RGD Reference Report - [Features of clinical manifestations of the globe, adnexal and orbital sarcoidosis]. - Rat Genome Database

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[Features of clinical manifestations of the globe, adnexal and orbital sarcoidosis].

Authors: Razumova, IIU  Vorob'eva, OK  Safonova, TN  Sheremet, NL  Eksarenko, OV 
Citation: Razumova IIu, etal., Vestn Oftalmol. 2013 Mar-Apr;129(2):35-40.
RGD ID: 7364872
Pubmed: PMID:23808178   (View Abstract at PubMed)

86 patients with verified diagnosis of sarcoidosis with globe, adnexa and orbit manifestations were observed. The age of the patients ranged from 21 to 43 years old (average 35,1+/-1,2 years), among them 25 males and 61 females with disease duration from 1 month till 12 years and 15 years follow-up. The study is based on different variants of globe, adnexal and orbital sarcoidosis. In our practice we observed sarcoidosis as a combination of several manifestations simultaneously. In 32 patients of 38 patients examined HLA-B-7, B-8, DR-2, DR-3, DR-15 were detected, that confirms genetic predisposition to sarcoidosis and determines the course of the disease. In 27 patients cellular and humoral immunity disbalance was found, that confirms the immune etiology of sarcoidosis as well. However the treatment of patients was pathogenic as the etiology of sarcoidosis is still unknown.



Disease Annotations    
sarcoidosis  (IAGP,ISO)

Phenotype Annotations    

Human Phenotype
Granulomatosis  (IAGP)
Objects Annotated

Genes (Rattus norvegicus)
RT1-CE13  (RT1 class I, locus CE13)

Genes (Mus musculus)
H2-Q4  (histocompatibility 2, Q region locus 4)

Genes (Homo sapiens)
HLA-B  (major histocompatibility complex, class I, B)


Additional Information