LY6E (lymphocyte antigen 6 family member E) - Rat Genome Database

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Gene: LY6E (lymphocyte antigen 6 family member E) Homo sapiens
Analyze
Symbol: LY6E
Name: lymphocyte antigen 6 family member E
RGD ID: 1351321
HGNC Page HGNC
Description: Predicted to have acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Involved in negative regulation of viral entry into host cell. Predicted to localize to anchored component of membrane and plasma membrane; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2-bromohexadecanoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ly-6E; lymphocyte antigen 6 complex, locus E; lymphocyte antigen 6E; retinoic acid induced gene E; retinoic acid-induced gene E protein; RIG-E; RIGE; SCA-2; SCA2; stem cell antigen 2; thymic shared antigen 1; TSA-1
RGD Orthologs
Mouse
Rat
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8143,017,982 - 143,023,832 (+)EnsemblGRCh38hg38GRCh38
GRCh388143,018,529 - 143,022,409 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378144,099,946 - 144,103,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,171,300 - 144,175,199 (+)NCBINCBI36hg18NCBI36
Build 348144,171,299 - 144,175,199NCBI
Celera8140,409,515 - 140,413,440 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8139,353,438 - 139,357,363 (+)NCBIHuRef
CHM1_18144,140,603 - 144,144,526 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-bromohexadecanoic acid  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
aconitine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
amphetamine  (ISO)
arsenous acid  (EXP)
atrazine  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
cholesterol  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
cyclosporin A  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
diethylstilbestrol  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
etoposide  (EXP)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (ISO)
hydroquinone  (EXP)
lipopolysaccharide  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
mifepristone  (ISO)
N-nitrosodiethylamine  (ISO)
nimesulide  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
potassium chromate  (EXP)
prednisolone  (EXP)
progesterone  (ISO)
selenium atom  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
sodium aurothiomalate  (EXP)
sunitinib  (EXP)
tamibarotene  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thiophenes  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:8650192   PMID:8757598   PMID:9366413   PMID:9551972   PMID:9575182   PMID:11576217   PMID:11784869   PMID:12477932   PMID:12516096   PMID:15489334   PMID:16712791  
PMID:18755862   PMID:18990604   PMID:19672991   PMID:20237496   PMID:21873635   PMID:25225669   PMID:25344775   PMID:27197181   PMID:27589564   PMID:28130445   PMID:29117863   PMID:29448250  
PMID:30190477   PMID:30674630   PMID:32296183   PMID:32641482   PMID:32704094  


Genomics

Comparative Map Data
LY6E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8143,017,982 - 143,023,832 (+)EnsemblGRCh38hg38GRCh38
GRCh388143,018,529 - 143,022,409 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378144,099,946 - 144,103,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,171,300 - 144,175,199 (+)NCBINCBI36hg18NCBI36
Build 348144,171,299 - 144,175,199NCBI
Celera8140,409,515 - 140,413,440 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8139,353,438 - 139,357,363 (+)NCBIHuRef
CHM1_18144,140,603 - 144,144,526 (+)NCBICHM1_1
Ly6e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391574,826,874 - 74,831,753 (+)NCBIGRCm39mm39
GRCm39 Ensembl1574,826,900 - 74,831,754 (+)Ensembl
GRCm381574,955,025 - 74,959,904 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1574,955,051 - 74,959,905 (+)EnsemblGRCm38mm10GRCm38
MGSCv371574,785,481 - 74,790,335 (+)NCBIGRCm37mm9NCBIm37
MGSCv361574,782,911 - 74,786,586 (+)NCBImm8
Celera1576,460,639 - 76,465,493 (+)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.29NCBI
Ly6e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27106,935,530 - 106,939,689 (+)NCBI
Rnor_6.0 Ensembl7116,355,698 - 116,359,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07116,355,426 - 116,359,862 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07116,253,329 - 116,257,488 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47113,151,828 - 113,155,521 (+)NCBIRGSC3.4rn4RGSC3.4
Celera7103,308,659 - 103,312,352 (+)NCBICelera
Cytogenetic Map7q34NCBI
LY6E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11336,926,776 - 36,930,265 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1336,925,980 - 36,974,979 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1336,879,527 - 36,883,015 (+)NCBI
ROS_Cfam_1.01337,398,524 - 37,402,004 (+)NCBI
UMICH_Zoey_3.11337,071,189 - 37,074,676 (+)NCBI
UNSW_CanFamBas_1.01337,189,559 - 37,193,039 (+)NCBI
UU_Cfam_GSD_1.01337,666,368 - 37,669,857 (+)NCBI
Ly6e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053031,453,118 - 1,455,165 (-)NCBI
SpeTri2.0NW_0049364708,879,217 - 8,880,777 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LY6E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.141,336,112 - 1,341,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LY6E
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18137,265,510 - 137,269,397 (+)NCBI
ChlSab1.1 Ensembl8137,265,535 - 137,269,404 (+)Ensembl
Ly6e
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473513,616,129 - 13,619,538 (-)NCBI

Position Markers
RH80139  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378144,103,542 - 144,103,777UniSTSGRCh37
Build 368144,174,917 - 144,175,152RGDNCBI36
Celera8140,413,155 - 140,413,390RGD
Cytogenetic Map8q24.3UniSTS
HuRef8139,357,078 - 139,357,313UniSTS
GeneMap99-GB4 RH Map8546.79UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5980
Count of miRNA genes:835
Interacting mature miRNAs:1011
Transcripts:ENST00000292494, ENST00000429120, ENST00000517503, ENST00000519546, ENST00000519611, ENST00000519615, ENST00000520466, ENST00000520531, ENST00000521003, ENST00000521182, ENST00000521699, ENST00000522024, ENST00000522528, ENST00000522971, ENST00000523847
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 5 2 1 1 6 2 11 2 4 87 18 1 1 1
Medium 2407 2917 1706 608 1822 447 3946 1783 3719 380 1368 1577 175 1 1203 2388 5 2
Low 26 72 16 13 89 14 400 412 12 35 5 6 399
Below cutoff 1 3 2 16 2 1 1 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001127213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC083982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF085875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU625581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB138313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB458093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U42376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U56145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z68179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000292494   ⟹   ENSP00000292494
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,529 - 143,022,409 (+)Ensembl
RefSeq Acc Id: ENST00000429120   ⟹   ENSP00000414307
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,483 - 143,022,410 (+)Ensembl
RefSeq Acc Id: ENST00000517503   ⟹   ENSP00000428427
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,017,982 - 143,022,410 (+)Ensembl
RefSeq Acc Id: ENST00000519546   ⟹   ENSP00000428467
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,552 - 143,022,255 (+)Ensembl
RefSeq Acc Id: ENST00000519611   ⟹   ENSP00000430796
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,544 - 143,021,800 (+)Ensembl
RefSeq Acc Id: ENST00000519615
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,022,549 - 143,023,830 (+)Ensembl
RefSeq Acc Id: ENST00000520466   ⟹   ENSP00000428572
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,528 - 143,022,409 (+)Ensembl
RefSeq Acc Id: ENST00000520531   ⟹   ENSP00000430131
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,528 - 143,021,640 (+)Ensembl
RefSeq Acc Id: ENST00000521003   ⟹   ENSP00000428169
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,529 - 143,021,902 (+)Ensembl
RefSeq Acc Id: ENST00000521182   ⟹   ENSP00000430770
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,546 - 143,022,409 (+)Ensembl
RefSeq Acc Id: ENST00000521699   ⟹   ENSP00000427915
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,517 - 143,022,411 (+)Ensembl
RefSeq Acc Id: ENST00000522024   ⟹   ENSP00000428442
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,557 - 143,021,892 (+)Ensembl
RefSeq Acc Id: ENST00000522528   ⟹   ENSP00000428365
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,529 - 143,021,924 (+)Ensembl
RefSeq Acc Id: ENST00000522971   ⟹   ENSP00000428159
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,542 - 143,022,182 (+)Ensembl
RefSeq Acc Id: ENST00000523847   ⟹   ENSP00000430700
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,018,553 - 143,023,832 (+)Ensembl
RefSeq Acc Id: NM_001127213   ⟹   NP_001120685
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,018,529 - 143,022,409 (+)NCBI
GRCh378144,099,902 - 144,103,827 (+)ENTREZGENE
HuRef8139,353,438 - 139,357,363 (+)ENTREZGENE
CHM1_18144,140,603 - 144,144,526 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002346   ⟹   NP_002337
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,018,529 - 143,022,409 (+)NCBI
GRCh378144,099,902 - 144,103,827 (+)ENTREZGENE
Build 368144,171,300 - 144,175,199 (+)NCBI Archive
HuRef8139,353,438 - 139,357,363 (+)ENTREZGENE
CHM1_18144,140,603 - 144,144,526 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002337   ⟸   NM_002346
- Peptide Label: precursor
- UniProtKB: Q16553 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001120685   ⟸   NM_001127213
- Peptide Label: precursor
- UniProtKB: Q16553 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000428427   ⟸   ENST00000517503
RefSeq Acc Id: ENSP00000292494   ⟸   ENST00000292494
RefSeq Acc Id: ENSP00000428467   ⟸   ENST00000519546
RefSeq Acc Id: ENSP00000430796   ⟸   ENST00000519611
RefSeq Acc Id: ENSP00000414307   ⟸   ENST00000429120
RefSeq Acc Id: ENSP00000428572   ⟸   ENST00000520466
RefSeq Acc Id: ENSP00000430131   ⟸   ENST00000520531
RefSeq Acc Id: ENSP00000430770   ⟸   ENST00000521182
RefSeq Acc Id: ENSP00000428169   ⟸   ENST00000521003
RefSeq Acc Id: ENSP00000427915   ⟸   ENST00000521699
RefSeq Acc Id: ENSP00000428442   ⟸   ENST00000522024
RefSeq Acc Id: ENSP00000428365   ⟸   ENST00000522528
RefSeq Acc Id: ENSP00000428159   ⟸   ENST00000522971
RefSeq Acc Id: ENSP00000430700   ⟸   ENST00000523847
Protein Domains
UPAR/Ly6

Promoters
RGD ID:7214321
Promoter ID:EPDNEW_H12907
Type:initiation region
Name:LY6E_1
Description:lymphocyte antigen 6 family member E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,018,529 - 143,018,589EPDNEW
RGD ID:6807161
Promoter ID:HG_KWN:62245
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001127213,   NM_002346,   NR_026913,   UC003YXL.2,   UC003YXO.2
Position:
Human AssemblyChrPosition (strand)Source
Build 368144,170,336 - 144,171,842 (-)MPROMDB
RGD ID:6814424
Promoter ID:HG_MGC:970
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:BC119708,   BC119709
Position:
Human AssemblyChrPosition (strand)Source
Build 368144,173,536 - 144,174,036 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.21-24.3(chr8:128220912-145049449)x3 copy number gain See cases [RCV000050830] Chr8:128220912..145049449 [GRCh38]
Chr8:129233158..146274835 [GRCh37]
Chr8:129302340..146245639 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:139447227-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|See cases [RCV000053701] Chr8:139447227..145054775 [GRCh38]
Chr8:140459470..146280161 [GRCh37]
Chr8:140528652..146250965 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:142201468-144002730)x1 copy number loss See cases [RCV000135981] Chr8:142201468..144002730 [GRCh38]
Chr8:143282829..145076898 [GRCh37]
Chr8:143280736..145148886 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8q24.22-24.3(chr8:130639182-145068712)x3 copy number gain See cases [RCV000137644] Chr8:130639182..145068712 [GRCh38]
Chr8:131651428..146294098 [GRCh37]
Chr8:131720610..146264902 [NCBI36]
Chr8:8q24.22-24.3
pathogenic|conflicting data from submitters
GRCh38/hg38 8q24.3(chr8:139236824-145068712)x3 copy number gain See cases [RCV000137466] Chr8:139236824..145068712 [GRCh38]
Chr8:140249067..146294098 [GRCh37]
Chr8:140318249..146264902 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.3(chr8:139004218-145049449)x3 copy number gain See cases [RCV000137340] Chr8:139004218..145049449 [GRCh38]
Chr8:140016461..146274835 [GRCh37]
Chr8:140085643..146245639 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:141738068-144140607)x1 copy number loss See cases [RCV000140913] Chr8:141738068..144140607 [GRCh38]
Chr8:142764538..145195510 [GRCh37]
Chr8:142823655..145267498 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000148117] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:134825277-146280828)x3 copy number gain See cases [RCV000448348] Chr8:134825277..146280828 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136378789-146295771)x3 copy number gain See cases [RCV000512003] Chr8:136378789..146295771 [GRCh37]
Chr8:8q24.22-24.3
likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142840194-146280020) copy number gain Intellectual disability [RCV000626547] Chr8:142840194..146280020 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q23.3-24.3(chr8:114853126-146295771)x3 copy number gain See cases [RCV000512401] Chr8:114853126..146295771 [GRCh37]
Chr8:8q23.3-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121694649-146295771)x3 copy number gain not provided [RCV000683044] Chr8:121694649..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143815037-146295771)x3 copy number gain not provided [RCV000683020] Chr8:143815037..146295771 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144056476-144733805)x1 copy number loss not provided [RCV000747921] Chr8:144056476..144733805 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:144097119-144359147)x3 copy number gain not provided [RCV000747923] Chr8:144097119..144359147 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:144103435-144132364)x0 copy number loss not provided [RCV000747924] Chr8:144103435..144132364 [GRCh37]
Chr8:8q24.3
benign
NM_002346.3(LY6E):c.331G>A (p.Val111Ile) single nucleotide variant not provided [RCV000963654] Chr8:143021724 [GRCh38]
Chr8:144103141 [GRCh37]
Chr8:8q24.3
benign
NM_002346.3(LY6E):c.315C>T (p.Gly105=) single nucleotide variant not provided [RCV000971224] Chr8:143021708 [GRCh38]
Chr8:144103125 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
NM_002346.3(LY6E):c.310G>A (p.Asp104Asn) single nucleotide variant not provided [RCV000882711] Chr8:143021703 [GRCh38]
Chr8:144103120 [GRCh37]
Chr8:8q24.3
likely benign
NM_002346.3(LY6E):c.306G>A (p.Ala102=) single nucleotide variant not provided [RCV000963653] Chr8:143021699 [GRCh38]
Chr8:144103116 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:122193546-146295771)x3 copy number gain not provided [RCV000849762] Chr8:122193546..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142988974-144218537)x3 copy number gain not provided [RCV000846118] Chr8:142988974..144218537 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8q24.3(chr8:142132678-145569441)x1 copy number loss not provided [RCV001006150] Chr8:142132678..145569441 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143570920-144459613)x1 copy number loss not provided [RCV001006151] Chr8:143570920..144459613 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8q24.13-24.3(chr8:125496223-146295771)x3 copy number gain not provided [RCV000845705] Chr8:125496223..146295771 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136059859-146295771)x3 copy number gain not provided [RCV000847171] Chr8:136059859..146295771 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143616831-144930611)x1 copy number loss not provided [RCV001006152] Chr8:143616831..144930611 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.21-24.3(chr8:128877995-146295771)x3 copy number gain not provided [RCV001006146] Chr8:128877995..146295771 [GRCh37]
Chr8:8q24.21-24.3
pathogenic
GRCh37/hg19 8q24.23-24.3(chr8:139188797-146295771)x3 copy number gain not provided [RCV000846814] Chr8:139188797..146295771 [GRCh37]
Chr8:8q24.23-24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121042467-146295771)x3 copy number gain not provided [RCV001006140] Chr8:121042467..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6727 AgrOrtholog
COSMIC LY6E COSMIC
Ensembl Genes ENSG00000160932 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000278032 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000292494 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000414307 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000427915 UniProtKB/Swiss-Prot
  ENSP00000428159 UniProtKB/Swiss-Prot
  ENSP00000428169 UniProtKB/Swiss-Prot
  ENSP00000428365 UniProtKB/TrEMBL
  ENSP00000428427 UniProtKB/TrEMBL
  ENSP00000428442 UniProtKB/Swiss-Prot
  ENSP00000428467 UniProtKB/TrEMBL
  ENSP00000428572 UniProtKB/Swiss-Prot
  ENSP00000430131 UniProtKB/TrEMBL
  ENSP00000430700 UniProtKB/TrEMBL
  ENSP00000430770 UniProtKB/TrEMBL
  ENSP00000430796 UniProtKB/TrEMBL
  ENSP00000482517 UniProtKB/Swiss-Prot
  ENSP00000487664 UniProtKB/Swiss-Prot
  ENSP00000487700 UniProtKB/TrEMBL
  ENSP00000488115 UniProtKB/TrEMBL
  ENSP00000488121 UniProtKB/TrEMBL
  ENSP00000488311 UniProtKB/TrEMBL
  ENSP00000488414 UniProtKB/TrEMBL
  ENSP00000488421 UniProtKB/Swiss-Prot
  ENSP00000488443 UniProtKB/Swiss-Prot
  ENSP00000488556 UniProtKB/Swiss-Prot
  ENSP00000488559 UniProtKB/Swiss-Prot
  ENSP00000488627 UniProtKB/TrEMBL
  ENSP00000488743 UniProtKB/TrEMBL
  ENSP00000488891 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000292494 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000429120 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000517503 UniProtKB/TrEMBL
  ENST00000519546 UniProtKB/TrEMBL
  ENST00000519611 UniProtKB/TrEMBL
  ENST00000520466 UniProtKB/Swiss-Prot
  ENST00000520531 UniProtKB/TrEMBL
  ENST00000521003 UniProtKB/Swiss-Prot
  ENST00000521182 UniProtKB/TrEMBL
  ENST00000521699 UniProtKB/Swiss-Prot
  ENST00000522024 UniProtKB/Swiss-Prot
  ENST00000522528 UniProtKB/TrEMBL
  ENST00000522971 UniProtKB/Swiss-Prot
  ENST00000523847 UniProtKB/TrEMBL
  ENST00000619718 UniProtKB/Swiss-Prot
  ENST00000631568 UniProtKB/Swiss-Prot
  ENST00000632232 UniProtKB/TrEMBL
  ENST00000632424 UniProtKB/Swiss-Prot
  ENST00000632516 UniProtKB/Swiss-Prot
  ENST00000632519 UniProtKB/Swiss-Prot
  ENST00000632618 UniProtKB/TrEMBL
  ENST00000632812 UniProtKB/Swiss-Prot
  ENST00000632902 UniProtKB/TrEMBL
  ENST00000632978 UniProtKB/TrEMBL
  ENST00000633451 UniProtKB/Swiss-Prot
  ENST00000633551 UniProtKB/TrEMBL
  ENST00000633898 UniProtKB/TrEMBL
  ENST00000633934 UniProtKB/TrEMBL
GTEx ENSG00000160932 GTEx
  ENSG00000278032 GTEx
HGNC ID HGNC:6727 ENTREZGENE
Human Proteome Map LY6E Human Proteome Map
InterPro LY6_UPA_recep-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4061 UniProtKB/Swiss-Prot
NCBI Gene 4061 ENTREZGENE
OMIM 601384 OMIM
Pfam UPAR_LY6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30491 PharmGKB
SMART SM00134 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3DWJ1_HUMAN UniProtKB/TrEMBL
  E5RGI6_HUMAN UniProtKB/TrEMBL
  E5RI33_HUMAN UniProtKB/TrEMBL
  E5RI58_HUMAN UniProtKB/TrEMBL
  E5RIQ1_HUMAN UniProtKB/TrEMBL
  E7EWF8_HUMAN UniProtKB/TrEMBL
  LY6E_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2R4X5 UniProtKB/Swiss-Prot
  D3DWJ2 UniProtKB/Swiss-Prot
  Q0VDE5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-31 LY6E  lymphocyte antigen 6 family member E    lymphocyte antigen 6 complex, locus E  Symbol and/or name change 5135510 APPROVED