RGD Reference Report - [Correlation study between ischemic stroke and polymorphism of human leucocyte antigen gene]. - Rat Genome Database

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[Correlation study between ischemic stroke and polymorphism of human leucocyte antigen gene].

Authors: Chen, Wei  Feng, Huiyu  Xu, Mingming  Jia, Xiuping  Cai, Liangling  Xiao, Lulu  Liu, Weibin 
Citation: Chen W, etal., Zhonghua Yi Xue Za Zhi. 2014 Feb 25;94(7):499-502.
RGD ID: 401827096
Pubmed: PMID:24767290   (View Abstract at PubMed)


OBJECTIVE: To explore the correlation between ischemic stroke (IS) and the polymorphism of human leucocyte antigen (HLA) gene.
METHODS: Antigen, allele, haplotype of HLA-A, B, C, DRB1, DQB1 in 94 IS patients and 503 healthy controls were detected by PCR-SBT.
RESULTS: (1) There were 11 antigens, 17 alleles in HLA-A locus, 20 antigens, 34 alleles in HLA-B locus, 11 antigens, 16 alleles in HLA-C locus, 13 antigens, 26 alleles in HLA-DRB1 locus, 5 antigens, 13 alleles in HLA- DQB1 locus in IS group.(2) The allelic frequency of HLA-A*31: 01 (P = 0.016 9, RR = 2.827) , HLA-B* 37: 01 (P = 0.006 6, RR = 4.613) and HLA-DRB1*11: 06 (P = 0.000 2, RR = 37.981) in the IS patients was higher than that in healthy controls.(3) The haplotypic frequency of HLA-DRB1*11: 06-DQB1*03: 01 (P = 0.001, RR = 38.52) in the IS patients was higher than that in healthy controls.
CONCLUSION: The susceptibility association of HLA-B*37: 01, HLA-DRB1*11: 06 and HLA-DRB1*11: 06-DQB1*03: 01 with IS and HLA gene play a genetic role in the occurrence of.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HLA-AHumancerebral infarction susceptibilityIAGP DNA:polymorphism::HLA-A31:01 (human)RGD 
HLA-BHumancerebral infarction susceptibilityIAGP DNA:polymorphism::HLA-B37:01 (human)RGD 
HLA-DRB1Humancerebral infarction susceptibilityIAGP DNA:polymorphism and haplotype::HLA-B37:01 (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HLA-AHumanIschemic stroke susceptibilityIAGP DNA:polymorphism::HLA-A31:01 (human)RGD 
HLA-BHumanIschemic stroke susceptibilityIAGP DNA:polymorphism::HLA-B37:01 (human)RGD 
HLA-DRB1HumanIschemic stroke susceptibilityIAGP DNA:polymorphism and haplotype::HLA-B37:01 (human)RGD 
Objects Annotated

Genes (Homo sapiens)
HLA-A  (major histocompatibility complex, class I, A)
HLA-B  (major histocompatibility complex, class I, B)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)


Additional Information