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Gene: NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1) Homo sapiens
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Symbol: NDUFS1
Name: NADH:ubiquinone oxidoreductase core subunit S1
Description: Contributes to NADH dehydrogenase (ubiquinone) activity. Involved in several processes, including apoptotic mitochondrial changes; reactive oxygen species metabolic process; and regulation of mitochondrial membrane potential. Localizes to mitochondrial intermembrane space and mitochondrial respiratory chain complex I. Implicated in inherited metabolic disorder and mitochondrial complex I deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CI-75k; CI-75Kd; complex I 75kDa subunit; complex I, mitochondrial respiratory chain, 75-kD subunit; complex I-75kD; MC1DN5; MGC26839; mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase); NADH-coenzyme Q reductase; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; PRO1304
Orthologs:
Mus musculus (house mouse) : Ndufs1 (NADH:ubiquinone oxidoreductase core subunit S1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ndufs1 (NADH:ubiquinone oxidoreductase core subunit S1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ndufs1 (NADH:ubiquinone oxidoreductase core subunit S1)
Pan paniscus (bonobo/pygmy chimpanzee) : NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1)
Canis lupus familiaris (dog) : NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ndufs1 (NADH:ubiquinone oxidoreductase core subunit S1)
Sus scrofa (pig) : NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1)
Chlorocebus sabaeus (African green monkey) : NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1)
Heterocephalus glaber (naked mole-rat) : Ndufs1 (NADH:ubiquinone oxidoreductase core subunit S1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2206,114,817 - 206,159,509 (-)EnsemblGRCh38hg38GRCh38
GRCh382206,114,817 - 206,159,444 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372206,987,803 - 207,024,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362206,696,048 - 206,732,432 (-)NCBINCBI36hg18NCBI36
Build 342206,813,308 - 206,849,693NCBI
Celera2200,745,218 - 200,781,616 (-)NCBI
Cytogenetic Map2q33.3NCBI
HuRef2198,836,332 - 198,872,823 (-)NCBIHuRef
CHM1_12206,994,334 - 207,030,799 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NDUFS1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1350002
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.