CHEK2 (checkpoint kinase 2) - Rat Genome Database

Name: CHEK2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: CHEK2 (checkpoint kinase 2) Homo sapiens

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Symbol:

CHEK2

Name:

checkpoint kinase 2

RGD ID:

732861

HGNC Page

HGNC

Description:

Enables enzyme binding activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including intracellular signal transduction; protein phosphorylation; and protein stabilization. Acts upstream of or within signal transduction in response to DNA damage. Located in Golgi apparatus and PML body. Colocalizes with chromosome, telomeric region. Implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Biomarker of congestive heart failure; embryonal carcinoma; and seminoma.

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

CDS1; cds1 homolog; checkpoint-like protein CHK2; CHK2; CHK2 checkpoint homolog; hCds1; HuCds1; LFS2; PP1425; RAD53; serine/threonine-protein kinase Chk2

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Chek2 (checkpoint kinase 2)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Chek2 (checkpoint kinase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Chek2 (checkpoint kinase 2)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	CHEK2 (checkpoint kinase 2)	NCBI	Ortholog
Canis lupus familiaris (dog):	CHEK2 (checkpoint kinase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Chek2 (checkpoint kinase 2)	NCBI	Ortholog
Sus scrofa (pig):	CHEK2 (checkpoint kinase 2)	HGNC	Ensembl, NCBI, OrthoDB
Chlorocebus sabaeus (green monkey):	CHEK2 (checkpoint kinase 2)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Chek2 (checkpoint kinase 2)	NCBI	Ortholog
Other homologs ²
Canis lupus familiaris (dog):	TTC28 (tetratricopeptide repeat domain 28)	HGNC	EggNOG, Treefam
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Chek2 (checkpoint kinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Chek2 (checkpoint kinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	chek2 (checkpoint kinase 2)	Alliance	DIOPT (PhylomeDB\|TreeFam\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	RAD53	Alliance	DIOPT (InParanoid\|PANTHER\|Roundup)
Caenorhabditis elegans (roundworm):	T08D2.7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Caenorhabditis elegans (roundworm):	chk-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	lok	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	DUN1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB)

Related Pseudogenes:

CHEK2P1 CHEK2P2 CHEK2P3 CHEK2P4 CHEK2P5 CHEK2P7

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	22	28,687,743 - 28,742,422 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	22	28,687,743 - 28,741,866 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	22	29,083,731 - 29,137,822 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	27,413,731 - 27,467,822 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	22	27,408,284 - 27,462,376	NCBI
Celera	22	12,883,692 - 12,937,801 (-)	NCBI
Cytogenetic Map	22	q12.1	ENTREZGENE
HuRef	22	12,048,435 - 12,103,008 (-)	NCBI		HuRef
CHM1_1	22	29,042,794 - 29,096,883 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar