CHEK2 (checkpoint kinase 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CHEK2 (checkpoint kinase 2) Homo sapiens
Analyze
Symbol: CHEK2
Name: checkpoint kinase 2
RGD ID: 732861
HGNC Page HGNC
Description: Enables enzyme binding activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including intracellular signal transduction; protein phosphorylation; and protein stabilization. Acts upstream of or within signal transduction in response to DNA damage. Located in Golgi apparatus and PML body. Colocalizes with chromosome, telomeric region. Implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Biomarker of congestive heart failure; embryonal carcinoma; and seminoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDS1; cds1 homolog; checkpoint-like protein CHK2; CHK2; CHK2 checkpoint homolog; hCds1; HuCds1; LFS2; PP1425; RAD53; serine/threonine-protein kinase Chk2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: CHEK2P1   CHEK2P2   CHEK2P3   CHEK2P4   CHEK2P5   CHEK2P7  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2228,687,743 - 28,742,422 (-)EnsemblGRCh38hg38GRCh38
GRCh382228,687,743 - 28,741,866 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372229,083,731 - 29,137,822 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,413,731 - 27,467,822 (-)NCBINCBI36hg18NCBI36
Build 342227,408,284 - 27,462,376NCBI
Celera2212,883,692 - 12,937,801 (-)NCBI
Cytogenetic Map22q12.1ENTREZGENE
HuRef2212,048,435 - 12,103,008 (-)NCBIHuRef
CHM1_12229,042,794 - 29,096,883 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model