PCNA (proliferating cell nuclear antigen) - Rat Genome Database

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Gene: PCNA (proliferating cell nuclear antigen) Homo sapiens
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Symbol: PCNA
Name: proliferating cell nuclear antigen
RGD ID: 732094
HGNC Page HGNC:8729
Description: Enables several functions, including DNA binding activity; MutLalpha complex binding activity; and enzyme binding activity. Involved in several processes, including DNA repair; cellular response to UV; and positive regulation of DNA metabolic process. Located in centrosome; chromatin; and nuclear lumen. Part of PCNA complex and PCNA-p21 complex. Implicated in ataxia-telangiectasia-like disorder-2. Biomarker of several diseases, including Lewy body dementia; invasive ductal carcinoma; kidney cancer (multiple); seminoma; and stomach cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ATLD2; cyclin; DNA polymerase delta auxiliary protein; MGC8367
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: PCNAP1   PCNAP2   PCNAP3   PCNAP4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38205,114,953 - 5,126,622 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl205,114,953 - 5,126,626 (-)EnsemblGRCh38hg38GRCh38
GRCh37205,095,599 - 5,107,268 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36205,043,599 - 5,055,268 (-)NCBINCBI36Build 36hg18NCBI36
Build 34205,043,598 - 5,048,647NCBI
Celera205,165,620 - 5,177,289 (-)NCBICelera
Cytogenetic Map20p12.3NCBI
HuRef205,049,534 - 5,061,197 (-)NCBIHuRef
CHM1_1205,096,983 - 5,108,646 (-)NCBICHM1_1
T2T-CHM13v2.0205,154,376 - 5,166,040 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-quinic acid  (EXP)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichlorobenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-thiazolidine-2,4-dione  (EXP)
1,4-dichlorobenzene  (ISO)
1,4-dioxane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2':5',2''-terthiophene  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (ISO)
2-bromohexadecanoic acid  (EXP)
2-nitrofluorene  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5,5'-tetraiodothyroacetic acid  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (ISO)
3-aminobenzamide  (ISO)
3-BROMO-7-NITROINDAZOLE  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-nonylphenol  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methyltetrahydrofolic acid  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
acetamide  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP,ISO)
afimoxifene  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
alpha-amanitin  (EXP)
alpha-hexachlorocyclohexane  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
alvocidib  (EXP)
amifostine  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amoxicillin  (ISO)
amphibole asbestos  (EXP)
andrographolide  (EXP,ISO)
aniline  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
apigenin  (EXP)
apocynin  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite ion  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asiatic acid  (ISO)
astragaloside IV  (ISO)
atrazine  (EXP)
atropine  (EXP)
avobenzone  (EXP)
azadirachtin A  (EXP)
azathioprine  (EXP)
azoxystrobin  (EXP)
bafilomycin A1  (EXP)
baicalein  (EXP)
bathocuproine disulfonic acid  (EXP)
benazepril  (ISO)
benzamide  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
Besigomsin  (ISO)
beta-aminopropionitrile  (EXP)
beta-naphthoflavone  (ISO)
beta-tocopherol  (ISO)
betulinic acid  (EXP,ISO)
bezafibrate  (ISO)
bicalutamide  (EXP)
biochanin A  (ISO)
biphenyl-4-amine  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
boric acid  (ISO)
boron atom  (ISO)
brexpiprazole  (EXP)
bromocriptine  (ISO)
bromodichloromethane  (ISO)
bromoform  (ISO)
brucine  (ISO)
budesonide  (ISO)
buspirone  (ISO)
Butylbenzyl phthalate  (EXP)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (EXP)
calcitriol  (EXP,ISO)
camostat  (ISO)
cannabidiol  (EXP)
captafol  (ISO)
carbamate ester  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP,ISO)
cefaloridine  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
cerium trichloride  (EXP)
chelerythrine  (ISO)
Chlorodibromomethane  (ISO)
chloroethene  (ISO)
chloroform  (ISO)
chlorogenic acid  (ISO)
chloroprocaine  (EXP)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
cholic acid  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
chrysophanol  (EXP)
cilostazol  (EXP)
Cinobufagin  (EXP)
cisplatin  (EXP,ISO)
citral  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
coenzyme Q10  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
cortisol  (EXP)
costunolide  (ISO)
coumarin  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
CU-O LINKAGE  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyanidin cation  (ISO)
cycloastragenol  (ISO)
cyclohexanols  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
cylindrospermopsin  (EXP)
cypermethrin  (ISO)
cyprodinil  (EXP)
D-aspartic acid  (ISO)
D-glucose  (EXP,ISO)
daidzein  (EXP,ISO)
dapoxetine  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (EXP,ISO)
delta-tocopherol  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (EXP)
diamminedichloroplatinum  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP)
dicrotophos  (EXP)
dieckol  (EXP)
dieldrin  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
diheptyl phthalate  (ISO)
dihydroxyacetone  (EXP)
dimethomorph  (ISO)
dimethylarsinic acid  (ISO)
diminazene diaceturate  (EXP)
diosmin  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (EXP)
diuron  (EXP)
dodecanoic acid  (ISO)
doxorubicin  (EXP,ISO)
elemental boron  (ISO)
elemental selenium  (EXP)
ellagic acid  (ISO)
embelin  (EXP)
emodin  (ISO)
endosulfan  (EXP)
Enterolactone  (EXP)
entinostat  (ISO)
enzacamene  (EXP)
enzyme inhibitor  (EXP)
eriocitrin  (EXP)
estragole  (ISO)
ethanol  (ISO)
eugenol  (ISO)
eumelanin  (ISO)
famotidine  (ISO)
fenhexamid  (EXP)
fenofibrate  (EXP,ISO)
fenvalerate  (ISO)
finasteride  (ISO)
fipronil  (ISO)
fludioxonil  (EXP)
flufenoxuron  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
gallic acid  (ISO)
gamma-linolenic acid  (EXP)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
geranial  (ISO)
geraniol  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glycitein  (EXP)
glyphosate  (EXP,ISO)
gold atom  (EXP)
gold(0)  (EXP)
hesperetin  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (EXP,ISO)
histamine  (ISO)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP)
hydroxyurea  (EXP)
imidacloprid  (ISO)
imiquimod  (ISO)
indometacin  (EXP,ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dextran  (ISO)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoflavones  (ISO)
ivermectin  (EXP)
juglone  (EXP)
kaempferol  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (ISO)
L-glutamine  (EXP)
lanthanum trichloride  (EXP)
lapatinib  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
limonene  (ISO)
linsidomine  (ISO)
linuron  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lupeol  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
mabuterol  (ISO)
malachite green cation  (ISO)
malathion  (EXP)
maneb  (ISO)
masoprocol  (ISO)
Mecamylamine  (EXP)
mechlorethamine  (ISO)
melatonin  (EXP,ISO)
meloxicam  (EXP)
menadione  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (EXP,ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylseleninic acid  (EXP)
methyltestosterone  (ISO)
mevalonic acid  (EXP)
miconazole  (ISO)
mitomycin C  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP)
monocrotaline  (EXP)
Morroniside  (ISO)
myricitrin  (ISO)
N'-Nitrosonornicotine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N,N-bis(2-hydroxypropyl)nitrosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nelfinavir  (EXP)
nickel atom  (EXP)
nickel sulfate  (EXP)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitrofen  (EXP,ISO)
nitrogen dioxide  (ISO)
NORCANTHARIDIN  (EXP)
Nutlin-3  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olaparib  (EXP)
oleanolic acid  (EXP,ISO)
omeprazole  (ISO)
orlistat  (EXP)
ouabain  (EXP)
ozone  (ISO)
paclitaxel  (EXP,ISO)
palbociclib  (EXP)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP)
PD 0325901  (ISO)
pentachlorophenol  (ISO)
perfluorobutyric acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piclamilast  (ISO)
picoxystrobin  (EXP)
pifithrin-?  (ISO)
pinosylvin  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP)
poly(propylene imine) macromolecule  (EXP)
potassium dichromate  (ISO)
potassium iodide  (ISO)
potassium nitrate  (EXP)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probucol  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
propofol  (EXP)
pterostilbene  (ISO)
pyrethrins  (ISO)
pyrithione  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP,ISO)
Rebamipide  (ISO)
reparixin  (EXP)
reserpine  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (EXP)
rotenone  (ISO)
royal jelly  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (EXP)
SB 431542  (EXP)
scutellarin  (EXP)
selenium atom  (EXP)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
shikimic acid  (EXP)
Shikonin  (ISO)
sildenafil citrate  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
silver(1+) nitrate  (EXP)
simvastatin  (EXP)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
spiromesifen  (EXP)
stattic  (EXP)
stavudine  (ISO)
sterigmatocystin  (ISO)
streptozocin  (ISO)
sucrose  (ISO)
sulfadimethoxine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP)
sulindac  (ISO)
sulindac sulfone  (ISO)
sunitinib  (EXP)
Swertiamarin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (EXP)
tamoxifen  (EXP,ISO)
taurine  (ISO)
terephthalic acid  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachlorohydroquinone  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (EXP)
thapsigargin  (EXP)
thioacetamide  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
tolcapone  (ISO)
toluene 2,4-diisocyanate  (ISO)
Tomentosin  (EXP)
topotecan  (EXP)
trans-pinosylvin  (EXP)
transplatin  (EXP)
trichloroacetic acid  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (ISO)
triphenylstannane  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tungsten  (ISO)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
vinyl carbamate  (ISO)
vitamin D  (ISO)
vitamin E  (ISO)
Y-27632  (EXP)
zerumbone  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proliferating cell nuclear antigen and epidermal growth factor receptor (EGFr) status in renal cell carcinoma patients with polysomy of chromosome 7. Amare Kadam PS, etal., Cancer Genet Cytogenet. 2001 Mar;125(2):139-46.
2. Cardiac myocyte hypertrophy and proliferating cell nuclear antigen expression in Wistar rats infected with Trypanosoma cruzi. Arnaiz MR, etal., J Parasitol. 2002 Oct;88(5):919-25.
3. Changes in CLIP3 expression after sciatic nerve injury in adult rats. Deng X, etal., J Mol Histol. 2012 Dec;43(6):669-79. doi: 10.1007/s10735-012-9450-y. Epub 2012 Sep 27.
4. Mitofusin 2 Downregulation Triggers Pulmonary Artery Smooth Muscle Cell Proliferation and Apoptosis Imbalance in Rats With Hypoxic Pulmonary Hypertension Via the PI3K/Akt and Mitochondrial Apoptosis Pathways. Fang X, etal., J Cardiovasc Pharmacol. 2016 Feb;67(2):164-74. doi: 10.1097/FJC.0000000000000333.
5. Immunohistochemical analysis of proliferating cell nuclear antigen (PCNA) in infiltrating ductal carcinomas: comparison with clinical and pathologic variables. Frierson HF Jr Mod Pathol. 1993 May;6(3):290-4.
6. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
7. Towards non-surgical therapy for uterine fibroids: catechol-O-methyl transferase inhibitor shrinks uterine fibroid lesions in the Eker rat model. Hassan MH, etal., Hum Reprod. 2011 Nov;26(11):3008-18. doi: 10.1093/humrep/der280. Epub 2011 Sep 6.
8. Replication clamps and clamp loaders. Hedglin M, etal., Cold Spring Harb Perspect Biol. 2013 Apr 1;5(4):a010165. doi: 10.1101/cshperspect.a010165.
9. Contribution of cell proliferative activity to malignancy potential in testicular seminoma. Hori K, etal., Pathol Int. 1997 May;47(5):282-7.
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PMID:34379448   PMID:34428256   PMID:34433039   PMID:34642328   PMID:34645483   PMID:34645785   PMID:34650049   PMID:34667155   PMID:34671219   PMID:34709727   PMID:34728620   PMID:34795231  
PMID:34914965   PMID:34917906   PMID:35013218   PMID:35013556   PMID:35140242   PMID:35256949   PMID:35271311   PMID:35278611   PMID:35304440   PMID:35324534   PMID:35338135   PMID:35355521  
PMID:35446349   PMID:35459258   PMID:35509820   PMID:35545034   PMID:35562734   PMID:35563538   PMID:35570072   PMID:35676659   PMID:35677658   PMID:35689249   PMID:35799276   PMID:35819319  
PMID:35831314   PMID:35831895   PMID:35844135   PMID:35849344   PMID:35906200   PMID:35915203   PMID:35944360   PMID:35987950   PMID:36042349   PMID:36094642   PMID:36114006   PMID:36180527  
PMID:36180891   PMID:36215168   PMID:36228090   PMID:36244648   PMID:36339263   PMID:36424410   PMID:36426924   PMID:36517590   PMID:36526897   PMID:36564470   PMID:36604567   PMID:36607591  
PMID:36675081   PMID:36694148   PMID:36724073   PMID:36734974   PMID:36762613   PMID:36880596   PMID:36912080   PMID:36928068   PMID:36990095   PMID:36990216   PMID:37036693   PMID:37117180  
PMID:37118828   PMID:37314180   PMID:37314216   PMID:37316655   PMID:37317656   PMID:37398436   PMID:37536630   PMID:37592094   PMID:37616343   PMID:37689310   PMID:37739427   PMID:37824822  
PMID:37827155   PMID:38060446   PMID:38113892   PMID:38261971   PMID:38280406   PMID:38334954   PMID:38387257   PMID:38496616   PMID:38648458   PMID:38669181   PMID:38687509   PMID:38713100  
PMID:38943005   PMID:39147351  


Genomics

Comparative Map Data
PCNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38205,114,953 - 5,126,622 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl205,114,953 - 5,126,626 (-)EnsemblGRCh38hg38GRCh38
GRCh37205,095,599 - 5,107,268 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36205,043,599 - 5,055,268 (-)NCBINCBI36Build 36hg18NCBI36
Build 34205,043,598 - 5,048,647NCBI
Celera205,165,620 - 5,177,289 (-)NCBICelera
Cytogenetic Map20p12.3NCBI
HuRef205,049,534 - 5,061,197 (-)NCBIHuRef
CHM1_1205,096,983 - 5,108,646 (-)NCBICHM1_1
T2T-CHM13v2.0205,154,376 - 5,166,040 (-)NCBIT2T-CHM13v2.0
Pcna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392132,091,206 - 132,095,100 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2132,091,082 - 132,095,234 (-)EnsemblGRCm39 Ensembl
GRCm382132,249,286 - 132,253,180 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2132,249,162 - 132,253,314 (-)EnsemblGRCm38mm10GRCm38
MGSCv372132,075,022 - 132,078,916 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362131,940,727 - 131,944,621 (-)NCBIMGSCv36mm8
Celera2133,472,471 - 133,476,365 (-)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.15NCBI
Pcna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83139,951,948 - 139,955,820 (-)NCBIGRCr8
mRatBN7.23119,499,039 - 119,502,911 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3119,498,810 - 119,502,995 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3123,402,795 - 123,406,667 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,989,995 - 131,993,868 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03129,658,899 - 129,662,771 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03124,880,698 - 124,884,570 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3124,880,698 - 124,884,570 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03131,376,235 - 131,380,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43120,008,715 - 120,012,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13119,914,289 - 119,918,243 (-)NCBI
Celera3118,296,567 - 118,300,439 (-)NCBICelera
RH 3.4 Map31023.4RGD
Cytogenetic Map3q36NCBI
Pcna
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541515,744,601 - 15,749,673 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541515,744,601 - 15,748,910 (-)NCBIChiLan1.0ChiLan1.0
PCNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2216,062,480 - 6,074,144 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1206,059,299 - 6,070,967 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0205,134,930 - 5,146,603 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1204,927,731 - 4,939,440 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl204,927,731 - 4,939,440 (-)Ensemblpanpan1.1panPan2
PCNA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12416,478,774 - 16,485,992 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2416,478,769 - 16,484,992 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2416,301,671 - 16,308,866 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02416,892,157 - 16,899,336 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2416,892,161 - 16,899,332 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12416,489,199 - 16,496,352 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02416,596,221 - 16,603,283 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02416,929,896 - 16,937,077 (+)NCBIUU_Cfam_GSD_1.0
Pcna
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640165,334,861 - 165,339,851 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648513,766,221 - 13,771,215 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCNA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1714,136,886 - 14,142,744 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11714,137,746 - 14,142,584 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21715,127,978 - 15,132,806 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCNA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1232,936,600 - 32,953,635 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl232,948,196 - 32,953,991 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607111,581,432 - 11,598,250 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcna
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247416,143,332 - 6,148,898 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247416,143,584 - 6,148,055 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PCNA
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_182649.2(PCNA):c.683G>T (p.Ser228Ile) single nucleotide variant Ataxia-telangiectasia-like disorder 2 [RCV000132551] Chr20:5115472 [GRCh38]
Chr20:5096118 [GRCh37]
Chr20:20p12.3		 pathogenic|uncertain significance
GRCh38/hg38 20p13-11.21(chr20:89939-25697564)x3 copy number gain See cases [RCV000051227] Chr20:89939..25697564 [GRCh38]
Chr20:70580..25678200 [GRCh37]
Chr20:18580..25626200 [NCBI36]
Chr20:20p13-11.21		 pathogenic
GRCh38/hg38 20p13-11.23(chr20:89939-19146279)x3 copy number gain See cases [RCV000051041] Chr20:89939..19146279 [GRCh38]
Chr20:70580..19126923 [GRCh37]
Chr20:18580..19074923 [NCBI36]
Chr20:20p13-11.23		 pathogenic
GRCh38/hg38 20p13-12.3(chr20:5030412-5435054)x3 copy number gain See cases [RCV000052760] Chr20:5030412..5435054 [GRCh38]
Chr20:5011058..5415700 [GRCh37]
Chr20:4959058..5363700 [NCBI36]
Chr20:20p13-12.3		 uncertain significance
GRCh38/hg38 20p13-11.23(chr20:89939-19071495)x3 copy number gain See cases [RCV000052995] Chr20:89939..19071495 [GRCh38]
Chr20:70580..19052139 [GRCh37]
Chr20:18580..19000139 [NCBI36]
Chr20:20p13-11.23		 pathogenic
GRCh38/hg38 20p13-11.22(chr20:89939-21787252)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052996]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052996]|See cases [RCV000052996] Chr20:89939..21787252 [GRCh38]
Chr20:70580..21767890 [GRCh37]
Chr20:18580..21715890 [NCBI36]
Chr20:20p13-11.22		 pathogenic
GRCh38/hg38 20p13-12.1(chr20:89939-14818511)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052997]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052997]|See cases [RCV000052997] Chr20:89939..14818511 [GRCh38]
Chr20:70580..14799157 [GRCh37]
Chr20:18580..14747157 [NCBI36]
Chr20:20p13-12.1		 pathogenic
NM_002592.2(PCNA):c.216C>T (p.Leu72=) single nucleotide variant Malignant melanoma [RCV000072698] Chr20:5119583 [GRCh38]
Chr20:5100229 [GRCh37]
Chr20:5048229 [NCBI36]
Chr20:20p12.3		 not provided
GRCh38/hg38 20p13-q11.1(chr20:80106-30227427)x3 copy number gain See cases [RCV000133996] Chr20:80106..30227427 [GRCh38]
Chr20:60747..29462103 [GRCh37]
Chr20:8747..28075764 [NCBI36]
Chr20:20p13-q11.1		 pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33		 pathogenic
GRCh38/hg38 20p13-12.3(chr20:4343033-6911730)x1 copy number loss See cases [RCV000137695] Chr20:4343033..6911730 [GRCh38]
Chr20:4323680..6892377 [GRCh37]
Chr20:4271680..6840377 [NCBI36]
Chr20:20p13-12.3		 pathogenic
GRCh38/hg38 20p13-12.3(chr20:5039774-5645855)x3 copy number gain See cases [RCV000137853] Chr20:5039774..5645855 [GRCh38]
Chr20:5020420..5626501 [GRCh37]
Chr20:4968420..5574501 [NCBI36]
Chr20:20p13-12.3		 uncertain significance
GRCh38/hg38 20p13-12.1(chr20:80106-13029401)x3 copy number gain See cases [RCV000138677] Chr20:80106..13029401 [GRCh38]
Chr20:60747..13010049 [GRCh37]
Chr20:8747..12958049 [NCBI36]
Chr20:20p13-12.1		 pathogenic
GRCh38/hg38 20p13-12.3(chr20:80093-6386012)x3 copy number gain See cases [RCV000139597] Chr20:80093..6386012 [GRCh38]
Chr20:60734..6366659 [GRCh37]
Chr20:8734..6314659 [NCBI36]
Chr20:20p13-12.3		 pathogenic
GRCh38/hg38 20p13-12.3(chr20:4926195-5543771)x3 copy number gain See cases [RCV000139625] Chr20:4926195..5543771 [GRCh38]
Chr20:4906841..5524417 [GRCh37]
Chr20:4854841..5472417 [NCBI36]
Chr20:20p13-12.3		 uncertain significance
GRCh38/hg38 20p13-12.3(chr20:84402-6159078)x3 copy number gain See cases [RCV000141348] Chr20:84402..6159078 [GRCh38]
Chr20:65043..6139725 [GRCh37]
Chr20:13043..6087725 [NCBI36]
Chr20:20p13-12.3		 pathogenic
GRCh38/hg38 20p13-11.1(chr20:80927-26324843)x3 copy number gain See cases [RCV000142017] Chr20:80927..26324843 [GRCh38]
Chr20:61568..26305479 [GRCh37]
Chr20:9568..26253479 [NCBI36]
Chr20:20p13-11.1		 pathogenic
GRCh38/hg38 20p13-12.3(chr20:80927-5447679)x3 copy number gain See cases [RCV000142285] Chr20:80927..5447679 [GRCh38]
Chr20:61568..5428325 [GRCh37]
Chr20:9568..5376325 [NCBI36]
Chr20:20p13-12.3		 uncertain significance
GRCh38/hg38 20p13-12.3(chr20:1269303-8626911)x3 copy number gain See cases [RCV000142917] Chr20:1269303..8626911 [GRCh38]
Chr20:1249947..8607558 [GRCh37]
Chr20:1197947..8555558 [NCBI36]
Chr20:20p13-12.3		 pathogenic
GRCh38/hg38 20p13-11.23(chr20:80928-18688031)x3 copy number gain See cases [RCV000143426] Chr20:80928..18688031 [GRCh38]
Chr20:61569..18668675 [GRCh37]
Chr20:9569..18616675 [NCBI36]
Chr20:20p13-11.23		 pathogenic
GRCh37/hg19 20p13-12.3(chr20:121521-5564937)x3 copy number gain See cases [RCV000239772] Chr20:121521..5564937 [GRCh37]
Chr20:20p13-12.3		 pathogenic
GRCh37/hg19 20p13-11.1(chr20:80198-26075841)x3 copy number gain See cases [RCV000239954] Chr20:80198..26075841 [GRCh37]
Chr20:20p13-11.1		 pathogenic
GRCh37/hg19 20p13-12.1(chr20:4392930-12667768)x1 copy number loss See cases [RCV000446718] Chr20:4392930..12667768 [GRCh37]
Chr20:20p13-12.1		 pathogenic
GRCh37/hg19 20p13-q11.21(chr20:80198-26208081)x3 copy number gain not provided [RCV000487461] Chr20:80198..26208081 [GRCh37]
Chr20:20p13-q11.21		 pathogenic
GRCh37/hg19 20p13-12.3(chr20:213423-5483406)x3 copy number gain See cases [RCV000510531] Chr20:213423..5483406 [GRCh37]
Chr20:20p13-12.3		 uncertain significance
GRCh37/hg19 20p13-12.3(chr20:2463101-8185680)x1 copy number loss See cases [RCV000511897] Chr20:2463101..8185680 [GRCh37]
Chr20:20p13-12.3		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-12.2(chr20:61568-10486106)x3 copy number gain See cases [RCV000512556] Chr20:61568..10486106 [GRCh37]
Chr20:20p13-12.2		 likely pathogenic
GRCh37/hg19 20p13-12.1(chr20:3092739-17091453)x1 copy number loss not provided [RCV000684134] Chr20:3092739..17091453 [GRCh37]
Chr20:20p13-12.1		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
NM_182649.2(PCNA):c.261C>A (p.Ile87=) single nucleotide variant not provided [RCV000982732] Chr20:5118827 [GRCh38]
Chr20:5099473 [GRCh37]
Chr20:20p12.3		 likely benign
NM_182649.2(PCNA):c.645T>C (p.Phe215=) single nucleotide variant not provided [RCV000926041] Chr20:5115510 [GRCh38]
Chr20:5096156 [GRCh37]
Chr20:20p12.3		 likely benign
NM_182649.2(PCNA):c.235C>T (p.Leu79=) single nucleotide variant not provided [RCV000982777] Chr20:5118853 [GRCh38]
Chr20:5099499 [GRCh37]
Chr20:20p12.3		 likely benign
NM_182649.2(PCNA):c.42G>A (p.Lys14=) single nucleotide variant not provided [RCV000976068] Chr20:5119757 [GRCh38]
Chr20:5100403 [GRCh37]
Chr20:20p12.3		 likely benign
NM_182649.2(PCNA):c.726G>A (p.Ala242=) single nucleotide variant not provided [RCV000882941] Chr20:5115343 [GRCh38]
Chr20:5095989 [GRCh37]
Chr20:20p12.3		 benign
NM_182649.2(PCNA):c.702C>G (p.Pro234=) single nucleotide variant PCNA-related disorder [RCV003972881]|not provided [RCV000968767] Chr20:5115453 [GRCh38]
Chr20:5096099 [GRCh37]
Chr20:20p12.3		 benign
NM_182649.2(PCNA):c.33C>T (p.Ile11=) single nucleotide variant not provided [RCV000925801] Chr20:5119766 [GRCh38]
Chr20:5100412 [GRCh37]
Chr20:20p12.3		 likely benign
NM_182649.2(PCNA):c.443G>C (p.Cys148Ser) single nucleotide variant Ataxia-telangiectasia-like disorder 2 [RCV000990278] Chr20:5117609 [GRCh38]
Chr20:5098255 [GRCh37]
Chr20:20p12.3		 likely pathogenic
NM_182649.2(PCNA):c.612A>G (p.Gln204=) single nucleotide variant not provided [RCV000931181] Chr20:5115543 [GRCh38]
Chr20:5096189 [GRCh37]
Chr20:20p12.3		 likely benign
GRCh37/hg19 20p13-11.1(chr20:61568-26305479)x3 copy number gain not provided [RCV001007068] Chr20:61568..26305479 [GRCh37]
Chr20:20p13-11.1		 pathogenic
NC_000020.10:g.(?_5086814)_(5295015_?)dup duplication not provided [RCV003105399] Chr20:5086814..5295015 [GRCh37]
Chr20:20p13-12.3		 uncertain significance
NC_000020.10:g.(?_1959939)_(6760201_?)dup duplication Huntington disease-like 1 [RCV003110989]|Pigmentary pallidal degeneration [RCV003122285] Chr20:1959939..6760201 [GRCh37]
Chr20:20p13-12.3		 uncertain significance
GRCh37/hg19 20p13-12.2(chr20:3178539-11848383) copy number loss 20p12.3 microdeletion syndrome [RCV002280726] Chr20:3178539..11848383 [GRCh37]
Chr20:20p13-12.2		 pathogenic
NM_182649.2(PCNA):c.166G>A (p.Gly56Ser) single nucleotide variant not specified [RCV004087366] Chr20:5119633 [GRCh38]
Chr20:5100279 [GRCh37]
Chr20:20p12.3		 uncertain significance
GRCh37/hg19 20p13-12.3(chr20:3034557-5524417)x1 copy number loss See cases [RCV003158005] Chr20:3034557..5524417 [GRCh37]
Chr20:20p13-12.3		 likely pathogenic
GRCh38/hg38 20p13-11.21(chr20:87153-23635465)x3 copy number gain Renal agenesis [RCV003327640] Chr20:87153..23635465 [GRCh38]
Chr20:20p13-11.21		 pathogenic
NM_182649.2(PCNA):c.545T>G (p.Leu182Trp) single nucleotide variant not specified [RCV004353285] Chr20:5117507 [GRCh38]
Chr20:5098153 [GRCh37]
Chr20:20p12.3		 uncertain significance
NM_182649.2(PCNA):c.546G>T (p.Leu182Phe) single nucleotide variant not specified [RCV004356838] Chr20:5117506 [GRCh38]
Chr20:5098152 [GRCh37]
Chr20:20p12.3		 uncertain significance
GRCh37/hg19 20p13-12.2(chr20:61569-9542361)x3 copy number gain not provided [RCV003485207] Chr20:61569..9542361 [GRCh37]
Chr20:20p13-12.2		 pathogenic
GRCh37/hg19 20p13-12.1(chr20:68351-16142323)x3 copy number gain not provided [RCV003885494] Chr20:68351..16142323 [GRCh37]
Chr20:20p13-12.1		 pathogenic
GRCh37/hg19 20p13-11.21(chr20:68351-23860313)x3 copy number gain not provided [RCV003885495] Chr20:68351..23860313 [GRCh37]
Chr20:20p13-11.21		 pathogenic
NM_182649.2(PCNA):c.222-4C>T single nucleotide variant PCNA-related disorder [RCV003982329] Chr20:5118870 [GRCh38]
Chr20:5099516 [GRCh37]
Chr20:20p12.3		 benign
NC_000020.10:g.(?_3190198)_(6760201_?)del deletion Inosine triphosphatase deficiency [RCV004579445] Chr20:3190198..6760201 [GRCh37]
Chr20:20p13-12.3		 pathogenic
NM_182649.2(PCNA):c.125C>T (p.Ser42Leu) single nucleotide variant not specified [RCV004653398] Chr20:5119674 [GRCh38]
Chr20:5100320 [GRCh37]
Chr20:20p12.3		 uncertain significance
NM_182649.2(PCNA):c.153C>G (p.Thr51=) single nucleotide variant PCNA-related disorder [RCV004759134] Chr20:5119646 [GRCh38]
Chr20:5100292 [GRCh37]
Chr20:20p12.3		 likely benign
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR124-2hsa-miR-124-3pTarbaseexternal_infoMicroarrayNEGATIVE
MIR124-2hsa-miR-124-3pTarbaseexternal_infoProteomicsPOSITIVE
MIR24-2hsa-miR-24-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI19748357
MIR24-1hsa-miR-24-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI19748357

Predicted Target Of
Summary Value
Count of predictions:237
Count of miRNA genes:106
Interacting mature miRNAs:107
Transcripts:ENST00000379143, ENST00000379160
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407207797GWAS856773_Hbody height QTL GWAS856773 (human)1e-08body height (VT:0001253)body height (CMO:0000106)2051196925119693Human
407265566GWAS914542_Hbody height QTL GWAS914542 (human)3e-97body height (VT:0001253)body height (CMO:0000106)2051256415125642Human

Markers in Region
RH68739  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37205,095,639 - 5,095,873UniSTSGRCh37
GRCh37X45,917,891 - 45,918,125UniSTSGRCh37
Build 36X45,802,835 - 45,803,069RGDNCBI36
Celera205,165,660 - 5,165,894UniSTS
CeleraX50,109,806 - 50,110,040RGD
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map20pter-p12UniSTS
HuRef205,049,574 - 5,049,808UniSTS
HuRefX43,632,455 - 43,632,689UniSTS
RH80338  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37205,095,651 - 5,095,853UniSTSGRCh37
GRCh37X45,917,903 - 45,918,105UniSTSGRCh37
Build 36X45,802,847 - 45,803,049RGDNCBI36
Celera205,165,672 - 5,165,874UniSTS
CeleraX50,109,818 - 50,110,020RGD
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map20pter-p12UniSTS
HuRef205,049,586 - 5,049,788UniSTS
HuRefX43,632,467 - 43,632,669UniSTS
G43531  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37205,095,648 - 5,095,854UniSTSGRCh37
GRCh37X45,917,900 - 45,918,106UniSTSGRCh37
Build 36X45,802,844 - 45,803,050RGDNCBI36
Celera205,165,669 - 5,165,875UniSTS
CeleraX50,109,815 - 50,110,021RGD
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map20pter-p12UniSTS
HuRef205,049,583 - 5,049,789UniSTS
HuRefX43,632,464 - 43,632,670UniSTS
GDB:450240  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37205,095,939 - 5,096,179UniSTSGRCh37
GRCh37X45,918,191 - 45,918,345UniSTSGRCh37
Build 36X45,803,135 - 45,803,289RGDNCBI36
Celera205,165,960 - 5,166,200UniSTS
CeleraX50,110,106 - 50,110,260RGD
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map20pter-p12UniSTS
HuRef205,049,874 - 5,050,114UniSTS
HuRefX43,632,755 - 43,632,909UniSTS
PMC134733P7  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37205,100,421 - 5,100,671UniSTSGRCh37
Build 36205,048,421 - 5,048,671RGDNCBI36
Celera205,170,442 - 5,170,692RGD
Cytogenetic Map20pter-p12UniSTS
HuRef205,054,355 - 5,054,605UniSTS
RH78927  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37205,095,652 - 5,095,888UniSTSGRCh37
GRCh37X45,917,904 - 45,918,140UniSTSGRCh37
Build 36X45,802,848 - 45,803,084RGDNCBI36
CeleraX50,109,819 - 50,110,055RGD
Celera205,165,673 - 5,165,909UniSTS
Cytogenetic Map20pter-p12UniSTS
Cytogenetic MapXp11.3UniSTS
HuRefX43,632,468 - 43,632,704UniSTS
HuRef205,049,587 - 5,049,823UniSTS
GeneMap99-GB4 RH Map2028.85UniSTS
NCBI RH Map2040.4UniSTS
STS-M15796  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37205,095,849 - 5,096,129UniSTSGRCh37
GRCh37X45,918,101 - 45,918,295UniSTSGRCh37
Build 36X45,803,045 - 45,803,239RGDNCBI36
CeleraX50,110,016 - 50,110,210RGD
Celera205,165,870 - 5,166,150UniSTS
Cytogenetic Map20pter-p12UniSTS
Cytogenetic MapXp11.3UniSTS
HuRefX43,632,665 - 43,632,859UniSTS
HuRef205,049,784 - 5,050,064UniSTS
GeneMap99-GB4 RH MapX135.51UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2432 2788 2245 4942 1723 2345 4 622 1948 464 2268 7281 6454 52 3708 847 1731 1612 171

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_047066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_182649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF527838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL121924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY310162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY310163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY310164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY310165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG612192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU626265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB990423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR536501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000379143   ⟹   ENSP00000368438
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl205,114,953 - 5,119,958 (-)Ensembl
Ensembl Acc Id: ENST00000379160   ⟹   ENSP00000368458
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl205,114,953 - 5,126,626 (-)Ensembl
RefSeq Acc Id: NM_002592   ⟹   NP_002583
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38205,114,953 - 5,126,622 (-)NCBI
GRCh37205,095,599 - 5,107,268 (-)ENTREZGENE
Build 36205,043,599 - 5,055,268 (-)NCBI Archive
HuRef205,049,534 - 5,061,197 (-)ENTREZGENE
CHM1_1205,096,983 - 5,108,646 (-)NCBI
T2T-CHM13v2.0205,154,376 - 5,166,040 (-)NCBI
Sequence:
RefSeq Acc Id: NM_182649   ⟹   NP_872590
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38205,114,953 - 5,119,958 (-)NCBI
GRCh37205,095,599 - 5,107,268 (-)ENTREZGENE
Build 36205,043,599 - 5,048,647 (-)NCBI Archive
HuRef205,049,534 - 5,061,197 (-)ENTREZGENE
CHM1_1205,096,983 - 5,102,031 (-)NCBI
T2T-CHM13v2.0205,154,376 - 5,159,381 (-)NCBI
Sequence:
RefSeq Acc Id: NP_002583   ⟸   NM_002592
- UniProtKB: B2R897 (UniProtKB/Swiss-Prot),   D3DW02 (UniProtKB/Swiss-Prot),   P12004 (UniProtKB/Swiss-Prot),   Q6FI35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_872590   ⟸   NM_182649
- UniProtKB: B2R897 (UniProtKB/Swiss-Prot),   D3DW02 (UniProtKB/Swiss-Prot),   P12004 (UniProtKB/Swiss-Prot),   Q6FI35 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000368438   ⟸   ENST00000379143
Ensembl Acc Id: ENSP00000368458   ⟸   ENST00000379160
Protein Domains
Proliferating cell nuclear antigen PCNA C-terminal   Proliferating cell nuclear antigen PCNA N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12004-F1-model_v2 AlphaFold P12004 1-261 view protein structure

Promoters
RGD ID:6798893
Promoter ID:HG_KWN:38489
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000404149,   OTTHUMT00000077851
Position:
Human AssemblyChrPosition (strand)Source
Build 36205,048,349 - 5,048,849 (-)MPROMDB
RGD ID:6853402
Promoter ID:EP74526
Type:initiation region
Name:HS_PCNA
Description:Proliferating cell nuclear antigen.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36205,048,604 - 5,048,664EPD
RGD ID:6798891
Promoter ID:HG_KWN:38492
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000077852,   OTTHUMT00000077855,   OTTHUMT00000077856,   OTTHUMT00000077857,   OTTHUMT00000077858,   UC002WLR.1,   UC002WLU.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36205,055,126 - 5,056,287 (-)MPROMDB
RGD ID:13206301
Promoter ID:EPDNEW_H26732
Type:initiation region
Name:PCNA_1
Description:proliferating cell nuclear antigen
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26734  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38205,119,955 - 5,120,015EPDNEW
RGD ID:13206307
Promoter ID:EPDNEW_H26734
Type:initiation region
Name:PCNA_2
Description:proliferating cell nuclear antigen
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26732  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38205,126,592 - 5,126,652EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8729 AgrOrtholog
COSMIC PCNA COSMIC
Ensembl Genes ENSG00000132646 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000379143 ENTREZGENE
  ENST00000379143.10 UniProtKB/Swiss-Prot
  ENST00000379160 ENTREZGENE
  ENST00000379160.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.70.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA Polymerase III, subunit A, domain 2 UniProtKB/TrEMBL
GTEx ENSG00000132646 GTEx
HGNC ID HGNC:8729 ENTREZGENE
Human Proteome Map PCNA Human Proteome Map
InterPro DNA_clamp_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pr_cel_nuc_antig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pr_cel_nuc_antig_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pr_cel_nuc_antig_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pr_cel_nuc_antig_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5111 UniProtKB/Swiss-Prot
NCBI Gene 5111 ENTREZGENE
OMIM 176740 OMIM
PANTHER PROLIFERATING CELL NUCLEAR ANTIGEN UniProtKB/Swiss-Prot
  PROLIFERATING CELL NUCLEAR ANTIGEN UniProtKB/Swiss-Prot
  PROLIFERATING CELL NUCLEAR ANTIGEN UniProtKB/TrEMBL
  PROLIFERATING CELL NUCLEAR ANTIGEN UniProtKB/TrEMBL
Pfam PCNA_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCNA_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA263 PharmGKB
PRINTS PCNACYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PCNA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCNA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP DNA clamp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2R897 ENTREZGENE
  D3DW02 ENTREZGENE
  P12004 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6FHF5_HUMAN UniProtKB/TrEMBL
  Q6FI35 ENTREZGENE, UniProtKB/TrEMBL
  Q7Z6A0_HUMAN UniProtKB/TrEMBL
  Q7Z6A1_HUMAN UniProtKB/TrEMBL
  Q7Z6A2_HUMAN UniProtKB/TrEMBL
  Q7Z6A3_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2R897 UniProtKB/Swiss-Prot
  D3DW02 UniProtKB/Swiss-Prot