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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352836
Species: Homo sapiens
RGD Object: Gene
Symbol: HLA-B
Name: major histocompatibility complex, class I, B
Acc ID: CHEBI:421707
Term: abacavir
Definition: A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.
Chemical ID: MESH:C106538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HLA-Baffects response to substanceEXP 6480464CTDHLA-B protein affects the susceptibility to abacavirPMID:15024131
HLA-Bincreases response to substanceEXP 6480464CTDHLA-B gene polymorphism results in increased susceptibility to abacavir; HLA-B protein alternative form results in increased susceptibility to abacavir; HLA-B protein polymorphism results in increased susceptibility to abacavirPMID:11943262 PMID:23541086 PMID:34606953
HLA-Bmultiple interactionsEXP 6480464CTD[HLA-B protein alternative form results in increased susceptibility to abacavir] which results in increased expression of PDCD1; [HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of IFNG protein; [HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of IL13 protein; [HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of TNF proteinPMID:23541086 PMID:34606953
HLA-Bmultiple interactionsISOH2-M2 (Mus musculus)6480464CTDHLA-B gene polymorphism results in increased susceptibility to [CPG-oligonucleotide co-treated with abacavir]PMID:29319822
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