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Gene: WARS1 (tryptophanyl-tRNA synthetase 1) Homo sapiens
Symbol: WARS1
Name: tryptophanyl-tRNA synthetase 1
Description: Exhibits several functions, including kinase inhibitor activity; protein homodimerization activity; and tryptophan-tRNA ligase activity. Involved in several processes, including positive regulation of protein-containing complex assembly; regulation of angiogenesis; and regulation of protein modification process. Localizes to cytosol; nucleus; and protein-containing complex. Implicated in distal hereditary motor neuronopathy type 9.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GAMMA-2; HMN9; hWRS; IFI53; IFP53; interferon-induced protein 53; trpRS; tryptophan tRNA ligase 1, cytoplasmic; tryptophan--tRNA ligase; tryptophan--tRNA ligase, cytoplasmic; tryptophanyl-tRNA synthetase; tryptophanyl-tRNA synthetase, cytoplasmic; WARS
Mus musculus (house mouse) : Wars (tryptophanyl-tRNA synthetase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Wars1 (tryptophanyl-tRNA synthetase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wars1 (tryptophanyl-tRNA synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : WARS1 (tryptophanyl-tRNA synthetase 1)
Canis lupus familiaris (dog) : WARS1 (tryptophanyl-tRNA synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wars1 (tryptophanyl-tRNA synthetase 1)
Sus scrofa (pig) : WARS1 (tryptophanyl-tRNA synthetase 1)
Chlorocebus sabaeus (African green monkey) : WARS1 (tryptophanyl-tRNA synthetase 1)
Heterocephalus glaber (naked mole-rat) : Wars1 (tryptophanyl-tRNA synthetase 1)
more info ...
Related Pseudogenes: WARS1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl14100,333,790 - 100,376,805 (-)EnsemblGRCh38hg38GRCh38
GRCh3814100,333,789 - 100,376,327 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714100,800,125 - 100,842,680 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,869,878 - 99,912,433 (-)NCBINCBI36hg18NCBI36
Build 341499,869,877 - 99,911,680NCBI
Celera1480,854,751 - 80,897,310 (-)NCBI
Cytogenetic Map14q32.2NCBI
HuRef1480,981,470 - 81,024,059 (-)NCBIHuRef
CHM1_114100,737,895 - 100,780,446 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on WARS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317961
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.