NOS3 (nitric oxide synthase 3) - Rat Genome Database

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Gene: NOS3 (nitric oxide synthase 3) Homo sapiens
Symbol: NOS3
Name: nitric oxide synthase 3
RGD ID: 735618
HGNC Page HGNC:7876
Description: Enables several functions, including actin monomer binding activity; arginine binding activity; and heme binding activity. Involved in several processes, including nitric oxide biosynthetic process; positive regulation of guanylate cyclase activity; and removal of superoxide radicals. Located in Golgi apparatus and caveola. Implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); eye disease (multiple); reproductive organ cancer (multiple); and vasculitis (multiple). Biomarker of several diseases, including central sleep apnea; endometrial carcinoma; lymphangioleiomyomatosis; obstructive sleep apnea; and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cNOS; constitutive NOS; EC-NOS; ECNOS; endothelial NOS; eNOS; nitric oxide synthase 3 (endothelial cell); nitric oxide synthase 3 [endothelial cell]; nitric oxide synthase 3 transcript variant eNOS-delta20; nitric oxide synthase 3 transcript variant eNOS-delta20-21; nitric oxide synthase 3 transcript variant eNOS-delta21; nitric oxide synthase 3, endothelial cell; nitric oxide synthase, endothelial; NOS type III; NOSIII
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: BW383_H BW384_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387150,991,017 - 151,014,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7150,991,017 - 151,014,588 (+)EnsemblGRCh38hg38GRCh38
GRCh377150,688,105 - 150,711,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,319,080 - 150,342,609 (+)NCBINCBI36Build 36hg18NCBI36
Build 347150,125,794 - 150,149,323NCBI
Celera7145,245,139 - 145,269,020 (+)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,500,690 - 144,524,025 (+)NCBIHuRef
CHM1_17150,696,541 - 150,720,093 (+)NCBICHM1_1
T2T-CHM13v2.07152,163,824 - 152,187,711 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27150,017,398 - 150,041,276 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute chest syndrome  (IAGP)
acute kidney failure  (EXP,ISO)
Acute Liver Failure  (ISO)
acute lymphoblastic leukemia  (IAGP)
acute myeloid leukemia  (IAGP)
adenocarcinoma  (EXP)
Alzheimer's disease  (EXP,IAGP,IEP,IMP)
angle-closure glaucoma  (IAGP)
anterior ischemic optic neuropathy  (IAGP)
aortic valve disease  (ISS)
arteriosclerosis  (EXP)
Arteriovenous Fistula  (ISO)
asthma  (IAGP)
atherosclerosis  (EXP,IAGP,ISO)
atrial fibrillation  (EXP)
autism spectrum disorder  (EXP)
Behcet's disease  (IAGP)
bladder neck obstruction  (ISO)
Brain Hypoxia  (ISO)
brain ischemia  (ISO)
breast cancer  (IAGP)
Breast Neoplasms  (EXP)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
Cardiomegaly  (EXP,ISO)
cardiomyopathy  (IAGP,ISO)
Cardiotoxicity  (IAGP)
cardiovascular system disease  (EXP)
Carotid Artery Injuries  (ISO)
central sleep apnea  (IEP)
cerebral infarction  (IAGP)
Child Behavior Disorders  (IAGP)
cholestasis  (ISO)
Chronic Cerebral Hypoperfusion  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (EXP)
cleft lip  (EXP)
cleft palate  (EXP)
colitis  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (EXP,ISO)
coronary artery disease  (EXP,IAGP)
coronary artery vasospasm  (EXP,IAGP)
cystic fibrosis  (IAGP)
diabetic angiopathy  (EXP,ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Gastroparesis  (ISO)
Diabetic Nephropathies  (EXP,IAGP,ISO)
diabetic retinopathy  (IAGP,ISO)
Diaphragmatic Hernia  (EXP,ISO)
disease of cellular proliferation  (EXP)
Drug-Induced Enteropathy  (ISO)
end stage renal disease  (IAGP,ISO)
endometrial carcinoma  (IEP)
Endotoxemia  (ISO)
Esophageal Neoplasms  (EXP)
esophagus adenocarcinoma  (IAGP)
essential hypertension  (EXP,IAGP)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (EXP,ISO)
Experimental Liver Cirrhosis  (EXP,ISO)
extrahepatic cholestasis  (EXP)
familial hyperlipidemia  (EXP,ISO)
Fetal Growth Retardation  (EXP,ISO)
gastric ulcer  (EXP,ISO)
genetic disease  (IAGP)
Graft Occlusion, Vascular  (IAGP)
Hemorrhagic Shock  (ISO)
Hepatic Insufficiency  (EXP)
Hepatomegaly  (EXP)
hepatopulmonary syndrome  (ISO)
high grade glioma  (IEP)
Huntington's disease  (ISO)
Hyperemia  (IAGP)
hyperglycemia  (EXP)
hyperinsulinism  (EXP)
Hyperoxia  (ISO)
hypertension  (EXP,IAGP,ISO)
Hypertension Resistant to Conventional Therapy  (IAGP)
Hypertriglyceridemia  (ISO)
hypothyroidism  (ISO)
Hypoxia  (EXP)
ileus  (ISO)
impotence  (EXP,ISO)
Insulin Resistance  (EXP,ISO)
intestinal perforation  (EXP)
Intestinal Reperfusion Injury  (ISO)
Intimal Hyperplasia  (IDA)
intracranial aneurysm  (ISO)
Intracranial Hemorrhages  (ISO)
irritable bowel syndrome  (ISO)
ischemia  (EXP)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (IAGP)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (IEP)
lethal congenital glycogen storage disease of heart  (IAGP)
limb ischemia  (IMP,ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
long QT syndrome  (IAGP)
lung disease  (ISO)
Lung Reperfusion Injury  (ISO)
lymphangioleiomyomatosis  (IEP)
Lymphatic Metastasis  (IAGP)
macular retinal edema  (IAGP)
male infertility  (EXP)
Metabolic Syndrome  (EXP,IAGP,ISO)
migraine  (IAGP)
myocardial infarction  (EXP,IAGP,IMP,ISO)
Myocardial Ischemia  (EXP,IAGP)
Myocardial Reperfusion Injury  (EXP,ISO)
Nasal Polyps  (IEP)
Neoplasm Metastasis  (IAGP,IEP)
nephritis  (IAGP)
obesity  (ISO)
obstructive sleep apnea  (IAGP,IEP)
oligospermia  (EXP)
ovarian cancer  (IAGP)
overnutrition  (ISO)
Pain  (ISO)
Perennial Allergic Rhinitis  (IAGP)
perinatal necrotizing enterocolitis  (EXP)
persistent fetal circulation syndrome  (ISS)
Phyllodes Tumor  (IEP)
placental abruption  (EXP)
polycystic kidney disease  (ISO)
portal hypertension  (EXP,ISO)
pre-eclampsia  (EXP,ISO)
Pregnancy-Induced Hypertension  (EXP,IAGP)
primary biliary cholangitis  (EXP)
primary open angle glaucoma  (IAGP)
primary ovarian insufficiency  (IAGP)
prostate cancer  (IAGP)
Prostatic Neoplasms  (EXP)
pulmonary edema  (EXP,ISO)
pulmonary embolism  (ISO)
pulmonary emphysema  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary hypertension  (EXP,IAGP,IEP,ISO)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
Radiation Pneumonitis  (IAGP)
renal hypertension  (ISO)
renovascular hypertension  (EXP)
Reperfusion Injury  (EXP)
respiratory allergy  (IAGP)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
retinopathy of prematurity  (IAGP)
Right Ventricular Hypertrophy  (ISO)
Sepsis  (EXP,IEP)
sickle cell anemia  (IAGP)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
Stomach Neoplasms  (EXP)
Stroke  (IAGP,ISO)
Subarachnoid Hemorrhage  (ISO)
Sudden Hearing Loss  (IAGP)
telangiectasis  (IAGP)
Teratozoospermia  (EXP)
Testis Reperfusion Injury  (ISO)
Thromboembolism  (IAGP)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (EXP)
type 2 diabetes mellitus  (EXP,ISO)
uremia  (EXP)
ureteral obstruction  (EXP)
urinary bladder cancer  (IEP)
vasculitis  (IAGP)
Vaso-occlusive Crisis  (IAGP)
Venous Thrombosis  (IAGP)
Ventricular Dysfunction, Right  (ISO)
Ventricular Premature Complexes  (EXP)
Ventricular Tachycardia  (EXP)
vestibular disease  (EXP)
vulva cancer  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
11-deoxycorticosterone  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (EXP)
2,4,6-trinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
22-Hydroxycholesterol  (EXP)
25-hydroxycholesterol  (EXP)
26-hydroxycholesterol  (ISO)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3-diphenyl-N-(1-phenylethyl)-1-propanamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
5,6,7,8-tetrahydrobiopterin  (EXP,ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
5-methoxypsoralen  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
7,8-Diacetoxy-4-methylcoumarin  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
9,10-phenanthroquinone  (EXP)
acetylcholine  (ISO)
acetylsalicylic acid  (EXP)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
agmatine  (EXP)
AICA ribonucleotide  (ISO)
alcohol  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (EXP)
alkaloid  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (ISO)
allopurinol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-Zearalanol  (EXP)
aminoguanidine  (ISO)
amiodarone  (EXP)
amlodipine  (ISO)
ammonium chloride  (ISO)
anagliptin  (EXP)
apocynin  (EXP,ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
atorvastatin calcium  (EXP,ISO)
atrasentan  (ISO)
atrazine  (EXP)
axitinib  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (EXP)
benzoic acid  (EXP)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bosentan  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calcimycin  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calmidazolium  (ISO)
camostat  (ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (ISO)
cantharidin  (EXP)
capsaicin  (EXP,ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
Cardamonin  (ISO)
carvedilol  (ISO)
cetirizine  (ISO)
chelerythrine  (ISO)
chlorogenic acid  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
chromium atom  (ISO)
chrysin  (ISO)
cilostazol  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
cloricromen  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
curcumin  (EXP)
cyanidin cation  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
daidzein  (EXP)
Decursin  (ISO)
deguelin  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
digitoxin  (EXP)
digoxin  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
edaravone  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
eplerenone  (ISO)
equol  (EXP)
erucic acid  (ISO)
esculetin  (ISO)
estriol  (EXP)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
everolimus  (EXP)
fenofibrate  (EXP)
fenpyroximate  (EXP)
Fexofenadine hydrochloride  (ISO)
fipronil  (ISO)
fluoranthene  (EXP)
fluorene  (EXP)
flutamide  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formic acid  (ISO)
formononetin  (ISO)
fosinopril  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
furosemide  (ISO)
genistein  (EXP)
gentamycin  (ISO)
ginsenoside Re  (EXP)
Ginsenoside Rg5  (ISO)
gliclazide  (ISO)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (EXP)
GW 501516  (EXP)
hemin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexacosan-1-ol  (ISO)
hexadecanoic acid  (EXP,ISO)
high-density lipoprotein cholesterol  (EXP)
histamine  (ISO)
homocysteine  (EXP,ISO)
hydrochlorothiazide  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP)
icariin  (EXP,ISO)
indometacin  (ISO)
iron dextran  (EXP,ISO)
isoprenaline  (ISO)
isorhamnetin  (EXP)
isosorbide dinitrate  (EXP)
kaempferol  (ISO)
L-arginine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-erythro-7,8-dihydrobiopterin  (EXP)
lamivudine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (EXP)
levamisole  (EXP)
linoleic acid  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
lysophosphatidylcholine  (ISO)
Magnolol  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (ISO)
manidipine  (ISO)
masoprocol  (EXP)
medroxyprogesterone acetate  (EXP,ISO)
melatonin  (EXP)
menadione  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methacholine chloride  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
metoprolol  (ISO)
mevalonic acid  (EXP)
mifepristone  (EXP)
miquelianin  (EXP)
MK-2206  (ISO)
monocrotaline  (ISO)
myricitrin  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-desethylamiodarone  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naphthalene  (EXP)
nebivolol  (EXP,ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nicorandil  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
nifedipine  (EXP)
nitrates  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (EXP,ISO)
nitrofen  (ISO)
nitrogen dioxide  (ISO)
nitroglycerin  (ISO)
nitroprusside  (EXP)
notoginsenoside R1  (ISO)
oleic acid  (EXP)
olmesartan  (ISO)
orotic acid  (EXP)
orphenadrine  (ISO)
Osajin  (EXP)
ouabain  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
palytoxin  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
paricalcitol  (ISO)
PD123319  (EXP)
pentaerythritol tetranitrate  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
peroxynitrous acid  (EXP)
phenylarsine oxide  (EXP)
phenylephrine  (ISO)
phloretin  (EXP)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphane  (ISO)
picoxystrobin  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
plerixafor  (EXP)
Pomiferin  (EXP)
potassium chloride  (ISO)
pravastatin  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propazine  (EXP)
propranolol  (ISO)
protoporphyrin  (EXP)
puerarin  (EXP,ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (ISO)
rac-lactic acid  (EXP)
raloxifene  (ISO)
ramipril  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (EXP)
Rosavin  (EXP)
rosmarinic acid  (ISO)
rosuvastatin calcium  (EXP,ISO)
rotenone  (EXP)
roxarsone  (EXP)
salicylic acid  (ISO)
salsalate  (ISO)
sapropterin  (EXP,ISO)
sarpogrelate  (ISO)
SB 203580  (EXP)
scutellarin  (ISO)
selenium atom  (ISO)
sepiapterin  (EXP)
sibutramine  (EXP)
sildenafil citrate  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
SKF-96365 hydrochloride  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium azide  (EXP)
sodium chloride  (ISO)
sodium nitrate  (ISO)
Sodium salicylate  (EXP,ISO)
Soman  (ISO)
sorafenib  (ISO)
stilbenoid  (EXP)
streptozocin  (ISO)
sucrose  (ISO)
sulfur dioxide  (ISO)
superoxide  (EXP,ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
tangeretin  (ISO)
Tanshinone I  (EXP,ISO)
tebufenpyrad  (EXP)
telmisartan  (ISO)
tenofovir disoproxil fumarate  (EXP)
terbutylazine  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetrahydrocurcumin  (ISO)
tetramethylpyrazine  (EXP)
theaflavin  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
Tiron  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP)
torcetrapib  (EXP,ISO)
trans-caffeic acid  (EXP)
trans-cinnamic acid  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (EXP)
tyrphostin AG 1478  (EXP)
ubiquinones  (EXP)
udenafil  (ISO)
uranium atom  (ISO)
urethane  (ISO)
ursolic acid  (ISO)
valsartan  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vanillic acid  (EXP)
vitamin E  (ISO)
wortmannin  (EXP,ISO)
Y-27632  (EXP)
zidovudine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zolmitriptan  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
aortic valve morphogenesis  (IEA,ISS,TAS)
arginine catabolic process  (IBA,IDA)
blood vessel diameter maintenance  (IEA,ISS)
blood vessel remodeling  (IEA,ISS)
bone development  (ISO)
calcium ion transport  (IEA,ISO)
cell redox homeostasis  (TAS)
cellular biosynthetic process  (IEA)
cellular response to cAMP  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to heat  (ISO)
cellular response to high density lipoprotein particle stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to magnesium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to rotenone  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
endocardial cushion morphogenesis  (IEA,ISS)
endothelial cell migration  (IMP)
establishment of localization in cell  (IEA,ISO)
female pregnancy  (ISO)
homeostasis of number of cells within a tissue  (IEA,ISS)
in utero embryonic development  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
lung development  (IEA,ISO)
mitochondrion organization  (ISS)
negative regulation of biomineral tissue development  (IEA,ISS)
negative regulation of blood pressure  (IBA)
negative regulation of calcium ion transport  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISS)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISS)
negative regulation of hydrolase activity  (IEA,ISO)
negative regulation of muscle hyperplasia  (IEA,ISS)
negative regulation of platelet activation  (NAS)
negative regulation of potassium ion transport  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IEA,ISO)
nitric oxide biosynthetic process  (IBA,IDA,IEA,ISO)
nitric oxide mediated signal transduction  (IBA)
ovulation from ovarian follicle  (IEA,ISO)
positive regulation of angiogenesis  (IDA,IEA,ISS)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (IDA)
positive regulation of gene expression  (IEA,ISO,ISS)
positive regulation of guanylate cyclase activity  (IBA,IMP,ISS)
positive regulation of Notch signaling pathway  (IC)
potassium ion transport  (IEA,ISO)
pulmonary valve morphogenesis  (IEA,ISS)
regulation of blood pressure  (NAS)
regulation of nervous system process  (IEA,ISS)
regulation of sodium ion transport  (IEA,ISO)
regulation of systemic arterial blood pressure by endothelin  (IMP)
regulation of the force of heart contraction by chemical signal  (IEA,ISO)
removal of superoxide radicals  (IDA)
response to activity  (ISO)
response to amino acid  (ISO)
response to axon injury  (ISO)
response to carbohydrate  (ISO)
response to corticosterone  (ISO)
response to cytokine  (ISO)
response to erythropoietin  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to fluid shear stress  (IEP)
response to fructose  (ISO)
response to heat  (NAS)
response to hormone  (IBA)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to ketone  (ISO)
response to L-arginine  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (IBA,ISO)
response to magnetism  (ISO)
response to mechanical stimulus  (ISO)
response to mercury ion  (ISO)
response to metal ion  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to peptide  (ISO)
response to peptide hormone  (ISO)
response to salt  (ISO)
response to ultrasound  (ISO)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
smooth muscle hyperplasia  (IEA,ISS)
vasodilation  (ISO,NAS)
ventricular septum morphogenesis  (IEA)

Cellular Component
apical part of cell  (ISO)
caveola  (IDA,IEA,ISO)
cytoplasm  (IDA,IEA,ISS)
cytoskeleton  (IEA)
cytosol  (IBA,TAS)
endocytic vesicle membrane  (TAS)
Golgi apparatus  (IDA,IEA)
Golgi membrane  (TAS)
membrane  (IEA)
nucleus  (IBA,IEA,ISS)
plasma membrane  (IBA,IDA,IEA,TAS)
sarcolemma  (ISO)
vesicle membrane  (IBA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal electroretinogram  (IAGP)
Abnormal fundus fluorescein angiography  (IAGP)
Abnormal lymphocyte count  (IAGP)
Abnormal optical coherence tomography  (IAGP)
Abnormal posterior segment imaging  (IAGP)
Abnormal systemic blood pressure  (IAGP)
Abnormality of brain morphology  (IAGP)
Adult onset  (IAGP)
Albuminuria  (IAGP)
Alzheimer disease  (IAGP)
Arterial stenosis  (IAGP)
Autosomal dominant inheritance  (IAGP)
Coronary artery stenosis  (IAGP)
Decreased circulating GABA concentration  (IAGP)
Dementia  (IAGP)
Eclampsia  (IAGP)
Edema  (IAGP)
Elevated diastolic blood pressure  (IAGP)
Elevated hepatic transaminase  (IAGP)
Elevated mean arterial pressure  (IAGP)
Elevated systolic blood pressure  (IAGP)
Focal-onset seizure  (IAGP)
Genital ulcers  (IAGP)
Headache  (IAGP)
Hypertension  (IAGP)
Immunologic hypersensitivity  (IAGP)
Increased carotid artery intimal medial thickness  (IAGP)
Increased circulating IgE level  (IAGP)
Increased CSF lactate  (IAGP)
Increased cup-to-disc ratio  (IAGP)
Intrauterine growth retardation  (IAGP)
Ischemic stroke  (IAGP)
Localized skin lesion  (IAGP)
Long-tract signs  (IAGP)
Marcus Gunn pupil  (IAGP)
Maternal hypertension  (IAGP)
Multifactorial inheritance  (IAGP)
Neurofibrillary tangles  (IAGP)
Nyctalopia  (IAGP)
Ocular hypertension  (IAGP)
Optic neuropathy  (IAGP)
Oral ulcer  (IAGP)
Papilledema  (IAGP)
Parkinsonism  (IAGP)
Peripheral visual field loss  (IAGP)
Preeclampsia  (IAGP)
Premature ovarian insufficiency  (IAGP)
Prolonged QT interval  (IAGP)
Proteinuria  (IAGP)
Reduced left ventricular ejection fraction  (IAGP)
Seizure  (IAGP)
Stroke  (IAGP)
Thrombocytopenia  (IAGP)
Tricuspid regurgitation  (IAGP)
Uveitis  (IAGP)
Visual field defect  (IAGP)
Visual loss  (IAGP)

References - curated
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