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Gene: S100A8 (S100 calcium binding protein A8) Homo sapiens
Symbol: S100A8
Name: S100 calcium binding protein A8
Description: Predicted to have several functions, including arachidonic acid binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including leukocyte migration; neutrophil aggregation; and positive regulation of apoptotic process. Localizes to the cytosol; extracellular space; and intermediate filament cytoskeleton. Implicated in myocarditis. Biomarker of urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 60B8AG; CAGA; calgranulin A; calgranulin-A; calprotectin L1L subunit; CFAG; CGLA; CP-10; cystic fibrosis antigen; L1Ag; leukocyte L1 complex light chain; MA387; MIF; migration inhibitory factor-related protein 8; MRP-8; MRP8; NIF; P8; protein S100-A8; s100 calcium binding protein a8 (calgranulin a); S100 calcium-binding protein A8 (calgranulin A); urinary stone protein band A
Mus musculus (house mouse) : S100a8 (S100 calcium binding protein A8 (calgranulin A))  MGI  Alliance
Rattus norvegicus (Norway rat) : S100a8 (S100 calcium binding protein A8)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : S100A8 (S100 calcium binding protein A8)
Canis lupus familiaris (dog) : S100A8 (S100 calcium binding protein A8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : S100a8 (S100 calcium binding protein A8)
Sus scrofa (pig) : S100A8 (S100 calcium binding protein A8)
Chlorocebus sabaeus (African green monkey) : S100A8 (S100 calcium binding protein A8)
Heterocephalus glaber (naked mole-rat) : S100a8 (S100 calcium binding protein A8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1153,390,032 - 153,391,073 (-)EnsemblGRCh38hg38GRCh38
GRCh381153,390,032 - 153,422,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371153,362,508 - 153,395,054 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361151,629,132 - 151,630,173 (-)NCBINCBI36hg18NCBI36
Build 341150,175,581 - 150,176,622NCBI
Celera1126,433,763 - 126,434,804 (-)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1124,725,919 - 124,727,075 (-)NCBIHuRef
CHM1_11154,758,221 - 154,790,773 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on S100A8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1349531
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.