RGD Reference Report - Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features. - Rat Genome Database

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Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features.

Authors: Takejima, Priscila  Agondi, Rosana Câmara  Rodrigues, Helcio  Aun, Marcelo Vivolo  Kalil, Jorge  Giavina-Bianchi, Pedro 
Citation: Takejima P, etal., Int Arch Allergy Immunol. 2017;172(3):150-160. doi: 10.1159/000458151. Epub 2017 Apr 6.
RGD ID: 13506910
Pubmed: PMID:28380482   (View Abstract at PubMed)
DOI: DOI:10.1159/000458151   (Journal Full-text)


BACKGROUND: Identification of asthma phenotypes enables a better understanding and management of this heterogeneous disease. Studies have reported associations between human leukocyte antigens (HLA) and asthma in different populations, but the results have been inconclusive and they have rarely considered the distinct disease phenotypes. Our objective was to characterize allergic and nonallergic asthma phenotypes and evaluate possible associations with the HLA system.
METHODS: A total of 109 patients with asthma were prospectively followed during 2 years. They were divided into 2 groups, i.e., allergic and nonallergic asthma, according to their clinical history and skin prick test and serum-specific immunoglobulin E (IgE) results. The control group comprised 297 deceased donors of solid organs. Patients' features and HLA class I and II genotypes were assessed and compared.
RESULTS: This study showed different features between asthma phenotypes. Nonallergic patients were older at the onset of asthma symptoms and had a higher rate of intolerance to nonsteroidal anti-inflammatory drugs. Allergic patients had higher total serum IgE levels, reported atopic dermatitis and rhinoconjunctivitis more frequently, and, unexpectedly, had a greater disease severity. New associations between the HLA genotypes and allergic and nonallergic asthma were identified. The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype. The presence of the haplotype HLA-DPA1*03 DQA*05 was associated with allergic asthma, and the presence of HLA-DPA1*03 and the absence of HLA-DQA*05 with nonallergic asthma.
CONCLUSIONS: Allergic and nonallergic asthma have distinct phenotypic and genotypic features. New associations between asthma phenotypes and HLA class I and II were identified.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
allergic asthma susceptibilityISOHLA-B (Homo sapiens)13506910DNA:polymorphism:RGD 
allergic asthma susceptibilityISOHLA-DPA1 (Homo sapiens)13506910; 13506910DNA:polymorphism:RGD 
allergic asthma susceptibilityIAGP 13506910; 13506910; 13506910; 13506910DNA:polymorphism:RGD 
allergic asthma susceptibilityISOHLA-DPB1 (Homo sapiens)13506910DNA:polymorphism:RGD 
asthma susceptibilityISOHLA-B (Homo sapiens)13506910DNA:polymorphism:RGD 
asthma susceptibilityIAGP 13506910DNA:polymorphism:RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-B  (RT1 class II, locus B)
RT1-Ha  (RT1 class II, locus Ha)

Genes (Mus musculus)
H2-M2  (histocompatibility 2, M region locus 2)
H2-Pa  (histocompatibility 2, P region alpha locus)

Genes (Homo sapiens)
HLA-B  (major histocompatibility complex, class I, B)
HLA-C  (major histocompatibility complex, class I, C)
HLA-DPA1  (major histocompatibility complex, class II, DP alpha 1)
HLA-DPB1  (major histocompatibility complex, class II, DP beta 1)


Additional Information