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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732094
Species: Homo sapiens
RGD Object: Gene
Symbol: PCNA
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCNAincreases expressionEXP 6480464CTDEstradiol results in increased expression of PCNA mRNA; Estradiol results in increased expression of PCNA proteinPMID:15072547 PMID:16474171 PMID:17268063 PMID:24758408 PMID:26344002 PMID:27539251 PMID:31016752 PMID:33484789 PMID:33631300
PCNAmultiple interactionsEXP 6480464CTD2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased expression of PCNA protein]]; [afimoxifene results in decreased susceptibility to Estradiol] which results in decreased expression of PCNA protein; [sodium arsenite co-treated with Estradiol] results in increased expression of PCNA mRNA; [U 0126 results in decreased susceptibility to Estradiol] which results in decreased expression of PCNA protein; Estradiol inhibits the reaction [Fenofibrate results in increased expression of PCNA protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of PCNA protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of PCNA mRNA]PMID:23804311 PMID:24758408 PMID:29134746 PMID:29890199 PMID:33484789
PCNAaffects expressionISOPcna (Rattus norvegicus)6480464CTDEstradiol affects the expression of PCNA mRNA; Estradiol affects the expression of PCNA proteinPMID:22389237 PMID:32145629
PCNAaffects expressionISOPcna (Mus musculus)6480464CTDEstradiol affects the expression of PCNA mRNAPMID:15598610
PCNAdecreases expressionISOPcna (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of PCNA proteinPMID:36931579
PCNAincreases expressionISOPcna (Rattus norvegicus)6480464CTDEstradiol results in increased expression of PCNA mRNA; Estradiol results in increased expression of PCNA proteinPMID:16557470 PMID:20600213 PMID:23288143 PMID:26088557 PMID:26945725
PCNAincreases expressionISOPcna (Mus musculus)6480464CTDEstradiol results in increased expression of PCNA mRNA; Estradiol results in increased expression of PCNA proteinPMID:15591033 PMID:15845746 PMID:16985261
PCNAmultiple interactionsISOPcna (Rattus norvegicus)6480464CTD9,10-Dimethyl-1,2-benzanthracene promotes the reaction [Estradiol results in increased expression of PCNA mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein]; [Estradiol co-treated with Quercetin] results in increased expression of PCNA protein; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of PCNA protein]; Isoflavones inhibits the reaction [Estradiol results in increased expression of PCNA mRNA]; Plant Preparations inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [Estradiol results in increased expression of PCNA mRNA]]PMID:20600213 PMID:22389237 PMID:23288143 PMID:26945725 PMID:36931579
PCNAmultiple interactionsISOPcna (Mus musculus)6480464CTDEstradiol inhibits the reaction [perfluorooctanoic acid results in decreased expression of PCNA protein]; Estradiol promotes the reaction [Progesterone inhibits the reaction [perfluorooctanoic acid results in decreased expression of PCNA protein]]; Lithium Chloride inhibits the reaction [Progesterone inhibits the reaction [Estradiol results in increased expression of PCNA protein]]; Progesterone inhibits the reaction [Estradiol results in increased expression of PCNA protein]; Progesterone promotes the reaction [Estradiol inhibits the reaction [perfluorooctanoic acid results in decreased expression of PCNA protein]]PMID:15845746 PMID:22414604
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