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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732094
Species: Homo sapiens
RGD Object: Gene
Symbol: PCNA
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCNAincreases expressionEXP 6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCNA proteinPMID:29663660
PCNAmultiple interactionsEXP 6480464CTDmithramycin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCNA protein]PMID:29663660
PCNAincreases expressionISOPcna (Rattus norvegicus)6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCNA proteinPMID:22248470 PMID:27091720
PCNAincreases expressionISOPcna (Mus musculus)6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCNA mRNAPMID:20103723
PCNAmultiple interactionsISOPcna (Rattus norvegicus)6480464CTD9,10-Dimethyl-1,2-benzanthracene promotes the reaction [Estradiol results in increased expression of PCNA mRNA]; Plant Preparations inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [Estradiol results in increased expression of PCNA mRNA]]; Taurine inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCNA protein]PMID:26945725 PMID:27091720
PCNAmultiple interactionsISOPcna (Mus musculus)6480464CTD[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PCNA mRNA; [9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PCNA protein; [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCNA protein; [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCNA mRNA; [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCNA protein; [Glucaric Acid co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCNA mRNA]; [Resveratrol co-treated with Ellagic Acid] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCNA mRNA]; [Resveratrol co-treated with Plant Extracts] inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCNA mRNA]; [sodium arsenite results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]] which results in increased expression of PCNA protein; beta-elemene inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCNA mRNA]; Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PCNA mRNA]; Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PCNA protein]; Cisplatin promotes the reaction [NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PCNA mRNA]]; Cisplatin promotes the reaction [NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PCNA protein]]; Eugenol inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCNA protein]; Masoprocol affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCNA protein]; NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PCNA mRNA]; NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PCNA protein]; NPPC protein promotes the reaction [Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PCNA mRNA]]; NPPC protein promotes the reaction [Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of PCNA protein]]; Tacrolimus affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCNA protein]; Tacrolimus affects the reaction [Tacrolimus affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCNA protein]]PMID:20043298 PMID:20103723 PMID:25770929 PMID:32662567 PMID:35364107 PMID:37352108
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