegicus)6480464ursodoxicoltaurine inhibits the reaction [Nicotine results in increased expression of HSD11B1 mRNA]CTDPMID:26803847
HSD11B1Human(S)-nicotine increases expressionISOHsd11b1 (Mus musculus)6480464Nicotine results in increased expression of HSD11B1 mRNACTDPMID:21955143
HSD11B1Human1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane decreases activityEXP 64804642 more ...CTDPMID:23333641
HSD11B1Human1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsISOHsd11b1 (Rattus norvegicus)64804642 more ...CTDPMID:19414516
HSD11B1Human1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane decreases activityISOHsd11b1 (Rattus norvegicus)64804642 more ...CTDPMID:23333641
HSD11B1Human1,2-dimethylhydrazine multiple interactionsISOHsd11b1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HSD11B1 mRNACTDPMID:22206623
HSD11B1Human11-dehydrocorticosterone increases reductionISOHsd11b1 (Rattus norvegicus)6480464HSD11B1 protein results in increased reduction of 11-dehydrocorticosteroneCTDPMID:26859423
HSD11B1Human11-dehydrocorticosterone increases metabolic processingISOHsd11b1 (Rattus norvegicus)6480464HSD11B1 protein results in increased metabolism of 11-dehydrocorticosteroneCTDPMID:23814014
HSD11B1Human11-dehydrocorticosterone multiple interactionsISOHsd11b1 (Rattus norvegicus)6480464[HSD11B1 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone more ...CTDPMID:23814014 and PMID:26859423
HSD11B1Human11-dehydrocorticosterone affects response to substanceISOHsd11b1 (Mus musculus)6480464HSD11B1 gene affects the susceptibility to 11-dehydrocorticosteroneCTDPMID:16751407
HSD11B1Human11-dehydrocorticosterone affects abundanceISOHsd11b1 (Mus musculus)6480464HSD11B1 gene mutant form affects the abundance of 11-dehydrocorticosteroneCTDPMID:25061560
HSD11B1Human11-dehydrocorticosterone increases metabolic processingISOHsd11b1 (Mus musculus)6480464HSD11B1 protein results in increased metabolism of 11-dehydrocorticosteroneCTDPMID:16751407
HSD11B1Human17alpha-ethynylestradiol multiple interactionsISOHsd11b1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSD11B1 mRNACTDPMID:17942748
HSD11B1Human17alpha-ethynylestradiol multiple interactionsEXP 6480464Ethinyl Estradiol inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]CTDPMID:28257955
HSD11B1Human17alpha-ethynylestradiol decreases expressionISOHsd11b1 (Rattus norvegicus)6480464Ethinyl Estradiol results in decreased expression of HSD11B1 mRNACTDPMID:29097150
HSD11B1Human17alpha-ethynylestradiol increases expressionISOHsd11b1 (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of HSD11B1 mRNACTDPMID:12655037 more ...

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Biological Process
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Cellular Component
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HSD11B1Humanapical part of cell  ISOHsd11b1 (Rattus norvegicus)9068941 RGDPMID:12810566 and REF_RGD_ID:1625059
HSD11B1Humanendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
HSD11B1Humanendoplasmic reticulum membrane is_active_inIBAPANTHER:PTN000674090 and UniProtKB:P28845150520179 GO_CentralGO_REF:0000033
HSD11B1Humanendoplasmic reticulum membrane located_inTAS 150520179 ReactomeReactome:R-HSA-194023 and Reactome:R-HSA-9757706
HSD11B1Humanendoplasmic reticulum membrane located_inIDA 150520179 PMID:10497248UniProtPMID:10497248
HSD11B1Humanendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-0097150520179 UniProtGO_REF:0000044
HSD11B1Humanintracellular membrane-bounded organelle is_active_inIBAPANTHER:PTN001212922 more ...150520179 GO_CentralGO_REF:0000033
HSD11B1Humanmembrane located_inHDA 150520179 PMID:19946888UniProtPMID:19946888
HSD11B1Humanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
HSD11B1Humannuclear membrane  ISOHsd11b1 (Rattus norvegicus)9068941 RGDPMID:11250946 and REF_RGD_ID:1625110
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Molecular Function
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HSD11B1Human11-beta-hydroxysteroid dehydrogenase (NADP+) activity enablesIEAEC:1.1.1.146150520179 UniProtGO_REF:0000003
HSD11B1Human11-beta-hydroxysteroid dehydrogenase (NADP+) activity enablesIBAMGI:103562 more ...150520179 GO_CentralGO_REF:0000033
HSD11B1Human11-beta-hydroxysteroid dehydrogenase (NADP+) activity enablesIEARHEA:11388150520179 RHEAGO_REF:0000116
HSD11B1Human11-beta-hydroxysteroid dehydrogenase (NADP+) activity enablesIDA 150520179 PMID:10497248 more ...UniProtPMID:10497248 more ...
HSD11B1Human11-beta-hydroxysteroid dehydrogenase (NADP+) activity enablesIEAUniProtKB:P50172 and ensembl:ENSMUSP00000016338150520179 EnsemblGO_REF:0000107
HSD11B1Human7-beta-hydroxysteroid dehydrogenase (NADP+) activity enablesIEARHEA:20233150520179 RHEAGO_REF:0000116
HSD11B1Humancortisol dehydrogenase (NADP+) activity enablesIEARHEA:68616150520179 RHEAGO_REF:0000116
HSD11B1HumanNADP binding  ISOHsd11b1 (Rattus norvegicus)9068941 RGDPMID:15761036 and REF_RGD_ID:1625105
HSD11B1HumanNADP binding enablesIDA 150520179 PMID:15513927 more ...UniProtPMID:15513927 more ...
HSD11B1Humanoxidoreductase activity enablesIEAUniProtKB-KW:KW-0560150520179 UniProtGO_REF:0000043
HSD11B1Humanoxidoreductase activity enablesIEAInterPro:IPR020904150520179 InterProGO_REF:0000002
HSD11B1Humanprotein homodimerization activity enablesIDA 150520179 PMID:15513927 more ...UniProtPMID:15513927 more ...
HSD11B1Humansteroid binding  ISOcorticosterone9068941 RGDPMID:15761036 and REF_RGD_ID:1625105
HSD11B1Humansteroid binding enablesIBAPANTHER:PTN000674090 and Hsd11b1 (Rattus norvegicus)150520179 GO_CentralGO_REF:0000033
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Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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HSD11B1Humanaldosterone signaling pathway   IEA 6907045 KEGGhsa:04960
HSD11B1Humansteroid hormone biosynthetic pathway   IEA 6907045 KEGGhsa:00140
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HSD11B1HumanAbnormal systemic blood pressure  IAGP 329902060 RGD 
HSD11B1HumanDecreased HDL cholesterol concentration susceptibilityIAGP 329901919 RGD 
HSD11B1HumanDiabetes mellitus susceptibilityIAGP 329901929DNA:SNP: (rs12086634)T>G (human)RGD 
HSD11B1HumanDiabetes mellitus susceptibilityIAGP 11353457DNA:SNP:insertion: ins4436A (rs45487298) (human)RGD 
HSD11B1HumanElevated systolic blood pressure susceptibilityIAGP 329901909DNA:SNP:intron: (rs12086634) (human)RGD 
HSD11B1HumanElevated systolic blood pressure susceptibilityIAGP 329901929DNA:SNP: (rs12086634)T>G (human)RGD 
HSD11B1HumanHypercholesterolemia susceptibilityIAGP 329901929DNA:SNP: (rs12086634)T>G (human)RGD 
HSD11B1HumanHyperglycemia susceptibilityIAGP 329901909DNA:SNP:intron: (rs12086634) (human)RGD 
HSD11B1HumanHypertension susceptibilityIAGP 329902060DNA:SNP:5'utr: (rs846910) (human)RGD 
HSD11B1HumanHypertension susceptibilityIAGP 11353457DNA:SNP:insertion: ins4436A (rs45487298) (human)RGD 
HSD11B1HumanHypertension susceptibilityIAGP 329901919 RGD 
HSD11B1HumanHypocholesterolemia susceptibilityIAGP 11353457DNA:SNP:insertion: ins4436A (rs45487298) (human)RGD 
HSD11B1HumanIncreased body mass index susceptibilityIAGP 329902062DNA:SNP:intron: (rs846906) (human)RGD 
HSD11B1HumanInsulin resistance susceptibilityIAGP 329901929DNA:SNP: (rs12086634)T>G (human)RGD 
HSD11B1HumanInsulin resistance susceptibilityIAGP 329901919 RGD 
HSD11B1HumanInsulin resistance susceptibilityIAGP 329901909DNA:SNP:: (rs846910) (human)RGD 
HSD11B1HumanLeft ventricular hypertrophy susceptibilityIAGP 329901915DNA:SNP:5'utr: (rs846910) (human)RGD 
HSD11B1HumanNephropathy susceptibilityIAGP 329902062DNA:SNO:intron: (rs17389016 and rs11799643) (human)RGD 
HSD11B1HumanPreeclampsia susceptibilityIAGP 329901926DNA:SNPs more ...RGD 
HSD11B1HumanPulmonary arterial hypertension susceptibilityIAGP 329902062DNA:SNP:intron: (rs846906) (human)RGD 
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HSD11B1HumanGastrointestinal stroma tumor  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
HSD11B1HumanParathyroid carcinoma  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532

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#
Reference Title
Reference Citation
1. The role of mediastinal adipose tissue 11β-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease. Atalar F, etal., Cardiovasc Diabetol. 2012 Sep 25;11:115. doi: 10.1186/1475-2840-11-115.
2. 11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease. Atalar F, etal., Genet Mol Res. 2012 Aug 31;11(3):3122-32. doi: 10.4238/2012.August.31.10.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. Association of HSD11B1 gene polymorphisms with type 2 diabetes and metabolic syndrome in South Indian population. Devang N, etal., Diabetes Res Clin Pract. 2017 Sep;131:142-148. doi: 10.1016/j.diabres.2017.07.011. Epub 2017 Jul 13.
5. Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Draper N, etal., Nat Genet. 2003 Aug;34(4):434-9.
6. Interaction between an 11betaHSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians. Franks PW, etal., Hypertension. 2004 Nov;44(5):681-8. doi: 10.1161/01.HYP.0000144294.28985.d5. Epub 2004 Sep 27.
7. A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome. Gambineri A, etal., Eur J Endocrinol. 2011 Aug;165(2):283-92. doi: 10.1530/EJE-11-0091. Epub 2011 May 27.
8. Association between a 11β-hydroxysteroid dehydrogenase type 1 gene polymorphism and metabolic syndrome in a South Indian population. Gandhi K, etal., Metab Syndr Relat Disord. 2013 Dec;11(6):397-402. doi: 10.1089/met.2013.0049. Epub 2013 Jul 20.
9. Association between ins4436A in 11beta-hydroxysteroid dehydrogenase type 1 gene and essential hypertension in Polish population. Hejduk P, etal., Postepy Hig Med Dosw (Online). 2015 Nov 17;69:1245-50.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome. Mariniello B, etal., Eur J Endocrinol. 2006 Sep;155(3):435-41.
12. Variants in HSD11B1 gene modulate susceptibility to diabetes kidney disease and to insulin resistance in type 1 diabetes. Mori RC, etal., Diabetes Metab Res Rev. 2021 Jan;37(1):e3352. doi: 10.1002/dmrr.3352. Epub 2020 Jun 21.
13. 11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI. Mylonas KJ, etal., J Endocrinol. 2017 Jun;233(3):315-327. doi: 10.1530/JOE-16-0501.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. Common variation at the 11-β hydroxysteroid dehydrogenase type 1 gene is associated with left ventricular mass. Rahman TJ, etal., Circ Cardiovasc Genet. 2011 Apr;4(2):156-62. doi: 10.1161/CIRCGENETICS.110.958496. Epub 2011 Mar 14.
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
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PMID:1885595   PMID:7545619   PMID:7670488   PMID:9034789   PMID:9543163   PMID:9555943   PMID:10497248   PMID:10497258   PMID:10645953   PMID:10962348   PMID:11114699   PMID:11755176  
PMID:11956655   PMID:12109593   PMID:12202416   PMID:12390875   PMID:12414862   PMID:12477932   PMID:12530648   PMID:12530692   PMID:12788882   PMID:12861241   PMID:12915682   PMID:12915696  
PMID:12960005   PMID:14557491   PMID:14583441   PMID:14682470   PMID:14742837   PMID:15095019   PMID:15152005   PMID:15156315   PMID:15167446   PMID:15172126   PMID:15181046   PMID:15280030  
PMID:15455200   PMID:15466942   PMID:15489334   PMID:15513927   PMID:15536220   PMID:15583024   PMID:15591536   PMID:15827106   PMID:15855321   PMID:15941907   PMID:16091483   PMID:16236446  
PMID:16343739   PMID:16368752   PMID:16406280   PMID:16412558   PMID:16469798   PMID:16551740   PMID:16580270   PMID:16603347   PMID:16622297   PMID:16710414   PMID:16855188   PMID:16996097  
PMID:17032748   PMID:17062770   PMID:17070044   PMID:17306259   PMID:17467270   PMID:17495191   PMID:17519316   PMID:17588937   PMID:17766714   PMID:17825335   PMID:17912154   PMID:17919905  
PMID:17922306   PMID:18031327   PMID:18069989   PMID:18261751   PMID:18313835   PMID:18379559   PMID:18388900   PMID:18434359   PMID:18485702   PMID:18553955   PMID:18573267   PMID:18592327  
PMID:18611262   PMID:18633104   PMID:18665910   PMID:18716005   PMID:18769825   PMID:18778749   PMID:18818748   PMID:18837961   PMID:18963204   PMID:19010388   PMID:19019335   PMID:19022342  
PMID:19022912   PMID:19027726   PMID:19088256   PMID:19121282   PMID:19129713   PMID:19158196   PMID:19167490   PMID:19217779   PMID:19235128   PMID:19251840   PMID:19282465   PMID:19336370  
PMID:19429429   PMID:19453261   PMID:19491387   PMID:19527514   PMID:19535162   PMID:19540999   PMID:19542242   PMID:19549748   PMID:19564704   PMID:19567539   PMID:19571556   PMID:19598235  
1 to 10 of 22 rows



HSD11B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381209,686,179 - 209,734,929 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1209,686,178 - 209,734,949 (+)EnsemblGRCh38hg38GRCh38
GRCh371209,859,524 - 209,908,274 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361207,926,173 - 207,974,918 (+)NCBINCBI36Build 36hg18NCBI36
Build 341206,266,585 - 206,296,690NCBI
Celera1183,090,437 - 183,139,187 (+)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1180,534,794 - 180,583,575 (+)NCBIHuRef
CHM1_11211,131,921 - 211,180,673 (+)NCBICHM1_1
T2T-CHM13v2.01208,932,934 - 208,981,687 (+)NCBIT2T-CHM13v2.0
Hsd11b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391192,903,917 - 192,946,345 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1192,903,942 - 192,946,383 (-)EnsemblGRCm39 Ensembl
GRCm381193,221,640 - 193,264,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1193,221,634 - 193,264,075 (-)EnsemblGRCm38mm10GRCm38
MGSCv371195,047,834 - 195,090,239 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,922,413 - 194,964,769 (-)NCBIMGSCv36mm8
Celera1200,096,784 - 200,141,189 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map197.67NCBI
Hsd11b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813107,277,526 - 107,327,462 (-)NCBIGRCr8
mRatBN7.213104,728,539 - 104,798,884 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13104,728,539 - 104,788,687 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13107,266,432 - 107,292,403 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013108,650,289 - 108,676,261 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013105,868,245 - 105,894,215 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013111,946,626 - 111,996,536 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13111,926,442 - 111,972,603 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013116,502,230 - 116,551,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413109,063,491 - 109,089,468 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113109,252,609 - 109,278,318 (-)NCBI
Celera13104,178,893 - 104,204,865 (-)NCBICelera
Cytogenetic Map13q27NCBI
Hsd11b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554892,497,680 - 2,524,805 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554892,500,928 - 2,524,715 (-)NCBIChiLan1.0ChiLan1.0
HSD11B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2139,662,235 - 39,715,349 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1139,632,569 - 39,681,576 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01185,262,599 - 185,311,417 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11190,086,449 - 190,116,765 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1190,086,449 - 190,116,765 (+)Ensemblpanpan1.1panPan2
HSD11B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.178,344,380 - 8,409,901 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl78,344,447 - 8,409,897 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha77,959,522 - 7,986,906 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.078,045,319 - 8,110,393 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl78,045,392 - 8,110,389 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.178,012,426 - 8,039,787 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.078,109,437 - 8,136,847 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.078,170,917 - 8,198,302 (+)NCBIUU_Cfam_GSD_1.0
Hsd11b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934466,118,456 - 66,179,043 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365573,357,016 - 3,403,714 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365573,358,809 - 3,403,461 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD11B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9133,231,451 - 133,278,396 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19133,231,451 - 133,278,396 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HSD11B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12519,720,096 - 19,772,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2519,719,848 - 19,750,200 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605520,319,360 - 20,369,697 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd11b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248072,261,006 - 2,293,804 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248072,260,702 - 2,293,962 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in HSD11B1
26 total Variants

1 to 10 of 49 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_005525.4(HSD11B1):c.409C>T (p.Arg137Cys) single nucleotide variant Cortisone reductase deficiency 2 [RCV000024294] Chr1:209707020 [GRCh38]
Chr1:209880365 [GRCh37]
Chr1:1q32.2		 pathogenic
NM_005525.4(HSD11B1):c.561G>T (p.Lys187Asn) single nucleotide variant Cortisone reductase deficiency 2 [RCV000024295] Chr1:209732479 [GRCh38]
Chr1:209905824 [GRCh37]
Chr1:1q32.2		 pathogenic
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11		 pathogenic
GRCh38/hg38 1q32.1-32.2(chr1:204990129-210220258)x3 copy number gain See cases [RCV000051859] Chr1:204990129..210220258 [GRCh38]
Chr1:204959257..210572305 [GRCh37]
Chr1:203225880..208638928 [NCBI36]
Chr1:1q32.1-32.2		 pathogenic
GRCh38/hg38 1q32.2-44(chr1:209646207-248931113)x3 copy number gain See cases [RCV000051861] Chr1:209646207..248931113 [GRCh38]
Chr1:209819552..249225312 [GRCh37]
Chr1:207886175..247191935 [NCBI36]
Chr1:1q32.2-44		 pathogenic
GRCh38/hg38 1q32.2-32.3(chr1:208063461-211907812)x1 copy number loss See cases [RCV000138122] Chr1:208063461..211907812 [GRCh38]
Chr1:208236806..212081154 [GRCh37]
Chr1:206303429..210147777 [NCBI36]
Chr1:1q32.2-32.3		 likely benign
GRCh38/hg38 1q32.2(chr1:207583527-210159181)x1 copy number loss See cases [RCV000139025] Chr1:207583527..210159181 [GRCh38]
Chr1:207756872..210332526 [GRCh37]
Chr1:205823495..208399149 [NCBI36]
Chr1:1q32.2		 pathogenic
GRCh38/hg38 1q32.1-42.12(chr1:204764914-225408698)x3 copy number gain See cases [RCV000142054] Chr1:204764914..225408698 [GRCh38]
Chr1:204734042..225596400 [GRCh37]
Chr1:203000665..223663023 [NCBI36]
Chr1:1q32.1-42.12		 pathogenic
GRCh38/hg38 1q32.2-44(chr1:207346642-248930485)x3 copy number gain See cases [RCV000143727] Chr1:207346642..248930485 [GRCh38]
Chr1:207519987..249224684 [GRCh37]
Chr1:205586610..247191307 [NCBI36]
Chr1:1q32.2-44		 pathogenic
NM_005525.4(HSD11B1):c.331+53dup duplication Cortisone reductase deficiency 2 [RCV003486826] Chr1:209706871..209706872 [GRCh38]
Chr1:209880216..209880217 [GRCh37]
Chr1:1q32.2		 benign|uncertain significance
1 to 10 of 49 rows

Predicted Target Of
Summary Value
Count of predictions:436
Count of miRNA genes:161
Interacting mature miRNAs:169
Transcripts:ENST00000261465, ENST00000367027, ENST00000367028
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597481148GWAS1577222_Hmean corpuscular hemoglobin QTL GWAS1577222 (human)2e-12mean corpuscular hemoglobinmean corpuscular hemoglobin (CMO:0000290)1209727264209727265Human
597484894GWAS1580968_Hcleft lip QTL GWAS1580968 (human)2e-59cleft lip1209698839209698840Human
597305805GWAS1401879_Herythrocyte count QTL GWAS1401879 (human)2e-12erythrocyte countred blood cell count (CMO:0000025)1209721440209721441Human

PMC310500P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371209,907,621 - 209,907,822UniSTSGRCh37
Build 361207,974,244 - 207,974,445RGDNCBI36
Celera1183,138,513 - 183,138,714RGD
Cytogenetic Map1q32-q41UniSTS
HuRef1180,582,901 - 180,583,102UniSTS
D1S2136  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371209,871,457 - 209,871,700UniSTSGRCh37
Build 361207,938,080 - 207,938,323RGDNCBI36
Celera1183,102,347 - 183,102,586RGD
Cytogenetic Map1q32-q41UniSTS
HuRef1180,546,735 - 180,546,974UniSTS
Whitehead-YAC Contig Map1 UniSTS
RH69177  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371209,907,975 - 209,908,242UniSTSGRCh37
Build 361207,974,598 - 207,974,865RGDNCBI36
Celera1183,138,867 - 183,139,134RGD
Cytogenetic Map1q32-q41UniSTS
HuRef1180,583,255 - 180,583,522UniSTS
GeneMap99-GB4 RH Map1691.06UniSTS
NCBI RH Map11870.1UniSTS
SHGC-76294  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371209,880,056 - 209,880,408UniSTSGRCh37
Build 361207,946,679 - 207,947,031RGDNCBI36
Celera1183,110,942 - 183,111,294RGD
Cytogenetic Map1q32-q41UniSTS
HuRef1180,555,330 - 180,555,682UniSTS
TNG Radiation Hybrid Map1103254.0UniSTS
GeneMap99-GB4 RH Map1691.06UniSTS
NCBI RH Map11870.1UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2343 2787 2234 4726 1687 2190 5 597 1498 440 2064 6723 6015 40 3683 803 1672 1484 170 1


1 to 19 of 19 rows
RefSeq Transcripts NG_012081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001206741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_181755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH006349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL022398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL031316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG619051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM994393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX345837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB530075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF596989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF597174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ534869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENST00000261465   ⟹   ENSP00000261465
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1209,686,269 - 209,734,478 (+)Ensembl
Ensembl Acc Id: ENST00000367027   ⟹   ENSP00000355994
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1209,704,846 - 209,734,929 (+)Ensembl
Ensembl Acc Id: ENST00000367028   ⟹   ENSP00000355995
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1209,686,180 - 209,734,949 (+)Ensembl
Ensembl Acc Id: ENST00000615289   ⟹   ENSP00000478430
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1209,686,178 - 209,732,465 (+)Ensembl
RefSeq Acc Id: NM_001206741   ⟹   NP_001193670
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381209,686,179 - 209,734,929 (+)NCBI
GRCh371209,859,525 - 209,908,295 (+)ENTREZGENE
HuRef1180,534,794 - 180,583,575 (+)ENTREZGENE
CHM1_11211,131,921 - 211,180,673 (+)NCBI
T2T-CHM13v2.01208,932,934 - 208,981,687 (+)NCBI
Sequence:
RefSeq Acc Id: NM_005525   ⟹   NP_005516
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381209,704,846 - 209,734,929 (+)NCBI
GRCh371209,859,525 - 209,908,295 (+)ENTREZGENE
Build 361207,944,814 - 207,974,918 (+)NCBI Archive
HuRef1180,534,794 - 180,583,575 (+)ENTREZGENE
CHM1_11211,150,550 - 211,180,673 (+)NCBI
T2T-CHM13v2.01208,951,593 - 208,981,687 (+)NCBI
Sequence:
RefSeq Acc Id: NM_181755   ⟹   NP_861420
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381209,686,179 - 209,734,929 (+)NCBI
GRCh371209,859,525 - 209,908,295 (+)ENTREZGENE
Build 361207,926,173 - 207,974,918 (+)NCBI Archive
HuRef1180,534,794 - 180,583,575 (+)ENTREZGENE
CHM1_11211,131,921 - 211,180,673 (+)NCBI
T2T-CHM13v2.01208,932,934 - 208,981,687 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001193670   ⟸   NM_001206741
- UniProtKB: B2R9Z1 (UniProtKB/Swiss-Prot),   D3DT89 (UniProtKB/Swiss-Prot),   P28845 (UniProtKB/Swiss-Prot),   X5D2L1 (UniProtKB/TrEMBL),   A0A0A0MQV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_861420   ⟸   NM_181755
- UniProtKB: B2R9Z1 (UniProtKB/Swiss-Prot),   D3DT89 (UniProtKB/Swiss-Prot),   P28845 (UniProtKB/Swiss-Prot),   X5D2L1 (UniProtKB/TrEMBL),   A0A0A0MQV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_005516   ⟸   NM_005525
- UniProtKB: B2R9Z1 (UniProtKB/Swiss-Prot),   D3DT89 (UniProtKB/Swiss-Prot),   P28845 (UniProtKB/Swiss-Prot),   X5D2L1 (UniProtKB/TrEMBL),   A0A0A0MQV1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000478430   ⟸   ENST00000615289
Ensembl Acc Id: ENSP00000355994   ⟸   ENST00000367027

Name Modeler Protein Id AA Range Protein Structure
AF-P28845-F1-model_v2 AlphaFold P28845 1-292 view protein structure

RGD ID:6785739
Promoter ID:HG_KWN:7166
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:NM_005525
Position:
Human AssemblyChrPosition (strand)Source
Build 361207,943,711 - 207,944,211 (+)MPROMDB
RGD ID:6858864
Promoter ID:EPDNEW_H2597
Type:initiation region
Name:HSD11B1_2
Description:hydroxysteroid 11-beta dehydrogenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2598  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381209,686,190 - 209,686,250EPDNEW
RGD ID:6858866
Promoter ID:EPDNEW_H2598
Type:initiation region
Name:HSD11B1_1
Description:hydroxysteroid 11-beta dehydrogenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2597  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381209,704,848 - 209,704,908EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
COSMIC HSD11B1 COSMIC
Ensembl Genes ENSG00000117594 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000367027 ENTREZGENE
  ENST00000367027.5 UniProtKB/Swiss-Prot
  ENST00000367028 ENTREZGENE
  ENST00000367028.6 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
GTEx ENSG00000117594 GTEx
HGNC ID HGNC:5208 ENTREZGENE
Human Proteome Map HSD11B1 Human Proteome Map
InterPro 11-beta-HSD UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot
KEGG Report hsa:3290 UniProtKB/Swiss-Prot
NCBI Gene 3290 ENTREZGENE
OMIM 600713 OMIM
PANTHER CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1 UniProtKB/Swiss-Prot
  HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED UniProtKB/Swiss-Prot
Pfam adh_short UniProtKB/Swiss-Prot
PharmGKB PA29476 PharmGKB
PRINTS GDHRDH UniProtKB/Swiss-Prot
PROSITE ADH_SHORT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt A0A087WU76_HUMAN UniProtKB/TrEMBL
  A0A0A0MQV1 ENTREZGENE, UniProtKB/TrEMBL
  B2R9Z1 ENTREZGENE
  D3DT89 ENTREZGENE
  DHI1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  X5D2L1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2R9Z1 UniProtKB/Swiss-Prot
  D3DT89 UniProtKB/Swiss-Prot
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Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-07 HSD11B1  hydroxysteroid 11-beta dehydrogenase 1  HSD11B1  hydroxysteroid (11-beta) dehydrogenase 1  Symbol and/or name change 5135510 APPROVED