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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732094
Species: Homo sapiens
RGD Object: Gene
Symbol: PCNA
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCNAdecreases expressionEXP 6480464CTDCalcitriol results in decreased expression of PCNA mRNA; Calcitriol results in decreased expression of PCNA proteinPMID:15951637 PMID:21542014 PMID:21592394
PCNAmultiple interactionsEXP 6480464CTD[Testosterone co-treated with Calcitriol] results in decreased expression of PCNA mRNAPMID:21592394
PCNAdecreases expressionISOPcna (Rattus norvegicus)6480464CTDCalcitriol results in decreased expression of PCNA proteinPMID:15728789
PCNAdecreases expressionISOPcna (Mus musculus)6480464CTDCalcitriol results in decreased expression of PCNAPMID:19603526
PCNAincreases expressionISOPcna (Rattus norvegicus)6480464CTDCalcitriol results in increased expression of PCNA proteinPMID:19092814
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