CHEK1 Human (+)-schisandrin B multiple interactions ISO Chek1 (Mus musculus) 6480464 [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of CHEK1 protein] and [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] CTD PMID:22003191 CHEK1 Human (+)-schisandrin B multiple interactions ISO Chek1 (Rattus norvegicus) 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CHEK1 mRNA] CTD PMID:31150632 CHEK1 Human (S)-naringenin multiple interactions EXP 6480464 [naringenin co-treated with bisphenol A] results in increased expression of CHEK1 mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK1 mRNA CTD PMID:36235125 CHEK1 Human 1,1-dichloroethene increases expression ISO Chek1 (Mus musculus) 6480464 vinylidene chloride results in increased expression of CHEK1 mRNA CTD PMID:26682919 CHEK1 Human 1,3-dinitrobenzene increases expression ISO Chek1 (Rattus norvegicus) 6480464 3-dinitrobenzene results in increased expression of CHEK1 mRNA CTD PMID:22841810 CHEK1 Human 17alpha-ethynylestradiol affects expression ISO Chek1 (Mus musculus) 6480464 Ethinyl Estradiol affects the expression of CHEK1 mRNA CTD PMID:17555576 CHEK1 Human 17alpha-ethynylestradiol multiple interactions ISO Chek1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHEK1 mRNA CTD PMID:17942748 CHEK1 Human 17alpha-ethynylestradiol increases expression ISO Chek1 (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of CHEK1 mRNA CTD PMID:17942748 CHEK1 Human 17beta-estradiol multiple interactions ISO Chek1 (Mus musculus) 6480464 ESR1 protein promotes the reaction [Estradiol results in increased expression of CHEK1 mRNA] CTD PMID:25210133 CHEK1 Human 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of CHEK1 mRNA CTD PMID:16474171 and PMID:19167446 CHEK1 Human 17beta-estradiol affects expression ISO Chek1 (Mus musculus) 6480464 Estradiol affects the expression of CHEK1 mRNA CTD PMID:15598610 CHEK1 Human 17beta-estradiol increases expression ISO Chek1 (Mus musculus) 6480464 Estradiol results in increased expression of CHEK1 mRNA CTD PMID:25210133 CHEK1 Human 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression EXP 6480464 Metribolone results in increased expression of CHEK1 mRNA CTD PMID:19318562 CHEK1 Human 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases phosphorylation EXP 6480464 Metribolone results in increased phosphorylation of CHEK1 protein CTD PMID:23272087 CHEK1 Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Chek1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CHEK1 mRNA CTD PMID:17942748 CHEK1 Human 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Chek1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of CHEK1 mRNA CTD PMID:21570461 CHEK1 Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CHEK1 mRNA CTD PMID:21802500 CHEK1 Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Chek1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of CHEK1 mRNA CTD PMID:15667827 and PMID:19465110 CHEK1 Human 2,6-di-tert-butyl-4-methylphenol increases expression ISO Chek1 (Mus musculus) 6480464 Butylated Hydroxytoluene results in increased expression of CHEK1 mRNA CTD PMID:19000923 CHEK1 Human 2-methylcholine affects expression EXP 6480464 beta-methylcholine affects the expression of CHEK1 mRNA CTD PMID:21179406 CHEK1 Human 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Chek1 (Rattus norvegicus) 6480464 3 more ... CTD PMID:23196670 CHEK1 Human 3,3',5-triiodo-L-thyronine increases phosphorylation EXP 6480464 Triiodothyronine analog results in increased phosphorylation of CHEK1 protein CTD PMID:22383522 CHEK1 Human 3,4-methylenedioxymethamphetamine decreases expression ISO Chek1 (Mus musculus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of CHEK1 mRNA CTD PMID:20188158 CHEK1 Human 3-methyladenine multiple interactions EXP 6480464 3-methyladenine inhibits the reaction [BO-1012 results in increased phosphorylation of CHEK1 protein] CTD PMID:24823293 CHEK1 Human 4-hydroxynon-2-enal decreases expression ISO Chek1 (Mus musculus) 6480464 4-hydroxy-2-nonenal results in decreased expression of CHEK1 mRNA CTD PMID:19191707 CHEK1 Human 4-methoxy-TEMPO increases phosphorylation EXP 6480464 4-methoxy-2 more ... CTD PMID:28993908 CHEK1 Human 4-nitrophenol decreases expression ISO Chek1 (Mus musculus) 6480464 4-nitrophenol results in decreased expression of CHEK1 mRNA CTD PMID:34673133 CHEK1 Human 4-nonylphenol increases phosphorylation EXP 6480464 4-nonylphenol results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 CHEK1 Human 4-tert-Octylphenol increases phosphorylation EXP 6480464 4-tert-octylphenol results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 CHEK1 Human 5,7-dihydroxy-4'-methoxyflavone increases expression EXP 6480464 acacetin results in increased expression of CHK1 protein CTD PMID:36740148 CHEK1 Human 5-aza-2'-deoxycytidine affects localization EXP 6480464 Decitabine affects the localization of CHEK1 protein modified form CTD PMID:17991895 CHEK1 Human 5-fluorouracil affects response to substance EXP 6480464 CHEK1 protein affects the susceptibility to Fluorouracil CTD PMID:18698031 CHEK1 Human 5-fluorouracil decreases expression ISO Chek1 (Mus musculus) 6480464 Fluorouracil results in decreased expression of CHEK1 mRNA CTD PMID:19272435 CHEK1 Human 5-fluorouracil increases expression EXP 6480464 Fluorouracil results in increased expression of CHEK1 protein CTD PMID:15016801 CHEK1 Human 5-fluorouracil multiple interactions EXP 6480464 [CHEK1 protein co-treated with TP53 protein] affects the susceptibility to Fluorouracil more ... CTD PMID:15016801 more ... CHEK1 Human 6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine multiple interactions EXP 6480464 4-cyclohexylmethoxy-5-nitrosopyrimidine-2 and 6-diamine inhibits the reaction [1-(3-((2-(dimethylamino)ethyl)carbamoyl)phenyl)-3-(4-(bis(2-chloroethyl)amino)phenyl)urea results in increased phosphorylation of CHEK1 protein] CTD PMID:26208482 CHEK1 Human 6-propyl-2-thiouracil increases expression ISO Chek1 (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of CHEK1 mRNA CTD PMID:24780913 and PMID:30047161 CHEK1 Human 7,12-dimethyltetraphene increases expression ISO Chek1 (Mus musculus) 6480464 9 more ... CTD PMID:20025956 CHEK1 Human acrolein increases expression EXP 6480464 Acrolein results in increased expression of CHEK1 protein CTD PMID:34958888 CHEK1 Human acrylamide increases expression ISO Chek1 (Mus musculus) 6480464 Acrylamide results in increased expression of CHEK1 protein CTD PMID:20025956 CHEK1 Human aflatoxin B1 affects expression EXP 6480464 Aflatoxin B1 affects the expression of CHEK1 protein CTD PMID:20106945 CHEK1 Human aflatoxin B1 increases phosphorylation EXP 6480464 Aflatoxin B1 results in increased phosphorylation of CHEK1 protein CTD PMID:32106047 CHEK1 Human all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of CHEK1 mRNA CTD PMID:21934132 and PMID:33167477 CHEK1 Human all-trans-retinoic acid affects expression EXP 6480464 Tretinoin affects the expression of CHEK1 mRNA CTD PMID:23724009 CHEK1 Human all-trans-retinoic acid increases expression ISO Chek1 (Mus musculus) 6480464 Tretinoin results in increased expression of CHEK1 protein CTD PMID:20025956 CHEK1 Human amitrole increases expression ISO Chek1 (Rattus norvegicus) 6480464 Amitrole results in increased expression of CHEK1 mRNA CTD PMID:30047161 CHEK1 Human ammonium chloride affects expression ISO Chek1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of CHEK1 mRNA CTD PMID:16483693 CHEK1 Human ammonium chloride decreases expression ISO Chek1 (Rattus norvegicus) 6480464 Ammonium Chloride results in decreased expression of CHEK1 protein CTD PMID:16483693 CHEK1 Human anthocyanin increases phosphorylation EXP 6480464 Anthocyanins results in increased phosphorylation of CHEK1 protein CTD PMID:27444805 CHEK1 Human anthracene-1,8,9-triol increases expression ISO Chek1 (Mus musculus) 6480464 Anthralin results in increased expression of CHEK1 protein CTD PMID:20025956 CHEK1 Human antimycin A increases expression EXP 6480464 Antimycin A results in increased expression of CHEK1 mRNA CTD PMID:33512557 CHEK1 Human aphidicolin multiple interactions ISO Chek1 (Mus musculus) 6480464 [7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Aphidicolin results in increased expression of CHEK2 mRNA] and [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of CHEK1 protein] CTD PMID:22003191 CHEK1 Human aristolochic acid A decreases expression EXP 6480464 aristolochic acid I results in decreased expression of CHEK1 mRNA and aristolochic acid I results in decreased expression of CHEK1 protein CTD PMID:33212167 CHEK1 Human arsenite(3-) increases phosphorylation EXP 6480464 arsenite results in increased phosphorylation of CHEK1 protein CTD PMID:33097607 CHEK1 Human arsenite(3-) multiple interactions EXP 6480464 CHEK1 protein affects the reaction [arsenite promotes the reaction [TP53 protein binds to EP300 protein modified form binds to CREBBP protein modified form]] and CHEK1 protein affects the reaction [arsenite results in increased acetylation of TP53 protein] CTD PMID:33097607 CHEK1 Human arsenous acid increases phosphorylation ISO Chek1 (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:23337567 CHEK1 Human arsenous acid multiple interactions ISO Chek1 (Rattus norvegicus) 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of CHEK1 protein] CTD PMID:23337567 CHEK1 Human arsenous acid increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:16891316 CHEK1 Human arsenous acid increases phosphorylation EXP 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:16891316 CHEK1 Human artesunate increases phosphorylation EXP 6480464 Artesunate results in increased phosphorylation of CHEK1 protein CTD PMID:31664825 CHEK1 Human artesunate multiple interactions EXP 6480464 APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] CTD PMID:31664825 CHEK1 Human atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of CHEK1 mRNA CTD PMID:22378314 CHEK1 Human auraptene affects expression EXP 6480464 aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 CHEK1 Human azathioprine decreases expression EXP 6480464 Azathioprine results in decreased expression of CHEK1 mRNA CTD PMID:22623647 CHEK1 Human benzo[a]pyrene increases expression ISO Chek1 (Rattus norvegicus) 6480464 Benzo(a)pyrene results in increased expression of CHEK1 protein modified form CTD PMID:21604763 CHEK1 Human benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CHEK1 mRNA CTD PMID:32234424 CHEK1 Human benzo[a]pyrene affects methylation EXP 6480464 Benzo(a)pyrene affects the methylation of CHEK1 promoter CTD PMID:27901495 CHEK1 Human benzo[a]pyrene multiple interactions EXP 6480464 CLSPN mRNA affects the reaction [Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein] and cobaltous chloride promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein] CTD PMID:19464357 and PMID:20228066 CHEK1 Human benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CHEK1 mRNA CTD PMID:21802500 and PMID:32244372 CHEK1 Human benzo[a]pyrene increases phosphorylation EXP 6480464 Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein CTD PMID:19464357 more ... CHEK1 Human benzo[a]pyrene diol epoxide I multiple interactions ISO Chek1 (Mus musculus) 6480464 POLH protein affects the reaction [7 more ... CTD PMID:22331492 CHEK1 Human benzo[a]pyrene diol epoxide I increases expression EXP 6480464 7 more ... CTD PMID:26238291 CHEK1 Human benzo[a]pyrene diol epoxide I increases phosphorylation ISO Chek1 (Mus musculus) 6480464 7 more ... CTD PMID:22331492 CHEK1 Human benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:20018196 and PMID:20382639 CHEK1 Human berberine increases expression EXP 6480464 Berberine results in increased expression of CHEK1 protein modified form CTD PMID:23747414 CHEK1 Human biphenyl-4-amine decreases expression EXP 6480464 4-biphenylamine results in decreased expression of CHEK1 mRNA CTD PMID:24857880 CHEK1 Human bis(2-chloroethyl) sulfide multiple interactions EXP 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] more ... CTD PMID:22119920 and PMID:25448276 CHEK1 Human bis(2-chloroethyl) sulfide decreases expression EXP 6480464 Mustard Gas results in decreased expression of CHEK1 mRNA CTD PMID:33491125 CHEK1 Human bis(2-chloroethyl) sulfide increases phosphorylation EXP 6480464 Mustard Gas results in increased phosphorylation of CHEK1 protein CTD PMID:22119920 and PMID:25448276 CHEK1 Human bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form] CTD PMID:30720231 CHEK1 Human bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CHEK1 mRNA CTD PMID:16474171 CHEK1 Human bisphenol A increases phosphorylation EXP 6480464 bisphenol A results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 and PMID:38372072 CHEK1 Human bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with cylindrospermopsin] results in decreased expression of CHEK1 mRNA more ... CTD PMID:32244372 and PMID:36235125 CHEK1 Human bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CHEK1 mRNA and bisphenol A results in decreased expression of CHEK1 protein CTD PMID:29275510 more ... CHEK1 Human bisphenol A decreases expression ISO Chek1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of CHEK1 mRNA CTD PMID:25181051 more ... CHEK1 Human bisphenol A multiple interactions ISO Chek1 (Rattus norvegicus) 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of CHEK1 mRNA CTD PMID:26496021 CHEK1 Human Brevetoxin B increases expression EXP 6480464 brevetoxin 2 results in increased expression of CHEK1 mRNA CTD PMID:20498034 CHEK1 Human busulfan multiple interactions EXP 6480464 [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein CTD PMID:20933509 CHEK1 Human cadmium atom decreases expression EXP 6480464 Cadmium results in decreased expression of CHEK1 mRNA CTD PMID:21120746 CHEK1 Human cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of CHEK1 mRNA CTD PMID:38568856 CHEK1 Human caffeine multiple interactions EXP 6480464 Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]] more ... CTD PMID:15975956 more ... CHEK1 Human caffeine increases phosphorylation EXP 6480464 Caffeine results in increased phosphorylation of CHEK1 protein CTD PMID:29074359 CHEK1 Human caffeine multiple interactions ISO Chek1 (Mus musculus) 6480464 Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA] and Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] CTD PMID:22403396 CHEK1 Human caffeine decreases expression ISO Chek1 (Mus musculus) 6480464 Caffeine results in decreased expression of CHEK1 protein modified form CTD PMID:21505179 CHEK1 Human caffeine decreases phosphorylation EXP 6480464 Caffeine results in decreased phosphorylation of CHEK1 protein CTD PMID:21561856 and PMID:35688186 CHEK1 Human camptothecin multiple interactions EXP 6480464 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form] and Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form] CTD PMID:25269479 and PMID:30720231 CHEK1 Human camptothecin increases phosphorylation EXP 6480464 Camptothecin results in increased phosphorylation of CHEK1 protein CTD PMID:21646468 and PMID:30555576 CHEK1 Human camptothecin increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Camptothecin results in increased phosphorylation of CHEK1 protein CTD PMID:22403396 CHEK1 Human camptothecin multiple interactions ISO Chek1 (Mus musculus) 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] more ... CTD PMID:22403396 CHEK1 Human camptothecin increases expression ISO Chek1 (Mus musculus) 6480464 Camptothecin results in increased expression of CHEK1 mRNA CTD PMID:22403396 CHEK1 Human camptothecin decreases response to substance EXP 6480464 CHEK1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 CHEK1 Human camptothecin increases expression EXP 6480464 Camptothecin results in increased expression of CHEK1 protein modified form CTD PMID:25269479 and PMID:30720231 CHEK1 Human cannabidiol decreases expression EXP 6480464 Cannabidiol results in decreased expression of CHEK1 mRNA CTD PMID:36519830 CHEK1 Human carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of CHEK1 mRNA CTD PMID:24752500 CHEK1 Human carmustine multiple interactions EXP 6480464 ATR protein affects the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] more ... CTD PMID:19261750 CHEK1 Human catechol increases expression ISO Chek1 (Mus musculus) 6480464 catechol results in increased expression of CHEK1 protein CTD PMID:20025956 CHEK1 Human cefaloridine increases expression ISO Chek1 (Rattus norvegicus) 6480464 Cephaloridine results in increased expression of CHEK1 mRNA CTD PMID:18500788 CHEK1 Human chlorpyrifos decreases expression ISO Chek1 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of CHEK1 mRNA CTD PMID:20350560 and PMID:37019170 CHEK1 Human cholic acid increases expression ISO Chek1 (Mus musculus) 6480464 Cholic Acid results in increased expression of CHEK1 protein CTD PMID:20025956 CHEK1 Human choline affects expression EXP 6480464 Choline affects the expression of CHEK1 mRNA CTD PMID:17616785 CHEK1 Human choline multiple interactions ISO Chek1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHEK1 mRNA CTD PMID:20938992 CHEK1 Human ciprofloxacin increases expression ISO Chek1 (Rattus norvegicus) 6480464 Ciprofloxacin results in increased expression of CHEK1 protein CTD PMID:18512786 CHEK1 Human cisplatin multiple interactions EXP 6480464 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] more ... CTD PMID:20623183 more ... CHEK1 Human cisplatin multiple interactions ISO Chek1 (Rattus norvegicus) 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form] CTD PMID:26739623 CHEK1 Human cisplatin increases expression ISO Chek1 (Rattus norvegicus) 6480464 Cisplatin results in increased expression of CHEK1 protein modified form CTD PMID:26739623 CHEK1 Human cisplatin increases phosphorylation EXP 6480464 Cisplatin results in increased phosphorylation of CHEK1 protein CTD PMID:20623183 more ... CHEK1 Human cisplatin increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Cisplatin results in increased phosphorylation of CHEK1 protein CTD PMID:21285353 and PMID:22006019 CHEK1 Human cisplatin multiple interactions ISO Chek1 (Mus musculus) 6480464 [7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Cisplatin results in increased expression of CHEK2 mRNA] more ... CTD PMID:21324906 and PMID:22003191 CHEK1 Human cisplatin increases activity EXP 6480464 Cisplatin results in increased activity of CHEK1 protein CTD PMID:21324906 and PMID:21592546 CHEK1 Human cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of CHEK1 protein CTD PMID:12740909 CHEK1 Human clofarabine multiple interactions EXP 6480464 [clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CHEK1 protein CTD PMID:20933509 CHEK1 Human clofibrate increases expression ISO Chek1 (Mus musculus) 6480464 Clofibrate results in increased expression of CHEK1 protein CTD PMID:20025956 CHEK1 Human cobalt dichloride multiple interactions EXP 6480464 cobaltous chloride promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of CHEK1 protein] CTD PMID:20228066 CHEK1 Human cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of CHEK1 mRNA CTD PMID:19320972 and PMID:19376846 CHEK1 Human cobalt dichloride increases phosphorylation EXP 6480464 cobaltous chloride results in increased phosphorylation of CHEK1 protein CTD PMID:20228066 CHEK1 Human copper atom increases expression ISO Chek1 (Rattus norvegicus) 6480464 Copper results in increased expression of CHEK1 mRNA CTD PMID:22465980 CHEK1 Human copper atom multiple interactions EXP 6480464 [Chelating Agents binds to Copper] which results in increased expression of CHEK1 mRNA and [NSC 689534 binds to Copper] which results in decreased expression of CHEK1 mRNA CTD PMID:20971185 and PMID:30911355 CHEK1 Human copper(0) increases expression ISO Chek1 (Rattus norvegicus) 6480464 Copper results in increased expression of CHEK1 mRNA CTD PMID:22465980 CHEK1 Human copper(0) multiple interactions EXP 6480464 [Chelating Agents binds to Copper] which results in increased expression of CHEK1 mRNA and [NSC 689534 binds to Copper] which results in decreased expression of CHEK1 mRNA CTD PMID:20971185 and PMID:30911355 CHEK1 Human copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of CHEK1 mRNA CTD PMID:19549813 CHEK1 Human corosolic acid decreases expression EXP 6480464 corosolic acid results in decreased expression of CHEK1 mRNA and corosolic acid results in decreased expression of CHEK1 protein CTD PMID:37939859 CHEK1 Human coumarin decreases phosphorylation EXP 6480464 coumarin results in decreased phosphorylation of CHEK1 protein CTD PMID:35688186 CHEK1 Human coumestrol multiple interactions EXP 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 CHEK1 Human coumestrol increases expression EXP 6480464 Coumestrol results in increased expression of CHEK1 mRNA CTD PMID:19167446 CHEK1 Human crocidolite asbestos increases expression EXP 6480464 Asbestos and Crocidolite results in increased expression of CHEK1 protein CTD PMID:21570478 CHEK1 Human curcumin decreases response to substance EXP 6480464 CHEK1 protein results in decreased susceptibility to Curcumin CTD PMID:18602917 CHEK1 Human curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein] CTD PMID:27996348 CHEK1 Human curcumin increases activity EXP 6480464 Curcumin results in increased activity of CHEK1 protein CTD PMID:18602917 CHEK1 Human curcumin increases phosphorylation EXP 6480464 Curcumin results in increased phosphorylation of CHEK1 protein CTD PMID:19401701 CHEK1 Human CX-5461 increases phosphorylation EXP 6480464 CX 5461 results in increased phosphorylation of CHEK1 protein CTD PMID:28211448 CHEK1 Human cyclosporin A decreases expression ISO Chek1 (Mus musculus) 6480464 Cyclosporine results in decreased expression of CHEK1 mRNA CTD PMID:25270620 CHEK1 Human cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of CHEK1 mRNA CTD PMID:20106945 more ... CHEK1 Human cylindrospermopsin increases expression EXP 6480464 cylindrospermopsin results in increased expression of CHEK1 mRNA CTD PMID:23726867 CHEK1 Human cylindrospermopsin multiple interactions EXP 6480464 [bisphenol A co-treated with cylindrospermopsin] results in decreased expression of CHEK1 mRNA CTD PMID:32244372 CHEK1 Human Decamethylcyclopentasiloxane decreases expression EXP 6480464 decamethylcyclopentasiloxane results in decreased expression of CHEK1 mRNA CTD PMID:27601420 CHEK1 Human deguelin increases expression EXP 6480464 deguelin results in increased expression of CHEK1 mRNA CTD PMID:33512557 CHEK1 Human Diallyl sulfide increases phosphorylation EXP 6480464 allyl sulfide results in increased phosphorylation of CHEK1 protein CTD PMID:24650757 CHEK1 Human Diallyl sulfide multiple interactions EXP 6480464 CHEK1 protein promotes the reaction [allyl sulfide results in decreased expression of CCNB1 protein] and CHEK1 protein promotes the reaction [allyl sulfide results in decreased expression of CDC25C protein] CTD PMID:24650757 CHEK1 Human diarsenic trioxide increases phosphorylation ISO Chek1 (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:23337567 CHEK1 Human diarsenic trioxide increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:16891316 CHEK1 Human diarsenic trioxide increases phosphorylation EXP 6480464 Arsenic Trioxide results in increased phosphorylation of CHEK1 protein CTD PMID:16891316 CHEK1 Human diarsenic trioxide multiple interactions ISO Chek1 (Rattus norvegicus) 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of CHEK1 protein] CTD PMID:23337567 CHEK1 Human dibutyl phthalate decreases expression ISO Chek1 (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of CHEK1 mRNA CTD PMID:21266533 CHEK1 Human diclofenac affects expression EXP 6480464 Diclofenac affects the expression of CHEK1 mRNA CTD PMID:24752500 CHEK1 Human dicrotophos decreases expression EXP 6480464 dicrotophos results in decreased expression of CHEK1 mRNA CTD PMID:28302478 CHEK1 Human diepoxybutane increases phosphorylation ISO Chek1 (Mus musculus) 6480464 diepoxybutane results in increased phosphorylation of CHEK1 protein CTD PMID:25633853 CHEK1 Human diepoxybutane increases expression ISO Chek1 (Mus musculus) 6480464 diepoxybutane results in increased expression of CHEK1 protein modified form CTD PMID:25633853 CHEK1 Human diepoxybutane multiple interactions ISO Chek1 (Mus musculus) 6480464 7-hydroxystaurosporine inhibits the reaction [diepoxybutane results in increased expression of CHEK1 protein modified form] more ... CTD PMID:25633853 CHEK1 Human diethyl sulfate decreases expression EXP 6480464 diethyl sulfate results in decreased expression of CHEK1 protein modified form CTD PMID:23830811 CHEK1 Human diethyl sulfate increases expression EXP 6480464 diethyl sulfate results in increased expression of CHEK1 protein modified form CTD PMID:23830811 CHEK1 Human digitoxin decreases expression EXP 6480464 Digitoxin analog results in decreased expression of CHEK1 protein and Digitoxin results in decreased expression of CHEK1 protein CTD PMID:22037315 CHEK1 Human dioscin decreases expression EXP 6480464 dioscin results in decreased expression of CHEK1 mRNA and dioscin results in decreased expression of CHEK1 protein CTD PMID:33359023 CHEK1 Human doxorubicin multiple interactions EXP 6480464 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein] more ... CTD PMID:15489221 more ... CHEK1 Human doxorubicin decreases expression ISO Chek1 (Mus musculus) 6480464 Doxorubicin results in decreased expression of CHEK1 mRNA CTD PMID:29653124 CHEK1 Human doxorubicin increases phosphorylation EXP 6480464 Doxorubicin results in increased phosphorylation of CHEK1 protein CTD PMID:17085670 more ... CHEK1 Human doxorubicin affects response to substance EXP 6480464 CHEK1 protein affects the susceptibility to Doxorubicin CTD PMID:16217747 and PMID:18698031 CHEK1 Human doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of CHEK1 mRNA and Doxorubicin results in decreased expression of CHEK1 protein CTD PMID:15870702 more ... CHEK1 Human Echimidine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of echimidine] which results in decreased expression of CHEK1 mRNA CTD PMID:33884520 CHEK1 Human Enterolactone multiple interactions EXP 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CHEK1 mRNA CTD PMID:19167446 CHEK1 Human Enterolactone increases expression EXP 6480464 2 and 3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of CHEK1 mRNA CTD PMID:19167446 CHEK1 Human entinostat decreases expression EXP 6480464 entinostat results in decreased expression of CHEK1 protein CTD PMID:34665271 CHEK1 Human epoxiconazole increases expression ISO Chek1 (Mus musculus) 6480464 epoxiconazole results in increased expression of CHEK1 mRNA CTD PMID:35436446 CHEK1 Human equol decreases expression EXP 6480464 Equol results in decreased expression of CHEK1 mRNA CTD PMID:16865672 CHEK1 Human estragole increases expression ISO Chek1 (Rattus norvegicus) 6480464 estragole results in increased expression of CHEK1 protein CTD PMID:29054680 CHEK1 Human etoposide affects response to substance EXP 6480464 CHEK1 protein affects the susceptibility to Etoposide CTD PMID:18698031 CHEK1 Human etoposide multiple interactions EXP 6480464 TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Etoposide] CTD PMID:18698031 CHEK1 Human fenofibrate increases expression ISO Chek1 (Rattus norvegicus) 6480464 Fenofibrate results in increased expression of CHEK1 mRNA CTD PMID:17264098 CHEK1 Human fenpyroximate increases expression EXP 6480464 fenpyroximate results in increased expression of CHEK1 mRNA CTD PMID:33512557 CHEK1 Human fisetin increases expression EXP 6480464 fisetin results in increased expression of CHEK1 protein CTD PMID:28181380 CHEK1 Human flavonoids decreases expression ISO Chek1 (Rattus norvegicus) 6480464 Flavonoids results in decreased expression of CHEK1 mRNA CTD PMID:18035473 CHEK1 Human floxuridine multiple interactions EXP 6480464 Floxuridine results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21613406 and PMID:22194930 CHEK1 Human flumequine multiple interactions ISO Chek1 (Mus musculus) 6480464 [flumequine co-treated with 2-amino-3 more ... CTD PMID:23681119 CHEK1 Human folic acid affects expression EXP 6480464 Folic Acid affects the expression of CHEK1 mRNA CTD PMID:16361273 CHEK1 Human folic acid multiple interactions ISO Chek1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHEK1 mRNA CTD PMID:20938992 CHEK1 Human FR900359 decreases phosphorylation EXP 6480464 FR900359 results in decreased phosphorylation of CHEK1 protein CTD PMID:37730182 CHEK1 Human furan increases expression ISO Chek1 (Mus musculus) 6480464 furan results in increased expression of CHEK1 mRNA CTD PMID:20194422 CHEK1 Human furan increases expression ISO Chek1 (Rattus norvegicus) 6480464 furan results in increased expression of CHEK1 mRNA CTD PMID:20562052 more ... CHEK1 Human furazolidone increases expression EXP 6480464 Furazolidone results in increased expression of CHEK1 protein CTD PMID:27996348 CHEK1 Human furazolidone multiple interactions EXP 6480464 Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein] CTD PMID:27996348 CHEK1 Human furosemide affects expression ISO Chek1 (Rattus norvegicus) 6480464 Furosemide affects the expression of CHEK1 mRNA CTD PMID:17497460 CHEK1 Human genistein increases expression EXP 6480464 Genistein results in increased expression of CHEK1 mRNA CTD PMID:16474171 CHEK1 Human geraniol decreases expression EXP 6480464 geraniol results in decreased expression of CHEK1 mRNA CTD PMID:27683099 CHEK1 Human glyphosate decreases expression EXP 6480464 Glyphosate results in decreased expression of CHEK1 mRNA CTD PMID:31295307 CHEK1 Human Goe 6976 decreases activity EXP 6480464 Go 6976 results in decreased activity of CHEK1 protein CTD PMID:10998351 and PMID:20619533 CHEK1 Human Goe 6976 increases phosphorylation EXP 6480464 Go 6976 results in increased phosphorylation of CHEK1 protein CTD PMID:29074359 CHEK1 Human Goe 6976 multiple interactions EXP 6480464 xanthatin inhibits the reaction [Go 6976 results in increased phosphorylation of CHEK1 protein] CTD PMID:29074359 CHEK1 Human gold atom multiple interactions EXP 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA CTD PMID:28433809 CHEK1 Human gold atom decreases expression EXP 6480464 Gold analog results in decreased expression of CHEK1 mRNA CTD PMID:36057382 CHEK1 Human gold(0) multiple interactions EXP 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA CTD PMID:28433809 CHEK1 Human gold(0) decreases expression EXP 6480464 Gold analog results in decreased expression of CHEK1 mRNA CTD PMID:36057382 CHEK1 Human GW 4064 increases expression EXP 6480464 GW 4064 results in increased expression of CHEK1 mRNA CTD PMID:31437187 CHEK1 Human hexamethylcyclotrisiloxane decreases expression EXP 6480464 hexamethylcyclotrisiloxane results in decreased expression of CHEK1 mRNA CTD PMID:27601420 CHEK1 Human hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of CHEK1 mRNA CTD PMID:12414654 CHEK1 Human hydrogen peroxide increases phosphorylation EXP 6480464 Hydrogen Peroxide results in increased phosphorylation of CHEK1 protein CTD PMID:26208482 and PMID:29074359 CHEK1 Human hydrogen peroxide multiple interactions EXP 6480464 MIRLET7G mRNA inhibits the reaction [Hydrogen Peroxide results in increased expression of CHEK1 protein] CTD PMID:25972194 CHEK1 Human hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of CHEK1 mRNA and Hydrogen Peroxide results in increased expression of CHEK1 protein CTD PMID:25972194 CHEK1 Human hydroxyurea multiple interactions EXP 6480464 Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]] CTD PMID:18158334 CHEK1 Human hydroxyurea increases phosphorylation EXP 6480464 Hydroxyurea results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 CHEK1 Human hydroxyurea increases expression EXP 6480464 Hydroxyurea results in increased expression of CHK1 protein modified form CTD PMID:21840268 CHEK1 Human hydroxyurea decreases expression ISO Chek1 (Mus musculus) 6480464 Hydroxyurea results in decreased expression of CHEK1 mRNA CTD PMID:12929121 CHEK1 Human indole-3-methanol affects expression ISO Chek1 (Rattus norvegicus) 6480464 indole-3-carbinol affects the expression of CHEK1 mRNA CTD PMID:21396975 CHEK1 Human indole-3-methanol multiple interactions ISO Chek1 (Rattus norvegicus) 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CHEK1 mRNA CTD PMID:22129741 CHEK1 Human irinotecan multiple interactions EXP 6480464 Irinotecan results in increased phosphorylation of and results in increased activity of CHEK1 protein and SAR 020106 inhibits the reaction [Irinotecan results in increased phosphorylation of CHEK1 protein] CTD PMID:22111927 and PMID:22510560 CHEK1 Human irinotecan increases phosphorylation EXP 6480464 Irinotecan results in increased phosphorylation of CHEK1 protein CTD PMID:22111927 and PMID:22898888 CHEK1 Human iron dichloride increases expression ISO Chek1 (Mus musculus) 6480464 ferrous chloride results in increased expression of CHEK1 protein CTD PMID:20025956 CHEK1 Human iron trichloride increases expression ISO Chek1 (Mus musculus) 6480464 ferric chloride results in increased expression of CHEK1 protein CTD PMID:20025956 CHEK1 Human isoflurane decreases expression ISO Chek1 (Rattus norvegicus) 6480464 Isoflurane results in decreased expression of CHEK1 mRNA CTD PMID:16978161 CHEK1 Human kaempferol increases phosphorylation ISO Chek1 (Mus musculus) 6480464 kaempferol results in increased phosphorylation of CHEK1 protein CTD PMID:24595819 CHEK1 Human L-methionine multiple interactions ISO Chek1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHEK1 mRNA CTD PMID:20938992 CHEK1 Human Lasiocarpine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of CHEK1 mRNA CTD PMID:33884520 CHEK1 Human lead diacetate increases expression ISO Chek1 (Mus musculus) 6480464 lead acetate results in increased expression of CHEK1 mRNA CTD PMID:22609695 CHEK1 Human lead diacetate increases expression ISO Chek1 (Rattus norvegicus) 6480464 lead acetate results in increased expression of CHEK1 mRNA CTD PMID:33862172 CHEK1 Human lead(0) affects expression EXP 6480464 Lead affects the expression of CHEK1 mRNA CTD PMID:28903495 CHEK1 Human lead(0) affects methylation EXP 6480464 Lead affects the methylation of CHEK1 gene CTD PMID:31636367 CHEK1 Human leflunomide decreases expression ISO Chek1 (Rattus norvegicus) 6480464 leflunomide results in decreased expression of CHEK1 mRNA CTD PMID:24136188 CHEK1 Human leptomycin B decreases expression EXP 6480464 leptomycin B results in decreased expression of CHEK1 mRNA CTD PMID:20803015 CHEK1 Human lovastatin multiple interactions EXP 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein] and Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein] CTD PMID:17088865 and PMID:21356574 CHEK1 Human lovastatin multiple interactions ISO Chek1 (Rattus norvegicus) 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form] CTD PMID:26739623 CHEK1 Human MeIQx multiple interactions ISO Chek1 (Mus musculus) 6480464 [flumequine co-treated with 2-amino-3 more ... CTD PMID:23681119 CHEK1 Human melphalan increases phosphorylation EXP 6480464 Melphalan results in increased phosphorylation of CHEK1 protein CTD PMID:26208482 CHEK1 Human menadione decreases expression EXP 6480464 Vitamin K 3 results in decreased expression of CHEK1 mRNA CTD PMID:12414654 CHEK1 Human metformin multiple interactions EXP 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK1 mRNA CTD PMID:29309887 CHEK1 Human methapyrilene increases expression ISO Chek1 (Rattus norvegicus) 6480464 Methapyrilene results in increased expression of CHEK1 mRNA CTD PMID:26558467 CHEK1 Human methimazole increases expression ISO Chek1 (Rattus norvegicus) 6480464 Methimazole results in increased expression of CHEK1 mRNA CTD PMID:30047161 CHEK1 Human methotrexate increases expression EXP 6480464 Methotrexate results in increased expression of CHEK1 mRNA CTD PMID:22484375 CHEK1 Human methotrexate increases expression ISO Chek1 (Mus musculus) 6480464 Methotrexate results in increased expression of CHEK1 protein modified form CTD PMID:22484375 CHEK1 Human methotrexate multiple interactions EXP 6480464 Methotrexate promotes the reaction [E2F1 protein binds to CHEK1 promoter] and Methotrexate results in increased expression of and results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:22484375 CHEK1 Human methotrexate decreases response to substance EXP 6480464 CHEK1 protein results in decreased susceptibility to Methotrexate CTD PMID:22484375 CHEK1 Human methotrexate multiple interactions ISO Chek1 (Mus musculus) 6480464 Methotrexate promotes the reaction [E2F1 protein binds to CHEK1 promoter] CTD PMID:22484375 CHEK1 Human methyl isocyanate increases expression ISO Chek1 (Mus musculus) 6480464 methyl isocyanate results in increased expression of CHEK1 mRNA CTD PMID:22223508 CHEK1 Human methylmercury chloride decreases expression ISO Chek1 (Mus musculus) 6480464 methylmercuric chloride results in decreased expression of CHEK1 mRNA CTD PMID:20061341 CHEK1 Human Mezerein increases expression ISO Chek1 (Mus musculus) 6480464 mezerein results in increased expression of CHEK1 mRNA CTD PMID:19000923 CHEK1 Human mifepristone multiple interactions ISO Chek1 (Mus musculus) 6480464 Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of CHEK1 protein] CTD PMID:22403396 CHEK1 Human mitomycin C increases phosphorylation EXP 6480464 Mitomycin results in increased phosphorylation of CHEK1 protein CTD PMID:26208482 CHEK1 Human monocrotaline multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CHEK1 mRNA and [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CHEK1 mRNA CTD PMID:33884520 CHEK1 Human N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CHEK1 mRNA] and Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]] CTD PMID:15489221 and PMID:33971260 CHEK1 Human N-acetyl-L-cysteine multiple interactions ISO Chek1 (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CHEK1 protein modified form] CTD PMID:25633853 CHEK1 Human N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases expression ISO Chek1 (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CHEK1 mRNA CTD PMID:20061341 CHEK1 Human N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein] more ... CTD PMID:26921499 CHEK1 Human N-nitrosodiethylamine multiple interactions ISO Chek1 (Mus musculus) 6480464 ATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of CHEK1 mRNA] more ... CTD PMID:17854601 and PMID:19919837 CHEK1 Human N-nitrosodiethylamine multiple interactions ISO Chek1 (Rattus norvegicus) 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CHEK1 mRNA CTD PMID:22129741 CHEK1 Human N-nitrosodiethylamine increases expression ISO Chek1 (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of CHEK1 mRNA and Diethylnitrosamine results in increased expression of CHEK1 protein CTD PMID:17854601 and PMID:19919837 CHEK1 Human nickel atom decreases expression EXP 6480464 Nickel results in decreased expression of CHEK1 mRNA CTD PMID:24768652 CHEK1 Human nickel atom increases expression EXP 6480464 Nickel results in increased expression of CHEK1 mRNA CTD PMID:25583101 CHEK1 Human nimustine multiple interactions EXP 6480464 FOSL1 protein affects the reaction [Nimustine results in increased phosphorylation of CHEK1 protein] CTD PMID:22609303 CHEK1 Human nimustine increases phosphorylation EXP 6480464 Nimustine results in increased phosphorylation of CHEK1 protein CTD PMID:22609303 CHEK1 Human nocodazole decreases expression EXP 6480464 Nocodazole results in decreased expression of CHEK1 protein CTD PMID:26914363 CHEK1 Human NORCANTHARIDIN increases phosphorylation EXP 6480464 norcantharidin results in increased phosphorylation of CHEK1 protein CTD PMID:21266192 CHEK1 Human O-methyleugenol affects expression ISO Chek1 (Rattus norvegicus) 6480464 methyleugenol affects the expression of CHEK1 mRNA CTD PMID:26011634 CHEK1 Human ochratoxin A decreases acetylation EXP 6480464 ochratoxin A results in decreased acetylation of CHEK1 promoter CTD PMID:29098329 CHEK1 Human ochratoxin A increases expression ISO Chek1 (Rattus norvegicus) 6480464 ochratoxin A results in increased expression of CHEK1 mRNA CTD PMID:19237604 more ... CHEK1 Human octamethylcyclotetrasiloxane decreases expression EXP 6480464 octamethylcyclotetrasiloxane results in decreased expression of CHEK1 mRNA CTD PMID:27601420 CHEK1 Human olaparib increases phosphorylation EXP 6480464 olaparib results in increased phosphorylation of CHEK1 protein CTD PMID:25531448 CHEK1 Human oxaliplatin decreases expression ISO Chek1 (Rattus norvegicus) 6480464 oxaliplatin results in decreased expression of CHEK1 mRNA CTD PMID:25729387 CHEK1 Human oxaliplatin multiple interactions ISO Chek1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CHEK1 mRNA CTD PMID:25729387 CHEK1 Human oxfendazole affects expression ISO Chek1 (Rattus norvegicus) 6480464 oxfendazole affects the expression of CHEK1 mRNA CTD PMID:26558467 CHEK1 Human ozone increases expression ISO Chek1 (Mus musculus) 6480464 Ozone results in increased expression of CHEK1 mRNA CTD PMID:19555225 CHEK1 Human ozone multiple interactions ISO Chek1 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of CHEK1 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of CHEK1 mRNA CTD PMID:27106289 and PMID:34911549 CHEK1 Human p-anisidine decreases expression ISO Chek1 (Mus musculus) 6480464 4-anisidine results in decreased expression of CHEK1 mRNA CTD PMID:12929121 CHEK1 Human p-tert-Amylphenol increases phosphorylation EXP 6480464 4-tert-octylphenol results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 CHEK1 Human paclitaxel decreases expression ISO Chek1 (Mus musculus) 6480464 Paclitaxel results in decreased expression of CHEK1 mRNA CTD PMID:12929121 CHEK1 Human paclitaxel multiple interactions EXP 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK1 mRNA CTD PMID:29309887 CHEK1 Human paracetamol increases expression ISO Chek1 (Mus musculus) 6480464 Acetaminophen results in increased expression of CHEK1 protein CTD PMID:20025956 CHEK1 Human paracetamol multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CHEK1 mRNA] CTD PMID:33971260 CHEK1 Human paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of CHEK1 mRNA CTD PMID:33971260 CHEK1 Human paraquat multiple interactions ISO Chek1 (Mus musculus) 6480464 [ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CHEK1 mRNA CTD PMID:28012437 CHEK1 Human perfluorooctane-1-sulfonic acid multiple interactions ISO Chek1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of CHEK1 mRNA CTD PMID:36331819 CHEK1 Human PF-00477736 decreases activity EXP 6480464 PF 00477736 results in decreased activity of CHEK1 protein CTD PMID:21707865 CHEK1 Human PF-00477736 multiple interactions EXP 6480464 PF 00477736 inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] CTD PMID:25448276 CHEK1 Human phenobarbital affects expression ISO Chek1 (Mus musculus) 6480464 Phenobarbital affects the expression of CHEK1 mRNA CTD PMID:23091169 CHEK1 Human PhIP increases phosphorylation EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 CHEK1 Human phorbol 13-acetate 12-myristate increases expression ISO Chek1 (Mus musculus) 6480464 Tetradecanoylphorbol Acetate results in increased expression of CHEK1 mRNA CTD PMID:19000923 CHEK1 Human pirinixic acid increases expression ISO Chek1 (Mus musculus) 6480464 pirinixic acid results in increased expression of CHEK1 mRNA CTD PMID:20813756 CHEK1 Human pirinixic acid multiple interactions ISO Chek1 (Mus musculus) 6480464 [pirinixic acid co-treated with PPARA] results in increased expression of CHEK1 mRNA CTD PMID:20813756 CHEK1 Human platinum multiple interactions EXP 6480464 Platinum analog results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21107699 CHEK1 Human platinum(0) multiple interactions EXP 6480464 Platinum analog results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21107699 CHEK1 Human pregnenolone 16alpha-carbonitrile multiple interactions ISO Chek1 (Mus musculus) 6480464 [1 more ... CTD PMID:23626729 CHEK1 Human progesterone decreases expression ISO Chek1 (Rattus norvegicus) 6480464 Progesterone results in decreased expression of CHEK1 mRNA CTD PMID:20726854 CHEK1 Human progesterone multiple interactions ISO Chek1 (Mus musculus) 6480464 Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of CHEK1 protein] CTD PMID:22403396 CHEK1 Human progesterone increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Progesterone results in increased phosphorylation of CHEK1 protein CTD PMID:22403396 CHEK1 Human promethazine increases expression ISO Chek1 (Rattus norvegicus) 6480464 Promethazine results in increased expression of CHEK1 mRNA CTD PMID:26558467 CHEK1 Human promethazine decreases expression ISO Chek1 (Rattus norvegicus) 6480464 Promethazine results in decreased expression of CHEK1 mRNA CTD PMID:26011634 CHEK1 Human propiconazole increases expression ISO Chek1 (Mus musculus) 6480464 propiconazole results in increased expression of CHEK1 mRNA CTD PMID:21278054 CHEK1 Human Ptaquiloside increases phosphorylation EXP 6480464 ptaquiloside results in increased phosphorylation of CHEK1 protein CTD PMID:22143989 CHEK1 Human pyrimidifen increases expression EXP 6480464 pyrimidifen results in increased expression of CHEK1 mRNA CTD PMID:33512557 CHEK1 Human quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of CHEK1 mRNA CTD PMID:23727915 CHEK1 Human quercetin decreases expression ISO Chek1 (Mus musculus) 6480464 Quercetin results in decreased expression of CHEK1 mRNA CTD PMID:25862958 CHEK1 Human quercetin increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Quercetin results in increased phosphorylation of CHEK1 protein CTD PMID:24595819 CHEK1 Human quizartinib decreases expression EXP 6480464 quizartinib results in decreased expression of CHEK1 protein CTD PMID:34665271 CHEK1 Human quizartinib multiple interactions EXP 6480464 quizartinib promotes the reaction [RGFP966 results in decreased expression of CHEK1 protein] more ... CTD PMID:34665271 CHEK1 Human resveratrol increases expression EXP 6480464 resveratrol results in increased expression of CHEK1 mRNA CTD PMID:19167446 CHEK1 Human resveratrol decreases expression ISO Chek1 (Rattus norvegicus) 6480464 Resveratrol results in decreased expression of CHEK1 mRNA CTD PMID:33775663 CHEK1 Human resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of CHEK1 mRNA CTD PMID:18089832 CHEK1 Human resveratrol affects expression EXP 6480464 resveratrol affects the expression of CHEK1 protein CTD PMID:18089832 CHEK1 Human resveratrol multiple interactions EXP 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of CHEK1 mRNA more ... CTD PMID:15975956 and PMID:19167446 CHEK1 Human RGFP966 decreases expression EXP 6480464 RGFP966 results in decreased expression of CHEK1 protein CTD PMID:34665271 CHEK1 Human RGFP966 multiple interactions EXP 6480464 quizartinib promotes the reaction [RGFP966 results in decreased expression of CHEK1 protein] and RGFP966 promotes the reaction [quizartinib results in decreased expression of CHEK1 protein] CTD PMID:34665271 CHEK1 Human riddelliine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CHEK1 mRNA CTD PMID:33884520 CHEK1 Human rimonabant decreases phosphorylation EXP 6480464 Rimonabant results in decreased phosphorylation of CHEK1 protein CTD PMID:19479993 CHEK1 Human romidepsin multiple interactions EXP 6480464 romidepsin promotes the reaction [quizartinib results in decreased expression of and results in increased phosphorylation of CHEK1 protein] CTD PMID:34665271 CHEK1 Human rotenone increases expression EXP 6480464 Rotenone results in increased expression of CHEK1 mRNA CTD PMID:18191903 and PMID:33512557 CHEK1 Human saccharin increases expression ISO Chek1 (Mus musculus) 6480464 Saccharin results in increased expression of CHEK1 mRNA CTD PMID:19000923 CHEK1 Human selinexor multiple interactions EXP 6480464 [selinexor co-treated with INCB057643] results in decreased phosphorylation of CHEK1 protein CTD PMID:37899423 CHEK1 Human silver(1+) nitrate increases expression EXP 6480464 Silver Nitrate analog results in increased expression of CHEK1 mRNA CTD PMID:22831968 CHEK1 Human sodium arsenite increases phosphorylation EXP 6480464 sodium arsenite results in increased phosphorylation of CHEK1 protein CTD PMID:29039521 CHEK1 Human sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of CHEK1 mRNA CTD PMID:38568856 CHEK1 Human sodium nitrite increases expression ISO Chek1 (Mus musculus) 6480464 Sodium Nitrite results in increased expression of CHEK1 protein CTD PMID:20025956 CHEK1 Human stavudine increases phosphorylation ISO Chek1 (Mus musculus) 6480464 Stavudine results in increased phosphorylation of CHEK1 protein CTD PMID:32278789 CHEK1 Human sterigmatocystin multiple interactions EXP 6480464 ATR protein promotes the reaction [Sterigmatocystin results in increased phosphorylation of CHEK1 protein] and Sterigmatocystin results in increased expression of and results in increased phosphorylation of CHEK1 protein CTD PMID:26914363 CHEK1 Human sterigmatocystin increases expression EXP 6480464 Sterigmatocystin results in increased expression of CHEK1 protein modified form CTD PMID:26914363 CHEK1 Human styrene oxide increases expression ISO Chek1 (Mus musculus) 6480464 styrene oxide results in increased expression of CHEK1 protein CTD PMID:20025956 CHEK1 Human succimer multiple interactions ISO Chek1 (Mus musculus) 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CHEK1 mRNA CTD PMID:21641980 CHEK1 Human sulfadimethoxine increases expression ISO Chek1 (Rattus norvegicus) 6480464 Sulfadimethoxine results in increased expression of CHEK1 mRNA CTD PMID:30047161 CHEK1 Human sunitinib decreases expression EXP 6480464 Sunitinib results in decreased expression of CHEK1 mRNA CTD PMID:31533062 CHEK1 Human tamoxifen affects expression ISO Chek1 (Mus musculus) 6480464 Tamoxifen affects the expression of CHEK1 mRNA CTD PMID:17555576 CHEK1 Human temozolomide increases phosphorylation EXP 6480464 temozolomide results in increased phosphorylation of CHEK1 protein and temozolomide results in increased phosphorylation of CHK1 protein CTD PMID:15930307 and PMID:28122345 CHEK1 Human temozolomide increases expression EXP 6480464 Temozolomide results in increased expression of CHEK1 mRNA CTD PMID:31758290 CHEK1 Human temozolomide multiple interactions EXP 6480464 XAF1 protein promotes the reaction [temozolomide results in increased phosphorylation of CHK1 protein] CTD PMID:28122345 CHEK1 Human tert-butyl hydroperoxide decreases expression EXP 6480464 tert-Butylhydroperoxide results in decreased expression of CHEK1 mRNA CTD PMID:12414654 CHEK1 Human testosterone multiple interactions ISO Chek1 (Rattus norvegicus) 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of CHEK1 mRNA CTD PMID:26496021 CHEK1 Human tetrachloromethane decreases expression ISO Chek1 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in decreased expression of CHEK1 mRNA CTD PMID:31150632 CHEK1 Human tetrachloromethane increases expression ISO Chek1 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of CHEK1 mRNA CTD PMID:31919559 CHEK1 Human tetrachloromethane multiple interactions ISO Chek1 (Rattus norvegicus) 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CHEK1 mRNA] CTD PMID:31150632 CHEK1 Human thapsigargin decreases expression EXP 6480464 Thapsigargin results in decreased expression of CHEK1 mRNA CTD PMID:22378314 CHEK1 Human thioacetamide increases phosphorylation ISO Chek1 (Rattus norvegicus) 6480464 Thioacetamide results in increased phosphorylation of CHEK1 protein CTD PMID:22659510 CHEK1 Human thioacetamide increases expression ISO Chek1 (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of CHEK1 mRNA CTD PMID:22659510 more ... CHEK1 Human titanium dioxide decreases expression ISO Chek1 (Mus musculus) 6480464 titanium dioxide results in decreased expression of CHEK1 mRNA CTD PMID:35295148 CHEK1 Human titanium dioxide decreases methylation ISO Chek1 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of CHEK1 gene CTD PMID:35295148 CHEK1 Human topotecan multiple interactions ISO Chek1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CHEK1 mRNA CTD PMID:25729387 CHEK1 Human trichostatin A decreases expression EXP 6480464 trichostatin A results in decreased expression of CHEK1 mRNA CTD PMID:23770000 CHEK1 Human trimellitic anhydride increases expression ISO Chek1 (Mus musculus) 6480464 trimellitic anhydride results in increased expression of CHEK1 mRNA CTD PMID:19042947 CHEK1 Human triphenyl phosphate affects expression EXP 6480464 triphenyl phosphate affects the expression of CHEK1 mRNA CTD PMID:37042841 CHEK1 Human troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of CHEK1 mRNA CTD PMID:19140230 CHEK1 Human tungsten increases expression ISO Chek1 (Mus musculus) 6480464 Tungsten results in increased expression of CHEK1 mRNA CTD PMID:30912803 CHEK1 Human usnic acid increases expression EXP 6480464 usnic acid results in increased expression of CHEK1 protein modified form CTD PMID:27369375 CHEK1 Human valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of CHEK1 mRNA CTD PMID:25979313 CHEK1 Human valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of CHEK1 mRNA CTD PMID:20585447 more ... CHEK1 Human vemurafenib multiple interactions EXP 6480464 [(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of CHEK1 mRNA CTD PMID:27169980 CHEK1 Human versicolorin A increases phosphorylation EXP 6480464 versicolorin A results in increased phosphorylation of CHEK1 protein CTD PMID:32106047 CHEK1 Human wortmannin multiple interactions EXP 6480464 wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] and wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] CTD PMID:19261750 and PMID:22119920 CHEK1 Human wortmannin decreases expression EXP 6480464 wortmannin results in decreased expression of CHEK1 protein CTD PMID:22409540 CHEK1 Human Xanthatin multiple interactions EXP 6480464 TP53 protein promotes the reaction [xanthatin results in decreased phosphorylation of CHEK1 protein] more ... CTD PMID:29074359 CHEK1 Human Xanthatin affects phosphorylation EXP 6480464 xanthatin affects the phosphorylation of CHEK1 protein CTD PMID:29074359 CHEK1 Human zearalenone decreases phosphorylation ISO Chek1 (Mus musculus) 6480464 Zearalenone results in decreased phosphorylation of CHK1 protein CTD PMID:34716709 CHEK1 Human zearalenone increases expression ISO Chek1 (Mus musculus) 6480464 Zearalenone results in increased expression of CHEK1 protein CTD PMID:35504548 CHEK1 Human zidovudine increases phosphorylation EXP 6480464 Zidovudine results in increased phosphorylation of CHEK1 protein CTD PMID:19541796 CHEK1 Human zidovudine decreases expression EXP 6480464 Zidovudine results in decreased expression of CHEK1 protein CTD PMID:19541796 CHEK1 Human zinc dichloride increases expression ISO Chek1 (Mus musculus) 6480464 zinc chloride results in increased expression of CHEK1 mRNA CTD PMID:19000923
