HRK (harakiri, BCL2 interacting protein) - Rat Genome Database

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Gene: HRK (harakiri, BCL2 interacting protein) Homo sapiens
Analyze
Symbol: HRK
Name: harakiri, BCL2 interacting protein
RGD ID: 731025
HGNC Page HGNC
Description: Involved in positive regulation of apoptotic process; positive regulation of protein-containing complex assembly; and positive regulation of release of cytochrome c from mitochondria. Located in mitochondrion.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activator of apoptosis harakiri; activator of apoptosis Hrk; BCL2-interacting protein; BH3-interacting domain-containing protein 3; death protein 5; DP5; HARAKIRI; harakiri, BCL2 interacting protein (contains only BH3 domain); neuronal death protein DP5
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12116,856,144 - 116,881,441 (-)EnsemblGRCh38hg38GRCh38
GRCh3812116,856,144 - 116,881,441 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712117,293,949 - 117,319,246 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612115,783,410 - 115,803,615 (-)NCBINCBI36hg18NCBI36
Build 3412115,761,747 - 115,781,952NCBI
Celera12116,928,567 - 116,948,765 (-)NCBI
Cytogenetic Map12q24.22NCBI
HuRef12114,307,719 - 114,328,689 (-)NCBIHuRef
CHM1_112117,265,885 - 117,286,893 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-carnitine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
3,3'-diindolylmethane  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (EXP,ISO)
amiodarone  (EXP)
antirheumatic drug  (EXP)
arsenous acid  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (EXP)
carbon nanotube  (EXP)
choline  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
cypermethrin  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
disulfiram  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
entinostat  (EXP)
fipronil  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
furan  (ISO)
furosemide  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
isoflurane  (ISO)
ketamine  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (EXP)
manganese(II) chloride  (ISO)
mercury dibromide  (EXP)
methamphetamine  (EXP)
methylmercury chloride  (EXP)
motexafin gadolinium  (EXP)
N-acetylsphingosine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel dichloride  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
panobinostat  (EXP)
paraquat  (EXP)
pentanal  (EXP)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (EXP)
rotenone  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
sphingosine 1-phosphate  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP)
tetrachloromethane  (ISO)
trichostatin A  (EXP)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (EXP)
zidovudine  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
protein binding  (IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9130713   PMID:9228060   PMID:11076863   PMID:11331593   PMID:11483855   PMID:11796190   PMID:12217801   PMID:12477932   PMID:12606589   PMID:14596824   PMID:14695142   PMID:14702039  
PMID:15031724   PMID:15694340   PMID:15721256   PMID:16697956   PMID:18008329   PMID:18037991   PMID:19322201   PMID:19641496   PMID:20379614   PMID:20855536   PMID:21041309   PMID:21209886  
PMID:21666788   PMID:21731739   PMID:21873635   PMID:22005931   PMID:22504417   PMID:22504421   PMID:22773666   PMID:22964433   PMID:23090478   PMID:23192964   PMID:23580416   PMID:27737950  
PMID:28661478   PMID:31135059   PMID:32620849   PMID:32900773   PMID:33174041  


Genomics

Comparative Map Data
HRK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12116,856,144 - 116,881,441 (-)EnsemblGRCh38hg38GRCh38
GRCh3812116,856,144 - 116,881,441 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712117,293,949 - 117,319,246 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612115,783,410 - 115,803,615 (-)NCBINCBI36hg18NCBI36
Build 3412115,761,747 - 115,781,952NCBI
Celera12116,928,567 - 116,948,765 (-)NCBI
Cytogenetic Map12q24.22NCBI
HuRef12114,307,719 - 114,328,689 (-)NCBIHuRef
CHM1_112117,265,885 - 117,286,893 (-)NCBICHM1_1
Hrk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395118,307,829 - 118,327,543 (+)NCBIGRCm39mm39
GRCm39 Ensembl5118,302,713 - 118,327,543 (+)Ensembl
GRCm385118,169,764 - 118,189,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5118,164,648 - 118,189,478 (+)EnsemblGRCm38mm10GRCm38
MGSCv375118,619,773 - 118,639,487 (+)NCBIGRCm37mm9NCBIm37
MGSCv365118,430,794 - 118,450,508 (+)NCBImm8
Celera5115,265,345 - 115,284,637 (+)NCBICelera
Cytogenetic Map5FNCBI
Hrk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21238,387,484 - 38,409,652 (-)NCBImRatBN7.2
Rnor_6.01244,008,879 - 44,029,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01245,839,708 - 45,861,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,520,265 - 39,543,901 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11239,383,652 - 39,407,289 (-)NCBI
Celera1240,046,737 - 40,068,164 (-)NCBICelera
Cytogenetic Map12q16NCBI
HRK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v012114,432,755 - 114,458,044 (-)NCBIMhudiblu_PPA_v0panPan3
HRK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12613,481,095 - 13,501,276 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2613,475,701 - 13,495,708 (-)NCBI
ROS_Cfam_1.02613,741,064 - 13,761,072 (-)NCBI
UMICH_Zoey_3.12613,702,735 - 13,722,722 (-)NCBI
UNSW_CanFamBas_1.02613,780,661 - 13,800,651 (-)NCBI
UU_Cfam_GSD_1.02613,815,015 - 13,835,046 (-)NCBI
HRK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11435,612,920 - 35,632,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21437,832,636 - 37,849,017 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HRK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111112,171,912 - 112,195,256 (-)NCBI
ChlSab1.1 Ensembl11112,193,561 - 112,193,836 (-)Ensembl
Vero_WHO_p1.0NW_023666037132,884,361 - 132,909,787 (+)NCBI
Hrk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474716,365,938 - 16,387,841 (+)NCBI

Position Markers
SHGC-148297  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712117,307,987 - 117,308,271UniSTSGRCh37
Build 3612115,792,370 - 115,792,654RGDNCBI36
Celera12116,937,525 - 116,937,809RGD
Cytogenetic Map12q24.22UniSTS
HuRef12114,317,469 - 114,317,753UniSTS
SHGC-156031  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712117,307,282 - 117,307,556UniSTSGRCh37
Build 3612115,791,665 - 115,791,939RGDNCBI36
Celera12116,936,820 - 116,937,094RGD
Cytogenetic Map12q24.22UniSTS
HuRef12114,316,764 - 114,317,038UniSTS
UniSTS:487026  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X114,546,174 - 114,546,668UniSTSGRCh37
Build 36X114,452,430 - 114,452,924RGDNCBI36
CeleraX114,981,333 - 114,981,827RGD
HuRefX104,131,379 - 104,131,873UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3044
Count of miRNA genes:1241
Interacting mature miRNAs:1545
Transcripts:ENST00000257572, ENST00000550505, ENST00000552092, ENST00000586941
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2 18 121 21 5 76 7 23 19 1
Low 120 140 703 17 254 18 598 57 2223 83 526 577 5 142 191 1 1
Below cutoff 2146 2615 691 290 1258 132 3595 1979 1427 238 773 967 164 1002 2483 4

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000257572   ⟹   ENSP00000257572
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12116,856,144 - 116,881,441 (-)Ensembl
RefSeq Acc Id: ENST00000550505   ⟹   ENSP00000465379
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12116,861,333 - 116,881,088 (-)Ensembl
RefSeq Acc Id: ENST00000552092
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12116,861,127 - 116,879,617 (-)Ensembl
RefSeq Acc Id: ENST00000586941
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12116,869,477 - 116,878,497 (-)Ensembl
RefSeq Acc Id: NM_003806   ⟹   NP_003797
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812116,856,144 - 116,881,441 (-)NCBI
GRCh3712117,298,225 - 117,319,232 (-)NCBI
Build 3612115,783,410 - 115,803,615 (-)NCBI Archive
HuRef12114,307,719 - 114,328,689 (-)NCBI
CHM1_112117,265,885 - 117,286,893 (-)NCBI
Sequence:
RefSeq Acc Id: NR_073189
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812116,856,144 - 116,881,441 (-)NCBI
GRCh3712117,298,225 - 117,319,232 (-)NCBI
HuRef12114,307,719 - 114,328,689 (-)NCBI
CHM1_112117,265,885 - 117,286,893 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017020146   ⟹   XP_016875635
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812116,856,144 - 116,881,423 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_003797 (Get FASTA)   NCBI Sequence Viewer  
  XP_016875635 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC34931 (Get FASTA)   NCBI Sequence Viewer  
  EAW98093 (Get FASTA)   NCBI Sequence Viewer  
  O00198 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_003797   ⟸   NM_003806
- UniProtKB: O00198 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016875635   ⟸   XM_017020146
- Peptide Label: isoform X1
- UniProtKB: O00198 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000257572   ⟸   ENST00000257572
RefSeq Acc Id: ENSP00000465379   ⟸   ENST00000550505

Promoters
RGD ID:6810291
Promoter ID:HG_ACW:19144
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:HRK.BAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 3612115,801,756 - 115,802,256 (-)MPROMDB
RGD ID:6790119
Promoter ID:HG_KWN:16768
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3
Transcripts:NM_003806,   UC009ZWO.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3612115,803,094 - 115,803,594 (-)MPROMDB
RGD ID:7225525
Promoter ID:EPDNEW_H18508
Type:initiation region
Name:HRK_1
Description:harakiri, BCL2 interacting protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812116,881,439 - 116,881,499EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q24.21-24.22(chr12:116028938-117300100)x3 copy number gain See cases [RCV000051980] Chr12:116028938..117300100 [GRCh38]
Chr12:116466743..117737905 [GRCh37]
Chr12:114951126..116222288 [NCBI36]
Chr12:12q24.21-24.22
uncertain significance
GRCh38/hg38 12q24.21-24.33(chr12:115131583-133166920)x3 copy number gain See cases [RCV000053689] Chr12:115131583..133166920 [GRCh38]
Chr12:115569388..133743506 [GRCh37]
Chr12:114053771..132253579 [NCBI36]
Chr12:12q24.21-24.33
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q24.21-24.33(chr12:114268403-133201316)x3 copy number gain See cases [RCV000143656] Chr12:114268403..133201316 [GRCh38]
Chr12:114706208..133777902 [GRCh37]
Chr12:113190591..132287975 [NCBI36]
Chr12:12q24.21-24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12q24.21-24.23(chr12:116028864-118791808)x1 copy number loss See cases [RCV000445736] Chr12:116028864..118791808 [GRCh37]
Chr12:12q24.21-24.23
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q24.21-24.22(chr12:116421601-117740952)x3 copy number gain See cases [RCV000512569] Chr12:116421601..117740952 [GRCh37]
Chr12:12q24.21-24.22
uncertain significance
GRCh37/hg19 12q24.22-24.23(chr12:117104335-118209153)x1 copy number loss not provided [RCV000683457] Chr12:117104335..118209153 [GRCh37]
Chr12:12q24.22-24.23
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q24.22(chr12:117144412-117444785)x3 copy number gain not provided [RCV000750597] Chr12:117144412..117444785 [GRCh37]
Chr12:12q24.22
benign
GRCh37/hg19 12q24.21-24.22(chr12:116416809-117740952)x3 copy number gain not provided [RCV001006533] Chr12:116416809..117740952 [GRCh37]
Chr12:12q24.21-24.22
uncertain significance
GRCh37/hg19 12q24.22(chr12:117147027-117705774)x4 copy number gain not provided [RCV001006537] Chr12:117147027..117705774 [GRCh37]
Chr12:12q24.22
uncertain significance
GRCh37/hg19 12q24.21-24.23(chr12:116718607-119728623)x1 copy number loss not provided [RCV000847173] Chr12:116718607..119728623 [GRCh37]
Chr12:12q24.21-24.23
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5185 AgrOrtholog
COSMIC HRK COSMIC
Ensembl Genes ENSG00000135116 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000257572 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000465379 UniProtKB/TrEMBL
Ensembl Transcript ENST00000257572 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000550505 UniProtKB/TrEMBL
GTEx ENSG00000135116 GTEx
HGNC ID HGNC:5185 ENTREZGENE
Human Proteome Map HRK Human Proteome Map
InterPro Apoptosis_activator_harakiri UniProtKB/Swiss-Prot
  Bcl2_BH3_motif_CS UniProtKB/Swiss-Prot
KEGG Report hsa:8739 UniProtKB/Swiss-Prot
NCBI Gene 8739 ENTREZGENE
OMIM 603447 OMIM
PANTHER PTHR15056 UniProtKB/Swiss-Prot
Pfam Harakiri UniProtKB/Swiss-Prot
PharmGKB PA29459 PharmGKB
PIRSF BID3 UniProtKB/Swiss-Prot
PROSITE BH3 UniProtKB/Swiss-Prot
UniProt HRK_HUMAN UniProtKB/Swiss-Prot
  K7EJY7_HUMAN UniProtKB/TrEMBL
  O00198 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-12 HRK  harakiri, BCL2 interacting protein    harakiri, BCL2 interacting protein (contains only BH3 domain)  Symbol and/or name change 5135510 APPROVED