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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732094
Species: Homo sapiens
RGD Object: Gene
Symbol: PCNA
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:28925
Term: mechlorethamine
Definition: A nitrogen mustard that has formula C5H11Cl2N.
Chemical ID: MESH:D008466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCNAincreases expressionISOPcna (Rattus norvegicus)6480464CTDMechlorethamine results in increased expression of PCNA; Mechlorethamine results in increased expression of PCNA proteinPMID:22981630 PMID:28184907
PCNAmultiple interactionsISOPcna (Rattus norvegicus)6480464CTDValproic Acid inhibits the reaction [Mechlorethamine results in increased expression of PCNA protein]PMID:28184907
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