GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PCNA | decreases expression | EXP | | 6480464 | CTD | sodium arsenite results in decreased expression of PCNA mRNA; sodium arsenite results in decreased expression of PCNA protein | PMID:12760830 PMID:21642427 PMID:22714537 | PCNA | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of PCNA mRNA; sodium arsenite results in increased expression of PCNA protein; sodium arsenite results in increased expression of PCNA protein modified form | PMID:12634122 PMID:20375080 PMID:24866292 PMID:28595984 PMID:30090515 PMID:32890875 PMID:33781819 PMID:34032870 | PCNA | multiple interactions | EXP | | 6480464 | CTD | [Genistein co-treated with Lapatinib] affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; [sodium arsenite co-treated with Estradiol] results in increased expression of PCNA mRNA; [sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein; [sodium arsenite results in increased expression of EGFR protein] which results in increased phosphorylation of PCNA protein; AKT activator SC79 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of PCNA protein]]; ATF2 protein promotes the reaction [sodium arsenite results in increased expression of PCNA mRNA]; ATF2 protein promotes the reaction [sodium arsenite results in increased expression of PCNA protein]; CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; ERBB2 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; ERBB2 protein affects the reaction [sodium arsenite results in increased expression of PCNA protein]; Genistein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; Genistein affects the reaction [ERBB2 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]]; Glutamine deficiency inhibits the reaction [sodium arsenite results in increased expression of PCNA protein]; Lapatinib affects the reaction [CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]]; Lapatinib inhibits the reaction [sodium arsenite results in increased expression of PCNA protein]; LY 290042 affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; reparixin affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of PCNA protein]]; SLC1A5 protein affects the reaction [sodium arsenite results in increased expression of PCNA protein]; sodium arsenite results in increased phosphorylation of and results in decreased activity of PCNA protein; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of PCNA mRNA]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of PCNA protein]; stattic affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; stattic affects the reaction [CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]]; U 0126 affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; U 0126 affects the reaction [CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]]; U 0126 inhibits the reaction [ERBB2 protein affects the reaction [sodium arsenite results in increased expression of PCNA protein]] | PMID:23804311 PMID:25907674 PMID:28444938 PMID:30090515 PMID:32890875 PMID:33396024 PMID:33781819 | PCNA | affects expression | ISO | Pcna (Mus musculus) | 6480464 | CTD | sodium arsenite affects the expression of PCNA mRNA | PMID:16507464 PMID:17558810 | PCNA | decreases expression | ISO | Pcna (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased expression of PCNA mRNA; sodium arsenite results in decreased expression of PCNA protein | PMID:25787150 PMID:28003426 | PCNA | increases expression | ISO | Pcna (Rattus norvegicus) | 6480464 | CTD | sodium arsenite results in increased expression of PCNA mRNA; sodium arsenite results in increased expression of PCNA protein | PMID:11241755 PMID:11559025 PMID:16876216 PMID:31163222 | PCNA | increases expression | ISO | Pcna (Mus musculus) | 6480464 | CTD | sodium arsenite results in increased expression of PCNA protein | PMID:16507464 PMID:37668303 | PCNA | multiple interactions | ISO | Pcna (Rattus norvegicus) | 6480464 | CTD | Polysaccharides inhibits the reaction [sodium arsenite results in increased expression of PCNA protein] | PMID:31163222 | PCNA | multiple interactions | ISO | Pcna (Mus musculus) | 6480464 | CTD | [sodium arsenite results in increased abundance of arsenite] which results in increased expression of PCNA protein; [sodium arsenite results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]] which results in increased expression of PCNA protein; sodium arsenite inhibits the reaction [PDK4 gene mutant form results in increased expression of PCNA protein] | PMID:28003426 PMID:31513886 PMID:35364107 | | ||||||||||||||||||||||
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