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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732094
Species: Homo sapiens
RGD Object: Gene
Symbol: PCNA
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCNAaffects expressionEXP 6480464CTDVitamin K 3 affects the expression of PCNA mRNAPMID:20044591 PMID:21533478
PCNAdecreases expressionEXP 6480464CTDVitamin K 3 results in decreased expression of PCNA proteinPMID:21533478
PCNAmultiple interactionsEXP 6480464CTDAlpha-Amanitin inhibits the reaction [Vitamin K 3 results in decreased expression of PCNA protein]; Cycloheximide inhibits the reaction [Vitamin K 3 results in decreased expression of PCNA protein]; Dactinomycin inhibits the reaction [Vitamin K 3 results in decreased expression of PCNA protein]PMID:21533478
PCNAincreases expressionISOPcna (Mus musculus)6480464CTDVitamin K 3 results in increased expression of PCNA proteinPMID:20829426
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