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Gene: EPOR (erythropoietin receptor) Homo sapiens
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Symbol: EPOR
Name: erythropoietin receptor
Description: This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EPO-R; MGC138358
Orthologs:
Mus musculus (house mouse) : Epor (erythropoietin receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Epor (erythropoietin receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Epor (erythropoietin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : EPOR (erythropoietin receptor)
Canis lupus familiaris (dog) : EPOR (erythropoietin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Epor (erythropoietin receptor)
Sus scrofa (pig) : EPOR (erythropoietin receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,377,207 - 11,384,314 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371911,487,881 - 11,495,018 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,349,475 - 11,356,019 (-)NCBINCBI36hg18NCBI36
Build 341911,349,474 - 11,356,019NCBI
Celera1911,382,748 - 11,389,885 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1911,063,851 - 11,070,988 (-)NCBIHuRef
CHM1_11911,488,891 - 11,496,028 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on EPOR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736105
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.