Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: AFAP1 (actin filament associated protein 1) Homo sapiens
Analyze
Symbol: AFAP1
Name: actin filament associated protein 1
Description: Predicted to have SH2 domain binding activity and SH3 domain binding activity. Predicted to be involved in regulation of cytoskeleton organization and regulation of signal transduction. Localizes to actin cytoskeleton; cytosol; and focal adhesion. Implicated in open-angle glaucoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 110 kDa actin filament-associated protein; actin filament-associated protein 1; actin filament-associated protein, 110 kDa; AFAP; AFAP-110; AFAP110; FLJ56849
Orthologs:
Mus musculus (house mouse) : Afap1 (actin filament associated protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Afap1 (actin filament associated protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Afap1 (actin filament associated protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AFAP1 (actin filament associated protein 1)
Canis lupus familiaris (dog) : AFAP1 (actin filament associated protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Afap1 (actin filament associated protein 1)
Sus scrofa (pig) : AFAP1 (actin filament associated protein 1)
Chlorocebus sabaeus (African green monkey) : AFAP1 (actin filament associated protein 1)
Heterocephalus glaber (naked mole-rat) : Afap1 (actin filament associated protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl47,758,714 - 7,939,926 (-)EnsemblGRCh38hg38GRCh38
GRCh3847,758,713 - 7,939,926 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3747,760,440 - 7,941,653 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3647,811,340 - 7,992,553 (-)NCBINCBI36hg18NCBI36
Celera47,662,306 - 7,842,025 (-)NCBI
Cytogenetic Map4p16.1NCBI
HuRef47,682,587 - 7,779,433 (-)NCBIHuRef
HuRef47,791,849 - 7,862,997 (-)NCBIHuRef
CHM1_147,758,814 - 7,939,654 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on AFAP1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605642
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.