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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732094
Species: Homo sapiens
RGD Object: Gene
Symbol: PCNA
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCNAaffects expressionEXP 6480464CTDbisphenol A affects the expression of PCNA mRNAPMID:30903817
PCNAdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PCNA mRNA; bisphenol A results in decreased expression of PCNA proteinPMID:29275510 PMID:30036487 PMID:30352284 PMID:31675489 PMID:37567409
PCNAdecreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of PCNA genePMID:31601247
PCNAincreases expressionEXP 6480464CTDbisphenol A results in increased expression of PCNA; bisphenol A results in increased expression of PCNA mRNA; bisphenol A results in increased expression of PCNA proteinPMID:15461258 PMID:16474171 PMID:17268063 PMID:18246544 PMID:21277958 PMID:23222814 PMID:24831732 PMID:26363202 PMID:28466560 PMID:29307715 PMID:30677511
PCNAmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of PCNA gene; [naringenin co-treated with bisphenol A] results in increased expression of PCNA mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PCNA mRNA; Curcumin inhibits the reaction [bisphenol A results in increased expression of PCNA protein]; Phytochemicals inhibits the reaction [bisphenol A results in increased expression of PCNA]PMID:18246544 PMID:23222814 PMID:24831732 PMID:31601247 PMID:36235125
PCNAaffects expressionISOPcna (Rattus norvegicus)6480464CTDbisphenol A affects the expression of PCNA mRNAPMID:32145629
PCNAdecreases activityISOPcna (Mus musculus)6480464CTDbisphenol A results in decreased activity of PCNA proteinPMID:33485121
PCNAdecreases expressionISOPcna (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of PCNA mRNAPMID:23146694
PCNAdecreases expressionISOPcna (Mus musculus)6480464CTDbisphenol A results in decreased expression of PCNA mRNA; bisphenol A results in decreased expression of PCNA proteinPMID:24909818 PMID:26063408 PMID:33485121
PCNAincreases expressionISOPcna (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of PCNA mRNA; bisphenol A results in increased expression of PCNA proteinPMID:18839522 PMID:25004094 PMID:26088557 PMID:27830003 PMID:29050248 PMID:29323181 PMID:30677511 PMID:31771501
PCNAincreases expressionISOPcna (Mus musculus)6480464CTDbisphenol A results in increased expression of PCNA proteinPMID:10965916 PMID:26146954 PMID:26863571
PCNAmultiple interactionsISOPcna (Rattus norvegicus)6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of PCNA mRNAPMID:36041667
PCNAmultiple interactionsISOPcna (Mus musculus)6480464CTD4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [bisphenol A results in decreased activity of PCNA protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased activity of PCNA protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [bisphenol A results in decreased activity of PCNA protein]PMID:33485121
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