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Gene: GTF2H1 (general transcription factor IIH subunit 1) Homo sapiens
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Symbol: GTF2H1
Name: general transcription factor IIH subunit 1
Description: Exhibits thyroid hormone receptor binding activity. Predicted to contribute to DNA-dependent ATPase activity and RNA polymerase II CTD heptapeptide repeat kinase activity. Involved in positive regulation of transcription, DNA-templated and transcription by RNA polymerase II. Localizes to transcription factor TFIIH core complex and transcription factor TFIIH holo complex; PARTICIPATES IN nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 5-aza-2'-deoxycytidine; aflatoxin B1; aluminium sulfate (anhydrous).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: basic transcription factor 2 62 kDa subunit; BTF2; BTF2 p62; general transcription factor IIH polypeptide 1; general transcription factor IIH, polypeptide 1, 62kDa; P62; TFB1; TFIIH; TFIIH basal transcription factor complex p62 subunit
Orthologs:
Mus musculus (house mouse) : Gtf2h1 (general transcription factor II H, polypeptide 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gtf2h1 (general transcription factor IIH subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gtf2h1 (general transcription factor IIH subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GTF2H1 (general transcription factor IIH subunit 1)
Canis lupus familiaris (dog) : GTF2H1 (general transcription factor IIH subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gtf2h1 (general transcription factor IIH subunit 1)
Sus scrofa (pig) : GTF2H1 (general transcription factor IIH subunit 1)
Chlorocebus sabaeus (African green monkey) : GTF2H1 (general transcription factor IIH subunit 1)
Heterocephalus glaber (naked mole-rat) : Gtf2h1 (general transcription factor IIH subunit 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1118,322,295 - 18,367,045 (+)EnsemblGRCh38hg38GRCh38
GRCh381118,322,269 - 18,367,045 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371118,343,816 - 18,388,590 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,300,719 - 18,345,153 (+)NCBINCBI36hg18NCBI36
Build 341118,300,718 - 18,345,152NCBI
Celera1118,476,032 - 18,520,801 (+)NCBI
Cytogenetic Map11p15.1NCBI
HuRef1118,026,329 - 18,071,105 (+)NCBIHuRef
CHM1_11118,343,304 - 18,388,093 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GTF2H1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317878
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.