Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: CHEK2 (checkpoint kinase 2) Homo sapiens
Analyze
Symbol: CHEK2
Name: checkpoint kinase 2
Description: Exhibits enzyme binding activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular protein metabolic process; intracellular signal transduction; and protein stabilization. Localizes to Golgi apparatus and PML body. Colocalizes with chromosome, telomeric region. Implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Biomarker of congestive heart failure; embryonal carcinoma; and seminoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDS1; cds1 homolog; checkpoint-like protein CHK2; CHK2; CHK2 checkpoint homolog; hCds1; HuCds1; LFS2; PP1425; RAD53; serine/threonine-protein kinase Chk2
Orthologs:
Mus musculus (house mouse) : Chek2 (checkpoint kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Chek2 (checkpoint kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chek2 (checkpoint kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CHEK2 (checkpoint kinase 2)
Canis lupus familiaris (dog) : CHEK2 (checkpoint kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chek2 (checkpoint kinase 2)
Sus scrofa (pig) : CHEK2 (checkpoint kinase 2)
Chlorocebus sabaeus (African green monkey) : CHEK2 (checkpoint kinase 2)
Heterocephalus glaber (naked mole-rat) : Chek2 (checkpoint kinase 2)
more info ...
Related Pseudogenes: CHEK2P1   CHEK2P2   CHEK2P3   CHEK2P4   CHEK2P5  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2228,687,743 - 28,742,422 (-)EnsemblGRCh38hg38GRCh38
GRCh382228,687,743 - 28,741,866 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372229,083,731 - 29,137,822 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,413,731 - 27,467,822 (-)NCBINCBI36hg18NCBI36
Build 342227,408,284 - 27,462,376NCBI
Celera2212,883,692 - 12,937,801 (-)NCBI
Cytogenetic Map22q12.1ENTREZGENE
HuRef2212,048,435 - 12,103,008 (-)NCBIHuRef
CHM1_12229,042,794 - 29,096,883 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)