DCN (decorin) - Rat Genome Database

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Gene: DCN (decorin) Homo sapiens
Analyze
Symbol: DCN
Name: decorin
RGD ID: 1346102
HGNC Page HGNC
Description: Exhibits RNA binding activity. Involved in several processes, including positive regulation of cellular metabolic process; positive regulation of mitochondrial depolarization; and regulation of signal transduction. Localizes to collagen-containing extracellular matrix and extracellular space. Implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Biomarker of gestational diabetes and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bone proteoglycan II; CSCD; decorin proteoglycan; dermatan sulphate proteoglycans II; DSPG2; PG-S2; PG40; PGII; PGS2; proteoglycan core protein; SLRR1B; small leucine-rich protein 1B
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1291,140,484 - 91,183,217 (-)EnsemblGRCh38hg38GRCh38
GRCh381291,140,484 - 91,182,817 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371291,534,261 - 91,576,594 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361290,063,166 - 90,100,937 (-)NCBINCBI36hg18NCBI36
Build 341290,041,503 - 90,074,797NCBI
Celera1291,210,186 - 91,247,962 (-)NCBI
Cytogenetic Map12q21.33NCBI
HuRef1288,606,804 - 88,644,468 (-)NCBIHuRef
CHM1_11291,504,053 - 91,541,824 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,5-hexanedione  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (EXP)
2-nitrofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
anthracen-2-amine  (ISO)
antirheumatic drug  (EXP)
aristolochic acid  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
benzylpenicillin  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
calcium dichloride  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (ISO)
chlordecone  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
cytarabine  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
entinostat  (EXP)
ethanol  (ISO)
folic acid  (EXP,ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
graphite  (ISO)
hydrogen peroxide  (EXP)
indinavir  (ISO)
indometacin  (EXP)
isoflavones  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
levonorgestrel  (EXP)
losartan  (ISO)
medroxyprogesterone acetate  (EXP)
melphalan  (ISO)
mercury dichloride  (ISO)
methotrexate  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
potassium dichromate  (ISO)
retinyl acetate  (ISO)
Salinomycin  (EXP)
saquinavir  (ISO)
SB 431542  (EXP)
serpentine asbestos  (EXP)
sodium fluoride  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
testosterone undecanoate  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
Thiotepa  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trichloroethene  (ISO)
triclosan  (EXP)
troglitazone  (EXP,ISO)
Tungsten carbide  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin E  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. Biglari A, etal., Cancer Gene Ther. 2004 Nov;11(11):721-32.
2. Bolton K, etal., Int J Obes (Lond). 2008 Jul;32(7):1113-21. Epub 2008 Apr 15.
3. Chen CP, etal., Placenta. 2007 Feb-Mar;28(2-3):97-106. Epub 2006 Apr 21.
4. De Cosmo S, etal., Nephron. 2002 Sep;92(1):72-6.
5. GOA_HUMAN data from the GO Consortium
6. Goldoni S, etal., Am J Pathol. 2008 Sep;173(3):844-55. Epub 2008 Aug 7.
7. Jeansson M, etal., Diabetologia. 2006 Sep;49(9):2200-9. Epub 2006 Jul 26.
8. Knoll KE, etal., Physiol Genomics. 2005 Apr 14;21(2):222-9. Epub 2005 Feb 15.
9. Ohno T, etal., Otolaryngol Head Neck Surg. 2009 May;140(5):757-61. Epub 2009 Feb 26.
10. OMIM Disease Annotation Pipeline
11. Pini L, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Jun;290(6):L1052-8. Epub 2005 Dec 30.
12. Pipeline to import KEGG annotations from KEGG into RGD
13. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. RGD automated import pipeline for gene-chemical interactions
15. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
16. Schaefer L, etal., FASEB J. 2001 Mar;15(3):559-61. Epub 2001 Jan 19.
17. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
18. Simkhovich BZ, etal., Arch Biochem Biophys. 2003 Dec 15;420(2):268-78.
19. Suzuki K, etal., Exp Mol Pathol. 2005 Aug;79(1):68-73. Epub 2005 Mar 29.
20. Toeda K, etal., Mol Cell Biochem. 2005 Dec;280(1-2):47-56.
21. Williams KJ, etal., Am J Pathol. 2007 Nov;171(5):1441-50. Epub 2007 Sep 20.
22. Zhang J, etal., Am J Physiol Endocrinol Metab. 2007 Jan 23;.
Additional References at PubMed
PMID:1431141   PMID:1468447   PMID:1544908   PMID:1550960   PMID:1611907   PMID:1747115   PMID:1968422   PMID:2059554   PMID:2211661   PMID:2374594   PMID:2375748   PMID:2590169  
PMID:2647739   PMID:3194009   PMID:3484330   PMID:3597437   PMID:7638106   PMID:7798269   PMID:7961765   PMID:8093006   PMID:8432526   PMID:8432527   PMID:8440685   PMID:8889548  
PMID:9148753   PMID:9252349   PMID:9328841   PMID:9435313   PMID:9675033   PMID:9895299   PMID:9988678   PMID:10382266   PMID:10747008   PMID:10793130   PMID:11185075   PMID:11598131  
PMID:11723132   PMID:11879191   PMID:11979972   PMID:12071714   PMID:12105206   PMID:12106908   PMID:12176891   PMID:12372409   PMID:12387878   PMID:12477932   PMID:12482864   PMID:12601001  
PMID:12730206   PMID:12853035   PMID:14633702   PMID:14660661   PMID:15016081   PMID:15016829   PMID:15147736   PMID:15147741   PMID:15209389   PMID:15291816   PMID:15336555   PMID:15489334  
PMID:15652541   PMID:15671264   PMID:15785240   PMID:15811857   PMID:15923192   PMID:15949467   PMID:15994311   PMID:16258169   PMID:16344560   PMID:16434404   PMID:16467781   PMID:16583246  
PMID:16835231   PMID:16844696   PMID:16902402   PMID:16935612   PMID:16938379   PMID:16989735   PMID:17046817   PMID:17067743   PMID:17097211   PMID:17146610   PMID:17286067   PMID:17335953  
PMID:17396208   PMID:17516017   PMID:17558846   PMID:17651433   PMID:17952560   PMID:18029348   PMID:18373940   PMID:18413316   PMID:18413650   PMID:18436739   PMID:18505923   PMID:18514055  
PMID:18620607   PMID:18621549   PMID:18638554   PMID:18830193   PMID:19036156   PMID:19212830   PMID:19433454   PMID:19453261   PMID:19589127   PMID:19590249   PMID:19590686   PMID:19616852  
PMID:19678923   PMID:19684189   PMID:19737460   PMID:19834535   PMID:19864245   PMID:19913121   PMID:20026052   PMID:20301741   PMID:20357198   PMID:20360993   PMID:20398359   PMID:20484579  
PMID:20546727   PMID:20551380   PMID:20591329   PMID:20628086   PMID:20628624   PMID:20644730   PMID:20707770   PMID:20974860   PMID:21185747   PMID:21205989   PMID:21360479   PMID:21658281  
PMID:21702857   PMID:21723264   PMID:21791066   PMID:21791437   PMID:21809347   PMID:21840990   PMID:21873635   PMID:21958730   PMID:21993463   PMID:22104218   PMID:22159220   PMID:22261194  
PMID:22329809   PMID:22363530   PMID:22479366   PMID:22490077   PMID:22512703   PMID:22658674   PMID:22678721   PMID:22735579   PMID:22870031   PMID:22871215   PMID:22880013   PMID:22888166  
PMID:22990118   PMID:22992875   PMID:23007289   PMID:23029096   PMID:23193185   PMID:23431957   PMID:23685109   PMID:23747391   PMID:23798385   PMID:23851508   PMID:23889174   PMID:23939413  
PMID:23978385   PMID:24023624   PMID:24117774   PMID:24142880   PMID:24146840   PMID:24152495   PMID:24256371   PMID:24272200   PMID:24389353   PMID:24413633   PMID:24424784   PMID:24472739  
PMID:24552666   PMID:24947404   PMID:24996176   PMID:25026535   PMID:25037231   PMID:25232019   PMID:25244916   PMID:25304290   PMID:25331875   PMID:25400079   PMID:25407518   PMID:25524578  
PMID:25550184   PMID:25656619   PMID:25661523   PMID:25789606   PMID:26001829   PMID:26186194   PMID:26400336   PMID:26547587   PMID:26554635   PMID:26663310   PMID:26697491   PMID:26828927  
PMID:26871637   PMID:26926600   PMID:27068509   PMID:27096414   PMID:27315044   PMID:27559042   PMID:27644884   PMID:27860287   PMID:28327460   PMID:28459201   PMID:28514442   PMID:28567416  
PMID:28631095   PMID:28675934   PMID:28789706   PMID:28798237   PMID:28927971   PMID:29080840   PMID:29671669   PMID:29708036   PMID:29867136   PMID:29895842   PMID:30002123   PMID:30099770  
PMID:30320452   PMID:30585266   PMID:30604627   PMID:31009269   PMID:31182584   PMID:31271881   PMID:31446221   PMID:31478096   PMID:31659495   PMID:32041647   PMID:32306717   PMID:32353084  
PMID:32436194   PMID:32845500   PMID:33257596   PMID:33365011  


Genomics

Comparative Map Data
DCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1291,140,484 - 91,183,217 (-)EnsemblGRCh38hg38GRCh38
GRCh381291,140,484 - 91,182,817 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371291,534,261 - 91,576,594 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361290,063,166 - 90,100,937 (-)NCBINCBI36hg18NCBI36
Build 341290,041,503 - 90,074,797NCBI
Celera1291,210,186 - 91,247,962 (-)NCBI
Cytogenetic Map12q21.33NCBI
HuRef1288,606,804 - 88,644,468 (-)NCBIHuRef
CHM1_11291,504,053 - 91,541,824 (-)NCBICHM1_1
Dcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391097,315,362 - 97,354,025 (+)NCBIGRCm39mm39
GRCm39 Ensembl1097,315,471 - 97,354,005 (+)Ensembl
GRCm381097,479,500 - 97,518,163 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1097,479,609 - 97,518,143 (+)EnsemblGRCm38mm10GRCm38
MGSCv371096,942,134 - 96,980,796 (+)NCBIGRCm37mm9NCBIm37
MGSCv361096,912,055 - 96,947,839 (+)NCBImm8
Celera1099,450,242 - 99,488,904 (+)NCBICelera
Cytogenetic Map10C3NCBI
cM Map1050.27NCBI
Dcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2732,281,252 - 32,321,291 (+)NCBI
Rnor_6.0 Ensembl738,742,051 - 38,782,323 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0738,742,250 - 38,782,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0738,783,714 - 38,823,746 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4735,004,234 - 35,045,191 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1735,029,274 - 35,065,458 (+)NCBI
Celera729,318,664 - 29,358,499 (+)NCBICelera
Cytogenetic Map7q13NCBI
Dcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540528,332,545 - 28,372,323 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540528,335,493 - 28,371,912 (-)NCBIChiLan1.0ChiLan1.0
DCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11291,994,129 - 92,031,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1291,994,129 - 92,031,413 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01288,678,791 - 88,715,677 (-)NCBIMhudiblu_PPA_v0panPan3
DCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11531,833,492 - 31,887,699 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1531,833,746 - 31,877,417 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1532,288,559 - 32,331,901 (-)NCBI
ROS_Cfam_1.01532,489,958 - 32,545,511 (-)NCBI
UMICH_Zoey_3.11531,782,615 - 31,825,998 (-)NCBI
UNSW_CanFamBas_1.01531,846,288 - 31,889,835 (-)NCBI
UU_Cfam_GSD_1.01532,139,738 - 32,182,940 (-)NCBI
Dcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494528,312,653 - 28,348,182 (+)NCBI
SpeTri2.0NW_0049365077,887,259 - 7,923,055 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl591,678,608 - 91,714,235 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1591,678,601 - 91,713,925 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2596,109,666 - 96,144,030 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11186,552,392 - 86,590,229 (-)NCBI
ChlSab1.1 Ensembl1186,551,072 - 86,586,891 (-)Ensembl
Vero_WHO_p1.0NW_023666037158,594,516 - 158,631,419 (+)NCBI
Dcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475015,466,938 - 15,517,475 (+)NCBI

Position Markers
WI-17110  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371291,539,055 - 91,539,183UniSTSGRCh37
Build 361290,063,186 - 90,063,314RGDNCBI36
Celera1291,210,206 - 91,210,334RGD
Cytogenetic Map12q21.33UniSTS
HuRef1288,606,824 - 88,606,952UniSTS
GeneMap99-GB4 RH Map12354.67UniSTS
Whitehead-RH Map12456.6UniSTS
NCBI RH Map12593.5UniSTS
RH103594  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371291,569,503 - 91,569,642UniSTSGRCh37
Build 361290,093,634 - 90,093,773RGDNCBI36
Celera1291,240,659 - 91,240,798RGD
Cytogenetic Map12q21.33UniSTS
HuRef1288,637,165 - 88,637,304UniSTS
GeneMap99-GB4 RH Map12356.07UniSTS
GDB:197931  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371291,574,869 - 91,575,047UniSTSGRCh37
Build 361290,099,000 - 90,099,178RGDNCBI36
Celera1291,246,025 - 91,246,203RGD
Cytogenetic Map12q21.33UniSTS
HuRef1288,642,531 - 88,642,709UniSTS
GDB:384910  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371291,572,108 - 91,572,294UniSTSGRCh37
Build 361290,096,239 - 90,096,425RGDNCBI36
Celera1291,243,264 - 91,243,450RGD
Cytogenetic Map12q21.33UniSTS
HuRef1288,639,770 - 88,639,956UniSTS
SHGC-17552  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371291,549,288 - 91,549,541UniSTSGRCh37
Build 361290,073,419 - 90,073,672RGDNCBI36
Celera1291,220,439 - 91,220,692RGD
Cytogenetic Map12q21.33UniSTS
HuRef1288,616,956 - 88,617,209UniSTS
Whitehead-RH Map12456.8UniSTS
Whitehead-YAC Contig Map12 UniSTS
NCBI RH Map12593.5UniSTS
SHGC-53083  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371291,569,386 - 91,569,522UniSTSGRCh37
Build 361290,093,517 - 90,093,653RGDNCBI36
Celera1291,240,542 - 91,240,678RGD
Cytogenetic Map12q21.33UniSTS
HuRef1288,637,048 - 88,637,184UniSTS
RH68984  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371291,539,468 - 91,539,741UniSTSGRCh37
Build 361290,063,599 - 90,063,872RGDNCBI36
Celera1291,210,619 - 91,210,892RGD
Cytogenetic Map12q21.33UniSTS
HuRef1288,607,237 - 88,607,510UniSTS
GeneMap99-GB4 RH Map12352.74UniSTS
NCBI RH Map12593.5UniSTS
RH41859  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371291,539,711 - 91,539,856UniSTSGRCh37
Build 361290,063,842 - 90,063,987RGDNCBI36
Celera1291,210,862 - 91,211,007RGD
Cytogenetic Map12q21.33UniSTS
HuRef1288,607,480 - 88,607,625UniSTS
GeneMap99-GB4 RH Map12357.5UniSTS
NCBI RH Map12598.2UniSTS
WI-20146  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371291,539,367 - 91,539,493UniSTSGRCh37
Build 361290,063,498 - 90,063,624RGDNCBI36
Celera1291,210,518 - 91,210,644RGD
Cytogenetic Map12q21.33UniSTS
HuRef1288,607,136 - 88,607,262UniSTS
GeneMap99-GB4 RH Map12354.77UniSTS
Whitehead-RH Map12456.5UniSTS
NCBI RH Map12593.5UniSTS
MARC_12473-12474:997213223:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371291,550,876 - 91,552,158UniSTSGRCh37
Celera1291,222,027 - 91,223,309UniSTS
HuRef1288,618,543 - 88,619,825UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4458
Count of miRNA genes:1100
Interacting mature miRNAs:1373
Transcripts:ENST00000052754, ENST00000228329, ENST00000303320, ENST00000393155, ENST00000420120, ENST00000425043, ENST00000441303, ENST00000456569, ENST00000546370, ENST00000546391, ENST00000546745, ENST00000547568, ENST00000547937, ENST00000548218, ENST00000548768, ENST00000549513, ENST00000550099, ENST00000550563, ENST00000550758, ENST00000551354, ENST00000552145, ENST00000552962
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 17 26 1 1 121 16 47 40 9 85 54
Medium 2279 2197 1555 514 307 352 3961 2117 1335 254 1262 1355 166 1 1119 2722 4
Low 29 315 132 87 540 85 42 39 2315 96 67 46 2 12 2
Below cutoff 17 444 21 13 516 14 105 13 23 39 19 51 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF138300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF138301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF138302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF138303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF138304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF491944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL517167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW444736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG536640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG538290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM672011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX094949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX571756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD689331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR407676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA424244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA424310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA663155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000052754   ⟹   ENSP00000052754
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,140,484 - 91,182,817 (-)Ensembl
RefSeq Acc Id: ENST00000393155   ⟹   ENSP00000376862
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,145,259 - 91,179,582 (-)Ensembl
RefSeq Acc Id: ENST00000420120   ⟹   ENSP00000413723
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,146,058 - 91,178,552 (-)Ensembl
RefSeq Acc Id: ENST00000425043   ⟹   ENSP00000401021
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,145,259 - 91,178,552 (-)Ensembl
RefSeq Acc Id: ENST00000441303   ⟹   ENSP00000399815
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,146,058 - 91,178,552 (-)Ensembl
RefSeq Acc Id: ENST00000456569   ⟹   ENSP00000398514
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,146,236 - 91,178,552 (-)Ensembl
RefSeq Acc Id: ENST00000546370   ⟹   ENSP00000446527
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,169,634 - 91,179,439 (-)Ensembl
RefSeq Acc Id: ENST00000546391   ⟹   ENSP00000446530
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,146,166 - 91,179,513 (-)Ensembl
RefSeq Acc Id: ENST00000546745   ⟹   ENSP00000448857
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,172,142 - 91,182,709 (-)Ensembl
RefSeq Acc Id: ENST00000547568   ⟹   ENSP00000447674
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,146,058 - 91,182,805 (-)Ensembl
RefSeq Acc Id: ENST00000547937   ⟹   ENSP00000449782
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,158,296 - 91,180,365 (-)Ensembl
RefSeq Acc Id: ENST00000548218   ⟹   ENSP00000448853
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,145,526 - 91,146,208 (-)Ensembl
RefSeq Acc Id: ENST00000548768
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,179,199 - 91,180,481 (-)Ensembl
RefSeq Acc Id: ENST00000549513   ⟹   ENSP00000449438
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,158,476 - 91,180,976 (-)Ensembl
RefSeq Acc Id: ENST00000550099   ⟹   ENSP00000448057
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,172,528 - 91,179,495 (-)Ensembl
RefSeq Acc Id: ENST00000550563   ⟹   ENSP00000449014
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,158,312 - 91,179,355 (-)Ensembl
RefSeq Acc Id: ENST00000550758   ⟹   ENSP00000449408
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,150,783 - 91,153,149 (-)Ensembl
RefSeq Acc Id: ENST00000551354   ⟹   ENSP00000448274
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,175,118 - 91,179,533 (-)Ensembl
RefSeq Acc Id: ENST00000552145   ⟹   ENSP00000447886
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,158,298 - 91,182,652 (-)Ensembl
RefSeq Acc Id: ENST00000552962   ⟹   ENSP00000447654
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1291,145,736 - 91,182,824 (-)Ensembl
RefSeq Acc Id: NM_001920   ⟹   NP_001911
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381291,140,484 - 91,182,817 (-)NCBI
GRCh371291,539,035 - 91,576,806 (-)ENTREZGENE
Build 361290,063,166 - 90,100,937 (-)NCBI Archive
HuRef1288,606,804 - 88,644,468 (-)ENTREZGENE
CHM1_11291,502,072 - 91,541,919 (-)NCBI
Sequence:
RefSeq Acc Id: NM_133503   ⟹   NP_598010
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381291,140,484 - 91,179,479 (-)NCBI
GRCh371291,539,035 - 91,576,806 (-)ENTREZGENE
Build 361290,063,166 - 90,097,490 (-)NCBI Archive
HuRef1288,606,804 - 88,644,468 (-)ENTREZGENE
CHM1_11291,502,072 - 91,538,413 (-)NCBI
Sequence:
RefSeq Acc Id: NM_133504   ⟹   NP_598011
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381291,143,277 - 91,178,646 (-)NCBI
GRCh371291,539,035 - 91,576,806 (-)ENTREZGENE
Build 361290,063,166 - 90,096,460 (-)NCBI Archive
HuRef1288,606,804 - 88,644,468 (-)ENTREZGENE
CHM1_11291,502,072 - 91,537,441 (-)NCBI
Sequence:
RefSeq Acc Id: NM_133505   ⟹   NP_598012
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381291,143,277 - 91,178,646 (-)NCBI
GRCh371291,539,035 - 91,576,806 (-)ENTREZGENE
Build 361290,063,166 - 90,096,460 (-)NCBI Archive
HuRef1288,606,804 - 88,644,468 (-)ENTREZGENE
CHM1_11291,502,072 - 91,537,441 (-)NCBI
Sequence:
RefSeq Acc Id: NM_133506   ⟹   NP_598013
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381291,143,277 - 91,178,646 (-)NCBI
GRCh371291,539,035 - 91,576,806 (-)ENTREZGENE
Build 361290,063,166 - 90,096,460 (-)NCBI Archive
HuRef1288,606,804 - 88,644,468 (-)ENTREZGENE
CHM1_11291,502,072 - 91,537,441 (-)NCBI
Sequence:
RefSeq Acc Id: NM_133507   ⟹   NP_598014
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381291,143,277 - 91,178,646 (-)NCBI
GRCh371291,539,035 - 91,576,806 (-)ENTREZGENE
Build 361290,063,166 - 90,096,460 (-)NCBI Archive
HuRef1288,606,804 - 88,644,468 (-)ENTREZGENE
CHM1_11291,502,072 - 91,537,441 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001911 (Get FASTA)   NCBI Sequence Viewer  
  NP_598010 (Get FASTA)   NCBI Sequence Viewer  
  NP_598011 (Get FASTA)   NCBI Sequence Viewer  
  NP_598012 (Get FASTA)   NCBI Sequence Viewer  
  NP_598013 (Get FASTA)   NCBI Sequence Viewer  
  NP_598014 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA52301 (Get FASTA)   NCBI Sequence Viewer  
  AAB60901 (Get FASTA)   NCBI Sequence Viewer  
  AAD44713 (Get FASTA)   NCBI Sequence Viewer  
  AAD44714 (Get FASTA)   NCBI Sequence Viewer  
  AAD44715 (Get FASTA)   NCBI Sequence Viewer  
  AAF61437 (Get FASTA)   NCBI Sequence Viewer  
  AAF61438 (Get FASTA)   NCBI Sequence Viewer  
  AAH05322 (Get FASTA)   NCBI Sequence Viewer  
  AAL92176 (Get FASTA)   NCBI Sequence Viewer  
  AAV38603 (Get FASTA)   NCBI Sequence Viewer  
  ALQ33475 (Get FASTA)   NCBI Sequence Viewer  
  ALQ33476 (Get FASTA)   NCBI Sequence Viewer  
  ALQ33477 (Get FASTA)   NCBI Sequence Viewer  
  ALQ33478 (Get FASTA)   NCBI Sequence Viewer  
  BAF83998 (Get FASTA)   NCBI Sequence Viewer  
  CAE11881 (Get FASTA)   NCBI Sequence Viewer  
  CAG28604 (Get FASTA)   NCBI Sequence Viewer  
  CAG46744 (Get FASTA)   NCBI Sequence Viewer  
  EAW97450 (Get FASTA)   NCBI Sequence Viewer  
  EAW97451 (Get FASTA)   NCBI Sequence Viewer  
  EAW97452 (Get FASTA)   NCBI Sequence Viewer  
  EAW97453 (Get FASTA)   NCBI Sequence Viewer  
  EAW97454 (Get FASTA)   NCBI Sequence Viewer  
  EAW97455 (Get FASTA)   NCBI Sequence Viewer  
  EAW97456 (Get FASTA)   NCBI Sequence Viewer  
  EAW97457 (Get FASTA)   NCBI Sequence Viewer  
  EAW97458 (Get FASTA)   NCBI Sequence Viewer  
  EAW97459 (Get FASTA)   NCBI Sequence Viewer  
  EAW97460 (Get FASTA)   NCBI Sequence Viewer  
  P07585 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001911   ⟸   NM_001920
- Peptide Label: isoform a preproprotein
- UniProtKB: P07585 (UniProtKB/Swiss-Prot),   Q6FH10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_598010   ⟸   NM_133503
- Peptide Label: isoform a preproprotein
- UniProtKB: P07585 (UniProtKB/Swiss-Prot),   Q6FH10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_598014   ⟸   NM_133507
- Peptide Label: isoform e precursor
- UniProtKB: P07585 (UniProtKB/Swiss-Prot),   Q6FH10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_598012   ⟸   NM_133505
- Peptide Label: isoform c precursor
- UniProtKB: P07585 (UniProtKB/Swiss-Prot),   Q6FH10 (UniProtKB/TrEMBL),   A0A024RBG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_598011   ⟸   NM_133504
- Peptide Label: isoform b precursor
- UniProtKB: P07585 (UniProtKB/Swiss-Prot),   Q6FH10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_598013   ⟸   NM_133506
- Peptide Label: isoform d precursor
- UniProtKB: P07585 (UniProtKB/Swiss-Prot),   Q6FH10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000401021   ⟸   ENST00000425043
RefSeq Acc Id: ENSP00000446530   ⟸   ENST00000546391
RefSeq Acc Id: ENSP00000446527   ⟸   ENST00000546370
RefSeq Acc Id: ENSP00000448857   ⟸   ENST00000546745
RefSeq Acc Id: ENSP00000447674   ⟸   ENST00000547568
RefSeq Acc Id: ENSP00000449782   ⟸   ENST00000547937
RefSeq Acc Id: ENSP00000399815   ⟸   ENST00000441303
RefSeq Acc Id: ENSP00000448853   ⟸   ENST00000548218
RefSeq Acc Id: ENSP00000398514   ⟸   ENST00000456569
RefSeq Acc Id: ENSP00000449438   ⟸   ENST00000549513
RefSeq Acc Id: ENSP00000448057   ⟸   ENST00000550099
RefSeq Acc Id: ENSP00000449408   ⟸   ENST00000550758
RefSeq Acc Id: ENSP00000449014   ⟸   ENST00000550563
RefSeq Acc Id: ENSP00000376862   ⟸   ENST00000393155
RefSeq Acc Id: ENSP00000448274   ⟸   ENST00000551354
RefSeq Acc Id: ENSP00000413723   ⟸   ENST00000420120
RefSeq Acc Id: ENSP00000447886   ⟸   ENST00000552145
RefSeq Acc Id: ENSP00000052754   ⟸   ENST00000052754
RefSeq Acc Id: ENSP00000447654   ⟸   ENST00000552962
Protein Domains
LRRNT

Promoters
RGD ID:6853322
Promoter ID:EP74486
Type:initiation region
Name:HS_DCN
Description:Decorin, chromosome 12.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361290,100,225 - 90,100,285EPD
RGD ID:7224993
Promoter ID:EPDNEW_H18241
Type:initiation region
Name:DCN_1
Description:decorin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18242  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381291,179,479 - 91,179,539EPDNEW
RGD ID:7224991
Promoter ID:EPDNEW_H18242
Type:preliminary
Name:DCN_2
Description:decorin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18241  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381291,182,317 - 91,182,377EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001920.5(DCN):c.967del (p.Ser323fs) deletion Congenital stromal corneal dystrophy [RCV000018366] Chr12:91146171 [GRCh38]
Chr12:91539948 [GRCh37]
Chr12:12q21.33
pathogenic
NM_001920.5(DCN):c.941del (p.Pro314fs) deletion Congenital stromal corneal dystrophy [RCV000020465] Chr12:91146197 [GRCh38]
Chr12:91539974 [GRCh37]
Chr12:12q21.33
pathogenic
NM_001920.5(DCN):c.962del (p.Lys321fs) deletion Congenital stromal corneal dystrophy [RCV000114315] Chr12:91146176 [GRCh38]
Chr12:91539953 [GRCh37]
Chr12:12q21.33
pathogenic
GRCh38/hg38 12q21.33(chr12:90195589-91249888)x3 copy number gain See cases [RCV000051978] Chr12:90195589..91249888 [GRCh38]
Chr12:90589366..91643665 [GRCh37]
Chr12:89113497..90167796 [NCBI36]
Chr12:12q21.33
uncertain significance
GRCh38/hg38 12q21.33(chr12:90197297-91239004)x3 copy number gain See cases [RCV000051979] Chr12:90197297..91239004 [GRCh38]
Chr12:90591074..91632781 [GRCh37]
Chr12:89115205..90156912 [NCBI36]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.947del (p.Gly316fs) deletion Congenital stromal corneal dystrophy [RCV000055876] Chr12:91146191 [GRCh38]
Chr12:91539968 [GRCh37]
Chr12:12q21.33
pathogenic
GRCh38/hg38 12q21.33-22(chr12:90996508-94872818)x1 copy number loss See cases [RCV000138659] Chr12:90996508..94872818 [GRCh38]
Chr12:91390285..95266594 [GRCh37]
Chr12:89914416..93790725 [NCBI36]
Chr12:12q21.33-22
likely pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3 copy number gain See cases [RCV000142447] Chr12:91044318..109133210 [GRCh38]
Chr12:91438095..109571015 [GRCh37]
Chr12:89962226..108055398 [NCBI36]
Chr12:12q21.33-24.11
pathogenic
GRCh38/hg38 12q21.1-22(chr12:73485697-92795805)x1 copy number loss See cases [RCV000143099] Chr12:73485697..92795805 [GRCh38]
Chr12:73879477..93189581 [GRCh37]
Chr12:72165744..91713712 [NCBI36]
Chr12:12q21.1-22
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12q21.33(chr12:90910083-91560392)x3 copy number gain See cases [RCV000240332] Chr12:90910083..91560392 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.424A>G (p.Lys142Glu) single nucleotide variant Congenital stromal corneal dystrophy [RCV000300052]|not provided [RCV000948899] Chr12:91158410 [GRCh38]
Chr12:91552187 [GRCh37]
Chr12:12q21.33
benign
NM_001920.5(DCN):c.*160C>T single nucleotide variant Congenital stromal corneal dystrophy [RCV000267456] Chr12:91145898 [GRCh38]
Chr12:91539675 [GRCh37]
Chr12:12q21.33
benign
NM_001920.5(DCN):c.529A>T (p.Ile177Phe) single nucleotide variant Congenital stromal corneal dystrophy [RCV000396540] Chr12:91158305 [GRCh38]
Chr12:91552082 [GRCh37]
Chr12:12q21.33
benign|likely benign
NM_001920.5(DCN):c.54G>A (p.Pro18=) single nucleotide variant Congenital stromal corneal dystrophy [RCV000305864] Chr12:91178499 [GRCh38]
Chr12:91572276 [GRCh37]
Chr12:12q21.33
likely benign
NM_001920.5(DCN):c.-187A>G single nucleotide variant Congenital stromal corneal dystrophy [RCV000306630] Chr12:91182808 [GRCh38]
Chr12:91576585 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.-180A>T single nucleotide variant Congenital stromal corneal dystrophy [RCV000270165] Chr12:91182801 [GRCh38]
Chr12:91576578 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.4(DCN):c.-296C>T single nucleotide variant Congenital stromal corneal dystrophy [RCV000271450] Chr12:91182917 [GRCh38]
Chr12:91576694 [GRCh37]
Chr12:12q21.33
likely benign
NM_001920.5(DCN):c.*51A>G single nucleotide variant Congenital stromal corneal dystrophy [RCV000292070] Chr12:91146007 [GRCh38]
Chr12:91539784 [GRCh37]
Chr12:12q21.33
benign
NM_001920.5(DCN):c.944C>A (p.Pro315His) single nucleotide variant Congenital stromal corneal dystrophy [RCV000293139] Chr12:91146194 [GRCh38]
Chr12:91539971 [GRCh37]
Chr12:12q21.33
likely benign|uncertain significance
NM_001920.4(DCN):c.-325A>G single nucleotide variant Congenital stromal corneal dystrophy [RCV000385796] Chr12:91182946 [GRCh38]
Chr12:91576723 [GRCh37]
Chr12:12q21.33
likely benign
NM_001920.5(DCN):c.33A>G (p.Ala11=) single nucleotide variant Congenital stromal corneal dystrophy [RCV000360157]|not provided [RCV000957290] Chr12:91178520 [GRCh38]
Chr12:91572297 [GRCh37]
Chr12:12q21.33
benign|likely benign
NM_001920.5(DCN):c.*377T>C single nucleotide variant Congenital stromal corneal dystrophy [RCV000261456] Chr12:91145681 [GRCh38]
Chr12:91539458 [GRCh37]
Chr12:12q21.33
benign|likely benign
NM_001920.5(DCN):c.803C>T (p.Thr268Met) single nucleotide variant Congenital stromal corneal dystrophy [RCV000280004]|not provided [RCV000965905] Chr12:91151736 [GRCh38]
Chr12:91545513 [GRCh37]
Chr12:12q21.33
benign
NM_001920.4(DCN):c.-249A>G single nucleotide variant Congenital stromal corneal dystrophy [RCV000365929] Chr12:91182870 [GRCh38]
Chr12:91576647 [GRCh37]
Chr12:12q21.33
likely benign
NM_001920.5(DCN):c.212-6T>C single nucleotide variant Congenital stromal corneal dystrophy [RCV000394942] Chr12:91164723 [GRCh38]
Chr12:91558500 [GRCh37]
Chr12:12q21.33
benign|likely benign
NM_001920.5(DCN):c.*148T>G single nucleotide variant Congenital stromal corneal dystrophy [RCV000327162] Chr12:91145910 [GRCh38]
Chr12:91539687 [GRCh37]
Chr12:12q21.33
likely benign|uncertain significance
NM_001920.5(DCN):c.1062A>T (p.Gln354His) single nucleotide variant Congenital stromal corneal dystrophy [RCV000328205] Chr12:91146076 [GRCh38]
Chr12:91539853 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.917T>C (p.Val306Ala) single nucleotide variant Congenital stromal corneal dystrophy [RCV000352672]|not provided [RCV000957100] Chr12:91146221 [GRCh38]
Chr12:91539998 [GRCh37]
Chr12:12q21.33
benign|likely benign
NM_001920.5(DCN):c.879C>T (p.Tyr293=) single nucleotide variant Congenital stromal corneal dystrophy [RCV000405011] Chr12:91151660 [GRCh38]
Chr12:91545437 [GRCh37]
Chr12:12q21.33
likely benign
NM_001920.5(DCN):c.*105G>A single nucleotide variant Congenital stromal corneal dystrophy [RCV000381737] Chr12:91145953 [GRCh38]
Chr12:91539730 [GRCh37]
Chr12:12q21.33
benign|likely benign
NM_001920.5(DCN):c.621T>G (p.Ile207Met) single nucleotide variant Congenital stromal corneal dystrophy [RCV000335101] Chr12:91157106 [GRCh38]
Chr12:91550883 [GRCh37]
Chr12:12q21.33
likely benign|uncertain significance
NM_001920.5(DCN):c.975G>A (p.Ser325=) single nucleotide variant Congenital stromal corneal dystrophy [RCV000387412] Chr12:91146163 [GRCh38]
Chr12:91539940 [GRCh37]
Chr12:12q21.33
benign|likely benign
NM_001920.5(DCN):c.282C>T (p.Thr94=) single nucleotide variant Congenital stromal corneal dystrophy [RCV000340881]|not provided [RCV000965906] Chr12:91164647 [GRCh38]
Chr12:91558424 [GRCh37]
Chr12:12q21.33
benign
NM_001920.5(DCN):c.*220G>C single nucleotide variant Congenital stromal corneal dystrophy [RCV000362094] Chr12:91145838 [GRCh38]
Chr12:91539615 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.4(DCN):c.-307A>G single nucleotide variant Congenital stromal corneal dystrophy [RCV000331251] Chr12:91182928 [GRCh38]
Chr12:91576705 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.*443T>G single nucleotide variant Congenital stromal corneal dystrophy [RCV000353941] Chr12:91145615 [GRCh38]
Chr12:91539392 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.*289A>T single nucleotide variant Congenital stromal corneal dystrophy [RCV000323638] Chr12:91145769 [GRCh38]
Chr12:91539546 [GRCh37]
Chr12:12q21.33
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q21.33(chr12:90881837-91582957)x1 copy number loss See cases [RCV000511132] Chr12:90881837..91582957 [GRCh37]
Chr12:12q21.33
uncertain significance
GRCh37/hg19 12q21.32-21.33(chr12:87654236-91893923)x1 copy number loss not provided [RCV000683472] Chr12:87654236..91893923 [GRCh37]
Chr12:12q21.32-21.33
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q21.33(chr12:91352710-91776390)x3 copy number gain not provided [RCV000737992] Chr12:91352710..91776390 [GRCh37]
Chr12:12q21.33
benign
GRCh37/hg19 12q21.33(chr12:91496137-91749981)x3 copy number gain not provided [RCV000737993] Chr12:91496137..91749981 [GRCh37]
Chr12:12q21.33
benign
NM_001920.5(DCN):c.703A>C (p.Arg235=) single nucleotide variant Congenital stromal corneal dystrophy [RCV001110218]|not provided [RCV000905834] Chr12:91153139 [GRCh38]
Chr12:91546916 [GRCh37]
Chr12:12q21.33
benign
NM_001920.5(DCN):c.47_50del (p.Ala16fs) deletion Congenital stromal corneal dystrophy [RCV000779120] Chr12:91178503..91178506 [GRCh38]
Chr12:91572280..91572283 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.1066G>A (p.Gly356Arg) single nucleotide variant Congenital stromal corneal dystrophy [RCV001114244] Chr12:91146072 [GRCh38]
Chr12:91539849 [GRCh37]
Chr12:12q21.33
likely benign
NM_001920.5(DCN):c.*80C>T single nucleotide variant Congenital stromal corneal dystrophy [RCV001114243] Chr12:91145978 [GRCh38]
Chr12:91539755 [GRCh37]
Chr12:12q21.33
uncertain significance
GRCh37/hg19 12q21.2-22(chr12:77737623-94330526)x1 copy number loss not provided [RCV000848027] Chr12:77737623..94330526 [GRCh37]
Chr12:12q21.2-22
pathogenic
NM_001920.5(DCN):c.127G>A (p.Asp43Asn) single nucleotide variant Congenital stromal corneal dystrophy [RCV001110970] Chr12:91178426 [GRCh38]
Chr12:91572203 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.671C>T (p.Thr224Met) single nucleotide variant Congenital stromal corneal dystrophy [RCV001110219] Chr12:91153171 [GRCh38]
Chr12:91546948 [GRCh37]
Chr12:12q21.33
benign
NM_001920.5(DCN):c.632A>G (p.Asn211Ser) single nucleotide variant Congenital stromal corneal dystrophy [RCV001110220] Chr12:91157095 [GRCh38]
Chr12:91550872 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.560A>G (p.Lys187Arg) single nucleotide variant Congenital stromal corneal dystrophy [RCV001110221] Chr12:91157167 [GRCh38]
Chr12:91550944 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.*341A>G single nucleotide variant Congenital stromal corneal dystrophy [RCV001112884] Chr12:91145717 [GRCh38]
Chr12:91539494 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.555G>T (p.Pro185=) single nucleotide variant Congenital stromal corneal dystrophy [RCV001110222] Chr12:91157172 [GRCh38]
Chr12:91550949 [GRCh37]
Chr12:12q21.33
likely benign
NM_001920.5(DCN):c.*566T>A single nucleotide variant Congenital stromal corneal dystrophy [RCV001110884] Chr12:91145492 [GRCh38]
Chr12:91539269 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.210G>A (p.Leu70=) single nucleotide variant Congenital stromal corneal dystrophy [RCV001110969] Chr12:91178343 [GRCh38]
Chr12:91572120 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.*351T>C single nucleotide variant Congenital stromal corneal dystrophy [RCV001112883] Chr12:91145707 [GRCh38]
Chr12:91539484 [GRCh37]
Chr12:12q21.33
uncertain significance
NM_001920.5(DCN):c.*354A>G single nucleotide variant Congenital stromal corneal dystrophy [RCV001112882] Chr12:91145704 [GRCh38]
Chr12:91539481 [GRCh37]
Chr12:12q21.33
uncertain significance
GRCh37/hg19 12q21.33(chr12:90629021-91543515)x3 copy number gain not provided [RCV001259626] Chr12:90629021..91543515 [GRCh37]
Chr12:12q21.33
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2705 AgrOrtholog
COSMIC DCN COSMIC
Ensembl Genes ENSG00000011465 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000052754 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000376862 UniProtKB/TrEMBL
  ENSP00000398514 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000399815 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000401021 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000413723 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000446527 UniProtKB/TrEMBL
  ENSP00000446530 UniProtKB/TrEMBL
  ENSP00000447654 UniProtKB/Swiss-Prot
  ENSP00000447674 UniProtKB/Swiss-Prot
  ENSP00000447886 UniProtKB/TrEMBL
  ENSP00000448057 UniProtKB/TrEMBL
  ENSP00000448274 UniProtKB/TrEMBL
  ENSP00000448853 UniProtKB/TrEMBL
  ENSP00000448857 UniProtKB/TrEMBL
  ENSP00000449014 UniProtKB/TrEMBL
  ENSP00000449408 UniProtKB/TrEMBL
  ENSP00000449438 UniProtKB/TrEMBL
  ENSP00000449782 UniProtKB/TrEMBL
Ensembl Transcript ENST00000052754 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000393155 UniProtKB/TrEMBL
  ENST00000420120 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000425043 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000441303 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000456569 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000546370 UniProtKB/TrEMBL
  ENST00000546391 UniProtKB/TrEMBL
  ENST00000546745 UniProtKB/TrEMBL
  ENST00000547568 UniProtKB/Swiss-Prot
  ENST00000547937 UniProtKB/TrEMBL
  ENST00000548218 UniProtKB/TrEMBL
  ENST00000549513 UniProtKB/TrEMBL
  ENST00000550099 UniProtKB/TrEMBL
  ENST00000550563 UniProtKB/TrEMBL
  ENST00000550758 UniProtKB/TrEMBL
  ENST00000551354 UniProtKB/TrEMBL
  ENST00000552145 UniProtKB/TrEMBL
  ENST00000552962 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000011465 GTEx
HGNC ID HGNC:2705 ENTREZGENE
Human Proteome Map DCN Human Proteome Map
InterPro Decorin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLRP_I_decor/aspor/byglycan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1634 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1634 ENTREZGENE
OMIM 125255 OMIM
  610048 OMIM
PANTHER PTHR45712:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27177 PharmGKB
PIRSF SLRP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RBG6 ENTREZGENE, UniProtKB/TrEMBL
  A0A0S2Z3J8_HUMAN UniProtKB/TrEMBL
  A0A0S2Z3L3_HUMAN UniProtKB/TrEMBL
  A0A0S2Z3L8_HUMAN UniProtKB/TrEMBL
  A0A7I2PRI8_HUMAN UniProtKB/TrEMBL
  F8VNV6_HUMAN UniProtKB/TrEMBL
  F8VNW0_HUMAN UniProtKB/TrEMBL
  F8VSI3_HUMAN UniProtKB/TrEMBL
  F8VU58_HUMAN UniProtKB/TrEMBL
  F8VUF6_HUMAN UniProtKB/TrEMBL
  F8VWU0_HUMAN UniProtKB/TrEMBL
  F8VX58_HUMAN UniProtKB/TrEMBL
  F8VXZ8_HUMAN UniProtKB/TrEMBL
  H0YI87_HUMAN UniProtKB/TrEMBL
  H0YIH3_HUMAN UniProtKB/TrEMBL
  P07585 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6FH10 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q9P0Z0 UniProtKB/Swiss-Prot
  Q9P0Z1 UniProtKB/Swiss-Prot
  Q9Y5N8 UniProtKB/Swiss-Prot
  Q9Y5N9 UniProtKB/Swiss-Prot