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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732094
Species: Homo sapiens
RGD Object: Gene
Symbol: PCNA
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCNAdecreases expressionEXP 6480464CTDGenistein results in decreased expression of PCNA; Genistein results in decreased expression of PCNA proteinPMID:16149052 PMID:21161820
PCNAincreases expressionEXP 6480464CTDGenistein results in increased expression of PCNA mRNAPMID:16474171 PMID:22228119
PCNAmultiple interactionsEXP 6480464CTD[Genistein co-treated with Lapatinib] affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; Genistein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; Genistein affects the reaction [ERBB2 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]]PMID:33396024
PCNAdecreases expressionISOPcna (Rattus norvegicus)6480464CTDGenistein results in decreased expression of PCNA; Genistein results in decreased expression of PCNA mRNA; Genistein results in decreased expression of PCNA proteinPMID:12929590 PMID:17049845
PCNAdecreases expressionISOPcna (Mus musculus)6480464CTDGenistein results in decreased expression of PCNA mRNAPMID:21048042
PCNAincreases expressionISOPcna (Rattus norvegicus)6480464CTDGenistein results in increased expression of PCNA mRNA; Genistein results in increased expression of PCNA proteinPMID:21782745 PMID:29217487
PCNAincreases expressionISOPcna (Mus musculus)6480464CTDGenistein results in increased expression of PCNA mRNA; Genistein results in increased expression of PCNA proteinPMID:10965916 PMID:16985261
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