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Gene: SERPING1 (serpin family G member 1) Homo sapiens
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Symbol: SERPING1
Name: serpin family G member 1
Description: Exhibits serine-type endopeptidase inhibitor activity. Involved in negative regulation of complement activation, lectin pathway. Localizes to blood microparticle; collagen-containing extracellular matrix; and extracellular exosome. Implicated in angioedema (multiple); cerebral infarction; macular degeneration; pancreatitis; and toxic shock syndrome. Biomarker of acute myocardial infarction; autosomal dominant polycystic kidney disease; hereditary angioedema; and macular degeneration.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C1 esterase inhibitor; C1-inhibiting factor; C1-inhibitor; C1IN; C1INH; C1NH; complement component 1 inhibitor; HAE1; HAE2; plasma protease C1 inhibitor; serine (or cysteine) proteinase inhibitor, clade g (c1 inhibitor), member 1, (angioedema, hereditary); serine/cysteine proteinase inhibitor clade G member 1; serpin G1; serpin peptidase inhibitor clade G member 1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)
Orthologs:
Mus musculus (house mouse) : Serping1 (serine (or cysteine) peptidase inhibitor, clade G, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Serping1 (serpin family G member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Serping1 (serpin family G member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPING1 (serpin family G member 1)
Canis lupus familiaris (dog) : SERPING1 (serpin family G member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Serping1 (serpin family G member 1)
Sus scrofa (pig) : SERPING1 (serpin family G member 1)
Chlorocebus sabaeus (African green monkey) : SERPING1 (serpin family G member 1)
Heterocephalus glaber (naked mole-rat) : Serping1 (serpin family G member 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1157,597,387 - 57,614,848 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl1157,597,387 - 57,614,853 (+)EnsemblGRCh38hg38GRCh38
GRCh381157,597,685 - 57,614,848 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371157,365,027 - 57,382,326 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,121,603 - 57,138,902 (+)NCBINCBI36hg18NCBI36
Build 341157,121,733 - 57,138,895NCBI
Celera1154,721,543 - 54,738,843 (+)NCBI
Cytogenetic Map11q12.1NCBI
HuRef1153,713,821 - 53,731,117 (+)NCBIHuRef
CHM1_11157,231,240 - 57,248,536 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

Comparative Map Data
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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on SERPING1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344082
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-05-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.