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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732094
Species: Homo sapiens
RGD Object: Gene
Symbol: PCNA
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCNAincreases expressionEXP 6480464CTDarsenite results in increased expression of PCNA mRNA; arsenite results in increased expression of PCNA proteinPMID:28444938 PMID:31773452
PCNAincreases methylationEXP 6480464CTDarsenite results in increased methylation of PCNA promoterPMID:23974009
PCNAmultiple interactionsEXP 6480464CTDarsenite promotes the reaction [G3BP1 protein binds to PCNA mRNA]; EGFR affects the reaction [arsenite results in increased expression of PCNA protein]; ERBB2 affects the reaction [arsenite results in increased expression of PCNA protein]PMID:31773452 PMID:32406909
PCNAincreases expressionISOPcna (Mus musculus)6480464CTDarsenite results in increased expression of PCNA mRNAPMID:15345372
PCNAmultiple interactionsISOPcna (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of arsenite] which results in increased expression of PCNA proteinPMID:31513886
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