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Gene: HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1) Chlorocebus sabaeus

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Symbol:

HSD11B1

Name:

hydroxysteroid 11-beta dehydrogenase 1

RGD ID:

18497402

Description:

ENCODES a protein that exhibits NADP binding (ortholog); steroid binding (ortholog); INVOLVED IN cellular response to estradiol stimulus (ortholog); glucocorticoid biosynthetic process (ortholog); glucocorticoid catabolic process (ortholog); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH Abdominal Obesity (ortholog); allergic contact dermatitis (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN apical part of cell (ortholog); nuclear membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

11-beta-hydroxysteroid dehydrogenase 1; corticosteroid 11-beta-dehydrogenase isozyme 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	19,720,096 - 19,772,806 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	19,719,848 - 19,750,200 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	20,319,360 - 20,369,697 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
HSD11B1	Green Monkey	coronary artery disease	sexual_dimorphism	ISO	RGD:737091	9068941	associated with obesity;mRNA,protein:increased expression:multiple (human)	RGD	PMID:23009206\|REF_RGD_ID:329901914
HSD11B1	Green Monkey	cortisone reductase deficiency		ISO	RGD:737091	9068941	DNA:insertion,transversion:intron:86557insA, 83597T>G (human)	RGD	PMID:12858176\|REF_RGD_ID:1625067
HSD11B1	Green Monkey	Diabetic Nephropathies	susceptibility	ISO	RGD:737091	9068941	DNA:SNO:intron: (rs17389016, rs11799643) (human)	RGD	PMID:32453474\|REF_RGD_ID:329902062
HSD11B1	Green Monkey	essential hypertension	susceptibility	ISO	RGD:737091	9068941	DNA:SNP:insertion: ins4436A (rs45487298) (human)	RGD	PMID:26671915\|REF_RGD_ID:11353457
HSD11B1	Green Monkey	familial hyperlipidemia		ISO	RGD:2834	9068941	mRNA,protein:increased expression:islet cells:diabetic but not prediabetic Zucker Diabetic Fatty (fa/fa) rats	RGD	PMID:14697232\|REF_RGD_ID:1625074
HSD11B1	Green Monkey	hypertension	susceptibility	ISO	RGD:737091	9068941	DNA:SNP:5'utr: (rs846910) (human)	RGD	PMID:15452033\|REF_RGD_ID:329902060
HSD11B1	Green Monkey	Left Ventricular Hypertrophy	susceptibility	ISO	RGD:737091	9068941	DNA:SNP:5'utr: (rs846910) (human)	RGD	PMID:21402901\|REF_RGD_ID:329901915
HSD11B1	Green Monkey	Metabolic Syndrome		ISO	RGD:2834	9068941		RGD	PMID:14697232\|REF_RGD_ID:1625074
HSD11B1	Green Monkey	Metabolic Syndrome	susceptibility	ISO	RGD:737091	9068941	DNA:SNP: (rs12086634)T>G (human)	RGD	PMID:23869418\|REF_RGD_ID:329901929
HSD11B1	Green Monkey	Metabolic Syndrome	susceptibility	ISO	RGD:737091	9068941	DNA:SNP:: (rs846910) (human)	RGD	PMID:28750217\|REF_RGD_ID:329901909
HSD11B1	Green Monkey	Metabolic Syndrome	disease_progression	ISO	RGD:737091	9068941	mRNA:increased expression:ascending aorta,epicardial fat (human)	RGD	PMID:23007990\|REF_RGD_ID:329901930
HSD11B1	Green Monkey	Metabolic Syndrome	susceptibility	ISO	RGD:737091	9068941	DNA:SNPs:5'utr,enhancer: (rs846910,rs12086634) (human)	RGD	PMID:21622477\|REF_RGD_ID:329901919
HSD11B1	Green Monkey	myocardial infarction		ISO	RGD:10734	9068941		RGD	PMID:28522730\|REF_RGD_ID:329902054
HSD11B1	Green Monkey	myocardial infarction	ameliorates	ISO	RGD:10734	9068941		RGD	PMID:26465199\|REF_RGD_ID:11087531
HSD11B1	Green Monkey	obesity		ISO	RGD:2834	9068941		RGD	PMID:15131764\|REF_RGD_ID:1625073
HSD11B1	Green Monkey	obesity		ISO	RGD:737091	9068941	mRNA:increased expression:adipose tissue:13-fold higher in obese subjects than controls, protein expression also increased	RGD	PMID:16914598\|REF_RGD_ID:1625071
HSD11B1	Green Monkey	obesity		ISO	RGD:10734	9068941		RGD	PMID:16612591\|REF_RGD_ID:1625072
HSD11B1	Green Monkey	pre-eclampsia	susceptibility	ISO	RGD:737091	9068941	DNA:SNPs,haplotype: (rs2235543,rs846910) (human)	RGD	PMID:23659736\|REF_RGD_ID:329901926
HSD11B1	Green Monkey	status epilepticus		ISO	RGD:2834	9068941	mRNA:increased expression:hippocampus	RGD	PMID:22050960\|REF_RGD_ID:5686281
HSD11B1	Green Monkey	type 2 diabetes mellitus		ISO	RGD:2834	9068941	mRNA,protein:increased expression:islet cells:diabetic but not prediabetic Zucker Diabetic Fatty (fa/fa) rats	RGD	PMID:14697232\|REF_RGD_ID:1625074
HSD11B1	Green Monkey	type 2 diabetes mellitus	susceptibility	ISO	RGD:737091	9068941	DNA:SNPs:intron: (rs12086634,rs846910) (human)	RGD	PMID:28750217\|REF_RGD_ID:329901909

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
HSD11B1	Green Monkey	bladder exstrophy-epispadias-cloacal exstrophy complex		ISO	RGD:737091	8554872	ClinVar Annotator: match by term: Exstrophy-epispadias complex	ClinVar	PMID:25741868
HSD11B1	Green Monkey	cortisone reductase deficiency 2		ISO	RGD:737091	8554872	ClinVar Annotator: match by term: Cortisone reductase deficiency 2 \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:21325058\|PMID:25741868\|PMID:28492532
HSD11B1	Green Monkey	gastrointestinal stromal tumor		ISO	RGD:737091	8554872	ClinVar Annotator: match by term: Gastrointestinal stromal tumor	ClinVar	PMID:28492532
HSD11B1	Green Monkey	parathyroid carcinoma		ISO	RGD:737091	8554872	ClinVar Annotator: match by term: Parathyroid carcinoma	ClinVar	PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
HSD11B1	Green Monkey	Abdominal Obesity		ISO	RGD:737091	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:15199296
HSD11B1	Green Monkey	allergic contact dermatitis		ISO	RGD:737091	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:16033404
HSD11B1	Green Monkey	cortisone reductase deficiency		ISO	RGD:737091	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:25526675
HSD11B1	Green Monkey	Experimental Diabetes Mellitus		ISO	RGD:737091	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:14697232
HSD11B1	Green Monkey	hyperglycemia		ISO	RGD:737091	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:14697232
HSD11B1	Green Monkey	hypertension		ISO	RGD:737091	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:15199296\|PMID:21786805\|PMID:9683905
HSD11B1	Green Monkey	Insulin Resistance		ISO	RGD:737091	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:21786805
HSD11B1	Green Monkey	obesity		ISO	RGD:737091	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:17628001\|PMID:21786805
HSD11B1	Green Monkey	rheumatoid arthritis		ISO	RGD:737091	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:19192274

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
HSD11B1	Green Monkey	cortisone reductase deficiency 2		ISO	RGD:737091	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
HSD11B1	Green Monkey	cellular response to estradiol stimulus		ISO	RGD:2834	9068941		RGD	PMID:19380458\|REF_RGD_ID:4891036
HSD11B1	Green Monkey	glucocorticoid biosynthetic process		ISO	RGD:2834	9068941		RGD	PMID:12460758\|REF_RGD_ID:1625060
HSD11B1	Green Monkey	glucocorticoid catabolic process		ISO	RGD:2834	9068941		RGD	PMID:12460758\|REF_RGD_ID:1625060
HSD11B1	Green Monkey	lung development	acts_upstream_of_or_within	IEA	UniProtKB:P50172\|ensembl:ENSMUSP00000016338	150520179		Ensembl	GO_REF:0000107
HSD11B1	Green Monkey	mineralocorticoid metabolic process		ISO	RGD:2834	9068941		RGD	PMID:2808402\|REF_RGD_ID:728825
HSD11B1	Green Monkey	regulation of pentose-phosphate shunt		ISO	RGD:2834	9068941		RGD	PMID:16234247\|REF_RGD_ID:1625062
HSD11B1	Green Monkey	response to nutrient levels		ISO	RGD:2834	9068941	low protein diet	RGD	PMID:16941667\|REF_RGD_ID:4891037
HSD11B1	Green Monkey	steroid catabolic process	involved_in	IEA	PANTHER:PTN000674099	150520179		TreeGrafter	GO_REF:0000118

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
HSD11B1	Green Monkey	apical part of cell		ISO	RGD:2834	9068941		RGD	PMID:12810566\|REF_RGD_ID:1625059
HSD11B1	Green Monkey	endoplasmic reticulum	located_in	IEA	UniProtKB-KW:KW-0256	150520179		UniProt	GO_REF:0000043
HSD11B1	Green Monkey	endoplasmic reticulum membrane	located_in	IEA	UniProtKB:P28845\|ensembl:ENSP00000355994	150520179		Ensembl	GO_REF:0000107
HSD11B1	Green Monkey	endoplasmic reticulum membrane	located_in	IEA	UniProtKB-SubCell:SL-0097	150520179		UniProt	GO_REF:0000044
HSD11B1	Green Monkey	endoplasmic reticulum membrane	located_in	IEA	PANTHER:PTN000674099	150520179		TreeGrafter	GO_REF:0000118
HSD11B1	Green Monkey	membrane	located_in	IEA	UniProtKB-KW:KW-0472	150520179		UniProt	GO_REF:0000043
HSD11B1	Green Monkey	nuclear membrane		ISO	RGD:2834	9068941		RGD	PMID:11250946\|REF_RGD_ID:1625110

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
HSD11B1	Green Monkey	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	enables	IEA	PANTHER:PTN000674099	150520179		TreeGrafter	GO_REF:0000118
HSD11B1	Green Monkey	11-beta-hydroxysteroid dehydrogenase (NADP+) activity	enables	IEA	UniProtKB:P28845\|UniProtKB:P50172\|ensembl:ENSMUSP00000016338\|ensembl:ENSP00000355994	150520179		Ensembl	GO_REF:0000107
HSD11B1	Green Monkey	NADP binding		ISO	RGD:2834	9068941		RGD	PMID:15761036\|REF_RGD_ID:1625105
HSD11B1	Green Monkey	NADP binding	enables	IEA	UniProtKB:P28845\|ensembl:ENSP00000355994	150520179		Ensembl	GO_REF:0000107
HSD11B1	Green Monkey	oxidoreductase activity	enables	IEA	PANTHER:PTN000674099	150520179		TreeGrafter	GO_REF:0000118
HSD11B1	Green Monkey	oxidoreductase activity	enables	IEA	InterPro:IPR020904	150520179		InterPro	GO_REF:0000002
HSD11B1	Green Monkey	oxidoreductase activity	enables	IEA	UniProtKB-KW:KW-0560	150520179		UniProt	GO_REF:0000043
HSD11B1	Green Monkey	protein homodimerization activity	enables	IEA	UniProtKB:P28845\|ensembl:ENSP00000355994	150520179		Ensembl	GO_REF:0000107
HSD11B1	Green Monkey	steroid binding		ISO	CHEBI:16827	9068941		RGD	PMID:15761036\|REF_RGD_ID:1625105
HSD11B1	Green Monkey	steroid binding	enables	IEA	PANTHER:PTN000674099	150520179		TreeGrafter	GO_REF:0000118

Imported Annotations - SMPDB

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
HSD11B1	Green Monkey	11-beta-hydroxylase deficiency pathway		ISO	RGD:737091	9068941		SMPDB	SMP:00575
HSD11B1	Green Monkey	17-alpha-hydroxylase deficiency pathway		ISO	RGD:737091	9068941		SMPDB	SMP:00372
HSD11B1	Green Monkey	21-alpha-hydroxylase deficiency pathway		ISO	RGD:737091	9068941		SMPDB	SMP:00373
HSD11B1	Green Monkey	apparent mineralocorticoid excess syndrome pathway		ISO	RGD:737091	9068941		SMPDB	SMP:00717
HSD11B1	Green Monkey	lipoid congenital adrenal hyperplasia pathway		ISO	RGD:737091	9068941		SMPDB	SMP:00371
HSD11B1	Green Monkey	steroid hormone biosynthetic pathway		ISO	RGD:737091	9068941		SMPDB	SMP:00130

PMID:30032202

HSD11B1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	19,720,096 - 19,772,806 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	19,719,848 - 19,750,200 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	20,319,360 - 20,369,697 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

HSD11B1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	209,686,179 - 209,734,929 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	209,686,178 - 209,734,949 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	209,859,524 - 209,908,274 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	207,926,173 - 207,974,918 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	206,266,585 - 206,296,690	NCBI
Celera	1	183,090,437 - 183,139,187 (+)	NCBI		Celera
Cytogenetic Map	1	q32.2	NCBI
HuRef	1	180,534,794 - 180,583,575 (+)	NCBI		HuRef
CHM1_1	1	211,131,921 - 211,180,673 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	208,932,934 - 208,981,687 (+)	NCBI		T2T-CHM13v2.0

Hsd11b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	192,903,917 - 192,946,345 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	192,903,942 - 192,946,383 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	193,221,640 - 193,264,045 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	193,221,634 - 193,264,075 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	195,047,834 - 195,090,239 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	194,922,413 - 194,964,769 (-)	NCBI		MGSCv36	mm8
Celera	1	200,096,784 - 200,141,189 (-)	NCBI		Celera
Cytogenetic Map	1	H6	NCBI
cM Map	1	97.67	NCBI

Hsd11b1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	107,277,526 - 107,327,462 (-)	NCBI		GRCr8
mRatBN7.2	13	104,728,539 - 104,798,884 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	104,728,539 - 104,788,687 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	107,266,432 - 107,292,403 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	108,650,289 - 108,676,261 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	105,868,245 - 105,894,215 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	111,946,626 - 111,996,536 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	111,926,442 - 111,972,603 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	116,502,230 - 116,551,778 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	109,063,491 - 109,089,468 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	109,252,609 - 109,278,318 (-)	NCBI
Celera	13	104,178,893 - 104,204,865 (-)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

Hsd11b1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955489	2,497,680 - 2,524,805 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955489	2,500,928 - 2,524,715 (-)	NCBI	ChiLan1.0	ChiLan1.0

HSD11B1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	39,662,235 - 39,715,349 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	39,632,569 - 39,681,576 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	185,262,599 - 185,311,417 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	190,086,449 - 190,116,765 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	190,086,449 - 190,116,765 (+)	Ensembl	panpan1.1		panPan2

HSD11B1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	8,344,380 - 8,409,901 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	8,344,447 - 8,409,897 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	7,959,522 - 7,986,906 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	8,045,319 - 8,110,393 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	8,045,392 - 8,110,389 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	8,012,426 - 8,039,787 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	8,109,437 - 8,136,847 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	8,170,917 - 8,198,302 (+)	NCBI		UU_Cfam_GSD_1.0

Hsd11b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	66,118,456 - 66,179,043 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	3,357,016 - 3,403,714 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	3,358,809 - 3,403,461 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSD11B1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	133,231,451 - 133,278,396 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	133,231,451 - 133,278,396 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Hsd11b1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	2,261,006 - 2,293,804 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	2,260,702 - 2,293,962 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in HSD11B1
847 total Variants

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	19	35	35	60	20


RefSeq Transcripts	XM_007988591	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007988592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_073011537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JBLKOC010000025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000013349 ⟹ ENSCSAP00000011350

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	25	19,719,848 - 19,750,200 (-)	Ensembl

RefSeq Acc Id:

XM_007988591 ⟹ XP_007986782

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	25	19,720,096 - 19,752,079 (-)	NCBI
Vero_WHO_p1.0	NW_023666055	20,319,360 - 20,350,458 (-)	NCBI

Sequence:

show sequence

ATTATTAATCTGTTTGTGTCTTTGGGTTTAAATGTGTCTTTTGAGGCCACACAATGTTGGACTTCATTTTTTAATGGAGCCAACAATCAGCAATTGTTAATGCATTTGCTTTGTGTTCTATTACTCTG
CAGTTTATCTTACTCATTGTTATTTTTGCTTTCCTTAAATTTATGTTTTCTTAATGGACTTCAAAATTCATTATTTCTTTTTTATGTCAGACAATAAAGGTCCCTAGTCTGCCCATCTTTCTATCATT
TCAGCATCATCATATTTCAAAATAACTCATTGTTTCCTACAATTTTACTATTAATAGTATAGGATTAAGAAAATAAACCTTATCTGGGTTCTGGCTGGCACTTCCTTTCCTCTAGGGATGAAAACGGA
GTCTAGTCTGTGATACATCTTGCTATCATGCATATCTTTATAAAATTATACAAATGTATCTTACAGTTCTAAAGGCATGTAATCTAATTTTTACTTGAATTTTATCTTTTTTCTCTTTTTTCCTTCAT
AGACCTCGAGCTCTGTCTAGCCCTCAACTGTTCTCAAATCTCCATTGTTTTCTACAAGTGACCCTCACAGCTGTGAGCCTTTGTTGACAAATTGTTTCATCTCCTCTGGGTCTTAAATTATTTTTTCT
TACTCTAAAGTGAAAATTTGATGAGTGTTTCCAGATACTGCACTTGGAATCATAACTTAATTTCCCTTAACCTTGTGTAAATTCTGTCCCCCACTACTCCCAACTCCTATCCCTCCTCCAAAGCACTG
ATACTTATTATCACATTTAAATTTTTTCCCTGCTCTACTGATAACTTACAGAACGCAGGATTGCATTGTGATGGGGTAATTTCCATGATTTGATTGGTTGGTTTTAAGTTGAAAAAAACAATGATACA
GCTTAAATTCTTTGAGGATTGTTCCTTCATGAATTCATGCTACGGACATACTGAGGTGGTTATTTTTATATTCCCTGATAATAAATTCTAAATTGCTAGGAGTTTCTCACCACCCTCATCCTTTTACT
GTTACTAGATCTATTTTTAGCTGGTGTGGGCATCCCCAGCTAGTTTCACTTGCCTAATGCTAGTTCTTTTTTCTTCTACATCAGGTCGCCTCTTCCTAGCATCTTCTCCATGCTTCTTGTTCCTCTAC
AGAATTTACAAGACCCAGTTTAATAGTTTAGTGCCTTTTTTGTCACTCATTATTTCTTCTTTGTTCTCTGTTAAAGTAATAAGTGTACGATCCATTGCACTTGCCTTAGAGTCTTGAACCAGTCTTGG
ATTTCCCGCCATCTGGGTTCTGGCTGGCTTGCAATTTCTCCTTTGATGTTGTAATACTTTTTCATTGAACTTGAGTGTGGGGCTTATAGAGCTTGTTTGCTTTCATTATTTTTTCCCAAAATGTGCAC
ATTTTTTTTCTTAAGCTTATTTTGCTGTTTTGTGCTGTTATTTTTAATTGCTTCCGACTGGGTGGGGGACTAGGGGGACTGAAAGTGAGATTTGGCTTGAGTTTGGCTCTCTTTGCTATTACTCACAT
TTCCCCCCAGAAGCCCTACATGCACTCCTCTCTCTCTGTCTTTGACAAATCACTTTTGAAAGATCATTGATCCCTGGTGTAAATGGTGTTAAGAGTAAGATGGACTTGGGTAGGGATGCTCAGGAATC
CAGTCCTGTACAGTCATGAGCTTGGCCATCTGGAAGTCTCCTCTTGCTCAATGAAATGGAGTAAACATTGTCCATTATGAAATCCACCACACAGGCTGCCAGGGACGAATGGGATCCCACCCAAAGCC
AATCGCTGCTCTGACAGGGAAATTGGCTAGCACTGCCTGAGACTACTCCAGCCTCCCCCGTCCCTGATGTCACAATTCAGAGGCTGCTGCCTGCTTAGGAGGTTGTAGAAAGCTCTGTAGGTTCTCTC
TGTGTGTCCTACAGGAGTCTTCAGGCCAGCTCCCTGTCGGATGGCTTTTATGAAAAAATATCTCCTCCCCATTCTGGGGCTCTTCATGGCCTACTACTACTATTCTGCATATGAGGAATTCAGACCAG
AGATGCTCCAAGGAAAGAAAGTGATTGTCACAGGGGCCAGCAAAGGGATCGGAAGAGAGATGGCTTATCATCTGGCGAAGATGGGAGCCCACGTGGTGGTAACAGCGAGGTCAAAAGAAACTCTACAG
AAGGTGGTTTCCCACTGCCTGGAACTTGGAGCAGCCTCAGCACACTACATTGCTGGCACCATGGAAGACATGACCTTCGCAGAGCAATTTGTTGCCCAAGCAGGAAAGCTCATGGGAGGACTAGACAT
GCTCATTCTCAACCACATCACCAACACTTCTTTGAATCTTTTTCATGATGATATTCACCATGTGCGCAAAAGCATGGAGGTCAACTTCCTCAGTTATGTGGTCCTGACTGTAGCTGCCTTGCCCATGC
TGAAGCAGAGCAATGGAAGCATTGTTGTCGTCTCTTCTTTGGCTGGGAAAGTGGCTTATCCAATGGTTGCTGCCTATTCTGCAAGCAAGTTTGCTTTGGATGGGTTCTTCTCCTCCATCAGAAAGGAA
TATTCATTGGCCAAGGTCAATGTATCAATCACTCTCTGTGTTCTTGGCCTCATAGACACAGACACAGCCATGAAGGCAGTTTCTGGGATAATCAATATGCAAGCAGCTCCAAAGGAGGAATGTGCCCT
TGAGATCATCAAAGGGGGAGCTCTGCGCCAAGAAGAAGTATATTATGACAGCTCACTCTGGACCACTCTTCTGTTGAGAAATCCATGCAGGAAGATCCTGGAATTTCTTTACTCATCGACCTATAATA
TGGACAGATTCACAAAAAACTAGGAACTCTCTGAGGGCTGGGCATGCTGAGGGATTTTGGGACTGTTCTGTCTCATATTTATCTGAGCTCTTGTCCATGAAGACATCTTCCCAGAGTGTCCCCAGAGA
CATGCAAGTCATGGGTCACACCTGACAAATGGAAGGAGTTCCTCTAACATTTGCACAATGGAAATGTAATAATAATGAATGTCATGCACCACTGCAGCCAGCAGTTATAAAATTGTTAGTAAACATAG
GTATAATTACCAGATAGTTATATTAAATTTATCTCATATATAATAATATGTGATGATTAATACAATATTAATTATAATAAAGGTCACATAAATGTTATAAATTCATAA

hide sequence

RefSeq Acc Id:

XM_007988592 ⟹ XP_007986783

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	25	19,720,096 - 19,772,806 (-)	NCBI
Vero_WHO_p1.0	NW_023666055	20,319,439 - 20,369,697 (-)	NCBI

Sequence:

show sequence

TGGTATAAACTGGAGAGGAGATTTCTGGACTTGGAGGTTGCATCCAATTATACGATGCTAAGATTCTGTCTAATATTACCACCAAAAAGGGGATGTACTTCCCTTTCCAGCCTGTCTGTCCAGATCAT
CCCTTTCTTTAAATGCTTCTTTATTCTTTTTCTCAGCATATTGATAAATATGTTTCCTTTTTGCTCAATTACTATCAAATGTGATAAATTTGATTCCAAAATTAAATTATTTCTTGATTAAACTCATC
TAATTAATGCTTTTGCCTTTTGTAAAAATACCTTAACCTACTGGTCAAACCTAATAGTCTCAAATTTTGTCATAGTGAAATATCTATTAAAGGTATCTTCCTCTTCACAAAAGACCACAAAACTTTGA
TCAATTTATAGAAAGAAATATATATAGTTTTATGCTATATTATGTGCCTTCTCTTGCACTATATTCTAATGAAAACAAATAGTAGGTATCAACTGAGAATATTTAAAGTTTCCCACATTCGCAGGAAA
ATTTGATTGTTCTATAGTCATGCTAACCAGAACTAGTAGAAAACCCACTGGCTTAATAAATGACAACTCACCTGTTAAGCTTTTAGAAGCCAACCAATCAGTGATAGGCCCTCATTTCTGACAGTCAA
CCAATCAGGAAGGAACTCATGCCATTAACTGCATCTCAGAGTGCTAACCAATCAACGAATAGTCATGCTTCTATAGCTGATGTCAGTCCATTTATGTCTGGGAAAGTACACCAGTCCTTGACCTTCAT
GCATCCTCAAAAACCTATATGAGATCAGCAGGCTGCTGTTCAGACAGATTGAGCAGAAAAGCTTACCCTTACTATAATGAGCAACAAGTTTACTATTTTTGTTTTATTTTATATATTAAATGGTGGTC
TCATCATTCTTTGACAATTCTAGAAGCTCTACTGTGATTGGTTTAAAGACCTTCTCTTGGCAATATTCCAGGGAACATGGGACCAACAGGTACACTTACTGGGCTCCTTGTGCACAAGTGCATTTGTC
TCTTAGATCTGCTGCCCAGTGAGAAAATCTCAACAATAACCTGAGCTCTGACTAGTTTTATTAAGTTCTCATCGCTTCTGTAATTTGCAAGCAAACAAGTCTTTGTATAAGATCATTTTTCCTAGTTC
TTTGTATAATATAATTAGAAAATTTAGTCAACAGGTGCACACTTTAGTAAACAATTATACCTAGACCTTTGTATAAGGTCATTAGGCATTTTGTTTGGGAGGTACACCACTGAGTAATGGGACATAGG
TCTTGGTATAAGATCATTTGACATTTTGTGTGGGAAATATACCATTGGGTAGTTCAACATAGGTCTTTTTATAAGTTCATTAGACTTTTGGTTTTGGAGGCATAAATATTTTTACCATTAAACAGTTT
ATTCCCTTCCTACTCTATGTTTGCTTTTGCTTGTCCATATTAAAATGTCTTATTGTATTTTTTCTGGATTGCCTTATTTCTGATATAAGGGAGTGTTCCAGAGGAAATGAATGGAGATATATATTCCA
TAAGTTACCAATTCAATCCAAGCTAGTCCTCGGGGATAACAGTTGGAGGTCCAGTAGACTGAAAACCAATTTGTGAAAAGGCAATTGTCAGATCTATAAAAAACTTTCATGACAGCATGCCCTGTCTT
GTTAGTCTGTGATAGGATACTTTTAGTTTGTACACTGGGGTCAAAGATTTTGTCAGGTCATTAACTATGTGATCCTTTCTAACCTTTGCTTAGAAAGGGAACCCAAGGTACCATTGACAGGCACACAC
TTTTACTCAGTGGCACCTCTCGTCCTTCTTGGTTTCTTCCATGTCAAAACTGCAGCCTCCACTGGGAGAACTCCTGCTTTTCATATAAAATTGCACTGTAATCCTAACTCTTGCACTTATTTTTGTAA
ATTGCCAAAAAAAAAAAATTTGTTAGAATAGCAATGGCTATCTTGCAGAACTTCTGACATGTCAAAATGAATAAATTAAGATATTTAAGAGGAACTCCAGAAAAATTAGGAGACAAAGGCCCAAAGAG
GCAATAGTTAGCTTCTTTCATTGGCAAGCTAAGGCTTCAAAATAAAATTTTAACTCAAGAATGGTCTCTCTCAAAGACTCTGATGCCACCTAAAACCCACCCTCCTTTCATTTCTCTTTCTACTCGGC
ATTACCTGACCTTCAACATGAGCCACCCCTTTCTTCTTAGTTTTCTCTGGAAAAAAGTAATCACATTGTAAAACTGCTAAACCAGAGGGCAGCCCTAAAAAGCTGAATTTAAACCCTGGCCTAGAGCA
AAATTAAAAGTTACCATGAAAGATTTTCCAAAGCCTCAGGGGTGGTTGAGCAGAAATTAGTTAACAATTTAGGATTTTATTAGGTACTTATTGTTCTGGATTAAACATCTGTACCAAATGATTCAGTT
AAGTGTTAGTCTATCCAATAGAGAAAACAAATTTATAAGCAGCAGGGTAAGAAAAAAAATTAAATAACTCTGTTGTGCAATATGAAAAACAAATGCCTTAAATGGACAAGAAAAAATTGAAAATACAG
TACAAAAAGCAATGTCAAAAAAATCTTTCTTTTAAAAGTACATTAGACAAAGATTAAAAATTGTAAACTAAATAAAAATGAAAAGAGGCTTCAGAAAACTTTCAAAGAGCATTCTGGAGTACACTCAA
CAGCTGAAATAAAAGAAACATTGTCTTTATTTTTTCTATGAAAGGGCTCAAATATGAATTAGGGGATTTAATGAGAAAAAAGTAATTGAAATATGAAACTGACAGCTTAGAAAATATCCAGTACATAA
CTAGATATTTTCAGAGAGCTCTAGAAAGTAAATAAGCTAGAAATCAACAGAACATATGGTACTCTACATAAAAAACTTGCCCCTGAAATAAAAACAAGACCGAAAAGTCTTGCATTTTCTAAGAATTG
GGAACATATAGAGAGGGGTACTTGTAGATATTCCAAGCAAAAGGGTCATTCAAAGAACCAATGTTCCACATTGGCTAAGCAACAGAAGGATGACTATCCAAAATCTGTCTGATGGTGCTTTTCCAAAG
GAGACATTAGCACCCAACAATTACAGTCCTTCTTCTGAGCTTGTGTGCCCAAATCTCTATACTCTCCATCAGGGCATAGCTACATCCAGTATGGCTTACCACTCTATCCCCAGCCTCTAGCCCAGTGC
CTAGCATAGAGTAGGTGCTTATTAAATATTTGTTGAACAAATGAAGAAATAGAGGAAGAAAGTACATTTTTGTTTTGATACGCTGTAGTCCCTTCCTCAGTCCAGAGATCACAAACCTCTGAATTAGG
ATGTGACTCTCTCTGTCATTAATTGGCAAGAATCATGGTAGAATTACCGTCCCTATTTACAGAGTCTCTTTCCCTAATACATCCCATTGCAGATTCCTGTCTTCCCTTTACCATCCACTCCAGCATCA
GCTGATGCAGTCACTAAAATGGTTTATAAGTCACATATGAGATTCCCTAAGTTTATAATTGAGAAATGTGTGGACACACAGCCCTCACAGAATGCATTGGATTGCTAGAGTCTCTCCTGGTGAAAAAG
GAAAACCTGCCCAAACCCAGTTTTTGTTTCAGTAACTTCCTTTGAGACAAAGCCAGGAATCTGAGAGTGAGCACCTGCTAAGGGTGGGACAGGGGCTCTGTCTGGTATGCCTCTCCCATGTTAAGAGC
TAACAATAGTAATGGATAAGTCTCCAGGGAAACCAGGACCACTTCCAAGCATTCCTGTCTTGGGCTGCCTCAAGGGCTCCTCTGTCCTTTGGGTAGTACCGATTGATGCCTGATGCCCAGAACTGGTC
CACTCTGACTTCTCTTTGGAGCCGTCTCTGCCGGCACCTCCTGGCTGCCAGCTCAGTCCTAGCATAAGGGACTTCTTCCTTGGCCTGGGTTTCACCTTCTTGTATCAGGTGGCAGACCAGCTGGTTTC
AGTCCCAAATCAGGTCTTCTGACTCCTCCCAGAAACCAACCAACTTCTGAGCAGGAAATCCTGCCCCTCCCCAAAGAGTGGGAAACCGCAAAGGAAGAGAGAGATGAAACAGAAGGAAAGGCAGAGGA
GGAGGGAAAGAGAGAGAGAAGAGAAGCAAAAGAAAAAAGAACATCAATAAAAAGAAGTCAAATTTGTTCGAAATCTTGAGGAGTCTTCAGGCCAGCTCCCTGTCGGATGGCTTTTATGAAAAAATATC
TCCTCCCCATTCTGGGGCTCTTCATGGCCTACTACTACTATTCTGCATATGAGGAATTCAGACCAGAGATGCTCCAAGGAAAGAAAGTGATTGTCACAGGGGCCAGCAAAGGGATCGGAAGAGAGATG
GCTTATCATCTGGCGAAGATGGGAGCCCACGTGGTGGTAACAGCGAGGTCAAAAGAAACTCTACAGAAGGTGGTTTCCCACTGCCTGGAACTTGGAGCAGCCTCAGCACACTACATTGCTGGCACCAT
GGAAGACATGACCTTCGCAGAGCAATTTGTTGCCCAAGCAGGAAAGCTCATGGGAGGACTAGACATGCTCATTCTCAACCACATCACCAACACTTCTTTGAATCTTTTTCATGATGATATTCACCATG
TGCGCAAAAGCATGGAGGTCAACTTCCTCAGTTATGTGGTCCTGACTGTAGCTGCCTTGCCCATGCTGAAGCAGAGCAATGGAAGCATTGTTGTCGTCTCTTCTTTGGCTGGGAAAGTGGCTTATCCA
ATGGTTGCTGCCTATTCTGCAAGCAAGTTTGCTTTGGATGGGTTCTTCTCCTCCATCAGAAAGGAATATTCATTGGCCAAGGTCAATGTATCAATCACTCTCTGTGTTCTTGGCCTCATAGACACAGA
CACAGCCATGAAGGCAGTTTCTGGGATAATCAATATGCAAGCAGCTCCAAAGGAGGAATGTGCCCTTGAGATCATCAAAGGGGGAGCTCTGCGCCAAGAAGAAGTATATTATGACAGCTCACTCTGGA
CCACTCTTCTGTTGAGAAATCCATGCAGGAAGATCCTGGAATTTCTTTACTCATCGACCTATAATATGGACAGATTCACAAAAAACTAGGAACTCTCTGAGGGCTGGGCATGCTGAGGGATTTTGGGA
CTGTTCTGTCTCATATTTATCTGAGCTCTTGTCCATGAAGACATCTTCCCAGAGTGTCCCCAGAGACATGCAAGTCATGGGTCACACCTGACAAATGGAAGGAGTTCCTCTAACATTTGCACAATGGA
AATGTAATAATAATGAATGTCATGCACCACTGCAGCCAGCAGTTATAAAATTGTTAGTAAACATAGGTATAATTACCAGATAGTTATATTAAATTTATCTCATATATAATAATATGTGATGATTAATA
CAATATTAATTATAATAAAGGTCACATAAATGTTATAAATTCATAA

hide sequence


Protein RefSeqs	XP_007986783	(Get FASTA)	NCBI Sequence Viewer
	XP_072867638	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000011350.1

RefSeq Acc Id:	XP_007986783 ⟸ XM_007988592
- UniProtKB:	A0A0D9RRW1 (UniProtKB/TrEMBL)

RefSeq Acc Id:

XP_007986782 ⟸ XM_007988591

Ensembl Acc Id:

ENSCSAP00000011350 ⟸ ENSCSAT00000013349

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000015252	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000013349.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	11-beta-HSD	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	Sc_DH/Rdtase_CS	UniProtKB/TrEMBL
	SDR_fam	UniProtKB/TrEMBL
KEGG Report	csab:103230154	UniProtKB/TrEMBL
NCBI Gene	HSD11B1	ENTREZGENE
PANTHER	CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1	UniProtKB/TrEMBL
	HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED	UniProtKB/TrEMBL
Pfam	adh_short	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/TrEMBL
PROSITE	ADH_SHORT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A0A0D9RRW1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB