Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: HLA-B (major histocompatibility complex, class I, B) Homo sapiens
Analyze
Symbol: HLA-B
Name: major histocompatibility complex, class I, B
Description: Exhibits several functions, including TAP binding activity; chaperone binding activity; and peptide antigen binding activity. Involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; regulation of dendritic cell differentiation; and regulation of lymphocyte mediated immunity. Localizes to several cellular components, including Golgi apparatus; MHC class I protein complex; and cell surface. Implicated in several diseases, including Behcet's disease; asthma (multiple); bone inflammation disease (multiple); eye disease (multiple); and inner ear disease (multiple). Biomarker of uveal melanoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ankylosing spondylitis; AS; b'DT; B-4901; B-5001; bw-22; bw-4; bw-41; bw-44; Bw-45; bw-46; Bw-47; Bw-48; Bw-50; bw-52; bw-53; bw-54; bw-55; Bw-56; bw-57; Bw-58; bw-60; class I MHC, HLA-B antigen; epididymis secretory protein Li 83; HEL-S-83; histocompatibility antigen; HLA -B; HLA B-40011; HLA B44; HLA class I antigen HLA-B; HLA class I histocompatibility antigen, B alpha chain; HLA class I histocompatibility antigen, B-12 alpha chain; HLA class I histocompatibility antigen, B-21 alpha chain; HLA class I histocompatibility antigen, B-45 alpha chain; HLA class I histocompatibility antigen, B-47 alpha chain; HLA class I histocompatibility antigen, B-48 alpha chain; HLA class I histocompatibility antigen, B-5 alpha chain; HLA class I histocompatibility antigen, B-50 alpha chain; HLA class I histocompatibility antigen, B-56 alpha chain; HLA class I histocompatibility antigen, B-59 alpha chain; HLA class I histocompatibility antigen, B-67 alpha chain; HLA class I histocompatibility antigen, B-7 alpha chain; HLA class I histocompatibility antigen, B-73 alpha chain; HLA class I histocompatibility antigen, B-8 alpha chain; HLA class I histocompatibility antigen, B-82 alpha chain; HLA class I histocompatibility antigen, Cw-5 alpha chain; HLA locus; HLA molecule; HLA-B alpha chain; HLA-B alpha chain (B*2706); HLA-B alpha chain (B*5002); HLA-B alpha chain (HLA-B*7301); HLA-B alpha-chain; HLA-B*45ZJ; HLA-B*5901 antigen; HLA-B-3506; HLA-B-3905; HLA-B-5502; HLA-B-5601; HLA-B-5602; HLA-B-6701; HLA-B-7301; HLA-B15; HLA-B27; HLA-B35; HLA-B35 antigen; HLA-B39; HLA-B49; HLA-B50; HLA-B55; HLA-B59; HLA-B61; HLA-B73; HLA-Bw45 antigen; HLA-Bw50 antigen; HLA-C; HLA-Cw; HLA-DRB1; HLAB; HLAC; lecocyte antigen B; Leukocyte Antigen; leukocyte antigen class I-B; Leukoocyte Antigen; lymphocyte antigen; major histocompatability complex B antigen; MGC111087; MHC antigen; MHC class 1 antigen; MHC class I alpha chain; MHC class I anitgen; MHC class I antigen B*13; MHC class I antigen B*14; MHC class I antigen B*15; MHC class I antigen B*18; MHC class I antigen B*27; MHC class I antigen B*35; MHC class I antigen B*37; MHC class I antigen B*38; MHC class I antigen B*39; MHC class I antigen B*40; MHC class I antigen B*41; MHC class I antigen B*42; MHC class I antigen B*44; MHC class I antigen B*45; MHC class I antigen B*46; MHC class I antigen B*47; MHC class I antigen B*48; MHC class I antigen B*49; MHC class I antigen B*50; MHC class I antigen B*51; MHC class I antigen B*52; MHC class I antigen B*53; MHC class I antigen B*54; MHC class I antigen B*55; MHC class I antigen B*56; MHC class I antigen B*57; MHC class I antigen B*58; MHC class I antigen B*59; MHC class I antigen B*67; MHC class I antigen B*7; MHC class I antigen B*73; MHC class I antigen B*78; MHC class I antigen B*8; MHC class I antigen B*81; MHC class I antigen B*82; MHC class I antigen Cw*5; MHC class I antigen GN00104; MHC class I antigen HLA-B alpha chain; MHC class I antigen HLA-B heavy chain; MHC class I antigen SHCHA; MHC class I antigene; MHC Class I HLA heavy chain; MHC class I human leukocyte antigen; MHC class I molecule; MHC class II antigen; MHC class l antigen; MHC classI antigen; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC HLA-B27-HS; MHC HLA-B27d; MHC HLA-B39N; SPDA1; truncated class I antigen; truncated MHC class I antigen
Orthologs:
Mus musculus (house mouse) : H2-M2 (histocompatibility 2, M region locus 2)  MGI  Alliance
Canis lupus familiaris (dog) : DLA-64 (MHC class I DLA-64)
more info ...
Related Pseudogenes: HLA-T  
Allele / Splice: See ClinVar data
Is Marker For: Strains:   LEW-Tg(HLA-B*2705,B2M)33-3Trg   LEW-Tg(HLA-B*2705,B2M)21-4HTrg  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl631,269,491 - 31,357,188 (-)EnsemblGRCh38hg38GRCh38
GRCh38631,353,875 - 31,357,179 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,321,649 - 31,324,989 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,429,628 - 31,432,914 (-)NCBINCBI36hg18NCBI36
Build 34631,429,629 - 31,432,914NCBI
Celera632,921,554 - 32,924,897 (-)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,112,051 - 31,115,393 (-)NCBIHuRef
CHM1_1631,323,551 - 31,326,953 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences