RGD Reference Report - Gene expression of PCNA/cyclin in adult tissues and the R3230AC mammary tumor of rat. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Gene expression of PCNA/cyclin in adult tissues and the R3230AC mammary tumor of rat.

Authors: Liu, YC  Bambara, RA 
Citation: Liu YC and Bambara RA, Biochem Biophys Res Commun. 1989 Jun 15;161(2):873-82.
RGD ID: 10448972
Pubmed: PMID:2567593   (View Abstract at PubMed)

We have investigated the gene expression of PCNA (Proliferating Cell Nuclear Antigen)/cyclin in rat tissues and the R3230AC mammary tumor. The steady-state mRNA level of PCNA/cyclin in a tissue is related to the proliferation of the tissue. The observation was confirmed with the results from the studies of the immunoblotting analyses and the DNA polymerase activity measurements. Furthermore, an overexpression of PCNA/cyclin was found in the R3230AC mammary tumor, which is accompanied by an altered PCNA/cyclin gene structure detected with the Southern blot analysis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PCNAHumanExperimental Mammary Neoplasms  ISOPcna (Rattus norvegicus)mRNA and protein:increased expression:mammary gland:RGD 
PcnaRatExperimental Mammary Neoplasms  IEP mRNA and protein:increased expression:mammary gland:RGD 
PcnaMouseExperimental Mammary Neoplasms  ISOPcna (Rattus norvegicus)mRNA and protein:increased expression:mammary gland:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pcna  (proliferating cell nuclear antigen)

Genes (Mus musculus)
Pcna  (proliferating cell nuclear antigen)

Genes (Homo sapiens)
PCNA  (proliferating cell nuclear antigen)


Additional Information