DUSP3 (dual specificity phosphatase 3) - Rat Genome Database

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Gene: DUSP3 (dual specificity phosphatase 3) Homo sapiens
Analyze
Symbol: DUSP3
Name: dual specificity phosphatase 3
RGD ID: 1345861
HGNC Page HGNC
Description: Enables cytoskeletal protein binding activity; phosphoprotein phosphatase activity; and receptor tyrosine kinase binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of signal transduction; and regulation of cell-substrate junction organization. Located in cytosol; immunological synapse; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dual specificity protein phosphatase 3; dual specificity protein phosphatase VHR; serine/threonine specific protein phosphatase; vaccinia H1-related phosphatase; vaccinia virus phosphatase VH1-related; VHR
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AC136896.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1743,766,125 - 43,778,977 (-)EnsemblGRCh38hg38GRCh38
GRCh381743,766,125 - 43,778,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371741,843,493 - 41,856,345 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,199,015 - 39,211,872 (-)NCBINCBI36hg18NCBI36
Build 341739,199,015 - 39,211,872NCBI
Celera1738,551,496 - 38,564,369 (-)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1737,607,587 - 37,620,460 (-)NCBIHuRef
CHM1_11742,079,099 - 42,091,978 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (IBA,IDA)
immunological synapse  (IDA)
nucleoplasm  (IDA,TAS)
nucleus  (IDA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1281549   PMID:7829067   PMID:7829094   PMID:7874108   PMID:7876121   PMID:7961745   PMID:8650541   PMID:10224087   PMID:11085983   PMID:11238845   PMID:11863439   PMID:12447358  
PMID:12477932   PMID:12840032   PMID:14702039   PMID:15276183   PMID:15489334   PMID:16344560   PMID:16604064   PMID:17278098   PMID:17322878   PMID:17785772   PMID:18311544   PMID:18505570  
PMID:19010898   PMID:19322201   PMID:21262974   PMID:21832049   PMID:21873635   PMID:21921027   PMID:21988832   PMID:22119785   PMID:22572157   PMID:23322772   PMID:23376485   PMID:23918168  
PMID:24245651   PMID:24531476   PMID:24798147   PMID:24886454   PMID:24901344   PMID:25876765   PMID:26186194   PMID:27423135   PMID:27432908   PMID:27941812   PMID:28380382   PMID:28389334  
PMID:28514442   PMID:28625849   PMID:28675297   PMID:28759036   PMID:29955039   PMID:30021884   PMID:30048472   PMID:31091453   PMID:32296183   PMID:32348128   PMID:32380926   PMID:32475380  
PMID:33277362   PMID:33961781  


Genomics

Comparative Map Data
DUSP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1743,766,125 - 43,778,977 (-)EnsemblGRCh38hg38GRCh38
GRCh381743,766,125 - 43,778,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371741,843,493 - 41,856,345 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,199,015 - 39,211,872 (-)NCBINCBI36hg18NCBI36
Build 341739,199,015 - 39,211,872NCBI
Celera1738,551,496 - 38,564,369 (-)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1737,607,587 - 37,620,460 (-)NCBIHuRef
CHM1_11742,079,099 - 42,091,978 (-)NCBICHM1_1
Dusp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,861,967 - 101,877,839 (-)NCBIGRCm39mm39
GRCm39 Ensembl11101,861,969 - 101,877,839 (-)Ensembl
GRCm3811101,971,141 - 101,987,013 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,971,143 - 101,987,013 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,835,473 - 101,846,084 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611101,790,249 - 101,800,860 (-)NCBImm8
Celera11113,679,435 - 113,690,042 (-)NCBICelera
Cytogenetic Map11DNCBI
Dusp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21086,920,014 - 86,933,739 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1086,920,014 - 86,933,962 (-)Ensembl
Rnor_6.01089,904,578 - 89,918,296 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,904,560 - 89,918,427 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,697,004 - 89,710,720 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,031,206 - 91,044,858 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1085,639,184 - 85,651,010 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Dusp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545117,064,739 - 17,069,964 (-)NCBIChiLan1.0ChiLan1.0
DUSP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11713,784,618 - 13,797,045 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,784,594 - 13,797,045 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01713,618,860 - 13,631,743 (+)NCBIMhudiblu_PPA_v0panPan3
DUSP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,518,302 - 19,531,000 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,518,746 - 19,527,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,906,433 - 18,920,193 (+)NCBI
ROS_Cfam_1.0920,212,506 - 20,226,067 (+)NCBI
ROS_Cfam_1.0 Ensembl920,213,966 - 20,226,637 (+)Ensembl
UMICH_Zoey_3.1919,065,068 - 19,078,844 (+)NCBI
UNSW_CanFamBas_1.0919,248,263 - 19,261,805 (+)NCBI
UU_Cfam_GSD_1.0919,393,335 - 19,406,908 (+)NCBI
Dusp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,856,161 - 18,869,151 (+)NCBI
SpeTri2.0NW_004936541325,443 - 338,426 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,336,354 - 19,349,734 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,336,308 - 19,349,739 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,569,958 - 19,583,370 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,622,667 - 62,637,129 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,622,663 - 62,637,127 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607733,395,825 - 33,410,367 (+)NCBIVero_WHO_p1.0
Dusp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624795994,103 - 1,001,697 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
STS-N24113  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371741,845,787 - 41,845,970UniSTSGRCh37
Build 361739,201,313 - 39,201,496RGDNCBI36
Celera1738,553,794 - 38,553,977RGD
Cytogenetic Map17q21UniSTS
HuRef1737,609,885 - 37,610,068UniSTS
GeneMap99-GB4 RH Map17320.18UniSTS
NCBI RH Map17534.5UniSTS
D17S814E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371741,845,096 - 41,845,201UniSTSGRCh37
GRCh371741,845,171 - 41,845,411UniSTSGRCh37
Build 361739,200,622 - 39,200,727RGDNCBI36
Celera1738,553,103 - 38,553,208RGD
Celera1738,553,178 - 38,553,418UniSTS
Cytogenetic Map17q21UniSTS
HuRef1737,609,194 - 37,609,299UniSTS
HuRef1737,609,269 - 37,609,509UniSTS
GeneMap99-G3 RH Map172318.0UniSTS
SHGC-2457  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371741,843,650 - 41,843,815UniSTSGRCh37
Build 361739,199,176 - 39,199,341RGDNCBI36
Celera1738,551,657 - 38,551,822RGD
Cytogenetic Map17q21UniSTS
HuRef1737,607,748 - 37,607,913UniSTS
TNG Radiation Hybrid Map1719750.0UniSTS
SGC30031  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371741,843,506 - 41,843,632UniSTSGRCh37
Build 361739,199,032 - 39,199,158RGDNCBI36
Celera1738,551,513 - 38,551,639RGD
Cytogenetic Map17q21UniSTS
HuRef1737,607,604 - 37,607,730UniSTS
GeneMap99-GB4 RH Map17322.47UniSTS
Whitehead-RH Map17356.0UniSTS
DUSP3_588  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371741,845,649 - 41,846,316UniSTSGRCh37
Build 361739,201,175 - 39,201,842RGDNCBI36
Celera1738,553,656 - 38,554,323RGD
HuRef1737,609,747 - 37,610,414UniSTS
STS-N67742  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371741,846,540 - 41,846,741UniSTSGRCh37
Build 361739,202,066 - 39,202,267RGDNCBI36
Celera1738,554,547 - 38,554,748RGD
Cytogenetic Map17q21UniSTS
HuRef1737,610,638 - 37,610,839UniSTS
GeneMap99-GB4 RH Map17319.86UniSTS
NCBI RH Map17545.9UniSTS
D17S1216  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371741,843,746 - 41,843,841UniSTSGRCh37
Build 361739,199,272 - 39,199,367RGDNCBI36
Celera1738,551,753 - 38,551,848RGD
Cytogenetic Map17q21UniSTS
HuRef1737,607,844 - 37,607,939UniSTS
SGC30297  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371741,843,324 - 41,843,448UniSTSGRCh37
Build 361739,198,850 - 39,198,974RGDNCBI36
Celera1738,551,331 - 38,551,455RGD
Cytogenetic Map17q21UniSTS
HuRef1737,607,422 - 37,607,546UniSTS
GeneMap99-GB4 RH Map17329.09UniSTS
Whitehead-RH Map17357.3UniSTS
RH48877  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371741,844,500 - 41,844,665UniSTSGRCh37
Build 361739,200,026 - 39,200,191RGDNCBI36
Celera1738,552,507 - 38,552,672RGD
Cytogenetic Map17q21UniSTS
HuRef1737,608,598 - 37,608,763UniSTS
GeneMap99-GB4 RH Map17320.39UniSTS
NCBI RH Map17536.5UniSTS
A006E16  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371741,844,038 - 41,844,138UniSTSGRCh37
Build 361739,199,564 - 39,199,664RGDNCBI36
Celera1738,552,045 - 38,552,145RGD
Cytogenetic Map17q21UniSTS
HuRef1737,608,136 - 37,608,236UniSTS
GeneMap99-GB4 RH Map17320.28UniSTS
NCBI RH Map17534.5UniSTS
HUM0C12C02  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371741,843,505 - 41,843,713UniSTSGRCh37
Build 361739,199,031 - 39,199,239RGDNCBI36
Celera1738,551,512 - 38,551,720RGD
Cytogenetic Map17q21UniSTS
HuRef1737,607,603 - 37,607,811UniSTS
Stanford-G3 RH Map171817.0UniSTS
GeneMap99-G3 RH Map172318.0UniSTS
HUM000S655  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371741,843,650 - 41,843,697UniSTSGRCh37
Build 361739,199,176 - 39,199,223RGDNCBI36
Celera1738,551,657 - 38,551,704RGD
Cytogenetic Map17q21UniSTS
HuRef1737,607,748 - 37,607,795UniSTS
Stanford-G3 RH Map171813.0UniSTS
GeneMap99-G3 RH Map172314.0UniSTS
RH78942  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q21UniSTS
HuRef1737,609,149 - 37,609,279UniSTS
GeneMap99-GB4 RH Map17320.6UniSTS
D17S814E  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q21UniSTS
GeneMap99-G3 RH Map172318.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5027
Count of miRNA genes:1043
Interacting mature miRNAs:1260
Transcripts:ENST00000226004, ENST00000397937, ENST00000590342, ENST00000590753, ENST00000590935, ENST00000591618
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2431 2604 1717 620 1466 463 4355 2148 3475 415 1441 1602 170 1204 2788 4
Low 1 380 6 2 474 1 45 233 3 7 6 1
Below cutoff 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_004090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB451424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC003098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC055813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK226170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ575811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ652984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU177084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA075379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA104250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA167802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB171573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L05147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000226004   ⟹   ENSP00000226004
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1743,766,125 - 43,778,977 (-)Ensembl
RefSeq Acc Id: ENST00000590342   ⟹   ENSP00000467424
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1743,768,386 - 43,778,935 (-)Ensembl
RefSeq Acc Id: ENST00000590753   ⟹   ENSP00000466069
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1743,766,131 - 43,774,768 (-)Ensembl
RefSeq Acc Id: ENST00000590935   ⟹   ENSP00000468604
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1743,766,512 - 43,774,938 (-)Ensembl
RefSeq Acc Id: ENST00000591618
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1743,774,882 - 43,778,337 (-)Ensembl
RefSeq Acc Id: NM_004090   ⟹   NP_004081
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381743,766,125 - 43,778,977 (-)NCBI
GRCh371741,843,489 - 41,856,368 (-)ENTREZGENE
Build 361739,199,015 - 39,211,872 (-)NCBI Archive
HuRef1737,607,587 - 37,620,460 (-)ENTREZGENE
CHM1_11742,079,099 - 42,091,978 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004081   ⟸   NM_004090
- UniProtKB: P51452 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000467424   ⟸   ENST00000590342
RefSeq Acc Id: ENSP00000466069   ⟸   ENST00000590753
RefSeq Acc Id: ENSP00000468604   ⟸   ENST00000590935
RefSeq Acc Id: ENSP00000226004   ⟸   ENST00000226004
Promoters
RGD ID:6793963
Promoter ID:HG_KWN:26271
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_004090,   UC002IEE.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361739,211,581 - 39,212,081 (-)MPROMDB
RGD ID:7235197
Promoter ID:EPDNEW_H23344
Type:initiation region
Name:DUSP3_1
Description:dual specificity phosphatase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381743,778,945 - 43,779,005EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q12-21.31(chr17:39199873-45629579)x3 copy number gain See cases [RCV000052479] Chr17:39199873..45629579 [GRCh38]
Chr17:37356126..43706945 [GRCh37]
Chr17:34609652..41062728 [NCBI36]
Chr17:17q12-21.31
pathogenic
GRCh38/hg38 17q21.31(chr17:43570878-44762377)x1 copy number loss See cases [RCV000053429] Chr17:43570878..44762377 [GRCh38]
Chr17:41648246..42839745 [GRCh37]
Chr17:39003772..40195271 [NCBI36]
Chr17:17q21.31
pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh38/hg38 17q21.31(chr17:43387123-43865083)x3 copy number gain See cases [RCV000137096] Chr17:43387123..43865083 [GRCh38]
Chr17:41464491..41942451 [GRCh37]
Chr17:38820017..39297977 [NCBI36]
Chr17:17q21.31
uncertain significance
GRCh38/hg38 17q21.31(chr17:43080123-43897875)x3 copy number gain See cases [RCV000137690] Chr17:43080123..43897875 [GRCh38]
Chr17:41232140..41975243 [GRCh37]
Chr17:38485666..39330769 [NCBI36]
Chr17:17q21.31
uncertain significance
GRCh38/hg38 17q21.31(chr17:43088882-43865172)x3 copy number gain See cases [RCV000139057] Chr17:43088882..43865172 [GRCh38]
Chr17:41240899..41942540 [GRCh37]
Chr17:38494425..39298066 [NCBI36]
Chr17:17q21.31
uncertain significance
GRCh38/hg38 17q21.31(chr17:43322528-43849385)x3 copy number gain See cases [RCV000142192] Chr17:43322528..43849385 [GRCh38]
Chr17:41399892..41926753 [GRCh37]
Chr17:38755418..39282279 [NCBI36]
Chr17:17q21.31
likely benign|uncertain significance
GRCh38/hg38 17q21.31(chr17:43050945-43897883)x3 copy number gain See cases [RCV000143635] Chr17:43050945..43897883 [GRCh38]
Chr17:41202962..41975251 [GRCh37]
Chr17:38456488..39330777 [NCBI36]
Chr17:17q21.31
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q21.31(chr17:41540257-42044249)x1 copy number loss not provided [RCV000683936] Chr17:41540257..42044249 [GRCh37]
Chr17:17q21.31
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q21.31(chr17:41840802-41845956)x1 copy number loss not provided [RCV000739521] Chr17:41840802..41845956 [GRCh37]
Chr17:17q21.31
benign
GRCh37/hg19 17q21.31(chr17:41800157-41903109)x1 copy number loss not provided [RCV000848918] Chr17:41800157..41903109 [GRCh37]
Chr17:17q21.31
uncertain significance
GRCh37/hg19 17q21.31(chr17:41399892-42125780)x3 copy number gain not provided [RCV001006903] Chr17:41399892..42125780 [GRCh37]
Chr17:17q21.31
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3069 AgrOrtholog
COSMIC DUSP3 COSMIC
Ensembl Genes ENSG00000108861 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000226004 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000466069 UniProtKB/TrEMBL
  ENSP00000467424 UniProtKB/TrEMBL
  ENSP00000468604 UniProtKB/TrEMBL
Ensembl Transcript ENST00000226004 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000590342 UniProtKB/TrEMBL
  ENST00000590753 UniProtKB/TrEMBL
  ENST00000590935 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000108861 GTEx
HGNC ID HGNC:3069 ENTREZGENE
Human Proteome Map DUSP3 Human Proteome Map
InterPro Atypical_DUSP_famA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1845 UniProtKB/Swiss-Prot
NCBI Gene 1845 ENTREZGENE
OMIM 600183 OMIM
PANTHER PTHR45682 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27526 PharmGKB
PRINTS ADSPHPHTASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B5BUI8_HUMAN UniProtKB/TrEMBL
  DUS3_HUMAN UniProtKB/Swiss-Prot
  K7ELG5_HUMAN UniProtKB/TrEMBL
  K7EPK5_HUMAN UniProtKB/TrEMBL
  K7ES89_HUMAN UniProtKB/TrEMBL
  P51452 ENTREZGENE
UniProt Secondary D3DX45 UniProtKB/Swiss-Prot
  Q5U0J1 UniProtKB/Swiss-Prot
  Q8IYJ9 UniProtKB/Swiss-Prot