RGD Reference Report - Association between HLA-B*46 allele and Graves disease in Asian populations: a meta-analysis. - Rat Genome Database

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Association between HLA-B*46 allele and Graves disease in Asian populations: a meta-analysis.

Authors: Li, Y  Yao, Y  Yang, M  Shi, L  Li, X  Yang, Y  Zhang, Y  Xiao, C 
Citation: Li Y, etal., Int J Med Sci. 2013;10(2):164-70. doi: 10.7150/ijms.5158. Epub 2013 Jan 3.
RGD ID: 7365094
Pubmed: PMID:23329888   (View Abstract at PubMed)
PMCID: PMC3547214   (View Article at PubMed Central)
DOI: DOI:10.7150/ijms.5158   (Journal Full-text)

Graves' disease (GD) is a leading cause of hyperthyroidism, which affects 1.0-1.6% of the general population. Previous studies reported a higher GD prevalence in Asian populations compared to Caucasian populations. The etiology of GD involves complex interactions between predisposing genes and environmental triggers. Genetic studies have shown that the human leukocyte antigen (HLA) is an important candidate genetic region associated with GD in Asian populations. However, the results were inconsistent and inconclusive. Here, we performed a meta-analysis to evaluate the role of the HLA-B*46 allele in GD in Asian populations. A total of 14 case-controlled studies on the association of the HLA-B*46 allele in 1743 GD patients and 5689 controls were included. Our results showed a trend toward an increased risk of GD in HLA-B*46-positive subjects compared to those HLA-B*46-negative (OR = 2.48; 95% CI = 1.96-3.13, P < 0.01). However, there were some limitations to the current meta-analysis, such as heterogeneity (P(heterogeneity )< 0.01 and I(2 )= 68.0%) or the different typing methods (serological and genotyping methods). The meta-analysis indicated that the HLA-B*46 allele is a risk factor for GD in Asian populations. Future studies on the role of the HLA-B*46 allele in GD should consider complications such as periodic paralysis, ophthalmopathy and recurrence.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Graves' disease susceptibilityISOHLA-B (Homo sapiens)7365094; 7365094DNA:polymorphisms:cds:HLA-B*46 (human) RGD 
Graves' disease susceptibilityIAGP 7365094DNA:polymorphism:cds:HLA-B*46 (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Thyrotoxicosis with diffuse goiter susceptibilityIAGP 7365094DNA:polymorphism:cds:HLA-B*46 RGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-CE13  (RT1 class I, locus CE13)

Genes (Mus musculus)
H2-Q4  (histocompatibility 2, Q region locus 4)

Genes (Homo sapiens)
HLA-B  (major histocompatibility complex, class I, B)


Additional Information