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Gene: TYRP1 (tyrosinase related protein 1) Homo sapiens
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Symbol: TYRP1
Name: tyrosinase related protein 1
Description: Exhibits monophenol monooxygenase activity. Involved in positive regulation of melanin biosynthetic process. Localizes to the clathrin-coated endocytic vesicle membrane and endosome membrane. Implicated in oculocutaneous albinism; oculocutaneous albinism type III; and pigmentation disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5,6-dihydroxyindole-2-carboxylic acid oxidase; b-PROTEIN; CAS2; catalase B; CATB; DHICA oxidase; glycoprotein 75; GP75; melanoma antigen gp75; OCA3; SHEP11; TRP; TRP-1; TRP1; tyrosinase-related protein 1; TYRP
Orthologs:
Mus musculus (house mouse) : Tyrp1 (tyrosinase-related protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tyrp1 (tyrosinase-related protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyrp1 (tyrosinase related protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TYRP1 (tyrosinase related protein 1)
Canis lupus familiaris (dog) : TYRP1 (tyrosinase related protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyrp1 (tyrosinase related protein 1)
Sus scrofa (pig) : TYRP1 (tyrosinase related protein 1)
Chlorocebus sabaeus (green monkey) : TYRP1 (tyrosinase related protein 1)
Heterocephalus glaber (naked mole-rat) : Tyrp1 (tyrosinase related protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl912,685,439 - 12,710,285 (+)Ensembl
GRCh38912,693,375 - 12,710,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37912,693,385 - 12,710,285 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36912,683,449 - 12,700,258 (+)NCBINCBI36hg18NCBI36
Build 34912,683,448 - 12,700,258NCBI
Celera912,625,996 - 12,642,868 (+)NCBI
Cytogenetic Map9p23NCBI
HuRef912,658,087 - 12,674,962 (+)NCBIHuRef
CHM1_1912,693,770 - 12,710,634 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TYRP1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351708
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.