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Gene: PCNA (proliferating cell nuclear antigen) Homo sapiens
Symbol: PCNA
Name: proliferating cell nuclear antigen
Description: Exhibits several functions, including DNA binding activity; MutLalpha complex binding activity; and enzyme binding activity. Involved in several processes, including DNA repair; cellular response to UV; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including the PCNA complex; centrosome; and nucleus. Biomarker of Lewy body dementia; invasive ductal carcinoma; kidney cancer (multiple); leiomyoma; and seminoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATLD2; cyclin; DNA polymerase delta auxiliary protein; MGC8367
Mus musculus (house mouse) : Pcna (proliferating cell nuclear antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pcna (proliferating cell nuclear antigen)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pcna (proliferating cell nuclear antigen)
Pan paniscus (bonobo/pygmy chimpanzee) : PCNA (proliferating cell nuclear antigen)
Canis lupus familiaris (dog) : PCNA (proliferating cell nuclear antigen)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pcna (proliferating cell nuclear antigen)
Sus scrofa (pig) : PCNA (proliferating cell nuclear antigen)
more info ...
Related Pseudogenes: PCNAP1   PCNAP2   PCNAP3   PCNAP4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38205,114,953 - 5,126,622 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37205,095,599 - 5,107,268 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36205,043,599 - 5,055,268 (-)NCBINCBI36hg18NCBI36
Build 34205,043,598 - 5,048,647NCBI
Celera205,165,620 - 5,177,289 (-)NCBI
Cytogenetic Map20p12.3NCBI
HuRef205,049,534 - 5,061,197 (-)NCBIHuRef
CHM1_1205,096,983 - 5,108,646 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PCNA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732094
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.