RGD Reference Report - Gamma-delta T cells as orally induced suppressor cells in rats: in vitro characterization. - Rat Genome Database

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Gamma-delta T cells as orally induced suppressor cells in rats: in vitro characterization.

Authors: Wildner, G  Thurau, SR  Diedrichs-Mohring, M 
Citation: Wildner G, etal., Ann N Y Acad Sci. 2004 Dec;1029:416-21.
RGD ID: 7364916
Pubmed: PMID:15681796   (View Abstract at PubMed)
DOI: DOI:10.1196/annals.1309.050   (Journal Full-text)

Gamma-delta T cells from orally tolerized rats adoptively transfer suppression of experimental autoimmune uveitis. In vivo and in vitro these regulatory cells specifically recognize retinal autoantigen peptide PDSAg and its mimotope B27PD, but not other mimicry peptides. Proliferation of gamma/delta T cells was MHC class II and CD8 dependent.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Autoimmune Uveitis treatmentISOHLA-B (Homo sapiens)7364916; 7364916human HLA-B27 peptide in rat modelRGD 
Experimental Autoimmune Uveitis treatmentIDA 7364916human HLA-B27 peptide in rat modelRGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-CE13  (RT1 class I, locus CE13)

Genes (Mus musculus)
H2-Q4  (histocompatibility 2, Q region locus 4)

Genes (Homo sapiens)
HLA-B  (major histocompatibility complex, class I, B)


Additional Information