RGD Reference Report - HLA antigens in Asian Indian patients with Graves' disease. - Rat Genome Database

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HLA antigens in Asian Indian patients with Graves' disease.

Authors: Tandon, N  Mehra, NK  Taneja, V  Vaidya, MC  Kochupillai, N 
Citation: Tandon N, etal., Clin Endocrinol (Oxf). 1990 Jul;33(1):21-6.
RGD ID: 7365118
Pubmed: PMID:2401095   (View Abstract at PubMed)

A study of 57 Asian Indian patients with Graves' disease revealed a significant increase in the frequency of HLA-DQW2 (61.4%) as compared to the control population (22.6%) giving a relative risk of 5.4. Less prominent but statistically significant increase in the frequency of HLA-A10 (29.8% patients as opposed to 10.5% controls) and HLA-B8 (28.1% patients as opposed to 8.7% controls) was also observed. Further, patients carrying the phenotypes HLA-A10 and HLA-B8 were more prone to develop the disease at a younger age. Two HLA haplotypes, namely A10-B8 and B8-DR3, were found in significant linkage disequilibrium in our patients with Graves' disease. Patients carrying these haplotypes also had a tendency to develop the disease at an earlier age.



Disease Annotations    
Graves' disease  (IAGP,ISO)

Phenotype Annotations    

Human Phenotype
Objects Annotated

Genes (Rattus norvegicus)
RT1-CE13  (RT1 class I, locus CE13)

Genes (Mus musculus)
H2-Q4  (histocompatibility 2, Q region locus 4)

Genes (Homo sapiens)
HLA-B  (major histocompatibility complex, class I, B)


Additional Information