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Gene: TERT (telomerase reverse transcriptase) Homo sapiens
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Symbol: TERT
Name: telomerase reverse transcriptase
Description: Exhibits several functions, including chaperone binding activity; nucleic acid binding activity; and nucleotidyltransferase activity. Involved in several processes, including nucleic acid metabolic process; positive regulation of gene expression; and regulation of signal transduction. Localizes to several cellular components, including the TERT-RMRP complex; mitochondrial nucleoid; and nucleus. Colocalizes with the PML body. Implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Biomarker of several diseases, including beta thalassemia; cervix uteri carcinoma in situ; hematologic cancer (multiple); kidney cancer (multiple); and liver disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CMM9; DKCA2; DKCB4; EST2; hEST2; hTRT; PFBMFT1; TCS1; telomerase catalytic subunit; telomerase-associated protein 2; TP2; TRT
Orthologs:
Mus musculus (house mouse) : Tert (telomerase reverse transcriptase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tert (telomerase reverse transcriptase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tert (telomerase reverse transcriptase)
Pan paniscus (bonobo/pygmy chimpanzee) : TERT (telomerase reverse transcriptase)
Canis lupus familiaris (dog) : TERT (telomerase reverse transcriptase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tert (telomerase reverse transcriptase)
Sus scrofa (pig) : TERT (telomerase reverse transcriptase)
Chlorocebus sabaeus (African green monkey) : TERT (telomerase reverse transcriptase)
Heterocephalus glaber (naked mole-rat) : Tert (telomerase reverse transcriptase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl51,253,147 - 1,295,068 (-)Ensembl
GRCh38 Ensembl51,253,147 - 1,295,047 (-)Ensembl
GRCh3851,253,148 - 1,295,068 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3751,253,282 - 1,295,178 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,306,282 - 1,348,162 (-)NCBINCBI36hg18NCBI36
Build 3451,306,286 - 1,348,159NCBI
Celera51,290,088 - 1,332,097 (-)NCBI
Cytogenetic Map5p15.33NCBI
HuRef51,234,692 - 1,275,531 (-)NCBIHuRef
CHM1_151,253,108 - 1,294,322 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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RNA-SEQ Expression