Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CHEK2 (checkpoint kinase 2) Homo sapiens
Analyze
Symbol: CHEK2
Name: checkpoint kinase 2
Description: Exhibits enzyme binding activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular protein metabolic process; intracellular signal transduction; and protein stabilization. Localizes to Golgi apparatus and PML body. Colocalizes with chromosome, telomeric region. Implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Biomarker of congestive heart failure; embryonal carcinoma; and seminoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDS1; cds1 homolog; checkpoint-like protein CHK2; CHK2; CHK2 checkpoint homolog; hCds1; HuCds1; LFS2; PP1425; RAD53; serine/threonine-protein kinase Chk2
Orthologs:
Mus musculus (house mouse) : Chek2 (checkpoint kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Chek2 (checkpoint kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chek2 (checkpoint kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CHEK2 (checkpoint kinase 2)
Canis lupus familiaris (dog) : CHEK2 (checkpoint kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chek2 (checkpoint kinase 2)
Sus scrofa (pig) : CHEK2 (checkpoint kinase 2)
Chlorocebus sabaeus (African green monkey) : CHEK2 (checkpoint kinase 2)
Heterocephalus glaber (naked mole-rat) : Chek2 (checkpoint kinase 2)
more info ...
Related Pseudogenes: CHEK2P1   CHEK2P2   CHEK2P3   CHEK2P4   CHEK2P5  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2228,687,743 - 28,742,422 (-)EnsemblGRCh38hg38GRCh38
GRCh382228,687,743 - 28,741,866 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372229,083,731 - 29,137,822 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,413,731 - 27,467,822 (-)NCBINCBI36hg18NCBI36
Build 342227,408,284 - 27,462,376NCBI
Celera2212,883,692 - 12,937,801 (-)NCBI
Cytogenetic Map22q12.1ENTREZGENE
HuRef2212,048,435 - 12,103,008 (-)NCBIHuRef
CHM1_12229,042,794 - 29,096,883 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model