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Gene: FOXP3 (forkhead box P3) Homo sapiens
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Symbol: FOXP3
Name: forkhead box P3
Description: Exhibits several functions, including NFAT protein binding activity; enzyme binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of T cell activation; negative regulation of cytokine production; and regulation of transcription, DNA-templated. Localizes to the cytoplasm and nucleoplasm. Implicated in immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome and type 1 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AIID; DIETER; forkhead box protein P3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; scurfin; XPID
Orthologs:
Mus musculus (house mouse) : Foxp3 (forkhead box P3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Foxp3 (forkhead box P3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Foxp3 (forkhead box P3)
Pan paniscus (bonobo/pygmy chimpanzee) : FOXP3 (forkhead box P3)
Canis lupus familiaris (dog) : FOXP3 (forkhead box P3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Foxp3 (forkhead box P3)
Sus scrofa (pig) : FOXP3 (forkhead box P3)
Chlorocebus sabaeus (green monkey) : FOXP3 (forkhead box P3)
Heterocephalus glaber (naked mole-rat) : Foxp3 (forkhead box P3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX49,250,438 - 49,270,477 (-)Ensembl
GRCh38 EnsemblX49,250,436 - 49,270,477 (-)Ensembl
GRCh38X49,250,436 - 49,264,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X49,106,897 - 49,122,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,994,354 - 49,008,232 (-)NCBINCBI36hg18NCBI36
Build 34X48,863,780 - 48,877,659NCBI
CeleraX52,543,105 - 52,557,472 (+)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,763,332 - 46,777,541 (-)NCBIHuRef
CHM1_1X49,139,199 - 49,153,588 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on FOXP3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348507
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.