MOV10 (Mov10 RISC complex RNA helicase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MOV10 (Mov10 RISC complex RNA helicase) Homo sapiens
Analyze
Symbol: MOV10
Name: Mov10 RISC complex RNA helicase
RGD ID: 1321654
HGNC Page HGNC:7200
Description: Enables 5'-3' RNA helicase activity and RNA binding activity. Involved in defense response to virus; mRNA destabilization; and negative regulation of transposition, RNA-mediated. Located in P-body and cytosol. Implicated in hypertension.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: armitage homolog; DKFZp667O1423; FLJ32791; fSAP113; functional spliceosome-associated protein 113; gb110; helicase MOV-10; KIAA1631; moloney leukemia virus 10 protein; Mov10, Moloney leukemia virus 10, homolog; putative helicase MOV-10
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381112,674,439 - 112,700,739 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1112,673,141 - 112,700,756 (+)EnsemblGRCh38hg38GRCh38
GRCh371113,217,061 - 113,243,361 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361113,018,990 - 113,044,884 (+)NCBINCBI36Build 36hg18NCBI36
Build 341112,929,508 - 112,955,399NCBI
Celera1111,447,519 - 111,473,840 (+)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1111,075,416 - 111,101,735 (+)NCBIHuRef
CHM1_11113,332,297 - 113,358,614 (+)NCBICHM1_1
T2T-CHM13v2.01112,687,020 - 112,713,316 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
amphetamine  (ISO)
aristolochic acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
bisphenol A  (EXP,ISO)
butanal  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chlormequat chloride  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (EXP)
Cuprizon  (ISO)
cyclosporin A  (EXP)
decabromodiphenyl ether  (EXP,ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
fulvestrant  (EXP)
gentamycin  (ISO)
ivermectin  (EXP)
metacetamol  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
naphthalene  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
potassium chromate  (EXP)
SB 431542  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
succimer  (ISO)
sunitinib  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (EXP)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Genetic variations in MOV10 and CACNB2 are associated with hypertension in a Chinese Han population. Hong GL, etal., Genet Mol Res. 2013 Dec 4;12(4):6220-7. doi: 10.4238/2013.December.4.9.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:10997877   PMID:11076863   PMID:11230166   PMID:12226669   PMID:12477932   PMID:14702039   PMID:15489334   PMID:15489336   PMID:16289642   PMID:16344560   PMID:16381901  
PMID:16710414   PMID:17081983   PMID:17148452   PMID:17353931   PMID:17507929   PMID:17643375   PMID:17932509   PMID:18552826   PMID:19665004   PMID:20020773   PMID:20140200   PMID:20186120  
PMID:20215113   PMID:20360068   PMID:20543829   PMID:20668078   PMID:21145461   PMID:21282530   PMID:21642987   PMID:21873635   PMID:21903422   PMID:21909110   PMID:21909115   PMID:22105071  
PMID:22586326   PMID:22658674   PMID:22664934   PMID:22681889   PMID:22727223   PMID:22791714   PMID:22939629   PMID:22990118   PMID:23093941   PMID:23125361   PMID:23125841   PMID:23443559  
PMID:23455922   PMID:23663784   PMID:23754279   PMID:23926332   PMID:24332808   PMID:24457600   PMID:24463507   PMID:24726324   PMID:24778252   PMID:25010285   PMID:25220460   PMID:25249183  
PMID:25315684   PMID:25324306   PMID:25363768   PMID:25464849   PMID:25515538   PMID:25533532   PMID:25609649   PMID:25665578   PMID:25921289   PMID:25959826   PMID:26186194   PMID:26379090  
PMID:26472337   PMID:26496610   PMID:26618866   PMID:26725010   PMID:26777405   PMID:26831064   PMID:26842467   PMID:26949251   PMID:27016603   PMID:27173435   PMID:27609421   PMID:27634302  
PMID:27666477   PMID:27824329   PMID:27974568   PMID:28027390   PMID:28077445   PMID:28302793   PMID:28514442   PMID:28695742   PMID:29229926   PMID:29258557   PMID:29298432   PMID:29315404  
PMID:29357390   PMID:29395067   PMID:29467282   PMID:29509190   PMID:29511296   PMID:29568061   PMID:29802200   PMID:29845934   PMID:29884807   PMID:29955894   PMID:30122351   PMID:30209976  
PMID:30320910   PMID:30367120   PMID:30463901   PMID:30617221   PMID:30621721   PMID:30773093   PMID:30833792   PMID:30940648   PMID:30997501   PMID:31048545   PMID:31059266   PMID:31091453  
PMID:31300519   PMID:31527615   PMID:31586073   PMID:31640799   PMID:31722967   PMID:32353859   PMID:32460013   PMID:32707033   PMID:32788342   PMID:32807901   PMID:32877691   PMID:33001583  
PMID:33060197   PMID:33269545   PMID:33301849   PMID:33306668   PMID:33491517   PMID:33536335   PMID:33731348   PMID:33742100   PMID:33961781   PMID:34011540   PMID:34029587   PMID:34065512  
PMID:34133714   PMID:34143182   PMID:34226595   PMID:34244565   PMID:34316702   PMID:34517762   PMID:34578187   PMID:34650049   PMID:34709727   PMID:34728620   PMID:34921745   PMID:35013218  
PMID:35013556   PMID:35107372   PMID:35140242   PMID:35232816   PMID:35256949   PMID:35271311   PMID:35446349   PMID:35509820   PMID:35676246   PMID:35831314  


Genomics

Comparative Map Data
MOV10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381112,674,439 - 112,700,739 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1112,673,141 - 112,700,756 (+)EnsemblGRCh38hg38GRCh38
GRCh371113,217,061 - 113,243,361 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361113,018,990 - 113,044,884 (+)NCBINCBI36Build 36hg18NCBI36
Build 341112,929,508 - 112,955,399NCBI
Celera1111,447,519 - 111,473,840 (+)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1111,075,416 - 111,101,735 (+)NCBIHuRef
CHM1_11113,332,297 - 113,358,614 (+)NCBICHM1_1
T2T-CHM13v2.01112,687,020 - 112,713,316 (+)NCBIT2T-CHM13v2.0
Mov10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393104,702,144 - 104,725,935 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3104,702,152 - 104,725,879 (-)EnsemblGRCm39 Ensembl
GRCm383104,794,828 - 104,818,619 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3104,794,836 - 104,818,563 (-)EnsemblGRCm38mm10GRCm38
MGSCv373104,597,750 - 104,621,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363104,922,892 - 104,946,298 (-)NCBIMGSCv36mm8
Celera3106,990,191 - 107,011,975 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
Mov10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22192,292,041 - 192,315,142 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2192,293,470 - 192,315,083 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2199,888,027 - 199,909,444 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02197,760,315 - 197,781,745 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02192,577,259 - 192,598,688 (-)NCBIRnor_WKY
Rnor_6.02207,277,088 - 207,301,245 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2207,278,161 - 207,300,854 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02226,696,252 - 226,717,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42200,053,185 - 200,075,536 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2184,758,910 - 184,780,976 (-)NCBICelera
Cytogenetic Map2q34NCBI
Mov10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543516,092,790 - 16,117,206 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543516,093,471 - 16,114,735 (+)NCBIChiLan1.0ChiLan1.0
MOV10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11124,999,353 - 125,025,820 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1124,999,353 - 125,025,820 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01115,327,051 - 115,353,483 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MOV10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11762,872,607 - 62,896,208 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1762,872,756 - 62,896,395 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1762,386,061 - 62,409,727 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01764,045,735 - 64,069,398 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1764,042,029 - 64,069,411 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11762,780,369 - 62,803,954 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01762,838,471 - 62,862,202 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01763,598,180 - 63,621,792 (-)NCBIUU_Cfam_GSD_1.0
Mov10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505816,221,374 - 16,247,696 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366901,229,249 - 1,254,754 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOV10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4107,738,092 - 107,763,602 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14107,738,089 - 107,763,873 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24117,822,609 - 117,848,391 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOV10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12020,939,052 - 20,966,843 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2020,939,300 - 20,965,140 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603823,756,020 - 23,782,654 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mov10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247728,459,517 - 8,484,972 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247728,458,470 - 8,481,462 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MOV10
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5275
Count of miRNA genes:992
Interacting mature miRNAs:1243
Transcripts:ENST00000357443, ENST00000369644, ENST00000369645, ENST00000413052, ENST00000465579, ENST00000468624, ENST00000471160, ENST00000475429, ENST00000479858, ENST00000481711, ENST00000482545, ENST00000486416, ENST00000488160, ENST00000490413, ENST00000494319, ENST00000495374, ENST00000496577, ENST00000544796
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-75344  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371113,243,117 - 113,243,338UniSTSGRCh37
Build 361113,044,640 - 113,044,861RGDNCBI36
Celera1111,473,589 - 111,473,810RGD
Cytogenetic Map1p13.2UniSTS
HuRef1111,101,484 - 111,101,705UniSTS
TNG Radiation Hybrid Map161675.0UniSTS
GeneMap99-GB4 RH Map1369.63UniSTS
Whitehead-RH Map1436.3UniSTS
NCBI RH Map1803.2UniSTS
SHGC-146252  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371113,236,960 - 113,237,253UniSTSGRCh37
Build 361113,038,483 - 113,038,776RGDNCBI36
Celera1111,467,432 - 111,467,725RGD
Cytogenetic Map1p13.2UniSTS
HuRef1111,095,327 - 111,095,620UniSTS
TNG Radiation Hybrid Map161664.0UniSTS
D1S2002E  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1p13.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2389 1651 1692 598 1336 441 3467 1013 1408 348 1447 1590 170 1172 1909 4
Low 50 1338 34 26 609 24 889 1184 2321 71 13 23 5 1 32 879 1 2
Below cutoff 5 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001130079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001389562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001389563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005270869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005270870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047421071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047421074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047421077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047421080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047421082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001737185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001737186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001737187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007060173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_946657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB046851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK057353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK226011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL603832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX877520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU623853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB066263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000357443   ⟹   ENSP00000350028
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,745 - 112,700,710 (+)Ensembl
RefSeq Acc Id: ENST00000369644   ⟹   ENSP00000358658
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,698 - 112,700,734 (+)Ensembl
RefSeq Acc Id: ENST00000369645   ⟹   ENSP00000358659
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,659 - 112,700,739 (+)Ensembl
RefSeq Acc Id: ENST00000413052   ⟹   ENSP00000399797
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,421 - 112,700,746 (+)Ensembl
RefSeq Acc Id: ENST00000465579
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,737 - 112,688,483 (+)Ensembl
RefSeq Acc Id: ENST00000468624
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,720 - 112,700,726 (+)Ensembl
RefSeq Acc Id: ENST00000471160
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,697,860 - 112,699,761 (+)Ensembl
RefSeq Acc Id: ENST00000475429
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,709 - 112,689,441 (+)Ensembl
RefSeq Acc Id: ENST00000479858
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,693,905 - 112,694,584 (+)Ensembl
RefSeq Acc Id: ENST00000481711
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,698,308 - 112,698,975 (+)Ensembl
RefSeq Acc Id: ENST00000482545
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,696,819 - 112,698,679 (+)Ensembl
RefSeq Acc Id: ENST00000486416
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,673,141 - 112,674,883 (+)Ensembl
RefSeq Acc Id: ENST00000488160
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,696,739 - 112,699,192 (+)Ensembl
RefSeq Acc Id: ENST00000490413
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,698,308 - 112,700,739 (+)Ensembl
RefSeq Acc Id: ENST00000494319
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,699,687 - 112,700,725 (+)Ensembl
RefSeq Acc Id: ENST00000495374
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,699,214 - 112,700,756 (+)Ensembl
RefSeq Acc Id: ENST00000496577
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,706 - 112,700,734 (+)Ensembl
RefSeq Acc Id: ENST00000685268
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,990 - 112,700,446 (+)Ensembl
RefSeq Acc Id: ENST00000686097   ⟹   ENSP00000510374
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,684 - 112,700,720 (+)Ensembl
RefSeq Acc Id: ENST00000686428   ⟹   ENSP00000508727
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,695 - 112,700,720 (+)Ensembl
RefSeq Acc Id: ENST00000686923   ⟹   ENSP00000509824
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,675,486 - 112,696,782 (+)Ensembl
RefSeq Acc Id: ENST00000687174
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,699,405 - 112,700,739 (+)Ensembl
RefSeq Acc Id: ENST00000687333
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,693,716 - 112,700,699 (+)Ensembl
RefSeq Acc Id: ENST00000687509
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,912 - 112,700,725 (+)Ensembl
RefSeq Acc Id: ENST00000688698
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,693,729 - 112,700,692 (+)Ensembl
RefSeq Acc Id: ENST00000689955
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,990 - 112,700,681 (+)Ensembl
RefSeq Acc Id: ENST00000690243
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,674,695 - 112,700,722 (+)Ensembl
RefSeq Acc Id: NM_001130079   ⟹   NP_001123551
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,439 - 112,700,739 (+)NCBI
GRCh371113,217,048 - 113,243,368 (+)RGD
GRCh371113,217,048 - 113,243,368 (+)NCBI
Celera1111,447,519 - 111,473,840 (+)RGD
HuRef1111,075,302 - 111,101,735 (+)NCBI
CHM1_11113,332,344 - 113,358,614 (+)NCBI
T2T-CHM13v2.01112,687,020 - 112,713,316 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001286072   ⟹   NP_001273001
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,439 - 112,700,739 (+)NCBI
HuRef1111,075,302 - 111,101,735 (+)NCBI
CHM1_11113,332,183 - 113,358,614 (+)NCBI
T2T-CHM13v2.01112,687,020 - 112,713,316 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001321324   ⟹   NP_001308253
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,659 - 112,700,739 (+)NCBI
CHM1_11113,332,542 - 113,358,607 (+)NCBI
T2T-CHM13v2.01112,687,240 - 112,713,316 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001369507   ⟹   NP_001356436
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,738 - 112,700,739 (+)NCBI
T2T-CHM13v2.01112,687,319 - 112,713,316 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001389562   ⟹   NP_001376491
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,659 - 112,700,739 (+)NCBI
T2T-CHM13v2.01112,687,240 - 112,713,316 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001389563   ⟹   NP_001376492
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,659 - 112,700,739 (+)NCBI
T2T-CHM13v2.01112,687,240 - 112,713,316 (+)NCBI
Sequence:
RefSeq Acc Id: NM_020963   ⟹   NP_066014
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,439 - 112,700,739 (+)NCBI
GRCh371113,217,048 - 113,243,368 (+)RGD
GRCh371113,217,048 - 113,243,368 (+)NCBI
Build 361113,018,990 - 113,044,884 (+)NCBI Archive
Celera1111,447,519 - 111,473,840 (+)RGD
HuRef1111,075,302 - 111,101,735 (+)NCBI
CHM1_11113,332,183 - 113,358,614 (+)NCBI
T2T-CHM13v2.01112,687,020 - 112,713,316 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024447137   ⟹   XP_024302905
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,439 - 112,698,813 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047421071   ⟹   XP_047277027
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,738 - 112,700,739 (+)NCBI
RefSeq Acc Id: XM_047421074   ⟹   XP_047277030
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,675,491 - 112,700,739 (+)NCBI
RefSeq Acc Id: XM_047421077   ⟹   XP_047277033
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,738 - 112,700,739 (+)NCBI
RefSeq Acc Id: XM_047421080   ⟹   XP_047277036
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,439 - 112,699,786 (+)NCBI
RefSeq Acc Id: XM_047421082   ⟹   XP_047277038
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,439 - 112,699,786 (+)NCBI
RefSeq Acc Id: XR_007060173
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,439 - 112,699,709 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001123551 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273001 (Get FASTA)   NCBI Sequence Viewer  
  NP_001308253 (Get FASTA)   NCBI Sequence Viewer  
  NP_001356436 (Get FASTA)   NCBI Sequence Viewer  
  NP_001376491 (Get FASTA)   NCBI Sequence Viewer  
  NP_001376492 (Get FASTA)   NCBI Sequence Viewer  
  NP_066014 (Get FASTA)   NCBI Sequence Viewer  
  XP_024302905 (Get FASTA)   NCBI Sequence Viewer  
  XP_047277027 (Get FASTA)   NCBI Sequence Viewer  
  XP_047277030 (Get FASTA)   NCBI Sequence Viewer  
  XP_047277033 (Get FASTA)   NCBI Sequence Viewer  
  XP_047277036 (Get FASTA)   NCBI Sequence Viewer  
  XP_047277038 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH02548 (Get FASTA)   NCBI Sequence Viewer  
  AAH04499 (Get FASTA)   NCBI Sequence Viewer  
  AAH09312 (Get FASTA)   NCBI Sequence Viewer  
  BAB13457 (Get FASTA)   NCBI Sequence Viewer  
  BAB14514 (Get FASTA)   NCBI Sequence Viewer  
  BAB85000 (Get FASTA)   NCBI Sequence Viewer  
  BAG51905 (Get FASTA)   NCBI Sequence Viewer  
  BAH13436 (Get FASTA)   NCBI Sequence Viewer  
  CAE89762 (Get FASTA)   NCBI Sequence Viewer  
  EAW56528 (Get FASTA)   NCBI Sequence Viewer  
  EAW56529 (Get FASTA)   NCBI Sequence Viewer  
  EAW56530 (Get FASTA)   NCBI Sequence Viewer  
  EAW56531 (Get FASTA)   NCBI Sequence Viewer  
  Q9HCE1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_066014   ⟸   NM_020963
- Peptide Label: isoform 1
- UniProtKB: Q9BUJ9 (UniProtKB/Swiss-Prot),   Q9HCE1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001123551   ⟸   NM_001130079
- Peptide Label: isoform 1
- UniProtKB: Q9BUJ9 (UniProtKB/Swiss-Prot),   Q9HCE1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001273001   ⟸   NM_001286072
- Peptide Label: isoform 2
- UniProtKB: Q9HCE1 (UniProtKB/Swiss-Prot),   Q5JR04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001308253   ⟸   NM_001321324
- Peptide Label: isoform 1
- UniProtKB: Q9BUJ9 (UniProtKB/Swiss-Prot),   Q9HCE1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024302905   ⟸   XM_024447137
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001356436   ⟸   NM_001369507
- Peptide Label: isoform 1
- UniProtKB: Q9BUJ9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSP00000399797   ⟸   ENST00000413052
RefSeq Acc Id: ENSP00000358658   ⟸   ENST00000369644
RefSeq Acc Id: ENSP00000358659   ⟸   ENST00000369645
RefSeq Acc Id: ENSP00000350028   ⟸   ENST00000357443
RefSeq Acc Id: NP_001376491   ⟸   NM_001389562
- Peptide Label: isoform 2
- UniProtKB: Q5JR04 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001376492   ⟸   NM_001389563
- Peptide Label: isoform 2
- UniProtKB: Q5JR04 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000508727   ⟸   ENST00000686428
RefSeq Acc Id: ENSP00000510374   ⟸   ENST00000686097
RefSeq Acc Id: ENSP00000509824   ⟸   ENST00000686923
RefSeq Acc Id: XP_047277036   ⟸   XM_047421080
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047277038   ⟸   XM_047421082
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047277027   ⟸   XM_047421071
- Peptide Label: isoform X1
- UniProtKB: Q5JR04 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047277033   ⟸   XM_047421077
- Peptide Label: isoform X1
- UniProtKB: Q5JR04 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047277030   ⟸   XM_047421074
- Peptide Label: isoform X1
- UniProtKB: Q5JR04 (UniProtKB/TrEMBL)
Protein Domains
AAA_12

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9HCE1-F1-model_v2 AlphaFold Q9HCE1 1-1003 view protein structure

Promoters
RGD ID:6856650
Promoter ID:EPDNEW_H1490
Type:initiation region
Name:MOV10_2
Description:Mov10 RISC complex RNA helicase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H1491  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,439 - 112,674,499EPDNEW
RGD ID:6856658
Promoter ID:EPDNEW_H1491
Type:initiation region
Name:MOV10_1
Description:Mov10 RISC complex RNA helicase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H1490  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,674,694 - 112,674,754EPDNEW
RGD ID:6786053
Promoter ID:HG_KWN:4167
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:OTTHUMT00000032916
Position:
Human AssemblyChrPosition (strand)Source
Build 361113,016,636 - 113,017,187 (+)MPROMDB
RGD ID:6785312
Promoter ID:HG_KWN:4168
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000285733,   ENST00000369645,   NM_001130079,   OTTHUMT00000032906,   OTTHUMT00000032907,   OTTHUMT00000032909,   OTTHUMT00000032912,   OTTHUMT00000032914,   OTTHUMT00000032915,   UC001ECM.1,   UC001ECO.1,   UC009WGJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361113,017,611 - 113,019,182 (+)MPROMDB
RGD ID:6786559
Promoter ID:HG_KWN:4170
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000032918,   OTTHUMT00000032921,   OTTHUMT00000032924
Position:
Human AssemblyChrPosition (strand)Source
Build 361113,040,524 - 113,041,024 (-)MPROMDB
RGD ID:6786054
Promoter ID:HG_KWN:4171
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:OTTHUMT00000032913,   OTTHUMT00000032919,   OTTHUMT00000032920
Position:
Human AssemblyChrPosition (strand)Source
Build 361113,042,124 - 113,042,624 (+)MPROMDB
RGD ID:6786055
Promoter ID:HG_KWN:4172
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000032922,   OTTHUMT00000032923
Position:
Human AssemblyChrPosition (strand)Source
Build 361113,042,846 - 113,044,192 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p13.2(chr1:112687324-113216458)x3 copy number gain See cases [RCV000050585] Chr1:112687324..113216458 [GRCh38]
Chr1:113229946..113759080 [GRCh37]
Chr1:113031469..113560603 [NCBI36]
Chr1:1p13.2
uncertain significance
GRCh38/hg38 1p13.2(chr1:112147402-113470058)x3 copy number gain See cases [RCV000051203] Chr1:112147402..113470058 [GRCh38]
Chr1:112690024..114012680 [GRCh37]
Chr1:112491547..113814203 [NCBI36]
Chr1:1p13.2
uncertain significance
GRCh38/hg38 1p13.3-12(chr1:109756630-118650204)x3 copy number gain See cases [RCV000051827] Chr1:109756630..118650204 [GRCh38]
Chr1:110299252..119192827 [GRCh37]
Chr1:110100775..118994350 [NCBI36]
Chr1:1p13.3-12
pathogenic
NM_001130079.2(MOV10):c.672G>A (p.Ser224=) single nucleotide variant Malignant melanoma [RCV000059837] Chr1:112689934 [GRCh38]
Chr1:113232556 [GRCh37]
Chr1:113034079 [NCBI36]
Chr1:1p13.2
not provided
GRCh38/hg38 1p13.2(chr1:112625023-113046966)x3 copy number gain See cases [RCV000135999] Chr1:112625023..113046966 [GRCh38]
Chr1:113167645..113589588 [GRCh37]
Chr1:112969168..113391111 [NCBI36]
Chr1:1p13.2
likely benign
GRCh38/hg38 1p21.1-12(chr1:104325484-119977655)x3 copy number gain See cases [RCV000142953] Chr1:104325484..119977655 [GRCh38]
Chr1:104868106..120471049 [GRCh37]
Chr1:104669629..120321801 [NCBI36]
Chr1:1p21.1-12
pathogenic
GRCh37/hg19 1p13.2(chr1:113134186-113265713)x3 copy number gain Ductal breast carcinoma [RCV000207154] Chr1:113134186..113265713 [GRCh37]
Chr1:1p13.2
uncertain significance
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
GRCh37/hg19 1p13.2(chr1:113213652-113947403)x3 copy number gain See cases [RCV000240316] Chr1:113213652..113947403 [GRCh37]
Chr1:1p13.2
uncertain significance
GRCh37/hg19 1p13.2(chr1:112311427-113836310)x1 copy number loss See cases [RCV000448763] Chr1:112311427..113836310 [GRCh37]
Chr1:1p13.2
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p22.1-11.2(chr1:93837992-121343783)x3 copy number gain See cases [RCV000512354] Chr1:93837992..121343783 [GRCh37]
Chr1:1p22.1-11.2
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p13.2(chr1:113186778-113373705)x3 copy number gain not provided [RCV000736653] Chr1:113186778..113373705 [GRCh37]
Chr1:1p13.2
benign
NC_000001.10:g.113339006_113430121dup duplication Primary amenorrhea [RCV000754395] Chr1:112796384..112887499 [GRCh38]
Chr1:113339006..113430121 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_001321324.2(MOV10):c.1797C>T (p.Asp599=) single nucleotide variant not provided [RCV000905950] Chr1:112696165 [GRCh38]
Chr1:113238787 [GRCh37]
Chr1:1p13.2
benign
NM_001321324.2(MOV10):c.2979G>T (p.Leu993=) single nucleotide variant not provided [RCV000883813] Chr1:112700474 [GRCh38]
Chr1:113243096 [GRCh37]
Chr1:1p13.2
benign
NM_001321324.2(MOV10):c.1779+5T>C single nucleotide variant not provided [RCV000949231] Chr1:112695579 [GRCh38]
Chr1:113238201 [GRCh37]
Chr1:1p13.2
benign
NM_001321324.2(MOV10):c.774G>A (p.Arg258=) single nucleotide variant not provided [RCV000906975] Chr1:112690036 [GRCh38]
Chr1:113232658 [GRCh37]
Chr1:1p13.2
likely benign
NM_001321324.2(MOV10):c.2294G>A (p.Arg765His) single nucleotide variant not provided [RCV000968448] Chr1:112698089 [GRCh38]
Chr1:113240711 [GRCh37]
Chr1:1p13.2
likely benign
NM_001321324.2(MOV10):c.78G>A (p.Leu26=) single nucleotide variant not provided [RCV000964818] Chr1:112674990 [GRCh38]
Chr1:113217612 [GRCh37]
Chr1:1p13.2
benign
GRCh37/hg19 1p13.2(chr1:113234268-113743303)x3 copy number gain not provided [RCV000847789] Chr1:113234268..113743303 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_001321324.2(MOV10):c.537C>T (p.Phe179=) single nucleotide variant not provided [RCV000885294] Chr1:112689610 [GRCh38]
Chr1:113232232 [GRCh37]
Chr1:1p13.2
benign
NM_001321324.2(MOV10):c.1141-6C>T single nucleotide variant not provided [RCV000952855] Chr1:112694012 [GRCh38]
Chr1:113236634 [GRCh37]
Chr1:1p13.2
benign
NM_001321324.2(MOV10):c.1893G>C (p.Ser631=) single nucleotide variant not provided [RCV000961300] Chr1:112696446 [GRCh38]
Chr1:113239068 [GRCh37]
Chr1:1p13.2
benign
GRCh37/hg19 1p21.2-12(chr1:102021465-119737478) copy number loss Seizure [RCV001352640] Chr1:102021465..119737478 [GRCh37]
Chr1:1p21.2-12
pathogenic
NM_001321324.2(MOV10):c.2831A>G (p.Tyr944Cys) single nucleotide variant Premature ovarian failure [RCV001270187] Chr1:112700251 [GRCh38]
Chr1:113242873 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_001321324.2(MOV10):c.869C>T (p.Ala290Val) single nucleotide variant not provided [RCV001839063] Chr1:112691697 [GRCh38]
Chr1:113234319 [GRCh37]
Chr1:1p13.2
uncertain significance
GRCh37/hg19 1p13.3-11.2(chr1:111647582-121343783) copy number gain not specified [RCV002053602] Chr1:111647582..121343783 [GRCh37]
Chr1:1p13.3-11.2
pathogenic
GRCh37/hg19 1p21.3-13.2(chr1:95046805-114714931) copy number loss not specified [RCV002053503] Chr1:95046805..114714931 [GRCh37]
Chr1:1p21.3-13.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7200 AgrOrtholog
COSMIC MOV10 COSMIC
Ensembl Genes ENSG00000155363 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000350028 ENTREZGENE
  ENSP00000350028.2 UniProtKB/Swiss-Prot
  ENSP00000358658 ENTREZGENE
  ENSP00000358658.1 UniProtKB/TrEMBL
  ENSP00000358659 ENTREZGENE
  ENSP00000358659.1 UniProtKB/Swiss-Prot
  ENSP00000399797 ENTREZGENE
  ENSP00000399797.2 UniProtKB/Swiss-Prot
  ENSP00000508727.1 UniProtKB/TrEMBL
  ENSP00000509824.1 UniProtKB/TrEMBL
  ENSP00000510374 ENTREZGENE
  ENSP00000510374.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000357443 ENTREZGENE
  ENST00000357443.2 UniProtKB/Swiss-Prot
  ENST00000369644 ENTREZGENE
  ENST00000369644.5 UniProtKB/TrEMBL
  ENST00000369645 ENTREZGENE
  ENST00000369645.6 UniProtKB/Swiss-Prot
  ENST00000413052 ENTREZGENE
  ENST00000413052.6 UniProtKB/Swiss-Prot
  ENST00000686097 ENTREZGENE
  ENST00000686097.1 UniProtKB/TrEMBL
  ENST00000686428.1 UniProtKB/TrEMBL
  ENST00000686923.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000155363 GTEx
HGNC ID HGNC:7200 ENTREZGENE
Human Proteome Map MOV10 Human Proteome Map
InterPro DNA2/NAM7-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA2/NAM7-like_AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MOV-10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4343 UniProtKB/Swiss-Prot
NCBI Gene 4343 ENTREZGENE
OMIM 610742 OMIM
PANTHER PTHR10887 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10887:SF322 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA_12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30908 PharmGKB
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5KXC3_HUMAN UniProtKB/TrEMBL
  A0A8I5KZ07_HUMAN UniProtKB/TrEMBL
  A0A8I5QKW4_HUMAN UniProtKB/TrEMBL
  MOV10_HUMAN UniProtKB/Swiss-Prot
  Q5JR04 ENTREZGENE, UniProtKB/TrEMBL
  Q9BUJ9 ENTREZGENE
  Q9HCE1 ENTREZGENE
UniProt Secondary Q5JR03 UniProtKB/Swiss-Prot
  Q8TEF0 UniProtKB/Swiss-Prot
  Q9BSY3 UniProtKB/Swiss-Prot
  Q9BUJ9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-08 MOV10  Mov10 RISC complex RNA helicase    Mov10, Moloney leukemia virus 10, homolog (mouse)  Symbol and/or name change 5135510 APPROVED