RGD Reference Report - HLA B27 as predisposition factor to suffer age related macular degeneration. - Rat Genome Database

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HLA B27 as predisposition factor to suffer age related macular degeneration.

Authors: Villegas Becerril, E  Gonzalez Fernandez, R  Perula Torres, L  Lacomba, MS  Gallardo Galera, JM 
Citation: Villegas Becerril E, etal., Cell Mol Immunol. 2009 Aug;6(4):303-7. doi: 10.1038/cmi.2009.40.
RGD ID: 7365097
Pubmed: PMID:19728932   (View Abstract at PubMed)
PMCID: PMC4002722   (View Article at PubMed Central)
DOI: DOI:10.1038/cmi.2009.40   (Journal Full-text)

To research whether specific alleles HLA class I (HLA-A and HLA-B) and class II (HLA-DR) are risk factors for the development of exudative type of Age Related Macular Degeneration (ARMD), HLA antigens are expressed both in normal and affected eyes with ARMD. We designed a prospective case-controlled study. We recruited 75 patients with choroidal neovascularization predominantly classic or occult, secondary to ARMD, and treated with photodynamic therapy. Two hundred and fifty patients over 55 years old, without ophthalmologic pathology who went to hospital for an analytical routine check were used as control. The analysis of the data shows a significant difference between two groups. Allele HLA-B27 correlated positively with ARMD (p < 0.0113). However, we didn't find alleles negatively associated. Thus HLA-B27 is an allele predisposed to suffer ARMD.

Disease Annotations    

Phenotype Annotations    

Human Phenotype
Objects Annotated

Genes (Rattus norvegicus)
RT1-CE13  (RT1 class I, locus CE13)

Genes (Mus musculus)
H2-Q4  (histocompatibility 2, Q region locus 4)

Genes (Homo sapiens)
HLA-B  (major histocompatibility complex, class I, B)

Additional Information