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Frequency of HLA antigens in Graves' hyperthyroidism and mitral valve prolapse.

Authors: Kontopoulos, A  Harsoulis, P  Adam, K  Papadopoulos, G  Polymenidis, Z  Boudoulas, H 
Citation: Kontopoulos A, etal., J Heart Valve Dis. 1996 Sep;5(5):543-7.
Pubmed: (View Article at PubMed) PMID:8894996

BACKGROUND AND AIMS OF THE STUDY: An association between Graves' hyperthyroidism (G) and mitral valve prolapse (MVP) has been reported, but possible genetic linkage between the two disorders has not. METHODS: One hundred and five patients (pts) with G were studied after therapy, in a euthyroid state. MVP (auscultatory plus echocardiographic findings) was present in 33 pts (31%). Frequency of human lymphocyte antigens (HLA) in pts with G and in pts with G plus MVP was compared to 170 normal subjects (NL). There was no difference in HLA-A antigens among the three groups. RESULTS: The frequency of HLA B-15 was greater in pts with G plus MVP (18.9%) compared to NL (3%) and to G without MVP (4.2), p < 0.01. The frequency of HLA-B39 was greater in G without MVP (13.8%) compared to NL (4.1%), p < 0.01. The HLA DRB1*1601-2 was more frequent in G with (30.3%) or without (29.2%) MVP compared to NL (13.5%), p < 0.01. The frequency of HLA DRB1*1401-10 and DQA1*0104 were greater in NL (16.5%) compared to G with (3.0%) or without (4.2%) MVP, p < 0.01. CONCLUSIONS: The data confirmed previous observations that the frequency of MVP is high in pts with G. Further, the data indicated a possible genetic linkage between the two abnormalities.

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RGD Object Information
RGD ID: 7365110
Created: 2013-10-21
Species: All species
Last Modified: 2013-10-21
Status: ACTIVE



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