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Gene: ULK1 (unc-51 like autophagy activating kinase 1) Homo sapiens
Symbol: ULK1
Name: unc-51 like autophagy activating kinase 1
RGD ID: 1344835
Description: Exhibits Rab GTPase binding activity; identical protein binding activity; and protein serine/threonine kinase activity. Involved in several processes, including macroautophagy; positive regulation by symbiont of host autophagy; and protein phosphorylation. Localizes to Atg1/ULK1 kinase complex; cytosol; and extrinsic component of organelle membrane. Colocalizes with guanyl-nucleotide exchange factor complex; PARTICIPATES IN mTOR signaling pathway; autophagy pathway; mitochondrial autophagy pathway; INTERACTS WITH (+)-Tetrandrine; (-)-anisomycin; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATG1; ATG1 autophagy related 1 homolog; ATG1A; autophagy-related protein 1 homolog; FLJ38455; FLJ46475; hATG1; serine/threonine-protein kinase ULK1; UNC51; Unc51.1
Mus musculus (house mouse) : Ulk1 (unc-51 like kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ulk1 (unc-51 like autophagy activating kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ulk1 (unc-51 like autophagy activating kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ULK1 (unc-51 like autophagy activating kinase 1)
Canis lupus familiaris (dog) : ULK1 (unc-51 like autophagy activating kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ulk1 (unc-51 like autophagy activating kinase 1)
Sus scrofa (pig) : ULK1 (unc-51 like autophagy activating kinase 1)
Chlorocebus sabaeus (African green monkey) : ULK1 (unc-51 like autophagy activating kinase 1)
Heterocephalus glaber (naked mole-rat) : Ulk1 (unc-51 like autophagy activating kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl12131,894,622 - 131,923,150 (+)EnsemblGRCh38hg38GRCh38
GRCh3812131,894,622 - 131,923,150 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712132,379,279 - 132,407,707 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612130,945,232 - 130,973,649 (+)NCBINCBI36hg18NCBI36
Build 3412131,045,508 - 131,073,926NCBI
Celera12132,008,428 - 132,026,099 (+)NCBI
Cytogenetic Map12q24.33NCBI
HuRef12129,276,372 - 129,293,381 (+)NCBIHuRef
CHM1_112132,200,212 - 132,228,619 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ULK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344835
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.