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Gene: TCN2 (transcobalamin 2) Homo sapiens
Symbol: TCN2
Name: transcobalamin 2
Description: Exhibits cobalamin binding activity. Involved in cobalamin transport. Localizes to extracellular space. Implicated in Parkinson's disease; megaloblastic anemia; and transcobalamin II deficiency. Biomarker of acute lymphoblastic leukemia; acute myeloid leukemia; and cryoglobulinemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D22S676; D22S750; II; macrocytic anemia; TC; TC II; TC-2; TC2; TCII; transcobalamin II; transcobalamin-2; vitamin B12-binding protein 2
Mus musculus (house mouse) : Tcn2 (transcobalamin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tcn2 (transcobalamin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tcn2 (transcobalamin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TCN2 (transcobalamin 2)
Canis lupus familiaris (dog) : TCN2 (transcobalamin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tcn2 (transcobalamin 2)
Sus scrofa (pig) : TCN2 (transcobalamin 2)
Chlorocebus sabaeus (African green monkey) : TCN2 (transcobalamin 2)
Heterocephalus glaber (naked mole-rat) : Tcn2 (transcobalamin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2230,607,003 - 30,627,271 (+)EnsemblGRCh38hg38GRCh38
GRCh382230,607,083 - 30,627,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372231,003,070 - 31,023,047 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,333,161 - 29,353,047 (+)NCBINCBI36hg18NCBI36
Build 342229,327,714 - 29,347,601NCBI
Celera2214,802,947 - 14,823,211 (+)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2213,965,286 - 13,985,550 (+)NCBIHuRef
CHM1_12230,962,510 - 30,982,925 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TCN2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1347590
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.