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Gene: CDKN1B (cyclin dependent kinase inhibitor 1B) Homo sapiens
Symbol: CDKN1B
Name: cyclin dependent kinase inhibitor 1B
Description: Exhibits cyclin binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and enzyme binding activity. Involved in several processes, including cellular response to lithium ion; negative regulation of cell cycle; and negative regulation of vascular smooth muscle cell proliferation. Localizes to Cul4A-RING E3 ubiquitin ligase complex; cytoplasm; and nucleoplasm. Implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Biomarker of several diseases, including cervix uteri carcinoma in situ; chronic myeloid leukemia; lung carcinoma (multiple); prostate carcinoma in situ; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDKN4; cyclin-dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); KIP1; MEN1B; MEN4; P27KIP1
Mus musculus (house mouse) : Cdkn1b (cyclin-dependent kinase inhibitor 1B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdkn1b (cyclin-dependent kinase inhibitor 1B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdkn1b (cyclin dependent kinase inhibitor 1B)
Pan paniscus (bonobo/pygmy chimpanzee) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Canis lupus familiaris (dog) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdkn1b (cyclin dependent kinase inhibitor 1B)
Sus scrofa (pig) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Chlorocebus sabaeus (African green monkey) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Heterocephalus glaber (naked mole-rat) : Cdkn1b (cyclin dependent kinase inhibitor 1B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1212,715,058 - 12,722,369 (+)EnsemblGRCh38hg38GRCh38
GRCh381212,717,368 - 12,722,369 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371212,870,302 - 12,875,305 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,761,576 - 12,766,570 (+)NCBINCBI36hg18NCBI36
Build 341212,761,575 - 12,766,569NCBI
Celera1218,018,828 - 18,023,831 (+)NCBI
Cytogenetic Map12p13.1NCBI
HuRef1212,639,893 - 12,644,900 (+)NCBIHuRef
CHM1_11212,835,579 - 12,840,696 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences