MIR24-2 (microRNA 24-2) - Rat Genome Database
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Gene: MIR24-2 (microRNA 24-2) Homo sapiens
Analyze
Symbol: MIR24-2
Name: microRNA 24-2
RGD ID: 1344925
HGNC Page HGNC
Description: Predicted to have mRNA 3'-UTR binding activity. Predicted to be involved in several processes, including cellular response to leukemia inhibitory factor; cellular response to phenylalanine; and long-term synaptic potentiation.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: miR-24-2; MIRN24-2; miRNA24-2
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1913,836,287 - 13,836,359 (-)EnsemblGRCh38hg38GRCh38
GRCh381913,836,287 - 13,836,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,947,101 - 13,947,173 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,808,100 - 13,808,172 (-)NCBINCBI36hg18NCBI36
Celera1913,840,849 - 13,840,921 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,518,669 - 13,518,741 (-)NCBIHuRef
CHM1_11913,947,606 - 13,947,678 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11679670   PMID:11914277   PMID:14573789   PMID:15131085   PMID:15325244   PMID:15978578   PMID:16381832   PMID:17604727   PMID:17616659   PMID:18766170   PMID:19048628   PMID:19513126  
PMID:20158877   PMID:20195546   PMID:20347265   PMID:20815877   PMID:21037258   PMID:21463514   PMID:21593605   PMID:21788589   PMID:23142218   PMID:23322776   PMID:23649631   PMID:23774796  
PMID:23836801   PMID:23874542   PMID:23934711   PMID:24063572   PMID:24572376   PMID:24704866   PMID:24854275   PMID:24966325   PMID:25319395   PMID:25426560   PMID:25502080   PMID:25550847  
PMID:25601927   PMID:25943634   PMID:26044523   PMID:26045155   PMID:26252200   PMID:26517093   PMID:26646931   PMID:26801621   PMID:26847530   PMID:26996957   PMID:27099864   PMID:27538493  
PMID:27743162   PMID:27780140   PMID:27939727   PMID:27983982   PMID:28000900   PMID:28157714   PMID:28159509   PMID:28223160   PMID:28432871   PMID:28530238   PMID:28597079   PMID:28798470  
PMID:28990105   PMID:29050151   PMID:29115529   PMID:29171985   PMID:29407889   PMID:29457789   PMID:29565463   PMID:30175664   PMID:30402849   PMID:30575905   PMID:30703428   PMID:31894271  
PMID:32148236  


Genomics

Comparative Map Data
MIR24-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1913,836,287 - 13,836,359 (-)EnsemblGRCh38hg38GRCh38
GRCh381913,836,287 - 13,836,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,947,101 - 13,947,173 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,808,100 - 13,808,172 (-)NCBINCBI36hg18NCBI36
Celera1913,840,849 - 13,840,921 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,518,669 - 13,518,741 (-)NCBIHuRef
CHM1_11913,947,606 - 13,947,678 (-)NCBICHM1_1
Mir24-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,935,444 - 84,935,550 (+)NCBIGRCm39mm39
GRCm39 Ensembl884,935,444 - 84,935,550 (+)Ensembl
GRCm38884,208,815 - 84,208,921 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,208,815 - 84,208,921 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,732,714 - 86,732,820 (+)NCBIGRCm37mm9NCBIm37
Celera888,508,899 - 88,509,005 (+)NCBICelera
Cytogenetic Map8C2NCBI
Mir24-2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,954,683 - 23,954,790 (-)NCBI
Rnor_6.0 Ensembl1925,318,863 - 25,318,970 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01925,318,863 - 25,318,970 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01936,295,051 - 36,295,158 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1923,503,531 - 23,503,638 (-)NCBICelera
Cytogenetic Map19q11NCBI
MIR24-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2048,620,674 - 48,620,745 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12048,620,684 - 48,620,745 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
FEN1hsa-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI19748357
FAF1hsa-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20195546
NOTCH1hsa-miR-24-3pMirtarbaseexternal_infoReporter assayFunctional MTI15131085
DHFRhsa-miR-24-3pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI17686970
DHFRhsa-miR-24-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19748357
MAPK14hsa-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherFunctional MTI15131085
HNF4Ahsa-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20018894
HNF4Ahsa-miR-24-3pMirtarbaseexternal_infoELISA//Flow//Immunohistochemistry//ImmunoprecipitaFunctional MTI22153071
TRIB3hsa-miR-24-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI20019669
ACVR1Bhsa-miR-24-3pMirtarbaseexternal_infoWestern blot//Luciferase reporter assay//Reporter Functional MTI17906079
MLEChsa-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI15131085
MLEChsa-miR-24-3pMirtarbaseexternal_infoReporter assay;Western blot;OtherFunctional MTI19748357
CDKN2Ahsa-miR-24-3pMirtarbaseexternal_infoqRT-PCR//Western blot//Reporter assay;OtherFunctional MTI18365017
BRCA1hsa-miR-24-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI20018894
CDKN1Bhsa-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI17627278
CDKN1Bhsa-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20816961
CDKN1Bhsa-miR-24-3pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
CDKN1Bhsa-miR-24-3pMirtarbaseexternal_infoFlow//Luciferase reporter assay//qRT-PCR//Western Functional MTI23553486
KHSRPhsa-miR-24-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)19296935
TGFB1hsa-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI20945401
ZNF217hsa-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22815235
ST7Lhsa-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23142218
CNDP2hsa-miR-24-3pMirtarbaseexternal_infoqRT-PCR;MicroarrayFunctional MTI (Weak)19748357
H2AXhsa-miR-24-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI19377482
PAK4hsa-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23071155
SRRThsa-miR-24-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17686970
CDK1hsa-miR-24-3pMirtarbaseexternal_infoMicroarray//Reporter assay;Western blot;qRT-PCR;MiFunctional MTI19748357
C8orf33hsa-miR-24-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19296935
CMTM4hsa-miR-24-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20371350
VGLL3hsa-miR-24-3pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20138800
BCL2L11hsa-miR-24-3pMirtarbaseexternal_infoWestern blotFunctional MTI18308931
DEDDhsa-miR-24-3pMirtarbaseexternal_infoWestern blotFunctional MTI20138800
CD34hsa-miR-24-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)19748357
TMED7hsa-miR-24-3pMirtarbaseexternal_infoWestern blotFunctional MTI19748357
ZNF317hsa-miR-24-3pMirtarbaseexternal_infoqRT-PCR;MicroarrayFunctional MTI (Weak)17686970
STX16hsa-miR-24-3pMirtarbaseexternal_infoWestern blot;OtherFunctional MTI17150773
DHFRP1hsa-miR-24-3pMirtarbaseexternal_infoReporter assayFunctional MTI20816961
CHEK1hsa-miR-24-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCR;OtherFunctional MTI19748357
PCNAhsa-miR-24-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI19748357
PTPN9hsa-miR-24-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23418360
RPS7hsa-miR-24-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
CDKN2Ahsa-miR-24-3pTarbaseexternal_infoReporter GenePOSITIVE
MLEChsa-miR-24-3pTarbaseexternal_infoReporter GeneNEGATIVE
DHFRhsa-miR-24-3pTarbaseexternal_infoWesternblitPOSITIVE
MIDNhsa-miR-24-3pTarbaseexternal_infoMicroarrayPOSITIVE
CDK4hsa-miR-24-3pTarbaseexternal_infoqPCRPOSITIVE
HNF4Ahsa-miR-24-3pTarbaseexternal_infoOtherPOSITIVE
SESN1hsa-miR-24-3pTarbaseexternal_infoSequencingPOSITIVE
PTPN9hsa-miR-24-3pOncomiRDBexternal_infoNANA23418360
XIAPhsa-miR-24-3pOncomiRDBexternal_infoNANA22733138
HNF4Ahsa-miR-24-3pOncomiRDBexternal_infoNANA22153071
S100A8hsa-miR-24-3pOncomiRDBexternal_infoNANA22139384
FURINhsa-miR-24-3pOncomiRDBexternal_infoNANA21402698
DND1hsa-miR-24-3pOncomiRDBexternal_infoNANA20816961
FAF1hsa-miR-24-3pOncomiRDBexternal_infoNANA20195546
DUSP16hsa-miR-24-3pOncomiRDBexternal_infoNANA19826043
BCL2hsa-miR-24-2-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21463514
BCL2hsa-miR-24-2-5pTarbaseexternal_infoReporter GenePOSITIVE
PRKCAhsa-miR-24-2-5pOncomiRDBexternal_infoNANA22911661

Predicted Targets
Summary Value
Count of predictions:49073
Count of gene targets:17448
Count of transcripts:39702
Interacting mature miRNAs:hsa-miR-24-2-5p, hsa-miR-24-3p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 32 89 9 2 44 129 21 13 2 13 29 2 21 66
Below cutoff 12 37 4 2 17 1 42 20 7 1 2 5 1 14 23

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000386972
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1913,836,287 - 13,836,359 (-)Ensembl
RefSeq Acc Id: NR_029497
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381913,836,287 - 13,836,359 (-)NCBI
GRCh371913,947,101 - 13,947,173 (-)RGD
Celera1913,840,849 - 13,840,921 (-)RGD
HuRef1913,518,669 - 13,518,741 (-)ENTREZGENE
CHM1_11913,947,606 - 13,947,678 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.13-13.12(chr19:13533925-14258833)x1 copy number loss See cases [RCV000051051] Chr19:13533925..14258833 [GRCh38]
Chr19:13644739..14369645 [GRCh37]
Chr19:13505739..14230645 [NCBI36]
Chr19:19p13.13-13.12
uncertain significance
GRCh38/hg38 19p13.2-13.12(chr19:10315258-14048994)x3 copy number gain See cases [RCV000052909] Chr19:10315258..14048994 [GRCh38]
Chr19:10425934..14159806 [GRCh37]
Chr19:10286934..14020806 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12132052-14751798)x3 copy number gain See cases [RCV000052910] Chr19:12132052..14751798 [GRCh38]
Chr19:12242867..14862610 [GRCh37]
Chr19:12103867..14723610 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11227942-14532135)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|See cases [RCV000053944] Chr19:11227942..14532135 [GRCh38]
Chr19:11338618..14642947 [GRCh37]
Chr19:11199618..14503947 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31
pathogenic
GRCh38/hg38 19p13.13-13.12(chr19:13533925-15371089)x1 copy number loss See cases [RCV000136502] Chr19:13533925..15371089 [GRCh38]
Chr19:13644739..15481900 [GRCh37]
Chr19:13505739..15342900 [NCBI36]
Chr19:19p13.13-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12580427-14742673)x1 copy number loss See cases [RCV000135937] Chr19:12580427..14742673 [GRCh38]
Chr19:12691241..14853485 [GRCh37]
Chr19:12552241..14714485 [NCBI36]
Chr19:19p13.2-13.12
pathogenic|likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11525163-14155021)x1 copy number loss See cases [RCV000136909] Chr19:11525163..14155021 [GRCh38]
Chr19:11635978..14265833 [GRCh37]
Chr19:11496978..14126833 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:13802749-14003761)x3 copy number gain See cases [RCV000239944] Chr19:13802749..14003761 [GRCh37]
Chr19:19p13.2-13.12
uncertain significance
GRCh37/hg19 19p13.2-13.12(chr19:9678768-14853426) copy number gain See cases [RCV000446985] Chr19:9678768..14853426 [GRCh37]
Chr19:19p13.2-13.12
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:13592592-14717528)x1 copy number loss See cases [RCV000511445] Chr19:13592592..14717528 [GRCh37]
Chr19:19p13.2-13.12
likely pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:12574343-14726197)x1 copy number loss See cases [RCV000511130] Chr19:12574343..14726197 [GRCh37]
Chr19:19p13.2-13.12
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:11608072-14543046)x3 copy number gain See cases [RCV000511013] Chr19:11608072..14543046 [GRCh37]
Chr19:19p13.2-13.12
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31608 AgrOrtholog
COSMIC MIR24-2 COSMIC
Ensembl Genes ENSG00000284387 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000386972 ENTREZGENE
GTEx ENSG00000284387 GTEx
HGNC ID HGNC:31608 ENTREZGENE
Human Proteome Map MIR24-2 Human Proteome Map
miRBase MI0000081 ENTREZGENE
NCBI Gene 407013 ENTREZGENE
OMIM 610724 OMIM
PharmGKB PA164722616 PharmGKB
RNAcentral URS00000FFC8B RNACentral
  URS00001DEE11 RNACentral
  URS000059273E RNACentral